K07532                      KO                                     

Rho guanine nucleotide exchange factor 12
ko04270  Vascular smooth muscle contraction
ko04360  Axon guidance
ko04611  Platelet activation
ko04625  C-type lectin receptor signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05152  Tuberculosis
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
KEGG Orthology (KO) [BR:ko00001]
 Cellular Processes
  Cell motility
   04810 Regulation of actin cytoskeleton
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
 Organismal Systems
  Immune system
   04611 Platelet activation
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
   04625 C-type lectin receptor signaling pathway
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
  Circulatory system
   04270 Vascular smooth muscle contraction
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
   04360 Axon guidance
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
 Human Diseases
   05200 Pathways in cancer
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
   05205 Proteoglycans in cancer
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
  Infectious diseases
   05152 Tuberculosis
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
Membrane trafficking [BR:ko04131]
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
BRITE hierarchy
Other DBs
GO: 0005089
HSA: 23365(ARHGEF12)
PTR: 451618(ARHGEF12)
PPS: 100981550(ARHGEF12)
GGO: 101150763(ARHGEF12)
PON: 100457621(ARHGEF12)
NLE: 100602658(ARHGEF12)
MCC: 712096(ARHGEF12)
MCF: 102118758(ARHGEF12)
CSAB: 103248653(ARHGEF12)
RRO: 104657228(ARHGEF12)
RBB: 108528604(ARHGEF12)
CJC: 100411450(ARHGEF12)
SBQ: 101040423(ARHGEF12)
MMU: 69632(Arhgef12)
RNO: 367072(Arhgef12)
CGE: 100765006(Arhgef12)
NGI: 103727935(Arhgef12)
HGL: 101716885(Arhgef12)
CCAN: 109688211(Arhgef12)
OCU: 100340118(ARHGEF12)
TUP: 102469549(ARHGEF12)
CFA: 479409(ARHGEF12)
AML: 100471078(ARHGEF12)
UMR: 103662491(ARHGEF12)
ORO: 101372821(ARHGEF12)
FCA: 101085657(ARHGEF12)
PTG: 102949630(ARHGEF12)
AJU: 106974771(ARHGEF12)
BTA: 503575(ARHGEF12)
BOM: 102277776(ARHGEF12)
BIU: 109569536(ARHGEF12)
PHD: 102329916(ARHGEF12)
CHX: 102179302(ARHGEF12)
OAS: 101117190(ARHGEF12)
SSC: 100523324(ARHGEF12)
CFR: 102524302(ARHGEF12)
CDK: 105090126(ARHGEF12)
BACU: 103002190(ARHGEF12)
LVE: 103083833(ARHGEF12)
OOR: 101272295(ARHGEF12)
ECB: 100071503(ARHGEF12)
EPZ: 103546845(ARHGEF12)
EAI: 106842382(ARHGEF12)
MYB: 102243603(ARHGEF12)
MYD: 102761091(ARHGEF12)
HAI: 109393895(ARHGEF12)
RSS: 109438372(ARHGEF12)
PALE: 102879072(ARHGEF12)
LAV: 100661002(ARHGEF12)
TMU: 101358090
MDO: 100030904(ARHGEF12)
SHR: 100913854(ARHGEF12)
OAA: 100073922(ARHGEF12)
GGA: 419752(ARHGEF12)
MGP: 100548723(ARHGEF12)
CJO: 107324215(ARHGEF12)
APLA: 101801214(ARHGEF12)
ACYG: 106039779(ARHGEF12)
TGU: 100222469(ARHGEF12)
GFR: 102044369(ARHGEF12)
FAB: 101809691(ARHGEF12)
PHI: 102099232(ARHGEF12)
PMAJ: 107214410(ARHGEF12)
CCW: 104692104(ARHGEF12)
FPG: 101920266(ARHGEF12)
FCH: 102057692(ARHGEF12)
CLV: 102085287(ARHGEF12) 102098633
EGZ: 104125926(ARHGEF12)
AAM: 106487853(ARHGEF12)
ASN: 102372630(ARHGEF12)
AMJ: 102569441(ARHGEF12)
PSS: 102463682(ARHGEF12)
CMY: 102938930(ARHGEF12)
CPIC: 101932178(ARHGEF12)
ACS: 100566171(arhgef12)
PVT: 110078466(ARHGEF12)
PBI: 103067299(ARHGEF12)
GJA: 107108209(ARHGEF12)
XLA: 108696425(arhgef12.L) 398710(arhgef12.S)
XTR: 779951(arhgef12)
NPR: 108796163(ARHGEF12)
DRE: 562455(arhgef12a) 571031(arhgef12b)
AMEX: 103030748(arhgef12) 103038567
TRU: 101069223 101078165(arhgef12)
LCO: 104918032(arhgef12) 104923945 109138805
NCC: 104944501 104967384(arhgef12)
MZE: 101464277(arhgef12) 101466887
OLA: 101168230 101169798(arhgef12)
XMA: 102235138(arhgef12) 102238153
PRET: 103474575(arhgef12) 103476288
NFU: 107380349(arhgef12) 107387127
CSEM: 103378423(arhgef12) 103395343
LCF: 108886392(arhgef12) 108893642
HCQ: 109517468 109526407(arhgef12)
BPEC: 110154066(arhgef12) 110154588 110168228
SFM: 108928767 108936187(arhgef12)
LCM: 102353846(ARHGEF12)
CMK: 103190752 103191057(arhgef12)
TSP: Tsp_00331
 » show all
Kourlas PJ, Strout MP, Becknell B, Veronese ML, Croce CM, Theil KS, Krahe R, Ruutu T, Knuutila S, Bloomfield CD, Caligiuri MA
Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia.
Proc Natl Acad Sci U S A 97:2145-50 (2000)

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