KEGG   ORTHOLOGY: K07424
Entry
K07424                      KO                                     

Name
CYP3A
Definition
cytochrome P450 family 3 subfamily A [EC:1.14.14.1]
Pathway
ko00140  Steroid hormone biosynthesis
ko00591  Linoleic acid metabolism
ko00830  Retinol metabolism
ko01100  Metabolic pathways
ko05204  Chemical carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
   00591 Linoleic acid metabolism
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
 09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07424  CYP3A; cytochrome P450 family 3 subfamily A
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP3 family
   K07424  CYP3A; cytochrome P450 family 3 subfamily A
Other DBs
RN: R02356 R03408 R07055 R07056 R08390 R08391 R08392
Genes
MMU: 100041375(Cyp3a41b) 13112(Cyp3a11) 13113(Cyp3a13) 13114(Cyp3a16) 337924(Cyp3a44) 53973(Cyp3a41a) 56388(Cyp3a25)
MCAL: 110287807 110288178 110294273 110294771
MPAH: 110312811 110313181 110315701
RNO: 170509(Cyp3a62) 171352(Cyp3a9) 252931(Cyp3a18) 25642(Cyp3a23-3a1) 266682(Cyp3a2)
MUN: 110566940 110566943
CGE: 100766524 100767391 100773059 100773351
NGI: 103726479 103726480
HGL: 101700489
CCAN: 109701918 109702004
OCU: 100328954(CYP3A6)
TUP: 102494214
CFA: 415127(CYP3A26) 415129(CYP3A12) 479740(CYP3A4) 489851
ORO: 101368110
FCA: 100642187(CYP3A132) 100652377(CYP3A131)
PTG: 102957386(CYP3A131) 102957670
BTA: 282214(CYP3A5) 507988(CYP3A4) 517246(CYP3A24) 526682(CYP3A5)
SSC: 100126281(CYP3A46) 100144468(CYP3A22) 403324(CYP3A29)
BACU: 103014952
LVE: 103081108
PCAD: 102979137
ECB: 100067041(CYP3A93) 100067064(CYP3A89) 100067084(CYP3A94) 100067109(CYP3A95) 100067131(CYP3A96) 100067154(CYP3A97) 102149219
MYB: 102263738
MNA: 107540865
HAI: 109378053
GGA: 414832(CYP3A5) 416477(CYP3A4)
MGP: 678668(CYP3A80) 678669(CYP3A37)
SCAN: 103817855
AMJ: 102570482(CYP3A) 102570712
XLA: 100037189(cyp3a4) 108718493 398964 495363(cyp3a5.L)
XTR: 100487054 100487846 100494419(cyp3a4.2) 548503(cyp3a4.3)
DRE: 324340(cyp3c1) 492759(cyp3c3) 553969(cyp3a65) 558473(cyp3c2) 558541(cyp3c4)
IPU: 108257387(cyp3a40) 108258748(CYP3A125) 108258760(cyp3a27) 108258762(CYP3A128) 108258764(CYP3A127)
OLA: 100125817(cyp3a40) 101155293 101155406(cyp3a) 101155538
CVG: 107089887
CSEM: 103387006
POV: 109633951
MALB: 109970725
SALP: 112075201
LCM: 102365730
CMK: 103185125
RTP: 109917933
 » show all
Reference
PMID:3785219 (CYP3A2)
  Authors
Gonzalez FJ, Song BJ, Hardwick JP
  Title
Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation.
  Journal
Mol Cell Biol 6:2969-76 (1986)
DOI:10.1128/MCB.6.8.2969
  Sequence
[rno:266682]
Reference
PMID:1339292 (CYP3A11)
  Authors
Yanagimoto T, Itoh S, Muller-Enoch D, Kamataki T
  Title
Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone.
  Journal
Biochim Biophys Acta 1130:329-32 (1992)
DOI:10.1016/0167-4781(92)90447-8
  Sequence
[mmu:13112]
Reference
PMID:2001406 (CYP3A12)
  Authors
Ciaccio PJ, Graves PE, Bourque DP, Glinsmann-Gibson B, Halpert JR
  Title
cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily.
  Journal
Biochim Biophys Acta 1088:319-22 (1991)
DOI:10.1016/0167-4781(91)90072-t
  Sequence
[cfa:415129]
Reference
PMID:11284050 (CYP3A25)
  Authors
Dai D, Bai R, Hodgson E, Rose RL
  Title
Cloning, sequencing, heterologous expression, and characterization of murine cytochrome P450 3a25*(Cyp3a25), a testosterone 6beta-hydroxylase.
  Journal
J Biochem Mol Toxicol 15:90-9 (2001)
DOI:10.1002/jbt.4
  Sequence
[mmu:56388]
Reference
PMID:21781753 (CYP3A28)
  Authors
Natsuhori M, van Raak M, Ligtenberg M, Kleij L, Ten Berge D, Zweers-Zeilmaker WM, de Groene EM, van Miert AS, Witkamp RF, Horbach GJ
  Title
Isolation of a bovine full length cytochrome P450 (CYP3A) cDNA sequence and its functional expression in V79 cells.
  Journal
Environ Toxicol Pharmacol 3:17-24 (1997)
DOI:10.1016/s1382-6689(96)00133-0
  Sequence
[bta:282214]
Reference
PMID:9682441 (CYP3A29)
  Authors
Nissen PH, Wintero AK, Fredholm M
  Title
Mapping of porcine genes belonging to two different cytochrome P450 subfamilies.
  Journal
Anim Genet 29:7-11 (1998)
DOI:10.1046/j.1365-2052.1998.00225.x
  Sequence
[ssc:403324]
Reference
PMID:10775455 (CYP3A41)
  Authors
Sakuma T, Takai M, Endo Y, Kuroiwa M, Ohara A, Jarukamjorn K, Honma R, Nemoto N
  Title
A novel female-specific member of the CYP3A gene subfamily in the mouse liver.
  Journal
Arch Biochem Biophys 377:153-62 (2000)
DOI:10.1006/abbi.2000.1747
  Sequence
[mmu:53973]
Reference
PMID:16414346 (CYP3C1)
  Authors
Corley-Smith GE, Su HT, Wang-Buhler JL, Tseng HP, Hu CH, Hoang T, Chung WG, Buhler DR
  Title
CYP3C1, the first member of a new cytochrome P450 subfamily found in zebrafish (Danio rerio).
  Journal
Biochem Biophys Res Commun 340:1039-46 (2006)
DOI:10.1016/j.bbrc.2005.12.110
  Sequence
[dre:324340]
Reference
  Authors
McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC
  Title
Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.
  Journal
J Mol Evol 57:200-11 (2003)
DOI:10.1007/s00239-003-2466-x

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