KEGG   ORTHOLOGY: K07413
Entry
K07413                      KO                                     

Name
CYP2C
Definition
cytochrome P450 family 2 subfamily C [EC:1.14.14.1]
Pathway
ko00140  Steroid hormone biosynthesis
ko00590  Arachidonic acid metabolism
ko00591  Linoleic acid metabolism
ko00830  Retinol metabolism
ko01100  Metabolic pathways
ko04726  Serotonergic synapse
ko04750  Inflammatory mediator regulation of TRP channels
ko05204  Chemical carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
   00590 Arachidonic acid metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
   00591 Linoleic acid metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09150 Organismal Systems
  09156 Nervous system
   04726 Serotonergic synapse
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07413  CYP2C; cytochrome P450 family 2 subfamily C
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07413  CYP2C; cytochrome P450 family 2 subfamily C
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07413  CYP2C; cytochrome P450 family 2 subfamily C
Other DBs
RN: R03408 R07042 R07043 R07048 R07050 R07051 R07052 R07054 R07055 R07056 R08390 R08392
Genes
PON: 100449185
MCC: 100424240(CYP2C76)
MCF: 102114994(CYP2C76)
RRO: 104664669 104664684
RBB: 108543807 108543808
CJC: 100391987(CYP2C76)
SBQ: 101040831
MMU: 107141(Cyp2c50) 13095(Cyp2c29) 13096(Cyp2c37) 13097(Cyp2c38) 13098(Cyp2c39) 13099(Cyp2c40) 226105(Cyp2c70) 226143(Cyp2c23) 404195(Cyp2c54) 433247(Cyp2c68) 69888(Cyp2c66) 72082(Cyp2c55) 72303(Cyp2c65)
MCAL: 110285234 110285299 110285739 110288497
MPAH: 110318652 110321409 110323738
RNO: 171518(Cyp2c22) 171521(Cyp2c13) 25011(Cyp2c12) 29277(Cyp2c11) 29298(Cyp2c7) 293989(Cyp2c6v1) 499353(Cyp2c24) 83790(Cyp2c23)
MUN: 110540047 110540049 110541031 110546312 110552973 110554760
CGE: 100751762 100751778 100752064 100753681 100754177 100754462 100756757 100772776
NGI: 103732440 103732445 103744062 103752530
HGL: 101708592 101710990
CCAN: 109675594 109686866 109686867
OCU: 100328549(CYP2C5) 100328924(CYP2C2) 100328933(CYP2C) 100328935(CYP2C30) 100328936(CYP2C14) 100328938(CYP2C16) 100345193 100346305 100346743(CYP2C1) 100349436(CYP2C4) 100353460 103351405
TUP: 102467726 102501371 102503066
CFA: 100688697 415122(CYP2C18)
VVP: 112917651 112917654 112928780
AML: 100468534 100470213 100471407
UMR: 103659697 103670756
UAH: 113243099 113249437 113251748 113252105
ORO: 101365057 101365655 101383285
ELK: 111144935 111144947
FCA: 101089396 101089804
PTG: 102957879 102958169
PPAD: 109264681 109264682
AJU: 106965832 106965834
BTA: 505468 510380(CYP2C19) 511498 535243(CYP2C18) 616593(CYP2C87) 785540
BOM: 102266046 102268262 102279786 102280731 102282716 102285833
BIU: 109553136 109553148 109553149 109553151 109553186 109579059
BBUB: 102391944 102392701 102398418 102401059 102401347
CHX: 100861186 102169851 102180722 102185708 102185739 102188304 106503891 108633308
OAS: 100534653(CYP2C19) 100568290(CYP2C18) 101106641 101107056 101107486 101120535 114108598 114110259
SSC: 100739741 403106(CYP2C32) 403107(CYP2C33) 403108(CYP2C34) 403110(CYP2C36) 403111(CYP2C42) 403215(CYP2C49)
CFR: 102505530 102520553 102520945 102521185 102521601
CDK: 105084249 105084251 105084253 105084254 105084313
BACU: 103017669
