KEGG   ORTHOLOGY: K08011
Entry
K08011                      KO                                     

Name
NCF1, P47PHOX
Definition
neutrophil cytosolic factor 1
Pathway
ko04062  Chemokine signaling pathway
ko04145  Phagosome
ko04380  Osteoclast differentiation
ko04613  Neutrophil extracellular trap formation
ko04666  Fc gamma R-mediated phagocytosis
ko04670  Leukocyte transendothelial migration
ko05020  Prion disease
ko05140  Leishmaniasis
ko05415  Diabetic cardiomyopathy
ko05417  Lipid and atherosclerosis
ko05418  Fluid shear stress and atherosclerosis
Disease
H00098  Chronic granulomatous disease
H01167  Granulibacter infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
 09150 Organismal Systems
  09151 Immune system
   04613 Neutrophil extracellular trap formation
    K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
   04666 Fc gamma R-mediated phagocytosis
    K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
   04670 Leukocyte transendothelial migration
    K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
   04062 Chemokine signaling pathway
    K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
 09160 Human Diseases
  09174 Infectious disease: parasitic
   05140 Leishmaniasis
    K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
  09164 Neurodegenerative disease
   05020 Prion disease
    K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
   05418 Fluid shear stress and atherosclerosis
    K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
   05415 Diabetic cardiomyopathy
    K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
Membrane trafficking [BR:ko04131]
 Others
  NADPH oxidases (Nox) and associated proteins
   Nox associated proteins
    K08011  NCF1, P47PHOX; neutrophil cytosolic factor 1
Other DBs
GO: 0016175
Genes
HSA: 653361(NCF1)
PTR: 743307(NCF1)
PPS: 100976968(NCF1)
GGO: 101154464(NCF1)
PON: 100442050(NCF1)
NLE: 100580160(NCF1)
MCC: 694207(NCF1)
MCF: 102124562(NCF1)
CSAB: 103246614(NCF1)
RRO: 104681251(NCF1)
RBB: 108513939(NCF1)
CJC: 100402613(NCF1)
SBQ: 101054407(NCF1)
MMU: 17969(Ncf1)
MCAL: 110294592(Ncf1)
MPAH: 110312979(Ncf1)
RNO: 114553(Ncf1)
MUN: 110554210(Ncf1)
CGE: 100769204(Ncf1)
NGI: 103748483(Ncf1)
HGL: 101721191(Ncf1)
CCAN: 109686925(Ncf1)
OCU: 100008803(NCF1)
TUP: 102502283(NCF1)
CFA: 607700(NCF1)
VVP: 112934122(NCF1)
AML: 100472606(NCF1)
UMR: 103670166(NCF1)
UAH: 113267772(NCF1)
ORO: 101376795(NCF1)
ELK: 111145864
FCA: 101098840(NCF1)
PTG: 102958576(NCF1)
PPAD: 109250624(NCF1)
AJU: 106977527(NCF1)
BTA: 281345(NCF1)
BOM: 102266557(NCF1)
BIU: 109578828(NCF1)
BBUB: 102413685(NCF1)
CHX: 102176291(NCF1)
OAS: 780489(NCF1)
SSC: 100134857(NCF1)
CFR: 102503581(NCF1)
CDK: 105089687(NCF1)
BACU: 103021081
LVE: 103072544(NCF1)
OOR: 101276678(NCF1)
DLE: 111182060(NCF1)
PCAD: 102982542(NCF1)
ECB: 100146522(NCF1)
EPZ: 103556000(NCF1)
EAI: 106840982(NCF1)
MYB: 102252724(NCF1)
MYD: 102756232(NCF1)
MNA: 107546691(NCF1)
HAI: 109384978(NCF1)
DRO: 112314894(NCF1)
PALE: 102886343(NCF1)
RAY: 107514979(NCF1)
MJV: 108390671(NCF1)
LAV: 100673308(NCF1)
TMU: 101343104
MDO: 100014144(NCF1)
SHR: 100920650(NCF1)
PCW: 110221265(NCF1)
OAA: 100088825(NCF1)
GGA: 417485(NCF1)
MGP: 100551177(NCF1)
CJO: 107322658(NCF1)
NMEL: 110407656(NCF1)
APLA: 101802365(NCF1)
ACYG: 106041051(NCF1)
TGU: 101234037(NCF1)
LSR: 110476625(NCF1)
SCAN: 103823607(NCF1)
GFR: 102035803(NCF1)
FAB: 101806380(NCF1)
PHI: 102099699(NCF1)
PMAJ: 107212826(NCF1)
CCAE: 111937646(NCF1)
CCW: 104695773(NCF1)
ETL: 114063493(NCF1)
FPG: 101913107(NCF1)
FCH: 102060078(NCF1)
CLV: 102091881(NCF1)
EGZ: 104131774(NCF1)
NNI: 104016121(NCF1)
ACUN: 113487074(NCF1)
PADL: 103912872(NCF1)
AAM: 106485779
ASN: 102381152(NCF1)
AMJ: 102576900(NCF1)
PSS: 102463356(NCF1)
CMY: 102948027(NCF1)
CPIC: 101938877(NCF1)
ACS: 100559506(ncf1)
PVT: 110083289(NCF1)
PBI: 103053417(NCF1)
PMUR: 107294007(NCF1)
TSR: 106542925(NCF1)
PMUA: 114585825(NCF1)
GJA: 107116486(NCF1)
XTR: 100124318(ncf1)
NPR: 108784525(NCF1)
DRE: 378966(ncf1)
IPU: 108260388(ncf1)
PHYP: 113531669(ncf1)
AMEX: 103024742(ncf1)
EEE: 113573777(ncf1)
TRU: 445890(ncf1)
LCO: 104921787(ncf1)
NCC: 104953095(ncf1)
MZE: 101467208(ncf1)
ONL: 100692664(ncf1)
OLA: 101165540(ncf1)
XMA: 102233177(ncf1)
XCO: 114152605(ncf1)
PRET: 103476387(ncf1)
CVG: 107090299(ncf1)
NFU: 107384323(ncf1)
KMR: 108243598(ncf1)
ALIM: 106514660(ncf1)
AOCE: 111586256(ncf1)
CSEM: 103395607(ncf1)
POV: 109635664(ncf1)
SDU: 111221330(ncf1)
SLAL: 111668099(ncf1)
HCQ: 109513735(ncf1)
BPEC: 110166971(ncf1)
MALB: 109975053(ncf1)
SASA: 100270810(ncf1) 100306811(spd2b)
SALP: 111950246 111981824(ncf1)
ELS: 105010758(ncf1)
SFM: 108928212(ncf1)
PKI: 111847848(ncf1)
LCM: 102362630(NCF1)
RTP: 109925636(ncf1)
BFO: 118426287
 » show all
Reference
  Authors
Sumimoto H
  Title
Structure, regulation and evolution of Nox-family NADPH oxidases that produce reactive oxygen species.
  Journal
FEBS J 275:3249-77 (2008)
DOI:10.1111/j.1742-4658.2008.06488.x
Reference
PMID:2547247
  Authors
Lomax KJ, Leto TL, Nunoi H, Gallin JI, Malech HL
  Title
Recombinant 47-kilodalton cytosol factor restores NADPH oxidase in chronic granulomatous disease.
  Journal
Science 245:409-12 (1989)
DOI:10.1126/science.2547247
  Sequence
[hsa:653361]

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