KEGG   ORTHOLOGY: K07860
Entry
K07860                      KO                                     
Symbol
RAC2
Name
Ras-related C3 botulinum toxin substrate 2
Pathway
map04010  MAPK signaling pathway
map04014  Ras signaling pathway
map04015  Rap1 signaling pathway
map04024  cAMP signaling pathway
map04062  Chemokine signaling pathway
map04071  Sphingolipid signaling pathway
map04310  Wnt signaling pathway
map04360  Axon guidance
map04370  VEGF signaling pathway
map04510  Focal adhesion
map04520  Adherens junction
map04613  Neutrophil extracellular trap formation
map04650  Natural killer cell mediated cytotoxicity
map04662  B cell receptor signaling pathway
map04664  Fc epsilon RI signaling pathway
map04666  Fc gamma R-mediated phagocytosis
map04670  Leukocyte transendothelial migration
map04810  Regulation of actin cytoskeleton
map05020  Prion disease
map05135  Yersinia infection
map05163  Human cytomegalovirus infection
map05170  Human immunodeficiency virus 1 infection
map05200  Pathways in cancer
map05210  Colorectal cancer
map05212  Pancreatic cancer
map05231  Choline metabolism in cancer
map05415  Diabetic cardiomyopathy
map05416  Viral myocarditis
map05418  Fluid shear stress and atherosclerosis
Disease
H00099  Leukocyte adhesion deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04014 Ras signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04015 Rap1 signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04310 Wnt signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04370 VEGF signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04071 Sphingolipid signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04024 cAMP signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04520 Adherens junction
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04650 Natural killer cell mediated cytotoxicity
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04662 B cell receptor signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04664 Fc epsilon RI signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04666 Fc gamma R-mediated phagocytosis
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04670 Leukocyte transendothelial migration
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   04062 Chemokine signaling pathway
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
  09158 Development and regeneration
   04360 Axon guidance
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   05231 Choline metabolism in cancer
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   05212 Pancreatic cancer
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   05163 Human cytomegalovirus infection
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
  09164 Neurodegenerative disease
   05020 Prion disease
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   05415 Diabetic cardiomyopathy
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
   05416 Viral myocarditis
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04031 GTP-binding proteins
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
GTP-binding proteins [BR:ko04031]
 Small (monomeric) G-proteins
