KEGG   ORTHOLOGY: K07412
Entry
K07412                      KO                                     

Name
CYP2B
Definition
cytochrome P450 family 2 subfamily B [EC:1.14.14.1]
Pathway
ko00140  Steroid hormone biosynthesis
ko00590  Arachidonic acid metabolism
ko00830  Retinol metabolism
ko01100  Metabolic pathways
ko05204  Chemical carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
   00590 Arachidonic acid metabolism
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07412  CYP2B; cytochrome P450 family 2 subfamily B
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07412  CYP2B; cytochrome P450 family 2 subfamily B
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07412  CYP2B; cytochrome P450 family 2 subfamily B
Other DBs
RN: R03408 R07001 R07048 R07050 R07051 R07052 R08390 R08391 R08392
Genes
MMU: 13088(Cyp2b10) 13089(Cyp2b13) 13090(Cyp2b19) 13094(Cyp2b9) 243881(Cyp2b23)
MCAL: 110288965 110297861 110298448 110298729 110298847
MPAH: 110336742
RNO: 103691072 103691092 24300(Cyp2b1) 286953(Cyp2b3) 292728(Cyp2b21) 29295(Cyp2b12) 361523(Cyp2b2) 685222(Cyp2b15)
MUN: 110566202
CGE: 100759787 100760248 100762876 100763166 100763652 100765152 100765441 113837198 113838302
NGI: 103734444 103734445
HGL: 101700457 101713256
CCAN: 109680163 109703253
OCU: 100327257(CYP2B4) 100328947(CYP2B5) 100328948 100353574
CFA: 474177(CYP2B6)
VVP: 112928354
PPAD: 109261476
BTA: 504769(CYP2B6) 530571
SSC: 102165015 403104(CYP2B22)
MYB: 102245131
MYD: 102751643
DRO: 112319965
MJV: 108405662
TMU: 101341442
SHR: 100931571
OAA: 100074363
 » show all
Reference
PMID:6306654 (CYP2B2)
  Authors
Mizukami Y, Sogawa K, Suwa Y, Muramatsu M, Fujii-Kuriyama Y
  Title
Gene structure of a phenobarbital-inducible cytochrome P-450 in rat liver.
  Journal
Proc Natl Acad Sci U S A 80:3958-62 (1983)
DOI:10.1073/pnas.80.13.3958
  Sequence
[rno:361523]
Reference
PMID:3396451 (CYP2B3)
  Authors
Labbe D, Jean A, Anderson A
  Title
A constitutive member of the rat cytochrome P450IIB subfamily: full-length coding sequence of the P450IIB3 cDNA.
  Journal
DNA 7:253-60 (1988)
DOI:10.1089/dna.1988.7.253
  Sequence
[rno:286953]
Reference
PMID:3219345 (CYP2B9 CYP2B10)
  Authors
Noshiro M, Lakso M, Kawajiri K, Negishi M
  Title
Rip locus: regulation of female-specific isozyme (I-P-450(16 alpha) of testosterone 16 alpha-hydroxylase in mouse liver, chromosome localization, and cloning of P-450 cDNA.
  Journal
Biochemistry 27:6434-43 (1988)
DOI:10.1021/bi00417a035
  Sequence
[mmu:13094 13088]
Reference
PMID:2116765 (CYP2B11)
  Authors
Graves PE, Elhag GA, Ciaccio PJ, Bourque DP, Halpert JR
  Title
cDNA and deduced amino acid sequences of a dog hepatic cytochrome P450IIB responsible for the metabolism of 2,2',4,4',5,5'-hexachlorobiphenyl.
  Journal
Arch Biochem Biophys 281:106-15 (1990)
DOI:10.1016/0003-9861(90)90419-y
  Sequence
[cfa:474177]
Reference
PMID:1445240 (CYP2B12)
  Authors
Friedberg T, Grassow MA, Bartlomowicz-Oesch B, Siegert P, Arand M, Adesnik M, Oesch F
  Title
Sequence of a novel cytochrome CYP2B cDNA coding for a protein which is expressed in a sebaceous gland, but not in the liver.
  Journal
Biochem J 287 ( Pt 3):775-83 (1992)
DOI:10.1042/bj2870775
  Sequence
[rno:29295]
Reference
PMID:8294026 (CYP2B15)
  Authors
Nakayama K, Suwa Y, Mizukami Y, Sogawa K, Fujii-Kuriyama Y
  Title
Cloning and sequencing of a novel rat cytochrome P450 2B-encoding gene.
  Journal
Gene 136:333-6 (1993)
DOI:10.1016/0378-1119(93)90490-t
  Sequence
[rno:685222]
Reference
PMID:9799616 (CYP2B19)
  Authors
Keeney DS
  Title
The novel skin-specific cytochrome P450 Cyp2b19 maps to proximal chromosome 7 in the mouse, near a cluster of Cyp2 family genes.
  Journal
Genomics 53:417-9 (1998)
DOI:10.1006/geno.1998.5533
  Sequence
[mmu:13090]
Reference
PMID:11159754 (CYP2B21)
  Authors
Brookman-Amissah N, Mackay AG, Swann PF
  Title
Isolation and sequencing of the cDNA of a novel cytochrome P450 from rat oesophagus.
  Journal
Carcinogenesis 22:155-60 (2001)
DOI:10.1093/carcin/22.1.155
  Sequence
[rno:292728]
Reference
PMID:16315095 (CYP2B22)
  Authors
Kawahigashi H, Hirose S, Ozawa K, Ido Y, Kojima M, Ohkawa H, Ohkawa Y
  Title
Analysis of substrate specificity of pig CYP2B22 and CYP2C49 towards herbicides by transgenic rice plants.
  Journal
Transgenic Res 14:907-17 (2005)
DOI:10.1007/s11248-005-0199-x
  Sequence
[ssc:403104]

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