KEGG ORTHOLOGY: K07424

ORTHOLOGY: K07424

Entry

K07424 KO

Name

CYP3A

Definition

cytochrome P450 family 3 subfamily A [EC:1.14.14.1]

Pathway

ko00140

Steroid hormone biosynthesis

ko00591

Linoleic acid metabolism

ko00830

Retinol metabolism

ko01100

Metabolic pathways

ko05204

Chemical carcinogenesis

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09103 Lipid metabolism
   00140 Steroid hormone biosynthesis
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
   00591 Linoleic acid metabolism
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
09160 Human Diseases
  09161 Cancer: overview
   05204 Chemical carcinogenesis
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07424  CYP3A; cytochrome P450 family 3 subfamily A
Enzymes [BR:ko01000]
1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.14  With reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.14.1  unspecific monooxygenase
     K07424  CYP3A; cytochrome P450 family 3 subfamily A
Cytochrome P450 [BR:ko00199]
Cytochrome P450, animal type
  CYP3 family
   K07424  CYP3A; cytochrome P450 family 3 subfamily A

Other DBs

RN:	R02356 R03408 R07055 R07056 R08390 R08391 R08392

Genes

MMU:	100041375(Cyp3a41b) 13112(Cyp3a11) 13113(Cyp3a13) 13114(Cyp3a16) 337924(Cyp3a44) 53973(Cyp3a41a) 56388(Cyp3a25)

MCAL:

110287807 110288178 110294273 110294771

MPAH:

110312811 110313181 110315701

RNO:	170509(Cyp3a62) 171352(Cyp3a9) 252931(Cyp3a18) 25642(Cyp3a23-3a1) 266682(Cyp3a2)

MUN:	110566940 110566943

CGE:	100766524 100767391 100773059 100773351

NGI:	103726479 103726480

HGL:

101700489

CCAN:

109701918 109702004

OCU:	100328954(CYP3A6)

TUP:

102494214

CFA:	415127(CYP3A26) 415129(CYP3A12) 479740(CYP3A4) 489851

VVP:	112909983 112935742 112935745

AML:	100472647 105235077

UMR:	103669994 103669998 103669999

UAH:	113249444 113267901 113267902

ORO:

101368110

ELK:	111145601 111145602 111145608

FCA:	100642187(CYP3A132) 100652377(CYP3A131)

PTG:	102957386(CYP3A131) 102957670

PPAD:

109251249 109251250

AJU:	106981196 106981197

BTA:	282214(CYP3A5) 507988(CYP3A4) 517246(CYP3A24) 526682(CYP3A5)

BOM:	102284132 102284405 102284686 102284966

BBUB:

102405595 102405926 102406240 102412400

CHX:	102168966 102181382 102191011 102191297(CYP3A)

OAS:	100170111(CYP3A24) 101110202 101110727 114108597

SSC:	100126281(CYP3A46) 100144468(CYP3A22) 403324(CYP3A29)

CFR:	102505615 102512762 102514805

CDK:	105099349 105099350

BACU:

103014952

LVE:

103081108

PCAD:

102979137

ECB:	100067041(CYP3A93) 100067064(CYP3A89) 100067084(CYP3A94) 100067109(CYP3A95) 100067131(CYP3A96) 100067154(CYP3A97) 102149219

EPZ:	103542550 103564390 103564391 103564392 103566374 103566375

EAI:	106825164 106825167 106832276 106832277

MYB:

102263738

MYD:	102756525 102762686

MNA:

107540865

HAI:

109378053

DRO:	112314814 112314817

RAY:	107508095 107509342

LAV:	100658511 100658793 100677295

TMU:	101349229 101350229

MDO:	100010783 100013114

SHR:	100918011 100930770

PCW:	110201906 110201914 110201917

OAA:	100082218 100082250 100082275 100089880 100091970

GGA:	414832(CYP3A5) 416477(CYP3A4)