LVE: 103084494
OOR: 101280390 101281073
DLE: 111172397
PCAD: 102978514 102990258
ECB: 100061367 100061400 100061440(CYP2C92) 100061470 100061502 100061579(CYP2C113) 100061609 100070400
EPZ: 103555431 103555432 103559687 103559691 103563727 103564575
EAI: 106828038 106842115 106842116 106842117 106842118 106846096 106846703
MYB: 102259201 102262062
MYD: 102757298 102761651
MNA: 107542552 107542558 107543271
HAI: 109379576 109380905 109380969 109380970
DRO: 112300219
PALE: 102891905
MJV: 108409895
LAV: 100666635 100675653 100676133 100676880
TMU: 101340781 101346446 101346874 101350013 101350258
MDO: 100023149 100023204 100023235 100026569 100026598 100026637 100028608
SHR: 100915447 100920607 100927632 100928062 100933766
PCW: 110192769 110200600 110200601 110213986 110215468
GGA: 100858007(RP11-400G3.5) 414833(CYP2C45)
MGP: 100544448
CJO: 107315788
NMEL: 110399446
APLA: 101797318 101805432 113844003
ACYG: 106034197 106046725
TGU: 100219254 100228872
LSR: 110475152 110480306
SCAN: 103813978 103819903
GFR: 102041497 102043152
FAB: 101806491 101815619
PHI: 102100933 102107291
PMAJ: 107207028 107212622
CCAE: 111931097 111937179
CCW: 104695623 104697085
ETL: 114065370
FPG: 101913238 101916760
FCH: 102048002 102059256
CLV: 102087915 102098038
EGZ: 104125355 104129118
NNI: 104010978 104018935
ACUN: 113481765 113486792
PADL: 103915567 103918695
AAM: 106498947 106499405
ASN: 102372575 102385966 102386218
AMJ: 102572949 102573559 102573618
CMY: 102931882
CPIC: 101945572 101950120
ACS: 100552964 100553664 100554667 100561903 100562097 100562499 100565059
PVT: 110070438 110084010 110090724
PBI: 103054127 103067414
PMUR: 107296151
TSR: 106538299
PMUA: 114590635 114590645 114590725 114590727
XLA: 108699286 379297(cyp2c8.1.S) 444542(cyp2c8.2.L)
XTR: 448236(cyp2c8.2)
NPR: 108800780
RTP: 109917556
BFO: 118416246
AG: AAC08738(CYP2C41) BAA02001(CYP2C26) BAA02002(CYP2C27) BAA02003(CYP2C28) CAA44753(CYP2C25)
 » show all
Reference
PMID:2831965 (CYP2C2)
  Authors
Imai Y, Komori M, Sato R
  Title
Comparison of primary structures deduced from cDNA nucleotide sequences for various forms of liver microsomal cytochrome P-450 from phenobarbital-treated rabbits.
  Journal
Biochemistry 27:80-8 (1988)
DOI:10.1021/bi00401a014
  Sequence
[ocu:100328924]
Reference
PMID:3335521 (CYP2C7)
  Authors
Kimura H, Yoshioka H, Sogawa K, Sakai Y, Fujii-Kuriyama Y
  Title
Complementary DNA cloning of cytochrome P-450s related to P-450(M-1) from the complementary DNA library of female rat livers. Predicted primary structures for  P-450f, PB-1, and PB-1-related protein with a bizarre replacement block and their mode of transcriptional expression.
  Journal
J Biol Chem 263:701-7 (1988)
  Sequence
[rno:29298]
Reference
PMID:8611037 (CYP2C11)
  Authors
Biagini C, Celier C
  Title
cDNA-directed expression of two allelic variants of cytochrome P450 2C11 using COS1 and SF21 insect cells.
  Journal
Arch Biochem Biophys 326:298-305 (1996)
DOI:10.1006/abbi.1996.0079
  Sequence
[rno:29277]
Reference
PMID:2820951 (CYP2C14)
  Authors
Imai Y
  Title
Cytochrome P-450 related to P-4504 from phenobarbital-treated rabbit liver: molecular cloning of cDNA and characterization of cytochrome P-450 obtained by its expression in yeast cells.
