KEGG   ORTHOLOGY: K07418
Entry
K07418                      KO                                     

Name
CYP2J
Definition
cytochrome P450 family 2 subfamily J [EC:1.14.14.1 1.14.14.73 1.14.14.74 1.14.14.75]
Pathway
ko00590  Arachidonic acid metabolism
ko00591  Linoleic acid metabolism
ko01100  Metabolic pathways
ko04726  Serotonergic synapse
ko04750  Inflammatory mediator regulation of TRP channels
ko04913  Ovarian steroidogenesis
ko05417  Lipid and atherosclerosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00590 Arachidonic acid metabolism
    K07418  CYP2J; cytochrome P450 family 2 subfamily J
   00591 Linoleic acid metabolism
    K07418  CYP2J; cytochrome P450 family 2 subfamily J
 09150 Organismal Systems
  09152 Endocrine system
   04913 Ovarian steroidogenesis
    K07418  CYP2J; cytochrome P450 family 2 subfamily J
  09156 Nervous system
   04726 Serotonergic synapse
    K07418  CYP2J; cytochrome P450 family 2 subfamily J
  09157 Sensory system
   04750 Inflammatory mediator regulation of TRP channels
    K07418  CYP2J; cytochrome P450 family 2 subfamily J
 09160 Human Diseases
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K07418  CYP2J; cytochrome P450 family 2 subfamily J
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07418  CYP2J; cytochrome P450 family 2 subfamily J
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07418  CYP2J; cytochrome P450 family 2 subfamily J
    1.14.14.73  albendazole monooxygenase (sulfoxide-forming)
     K07418  CYP2J; cytochrome P450 family 2 subfamily J
    1.14.14.74  albendazole monooxygenase (hydroxylating)
     K07418  CYP2J; cytochrome P450 family 2 subfamily J
    1.14.14.75  fenbendazole monooxygenase (4'-hydroxylating)
     K07418  CYP2J; cytochrome P450 family 2 subfamily J
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP2 family
   K07418  CYP2J; cytochrome P450 family 2 subfamily J
Other DBs
RN: R07042 R07043 R07044 R07045 R07046 R07048 R07050 R07051 R07052 R07055 R07056
Genes
HSA: 1573(CYP2J2)
PTR: 456896(CYP2J2)
PPS: 100984148
GGO: 101148349
PON: 100447634
NLE: 100589053
MCC: 693631
MCF: 102119662(CYP2J2)
CSAB: 103224719(CYP2J2)
RRO: 104668045
RBB: 108532916
CJC: 100397287(CYP2J2)
SBQ: 101041470
MMU: 100066(Cyp2j11) 13109(Cyp2j5) 13110(Cyp2j6) 230459(Cyp2j13) 242546(Cyp2j12) 665095(Cyp2j8) 74519(Cyp2j9)
RNO: 100912642 313373(Cyp2j10) 313375(Cyp2j3) 502969(Cyp2j16) 65210(Cyp2j4)
CCAN: 109684284
OCU: 100301544(CYP2J1)
CFA: 610195(CYP2J2)
VVP: 112926087
AML: 100482335
UMR: 103663082
UAH: 113254606
ORO: 101382939
ELK: 111143525
FCA: 101097746
PTG: 102958105
PPAD: 109266776
AJU: 106974984
LVE: 103072875
OOR: 101287985
DLE: 111175878
PCAD: 102995526
ECB: 100067247
EPZ: 103564165
EAI: 106833456
MYB: 102259820
MYD: 102765527
MNA: 107531748
PALE: 102885276
RAY: 107518358
TMU: 101350163
OAA: 100087745
GGA: 101750603(CYP2J21) 424676(CYP2J23) 424677(CYP2J22) 424729(CYP2J19)
TGU: 100224220(CYP2J40) 100230439(CYP2J19A)
SCAN: 103815060 103815209(CYP2J19)
ETL: 114069063
FPG: 101919387
AMJ: 102557714(CYP2P10)
CMY: 102936353 102940076(CYP2J19)
ACS: 100567522
DRE: 100034366(cyp2p8) 100034406(cyp2p7) 393108(cyp2p6) 393592(cyp2p9) 399485(cyp2p10) 797309(cyp2j20)
SRX: 107737305
SANH: 107665313
AMEX: 103037239
TRU: 101075700
OLA: 100302452(cyp2p3) 105353996
CSEM: 103383190
POV: 109625616
BPEC: 110173990
SASA: 106584062
OTW: 112250281
SALP: 111971193
ELS: 105025359
CMK: 103185273
RTP: 109921744
 » show all
Reference
PMID:1717443 (CYP2J1)
  Authors
Kikuta Y, Sogawa K, Haniu M, Kinosaki M, Kusunose E, Nojima Y, Yamamoto S, Ichihara K, Kusunose M, Fujii-Kuriyama Y
  Title
A novel species of cytochrome P-450 (P-450ib) specific for the small intestine of rabbits. cDNA cloning and its expression in COS cells.
  Journal
J Biol Chem 266:17821-5 (1991)
  Sequence
[ocu:100301544]
Reference
PMID:8631948 (CYP2J2)
  Authors
Wu S, Moomaw CR, Tomer KB, Falck JR, Zeldin DC
  Title
Molecular cloning and expression of CYP2J2, a human cytochrome P450 arachidonic acid epoxygenase highly expressed in heart.
  Journal
J Biol Chem 271:3460-8 (1996)
DOI:10.1074/jbc.271.7.3460
  Sequence
[hsa:1573]
Reference
PMID:9139707 (CYP2J3)
  Authors
Wu S, Chen W, Murphy E, Gabel S, Tomer KB, Foley J, Steenbergen C, Falck JR, Moomaw CR, Zeldin DC
  Title
Molecular cloning, expression, and functional significance of a cytochrome P450 highly expressed in rat heart myocytes.
  Journal
J Biol Chem 272:12551-9 (1997)
DOI:10.1074/jbc.272.19.12551
  Sequence
[rno:313375]
Reference
PMID:9570962 (CYP2J5)
  Authors
Ma J, Ramachandran S, Fiedorek FT Jr, Zeldin DC
  Title
Mapping of the CYP2J cytochrome P450 genes to human chromosome 1 and mouse chromosome 4.
  Journal
Genomics 49:152-5 (1998)
DOI:10.1006/geno.1998.5235
  Sequence
[mmu:13109]
Reference
  Authors
Scarborough PE, Ma J, Qu W, Zeldin DC
  Title
P450 subfamily CYP2J and their role in the bioactivation of arachidonic acid in extrahepatic tissues.
  Journal
Drug Metab Rev 31:205-34 (1999)
DOI:10.1081/DMR-100101915

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