MGP:	678668(CYP3A80) 678669(CYP3A37)

CJO:	107320762 107320785

NMEL:

110405948 110406034

APLA:

101799374 101799795

ACYG:

106032071 106032170

TGU:	100223162 100226034

LSR:	110481576 110481678

SCAN:

103817855

GFR:	102042286 102042456

FAB:	101815550 101818071

PHI:	102105124 102105300

PMAJ:

107210919 107211377

CCAE:

111936102 111936103

CCW:	104684806 104684807

ETL:	114060192 114060195

FPG:	101911664 101911836

FCH:	102049918 102050092

CLV:	102087823 102088003

EGZ:	104132595 104132596

NNI:	104015095 104015219

ACUN:

113485635 113485844

PADL:

103913536 103913537

AAM:	106495217 106495220

ASN:	102368695 102368945 102369208

AMJ:	102570482(CYP3A) 102570712

PSS:	102447293 102447714

CMY:	102938524 102939531 119567199 119567257

CPIC:

101944980 101945439 101945909

ACS:	100555955 100557851

PVT:	110083729 110091550

PBI:	103050164 103050666

PMUR:

107290607 107290609 107290618

TSR:	106538078 106556514

PMUA:

114584054 114584534

GJA:	107117318 107117320 107123864 107125821

XLA:	100037189(cyp3a4) 108718493 398964 495363(cyp3a5.L)

XTR:	100487054 100487846 100494419(cyp3a4.2) 548503(cyp3a4.3)

NPR:	108790579 108804467

DRE:	324340(cyp3c1) 492759(cyp3c3) 553969(cyp3a65) 558473(cyp3c2) 558541(cyp3c4)

SRX:	107720069 107740699 107748444 107748668 107758392

SANH:

107662714 107680745 107680747 107703406 107703407

SGH:	107574731 107575037 107581712 107591821

CCAR:

109061438 109061483 109081405 109081406

IPU:	108257387(cyp3a40) 108258748(CYP3A125) 108258760(cyp3a27) 108258762(CYP3A128) 108258764(CYP3A127)

PHYP:

113524841 113524842 113524843 113536086 113536087

AMEX:

103030124 103031034

EEE:	113575193 113591419

TRU:	101069124 101075886 115246460

TNG:	GSTEN00006530G001 GSTEN00014304G001

LCO:	104925565 104931688

NCC:	104952908 104955725 104962345

MZE:	101471241 101477343 101478178

ONL:	100700772 100702245 100702592 102077052

OLA:	100125817(cyp3a40) 101155293 101155406(cyp3a) 101155538

XMA:	102219031 102222638 111606488 111606645 111606646 111608645

XCO:	114138344 114138479 114144494 114144495

PRET:

103476433 103476434

CVG:

107089887

NFU:	107375867 107388844

KMR:	108244157 108244648

ALIM:

106515376 106519642

AOCE:

111572716 111574386 111579974

CSEM:

103387006

POV:

109633951

LCF:	108877940 108896255 108899376

SDU:	111216641 111227399

SLAL:

111645298 111663301

HCQ:	109511276 109512513 109528492

BPEC:

110156796 110158274

MALB:

109970725

SASA:

106568073 106591782 106591899 106593341 106594168(CP3AR)

OTW:	112214885 112222821 112239077

SALP:

112075201

ELS:	105009625 105009626 105009627

SFM:	108922555 108926524 108927524

PKI:	111845480 111854069

LCM:

CMK:

RTP:

Reference

PMID:3785219 (CYP3A2)

Authors

Gonzalez FJ, Song BJ, Hardwick JP

Title

Pregnenolone 16 alpha-carbonitrile-inducible P-450 gene family: gene conversion and differential regulation.