  Journal
J Biochem 101:1129-39 (1987)
DOI:10.1093/oxfordjournals.jbchem.a121977
  Sequence
[ocu:100328936]
Reference
PMID:2263487 (CYP2C23)
  Authors
Cook EA, Groenewegen WA, Gloger IS, Piggott JR, Suckling KE, Wolf CR
  Title
cDNA and deduced amino acid sequence of a novel cytochrome P-450 from female rat liver mRNA with high homology to P-450 IIC family.
  Journal
Nucleic Acids Res 18:7156 (1990)
DOI:10.1093/nar/18.23.7156
  Sequence
[rno:83790]
Reference
PMID:8114672 (CYP2C25 CYP2C26 CYP2C27)
  Authors
Sakuma T, Masaki K, Itoh S, Yokoi T, Kamataki T
  Title
Sex-related differences in the expression of cytochrome P450 in hamsters: cDNA cloning and examination of the expression of three distinct CYP2C cDNAs.
  Journal
Mol Pharmacol 45:228-36 (1994)
  Sequence
Reference
PMID:7771794 (CYP2C28)
  Authors
Sakuma T, Yokoi T, Kamataki T
  Title
Isolation and characterization of a new cDNA clone belonging to the cytochrome P450 2C gene subfamily in hamsters.
  Journal
Arch Biochem Biophys 319:267-73 (1995)
DOI:10.1006/abbi.1995.1291
  Sequence
Reference
PMID:8130255 (CYP2C29)
  Authors
Matsunaga T, Watanabe K, Yamamoto I, Negishi M, Gonzalez FJ, Yoshimura H
  Title
cDNA cloning and sequence of CYP2C29 encoding P-450 MUT-2, a microsomal aldehyde oxygenase.
  Journal
Biochim Biophys Acta 1184:299-301 (1994)
DOI:10.1016/0005-2728(94)90237-2
  Sequence
[mmu:13095]
Reference
PMID:9721182 (CYP2C37)
  Authors
Luo G, Zeldin DC, Blaisdell JA, Hodgson E, Goldstein JA
  Title
Cloning and expression of murine CYP2Cs and their ability to metabolize arachidonic acid.
  Journal
Arch Biochem Biophys 357:45-57 (1998)
DOI:10.1006/abbi.1998.0806
  Sequence
[mmu:13096]
Reference
PMID:9492393 (CYP2C41)
  Authors
Blaisdell J, Goldstein JA, Bai SA
  Title
Isolation of a new canine cytochrome P450 CDNA from the cytochrome P450 2C subfamily (CYP2C41) and evidence for polymorphic differences in its expression.
  Journal
Drug Metab Dispos 26:278-83 (1998)
  Sequence
Reference
PMID:15102943 (CYP2C50)
  Authors
Wang H, Zhao Y, Bradbury JA, Graves JP, Foley J, Blaisdell JA, Goldstein JA, Zeldin DC
  Title
Cloning, expression, and characterization of three new mouse cytochrome p450 enzymes and partial characterization of their fatty acid oxidation activities.
  Journal
Mol Pharmacol 65:1148-58 (2004)
DOI:10.1124/mol.65.5.1148
  Sequence
[mmu:107141]
Reference
PMID:2263625 (CYP2C70)
  Authors
Emi Y, Chijiiwa C, Omura T
  Title
A different cytochrome P450 form is induced in primary cultures of rat hepatocytes.
  Journal
Proc Natl Acad Sci U S A 87:9746-50 (1990)
DOI:10.1073/pnas.87.24.9746
  Sequence
[rno:171518]

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Ontology (3)   
   KEGG BRITE (3)   
Pathway (16)   
   KEGG PATHWAY (16)   
Chemical reaction (20)   
   KEGG ENZYME (1)   
   KEGG REACTION (12)   
   KEGG RCLASS (7)   
Gene (368)   
   KEGG GENES (310)   
   KEGG MGENES (6)   
   RefGene (50)   
   OC (2)   
Literature (12)   
   PubMed (12)   
All databases (419)   

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