KEGG   ORTHOLOGY: K07415
Entry
K07415                      KO                                     
Symbol
CYP2E1
Name
cytochrome P450 family 2 subfamily E1 [EC:1.14.14.-]
Pathway
map00140  Steroid hormone biosynthesis
map00590  Arachidonic acid metabolism
map00591  Linoleic acid metabolism
map00980  Metabolism of xenobiotics by cytochrome P450
map00982  Drug metabolism - cytochrome P450
map00983  Drug metabolism - other enzymes
map01100  Metabolic pathways
map04932  Non-alcoholic fatty liver disease
map04936  Alcoholic liver disease
map05204  Chemical carcinogenesis - DNA adducts
map05208  Chemical carcinogenesis - reactive oxygen species
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00590 Arachidonic acid metabolism
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00591 Linoleic acid metabolism
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
  09111 Xenobiotics biodegradation and metabolism
   00980 Metabolism of xenobiotics by cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00982 Drug metabolism - cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   00983 Drug metabolism - other enzymes
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis - DNA adducts
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   05208 Chemical carcinogenesis - reactive oxygen species
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
  09167 Endocrine and metabolic disease
   04936 Alcoholic liver disease
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
   04932 Non-alcoholic fatty liver disease
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.-
     K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07415  CYP2E1; cytochrome P450 family 2 subfamily E1
Other DBs
RN: R03408 R07000 R07001 R07021 R07022 R07046 R07055 R07056 R07066 R07068 R07075 R07088 R07089 R07090 R07098 R07099 R07107 R07112 R08303 R08304 R09421 R11904
Genes
HSA: 1571(CYP2E1)
PTR: 450857(CYP2E1)
PPS: 100981327(CYP2E1)
GGO: 101151246
PON: 100173813(CYP2E1)
NLE: 100594173
MCC: 114669719 114669866 678688(CYP2E1)
MCF: 102136686
CSAB: 103245979(CYP2E1)
CATY: 105598973 105599024
RRO: 104680852
RBB: 108543398
TFN: 117082874
PTEH: 111522057
CJC: 100397922(CYP2E1)
SBQ: 101046377
CSYR: 103265545
MMUR: 105861495
OGA: 100958050
MMU: 13106(Cyp2e1)
MCAL: 110297258
MPAH: 110329381
RNO: 25086(Cyp2e1)
MCOC: 116103187
MUN: 110540184
CGE: 100765891
PLEU: 114693387
NGI: 103725848
HGL: 101722366
CPOC: 100727914
CCAN: 109701182
NCAR: 124974930
OCU: 100342322 100342572(CYP2E)
OPI: 101532509
TUP: 102496668
CFA: 415128(CYP2E1)
VVP: 112928781
VLG: 121485389
AML: 100472056
UMR: 103658635
UAH: 113252104
UAR: 123800068
ELK: 111145414
LLV: 125085126
MPUF: 101673971
ORO: 101365364
EJU: 114221828
ZCA: 113923429
MLX: 117998120
FCA: 554227(CYP2E2)
PYU: 121037436
PBG: 122493427
PTG: 102969051
PPAD: 109256725
AJU: 106987509
HHV: 120245389
BTA: 282213(CYP2E1)
BOM: 102281471
BIU: 109553162
BBUB: 102416619
CHX: 102182294
OAS: 100568285(CYP2E1)
ODA: 120873945
CCAD: 122446540
SSC: 403216(CYP2E1)
CFR: 102510124
CBAI: 105067428
CDK: 105096474
VPC: 102526191
BACU: 102997947
LVE: 103086718
OOR: 101275906
DLE: 111172152
PCAD: 102993260
PSIU: 116741596
ECB: 100066422(CYP2E1)
EPZ: 103556383
EAI: 106841091
MYB: 102260262
MYD: 102760593
MMYO: 118669676
MLF: 102427162
PKL: 118719546
HAI: 109383522(CYP2E1)
DRO: 112300228
AJM: 119059516
PDIC: 114497239
PHAS: 123828775
MMF: 118632687
RFQ: 117036334
TOD: 119234161
DNM: 101420221
MDO: 100015828
GAS: 123236454
PCW: 110214053
OAA: 100092254
MMER: 123542169
 » show all
Reference
PMID:3782137
  Authors
Song BJ, Gelboin HV, Park SS, Yang CS, Gonzalez FJ
  Title
Complementary DNA and protein sequences of ethanol-inducible rat and human cytochrome P-450s. Transcriptional and post-transcriptional regulation of the rat enzyme.
  Journal
J Biol Chem 261:16689-97 (1986)
  Sequence
[hsa:1571]

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