Journal

Mol Cell Biol 6:2969-76 (1986)
DOI:10.1128/MCB.6.8.2969

Sequence

[rno:266682]

Reference

PMID:1339292 (CYP3A11)

Authors

Yanagimoto T, Itoh S, Muller-Enoch D, Kamataki T

Title

Mouse liver cytochrome P-450 (P-450IIIAM1): its cDNA cloning and inducibility by dexamethasone.

Journal

Biochim Biophys Acta 1130:329-32 (1992)
DOI:10.1016/0167-4781(92)90447-8

Sequence

[mmu:13112]

Reference

PMID:2001406 (CYP3A12)

Authors

Ciaccio PJ, Graves PE, Bourque DP, Glinsmann-Gibson B, Halpert JR

Title

cDNA and deduced amino acid sequences of a dog liver cytochrome P-450 of the IIIA gene subfamily.

Journal

Biochim Biophys Acta 1088:319-22 (1991)
DOI:10.1016/0167-4781(91)90072-t

Sequence

[cfa:415129]

Reference

PMID:11284050 (CYP3A25)

Authors

Dai D, Bai R, Hodgson E, Rose RL

Title

Cloning, sequencing, heterologous expression, and characterization of murine cytochrome P450 3a25*(Cyp3a25), a testosterone 6beta-hydroxylase.

Journal

J Biochem Mol Toxicol 15:90-9 (2001)
DOI:10.1002/jbt.4

Sequence

[mmu:56388]

Reference

PMID:21781753 (CYP3A28)

Authors

Natsuhori M, van Raak M, Ligtenberg M, Kleij L, Ten Berge D, Zweers-Zeilmaker WM, de Groene EM, van Miert AS, Witkamp RF, Horbach GJ

Title

Isolation of a bovine full length cytochrome P450 (CYP3A) cDNA sequence and its functional expression in V79 cells.

Journal

Environ Toxicol Pharmacol 3:17-24 (1997)
DOI:10.1016/s1382-6689(96)00133-0

Sequence

[bta:282214]

Reference

PMID:9682441 (CYP3A29)

Authors

Nissen PH, Wintero AK, Fredholm M

Title

Mapping of porcine genes belonging to two different cytochrome P450 subfamilies.

Journal

Anim Genet 29:7-11 (1998)
DOI:10.1046/j.1365-2052.1998.00225.x

Sequence

[ssc:403324]

Reference

PMID:10775455 (CYP3A41)

Authors

Sakuma T, Takai M, Endo Y, Kuroiwa M, Ohara A, Jarukamjorn K, Honma R, Nemoto N

Title

A novel female-specific member of the CYP3A gene subfamily in the mouse liver.

Journal

Arch Biochem Biophys 377:153-62 (2000)
DOI:10.1006/abbi.2000.1747

Sequence

[mmu:53973]

Reference

PMID:16414346 (CYP3C1)

Authors

Corley-Smith GE, Su HT, Wang-Buhler JL, Tseng HP, Hu CH, Hoang T, Chung WG, Buhler DR

Title

CYP3C1, the first member of a new cytochrome P450 subfamily found in zebrafish (Danio rerio).

Journal

Biochem Biophys Res Commun 340:1039-46 (2006)
DOI:10.1016/j.bbrc.2005.12.110

Sequence

[dre:324340]

Reference

PMID:14562963

Authors

McArthur AG, Hegelund T, Cox RL, Stegeman JJ, Liljenberg M, Olsson U, Sundberg P, Celander MC

Title

Phylogenetic analysis of the cytochrome P450 3 (CYP3) gene family.

Journal

J Mol Evol 57:200-11 (2003)
DOI:10.1007/s00239-003-2466-x

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (10)   
   KEGG PATHWAY (10)   
Chemical reaction (13)   
   KEGG ENZYME (1)   
   KEGG REACTION (7)   
   KEGG RCLASS (5)   
Gene (1917)   
   KEGG GENES (336)   
   KEGG MGENES (61)   
   RefGene (1517)   
   OC (3)   
Literature (9)   
   PubMed (9)   
All databases (1952)   

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