KEGG   ORTHOLOGY: K07514
Entry
K07514                      KO                                     

Name
EHHADH
Definition
enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
Pathway
ko00071  Fatty acid degradation
ko00280  Valine, leucine and isoleucine degradation
ko00310  Lysine degradation
ko00380  Tryptophan metabolism
ko00410  beta-Alanine metabolism
ko00627  Aminobenzoate degradation
ko00640  Propanoate metabolism
ko00650  Butanoate metabolism
ko00930  Caprolactam degradation
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
ko01212  Fatty acid metabolism
ko03320  PPAR signaling pathway
ko04146  Peroxisome
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00087  beta-Oxidation
Disease
H01198  Fanconi renotubular syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00640 Propanoate metabolism
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
   00650 Butanoate metabolism
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
   00310 Lysine degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
   00380 Tryptophan metabolism
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
  09111 Xenobiotics biodegradation and metabolism
   00627 Aminobenzoate degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
   00930 Caprolactam degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35  3-hydroxyacyl-CoA dehydrogenase
     K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.17  enoyl-CoA hydratase
     K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.8  Delta3-Delta2-enoyl-CoA isomerase
     K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
Other DBs
RN: R01975 R03026 R03045 R04137 R04170 R04203 R04204 R04224 R04737 R04738 R04739 R04740 R04741 R04743 R04744 R04745 R04746 R04748 R04749 R04756 R05066 R05595 R06941 R06942
GO: 0004300 0003857 0004165
Genes
HSA: 1962(EHHADH)
PTR: 460996(EHHADH)
PPS: 100985141(EHHADH)
GGO: 101130472(EHHADH)
PON: 100174685(EHHADH)
NLE: 100586768(EHHADH)
MCC: 701193(EHHADH)
MCF: 102118537(EHHADH)
CSAB: 103221115(EHHADH)
RRO: 104672740(EHHADH)
RBB: 108525336(EHHADH)
CJC: 100395397(EHHADH)
SBQ: 101049266(EHHADH)
MMU: 74147(Ehhadh)
MCAL: 110311920(Ehhadh)
MPAH: 110330110(Ehhadh)
RNO: 171142(Ehhadh)
MUN: 110561900(Ehhadh)
CGE: 100754698(Ehhadh)
NGI: 103732668(Ehhadh)
HGL: 101699730(Ehhadh)
CCAN: 109695163
OCU: 100346381(EHHADH)
TUP: 102502891(EHHADH)
CFA: 488110(EHHADH)
VVP: 112926276(EHHADH)
AML: 100468058(EHHADH)
UMR: 103676178(EHHADH)
UAH: 113254101(EHHADH)
ORO: 101370722(EHHADH)
ELK: 111150208
FCA: 101083876(EHHADH)
PTG: 102965690(EHHADH)
PPAD: 109275245(EHHADH)
AJU: 106967987(EHHADH)
BTA: 518852(EHHADH)
BOM: 102285943(EHHADH)
BIU: 109557289(EHHADH)
BBUB: 102404255(EHHADH)
CHX: 102179598(EHHADH)
OAS: 101117635(EHHADH)
SSC: 448846(EHHADH)
CFR: 102519802(EHHADH)
CDK: 105085864(EHHADH)
BACU: 102997304(EHHADH)
LVE: 103073756(EHHADH)
OOR: 101277611(EHHADH)
DLE: 111173099(EHHADH)
PCAD: 102985760(EHHADH)
ECB: 100067714(EHHADH)