  Rho Family
   Rac/Cdc42 [OT]
    K07860  RAC2; Ras-related C3 botulinum toxin substrate 2
Genes
HSA: 5880(RAC2)
PTR: 742575(RAC2)
PPS: 100993959(RAC2)
GGO: 101141534(RAC2)
PON: 100431483(RAC2)
NLE: 100598232(RAC2)
MCC: 696709(RAC2)
MCF: 102137056(RAC2)
CSAB: 103223272(RAC2)
CATY: 105575821(RAC2)
PANU: 101016465(RAC2)
TGE: 112633210(RAC2)
RRO: 104682502(RAC2)
RBB: 108512764(RAC2)
TFN: 117070036(RAC2)
PTEH: 111549042(RAC2)
CJC: 100395636(RAC2)
SBQ: 101029481(RAC2)
CSYR: 103258883(RAC2)
MMUR: 105883746(RAC2)
LCAT: 123639294(RAC2)
OGA: 100957182(RAC2)
MMU: 19354(Rac2)
MCAL: 110310226(Rac2)
MPAH: 110334678(Rac2)
RNO: 366957(Rac2)
MCOC: 116075508(Rac2)
MUN: 110548466(Rac2)
CGE: 100767225
MAUA: 101824666(Rac2)
PLEU: 114694231(Rac2)
MORG: 121461239(Rac2)
AAMP: 119822752(Rac2)
NGI: 103748617(Rac2)
HGL: 101725000(Rac2)
CPOC: 100731468(Rac2)
CCAN: 109698248(Rac2)
DORD: 105992088(Rac2)
DSP: 122119204(Rac2)
NCAR: 124982630
OCU: 100356520(RAC2)
OPI: 101531979(RAC2)
TUP: 102495436(RAC2)
CFA: 481271(RAC2)
CLUD: 112668452(RAC2)
VVP: 112929159(RAC2)
VLG: 121490389(RAC2)
AML: 100469737(RAC2)
UMR: 103676407(RAC2)
UAH: 113241811(RAC2)
UAR: 123780787(RAC2)
ELK: 111157484
LLV: 125107249
MPUF: 101676559(RAC2)
ORO: 101385830(RAC2)
EJU: 114218556(RAC2)
ZCA: 113922696(RAC2)
MLX: 117998715(RAC2)
FCA: 101096744(RAC2)
PYU: 121040395(RAC2)
PBG: 122472709(RAC2)
PTG: 102961922(RAC2)
PPAD: 109265228(RAC2)
AJU: 106981077(RAC2)
HHV: 120241186(RAC2)
BTA: 327671(RAC2)
BOM: 102277352(RAC2)
BIU: 109559531(RAC2)
BBUB: 102393591(RAC2)
CHX: 102178149(RAC2)
OAS: 101107592(RAC2)
CCAD: 122423661(RAC2)
SSC: 100621675(RAC2)
CFR: 102519112(RAC2)
CBAI: 105073153(RAC2)
CDK: 105101582(RAC2)
VPC: 102541733(RAC2)
BACU: 103006132(RAC2)
LVE: 103076541(RAC2)
OOR: 101269741(RAC2)
DLE: 111186216(RAC2)
PCAD: 102990552(RAC2)
PSIU: 116760236(RAC2)
ECB: 100054701(RAC2)
EPZ: 103564464(RAC2)
EAI: 106837585(RAC2)
MYB: 102239988(RAC2)
MYD: 102768116(RAC2)
MMYO: 118651367(RAC2)
MLF: 102418852(RAC2)
MNA: 107545262(RAC2)
PKL: 118730331(RAC2)
HAI: 109394502(RAC2)
DRO: 112321719(RAC2)
SHON: 119002327(RAC2)
AJM: 119060271(RAC2)
PDIC: 114513229(RAC2)
PHAS: 123816243(RAC2)
MMF: 118624097(RAC2)
RFQ: 117029121(RAC2)
PALE: 102885507(RAC2)
PGIG: 120614848(RAC2)
PVP: 105311532(RAC2)
RAY: 107519267(RAC2)
MJV: 108392664(RAC2)
TOD: 119248240(RAC2)
SARA: 101555118(RAC2)
LAV: 100670080(RAC2)
TMU: 101355428
DNM: 101443248
MDO: 100017517(RAC2)
GAS: 123250082(RAC2)
SHR: 100932383(RAC2)
PCW: 110205748(RAC2)
OAA: 100092844(RAC2)
GGA: 418044(RAC2)
PCOC: 116233311(RAC2)
MGP: 100547045(RAC2)
CJO: 107313854(RAC2)
NMEL: 110393190(RAC2)
APLA: 101790794(RAC2)
ACYG: 106035903(RAC2)
AFUL: 116496135(RAC2)
TGU: 100230090(RAC2)
LSR: 110483874(RAC2)
SCAN: 103813234(RAC2)
PMOA: 120510095(RAC2)
OTC: 121342323(RAC2)
PRUF: 121361104(RAC2)
GFR: 102031835(RAC2)
FAB: 101808708(RAC2)
PHI: 102106942(RAC2)
PMAJ: 107205038(RAC2)
CCAE: 111944780
CCW: 104696295(RAC2)
CBRC: 103618070(RAC2)
ETL: 114055413(RAC2)
ZAB: 102072417(RAC2)
ACHL: 103798433(RAC2)
FPG: 101915778(RAC2)
FCH: 102059263(RAC2)
CLV: 102092145(RAC2)
EGZ: 104134300(RAC2)
NNI: 104021590(RAC2)
PLET: 104615543
