KEGG   ORTHOLOGY: K07431Help
Entry
K07431                      KO                                     

Name
CYP8B1
Definition
sterol 12-alpha-hydroxylase [EC:1.14.18.8 1.14.13.96]
Pathway
ko00120  Primary bile acid biosynthesis
ko01100  Metabolic pathways
ko03320  PPAR signaling pathway
Module
M00104  Bile acid biosynthesis, cholesterol => cholate/chenodeoxycholate
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Lipid metabolism
   00120 Primary bile acid biosynthesis
    K07431  CYP8B1; sterol 12-alpha-hydroxylase
 Organismal Systems
  Endocrine system
   03320 PPAR signaling pathway
    K07431  CYP8B1; sterol 12-alpha-hydroxylase
KEGG modules [BR:ko00002]
 Pathway module
  Carbohydrate and lipid metabolism
   Sterol biosynthesis
    M00104  Bile acid biosynthesis, cholesterol => cholate
     K07431  CYP8B1; sterol 12-alpha-hydroxylase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.13  With NADH or NADPH as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.13.96  5beta-cholestane-3alpha,7alpha-diol 12alpha-hydroxylase
     K07431  CYP8B1; sterol 12-alpha-hydroxylase
   1.14.18  With another compound as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.18.8  7alpha-hydroxycholest-4-en-3-one 12alpha-hydroxylase
     K07431  CYP8B1; sterol 12-alpha-hydroxylase
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP8 family
   K07431  CYP8B1; sterol 12-alpha-hydroxylase
BRITE hierarchy
Other DBs
RN: R04826
GO: 0008397
Genes
HSA: 1582(CYP8B1)
PTR: 736962(CYP8B1)
PPS: 100969929
GGO: 101147556
PON: 100433242
NLE: 100605497
MCC: 717247
MCF: 102132602
CSAB: 103227471(CYP8B1)
RRO: 104670956
RBB: 108532333
CJC: 100402181(CYP8B1)
SBQ: 101037790
MMU: 13124(Cyp8b1)
RNO: 81924(Cyp8b1)
CGE: 100770995
NGI: 103747146
CCAN: 109691739
OCU: 100009301(CYP8B1)
TUP: 102479742
CFA: 485619
AML: 100464768
UMR: 103682072
ORO: 101374077
FCA: 101082004
PTG: 102956513
AJU: 106966675
BTA: 538964(CYP8B1)
BOM: 102278686
BIU: 109576421
PHD: 102335997
CHX: 102173339
OAS: 101119853
SSC: 403328(CYP8B1)
CFR: 102524173
CDK: 105084606
BACU: 103000983
LVE: 103085360
OOR: 101285967
ECB: 100054970
EPZ: 103559259
EAI: 106843165
MYB: 102245777
MYD: 102765424
HAI: 109377081
RSS: 109445294
PALE: 102877747
LAV: 100665029
TMU: 101356001
MDO: 100026549(CYP8B)
OAA: 100082225
GGA: 425055(CYP8B1)
MGP: 100546803
CJO: 107308837
APLA: 101797490
ACYG: 106036789
TGU: 100217899
GFR: 102041987
FAB: 101809893
PHI: 102112501
PMAJ: 107201006
CCW: 104686389
FPG: 101924073
FCH: 102052323
CLV: 102083443
EGZ: 104124585
ASN: 102374897
AMJ: 102573091(CYP8B1)
PSS: 102444673
CMY: 102934823
CPIC: 101950173
XLA: 108718630 108718631(cyp8b1.L) 379482(cyp8b1.S)
XTR: 100488015 100488168(cyp8b1)
NPR: 108788787
DRE: 445281(cyp8b1)
AMEX: 103039627
OLA: 101157008
XMA: 102227191
PRET: 103479711
NFU: 107383849
CSEM: 103396384
HCQ: 109521313
CMK: 103188298
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Gafvels M, Olin M, Chowdhary BP, Raudsepp T, Andersson U, Persson B, Jansson M, Bjorkhem I, Eggertsen G
  Title
Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns.
  Journal
Genomics 56:184-96 (1999)
DOI:10.1006/geno.1998.5606
  Sequence
[hsa:1582] [mmu:13124]
Reference
  Authors
Russell DW
  Title
The enzymes, regulation, and genetics of bile acid synthesis.
  Journal
Annu Rev Biochem 72:137-74 (2003)
DOI:10.1146/annurev.biochem.72.121801.161712

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