EPZ: 103565918(EHHADH)
EAI: 106834502(EHHADH)
MYB: 102240784(EHHADH)
MYD: 102771761(EHHADH)
MNA: 107527318(EHHADH)
HAI: 109396830(EHHADH)
DRO: 112308135(EHHADH)
PALE: 102880064(EHHADH)
RAY: 107518255(EHHADH)
MJV: 108410174(EHHADH)
LAV: 100677184(EHHADH)
TMU: 101352903
MDO: 100026751(EHHADH)
SHR: 100913272(EHHADH)
PCW: 110221285(EHHADH)
OAA: 100082172(EHHADH)
GGA: 424877(EHHADH)
MGP: 100551164(EHHADH)
CJO: 107317934(EHHADH)
NMEL: 110398159(EHHADH)
APLA: 101795970(EHHADH)
ACYG: 106039208(EHHADH)
TGU: 100229171(EHHADH)
LSR: 110474075(EHHADH)
SCAN: 103815479(EHHADH)
GFR: 102040622(EHHADH)
FAB: 101818793(EHHADH)
PHI: 102112202(EHHADH)
PMAJ: 107208675(EHHADH)
CCAE: 111945334(EHHADH)
CCW: 104696695(EHHADH)
ETL: 114054815(EHHADH)
FPG: 101918474(EHHADH)
FCH: 102057870(EHHADH)
CLV: 102091542(EHHADH)
EGZ: 104131306(EHHADH)
NNI: 104010666(EHHADH)
ACUN: 113483679(EHHADH)
PADL: 103916934(EHHADH)
AAM: 106493091(EHHADH)
ASN: 102381971(EHHADH)
AMJ: 102558567(EHHADH)
PSS: 102453335(EHHADH)
CMY: 102939101(EHHADH)
CPIC: 101941626(EHHADH)
ACS: 100558466(ehhadh)
PVT: 110075819(EHHADH)
PBI: 103052873(EHHADH)
PMUR: 107285887(EHHADH)
TSR: 106540162(EHHADH)
PMUA: 114597690(EHHADH)
GJA: 107123582(EHHADH)
XLA: 108703045(ehhadh.S)
XTR: 100216115(ehhadh)
NPR: 108795601(EHHADH)
DRE: 100000859(ehhadh)
SRX: 107749878(ehhadh)
SANH: 107663901(ehhadh)
SGH: 107596516
IPU: 108266325(ehhadh)
PHYP: 113525435(ehhadh)
AMEX: 103032907(ehhadh)
EEE: 113574639(ehhadh)
TRU: 101073728(ehhadh)
LCO: 104919050(ehhadh)
NCC: 104957955(ehhadh)
MZE: 101484421(ehhadh)
ONL: 100709434(ehhadh)
OLA: 101170799(ehhadh)
XMA: 102219640(ehhadh)
XCO: 114148066(ehhadh)
PRET: 103461662(ehhadh)
CVG: 107087127(ehhadh)
NFU: 107390106(ehhadh)
KMR: 108240797(ehhadh)
ALIM: 106523328(ehhadh)
AOCE: 111588505(ehhadh)
CSEM: 103392204(ehhadh)
POV: 109631473(ehhadh)
LCF: 108901033(ehhadh)
SDU: 111218377(ehhadh)
SLAL: 111651262(ehhadh)
HCQ: 109523309(ehhadh)
BPEC: 110166609(ehhadh)
MALB: 109957167(ehhadh)
SASA: 100195275(ehhadh)
OTW: 112218409(ehhadh)
SALP: 112072998(ehhadh)
ELS: 105029884(ehhadh)
SFM: 108928073(ehhadh)
PKI: 111841633(ehhadh)
LCM: 102356308(EHHADH)
APLC: 110973407
PCAN: 112564830
MYI: 110465017
LAK: 106165251
 » show all
Reference
PMID:8188243
  Authors
Hoefler G, Forstner M, McGuinness MC, Hulla W, Hiden M, Krisper P, Kenner L, Ried T, Lengauer C, Zechner R, et al.
  Title
cDNA cloning of the human peroxisomal enoyl-CoA hydratase: 3-hydroxyacyl-CoA dehydrogenase bifunctional enzyme and localization to chromosome 3q26.3-3q28: a free left Alu Arm is inserted in the 3' noncoding region.
  Journal
Genomics 19:60-7 (1994)
DOI:10.1006/geno.1994.1013
  Sequence
[hsa:1962]
Reference
  Authors
Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL
  Title
Regulation of cellular metabolism by protein lysine acetylation.
  Journal
Science 327:1000-4 (2010)
DOI:10.1126/science.1179689

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