PCRI: 104029725
ACUN: 113490117(RAC2)
TALA: 104367551(RAC2)
PADL: 103924148(RAC2)
ACHC: 115352715(RAC2)
HALD: 104322691(RAC2)
CCRI: 104165505(RAC2)
CSTI: 104557969(RAC2)
EHS: 104512767(RAC2)
CMAC: 104477102(RAC2)
MUI: 104542787(RAC2)
FGA: 104080594
GSTE: 104252532
LDI: 104348238(RAC2)
MNB: 103778948(RAC2)
OHA: 104332368(RAC2)
AAM: 106488354(RAC2)
AROW: 112969352(RAC2)
NPD: 112947758(RAC2)
DNE: 112993915(RAC2)
ASN: 102388854(RAC2)
AMJ: 102567702(RAC2)
CPOO: 109316638(RAC2)
GGN: 109296048(RAC2)
PSS: 102457520(RAC2)
CMY: 102936049(RAC2)
CPIC: 101933538(RAC2)
TST: 117880762(RAC2)
CABI: 116824114(RAC2)
MRV: 120389073(RAC2)
ACS: 100557692(rac2)
PVT: 110075970(RAC2)
SUND: 121931146(RAC2)
PBI: 103057074(RAC2)
PMUR: 107302789(RAC2)
TSR: 106551146
PGUT: 117655458(RAC2)
VKO: 123028894(RAC2)
PMUA: 114605675(RAC2)
ZVI: 118091269(RAC2)
GJA: 107120055(RAC2)
STOW: 125435678(RAC2)
XLA: 108715797 444184(rac2.L)
XTR: 496738(rac2)
NPR: 108783678(RAC2)
RTEM: 120945320(RAC2)
BBUF: 120978595(RAC2)
BGAR: 122943080(RAC2)
DRE: 415151(rac2)
PPRM: 120489161(rac2)
MAMB: 125276092(rac2)
IPU: 108276437(rac2)
PHYP: 113523793
SMEO: 124397345(rac2)
TFD: 113662474(rac2)
AMEX: 111193007
EEE: 113572862
TRU: 101071607
LCO: 104925434(rac2)
CGOB: 115006129
ELY: 117254575(rac2)
EFO: 125885446(rac2)
PLEP: 121941566(rac2)
SLUC: 116042633(rac2)
ECRA: 117952575(rac2)
ESP: 116704504
PFLV: 114565746
PPUG: 119218038(rac2)
MSAM: 119898608(rac2)
CUD: 121508527
ALAT: 119026213(rac2)
MZE: 101488012
ONL: 100708296
OAU: 116317352(rac2)
OLA: 101163549
OML: 112137136(rac2)
XMA: 102225118
XCO: 114144415
XHE: 116720213
PRET: 103479675
PFOR: 103156059(rac2)
PLAI: 106953407
PMEI: 106923892
GAF: 122830335(rac2)
CVG: 107084283(rac2)
CTUL: 119774841(rac2)
GMU: 124869199(rac2)
NFU: 107391413
KMR: 108231305(rac2)
ALIM: 106522484
NWH: 119422417
AOCE: 111577589
MCEP: 125004257(rac2)
CSEM: 103383441(rac2)
POV: 109639279
SSEN: 122771109(rac2)
HHIP: 117759561(rac2)
HSP: 118124698(rac2)
LCF: 108889053(rac2) 108889076
SDU: 111235860
SLAL: 111671871
XGL: 120800140(rac2)
HCQ: 109511299
BPEC: 110157785
MALB: 109975044
SASA: 106564435(RAC2) 106590297(RAC2) 106601466(RAC2) 106601467(RAC2)
ONE: 115104321
SALP: 111981081
ELS: 105022954(rac2) 105031187(rac2)
AANG: 118216908(rac2)
LOC: 102692563(rac2)
LCM: 102351732(RAC2)
SCLV: 120337580
SCAC: 106095221
DCI: 103516089
LSM: 121119487
EGL: EGR_07105
 » show all
Reference
PMID:2674130
  Authors
Didsbury J, Weber RF, Bokoch GM, Evans T, Snyderman R
  Title
rac, a novel ras-related family of proteins that are botulinum toxin substrates.
  Journal
J Biol Chem 264:16378-82 (1989)
  Sequence
[hsa:5880]
Reference
  Authors
Holland M, Castro FV, Alexander S, Smith D, Liu J, Walker M, Bitton D, Mulryan K, Ashton G, Blaylock M, Bagley S, Connolly Y, Bridgeman J, Miller C, Krishnan S, Dempsey C, Masurekar A, Stern P, Whetton A, Saha V
  Title
RAC2, AEP, and ICAM1 expression are associated with CNS disease in a mouse model of pre-B childhood acute lymphoblastic leukemia.
  Journal
Blood 118:638-49 (2011)
DOI:10.1182/blood-2010-09-307330
  Sequence
[mmu:19354]

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