KEGG   ORTHOLOGY: K07415Help
Entry
K07415                      KO                                     

Name
CYP2E1
Definition
cytochrome P450 family 2 subfamily E polypeptide 1 [EC:1.14.13.-]
Pathway
ko00140  Steroid hormone biosynthesis
ko00590  Arachidonic acid metabolism
ko00591  Linoleic acid metabolism
ko00980  Metabolism of xenobiotics by cytochrome P450
ko00982  Drug metabolism - cytochrome P450
ko00983  Drug metabolism - other enzymes
ko01100  Metabolic pathways
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko05204  Chemical carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E polypeptide 1
   00590 Arachidonic acid metabolism
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E polypeptide 1
   00591 Linoleic acid metabolism
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E polypeptide 1
  Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E polypeptide 1
   00982 Drug metabolism - cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E polypeptide 1
   00983 Drug metabolism - other enzymes
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E polypeptide 1
 Human Diseases
  Cancers
   05204 Chemical carcinogenesis
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E polypeptide 1
  Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E polypeptide 1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.-  
     K07415  CYP2E1; cytochrome P450 family 2 subfamily E polypeptide 1
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07415  CYP2E1; cytochrome P450 family 2 subfamily E polypeptide 1
BRITE hierarchy
Other DBs
RN: R03408 R07000 R07001 R07021 R07022 R07046 R07055 R07056 R07066 R07068 R07075 R07088 R07089 R07090 R07098 R07099 R07107 R07112 R08303 R08304 R09421 R11904
Genes
HSA: 1571(CYP2E1)
PTR: 450857(CYP2E1)
PPS: 100981327
GGO: 101150276 101151246
PON: 100173813(CYP2E1)
NLE: 100594173
MCC: 678688(CYP2E1)
MCF: 102136686(CYP2E1) 107130915
CSAB: 103245979(CYP2E1)
RRO: 104680852
RBB: 108543398
CJC: 100397922(CYP2E1)
SBQ: 101046377
MMU: 13106(Cyp2e1)
RNO: 25086(Cyp2e1)
CGE: 100765891
NGI: 103725848
HGL: 101722366
CCAN: 109701182
OCU: 100342322 100342572(CYP2E)
TUP: 102496668
CFA: 415128(CYP2E1)
AML: 100472056
UMR: 103658635
ORO: 101365364
FCA: 111559107 554227(CYP2E2)
PTG: 102969051
AJU: 106987509
BTA: 282213(CYP2E1)
BOM: 102281471
BIU: 109553162
PHD: 102322636
CHX: 102182294
OAS: 100568285(CYP2E1)
SSC: 403216(CYP2E1)
CFR: 102510124
CDK: 105096474
BACU: 102997947
LVE: 103086718
OOR: 101275906
ECB: 100066422(CYP2E1)
EPZ: 103556383
EAI: 106841091
MYB: 102260262
MYD: 102760593
HAI: 109383522(CYP2E1)
RSS: 109445723
MDO: 100015828
SHR: 100915303
OAA: 100087763
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3782137
  Authors
Song BJ, Gelboin HV, Park SS, Yang CS, Gonzalez FJ
  Title
Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.
  Journal
J Biol Chem 261:16689-97 (1986)
  Sequence
[hsa:1571]

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