KEGG ORTHOLOGY: K08026

ORTHOLOGY: K08026

Entry

K08026                      KO

Symbol

ONECUT1, HNF6

Name

one cut domain, family member 1 (hepatocyte nuclear factor 6)

Pathway

map04550

Signaling pathways regulating pluripotency of stem cells

map04950

Maturity onset diabetes of the young

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K08026  ONECUT1, HNF6; one cut domain, family member 1 (hepatocyte nuclear factor 6)
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04950 Maturity onset diabetes of the young
    K08026  ONECUT1, HNF6; one cut domain, family member 1 (hepatocyte nuclear factor 6)
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08026  ONECUT1, HNF6; one cut domain, family member 1 (hepatocyte nuclear factor 6)
Transcription factors [BR:ko03000]
Eukaryotic type
  Helix-turn-helix
   Homeo domain CUT
    K08026  ONECUT1, HNF6; one cut domain, family member 1 (hepatocyte nuclear factor 6)

Genes

HSA:	3175(ONECUT1)

PTR:	746173(ONECUT1)

PPS:	100983846(ONECUT1)

GGO:	101148273(ONECUT1)

PON:	100448974(ONECUT1)

PPYG:

129014457(ONECUT1)

NLE:	100595628(ONECUT1)

HMH:	116482104(ONECUT1)

SSYN:

129481798(ONECUT1)

MCC:	696311(ONECUT1)

MCF:	135964334(ONECUT1)

MTHB:

126959040

MNI:	105490081(ONECUT1)

CSAB:

103245602(ONECUT1)

CATY:

105601133(ONECUT1)

PANU:

101009090 116275831

TGE:	112627851(ONECUT1)

MLEU:

105544145(ONECUT1)

RRO:	104660897(ONECUT1)

RBB:	108538120(ONECUT1)

TFN:	117070631(ONECUT1)

PTEH:

111552817(ONECUT1)

CANG:

105502233(ONECUT1)

CJC:	100404072(ONECUT1)

SBQ:	101039550(ONECUT1)

CIMI:

108286636(ONECUT1)

ANAN:

105710124(ONECUT1)

CSYR:

103270941(ONECUT1)

MMUR:

105862120(ONECUT1)

LCAT:

123622911(ONECUT1)

PCOQ:

105821324(ONECUT1)

OGA:	100955720(ONECUT1)

MMU:	15379(Onecut1)

MCAL:

110301435(Onecut1)

MPAH:

110328067(Onecut1)

RNO:	25231(Onecut1)

MCOC:

116073001(Onecut1)

ANU:	117712339(Onecut1)

MUN:	110551459(Onecut1)

CGE:	100765766(Onecut1)

MAUA:

101827414(Onecut1)

PROB:

127231976(Onecut1)

PLEU:

114690428(Onecut1)

MORG:

121465930(Onecut1)

MFOT:

126490287

AAMP:

119808939(Onecut1)

NGI:	103731413(Onecut1)

HGL:	101725703(Onecut1)

CPOC:

100723740(Onecut1)

CCAN:

109695944(Onecut1)

DORD:

105981086(Onecut1)

DSP:	122114677(Onecut1)

PLOP:

125340894(Onecut1)

NCAR:

124977664

MMMA:

107138089(Onecut1)

OCU:

100353620

OPI:	101516394(ONECUT1)

TUP:	102485472(ONECUT1)

GVR:	103603163(ONECUT1)

CFA:	487558(ONECUT1)

CLUD:

112675913(ONECUT1)

VVP:	112916776(ONECUT1)

VLG:	121484773(ONECUT1)

NPO:	129506139(ONECUT1)

AML:	100468514(ONECUT1)

UMR:	103676760(ONECUT1)

UAH:	113269640(ONECUT1)

UAR:	123801853(ONECUT1)

ELK:

111140668

LLV:

125105155

MPUF:

101676214(ONECUT1)

MNP:	131999772(ONECUT1)

MLK:	131836306(ONECUT1)

NVS:	122893835(ONECUT1)

ORO:	101364067(ONECUT1)

EJU:	114206477(ONECUT1)

ZCA:	113910263(ONECUT1)

MLX:	118003064(ONECUT1)

NSU:	110583972(ONECUT1)

LWW:	102743297(ONECUT1)

FCA:	101092522(ONECUT1)

PYU:	121041724(ONECUT1)

PCOO:

112856198(ONECUT1)

PBG:	122468628(ONECUT1)

PVIV:

125167191(ONECUT1)

LRUF:

124508225

PTG:	102956087(ONECUT1)

PPAD:

109262968(ONECUT1)

PUC:

125910010

AJU:

106967253

HHV:	120235036(ONECUT1)

BTA:	503584(ONECUT1)

BOM:	102284576(ONECUT1)

BIU:	109565114(ONECUT1)

BBUB:

102395484(ONECUT1)

BBIS:

104986316(ONECUT1)

CHX:	102174031(ONECUT1)

OAS:	101102397(ONECUT1)

BTAX:

128054516(ONECUT1)

ODA:	120853008(ONECUT1)

CCAD:

122443587(ONECUT1)

MBEZ:

129563248(ONECUT1)

SSC:	100152052(ONECUT1)

CFR:	102509400(ONECUT1)

CBAI:

105080488(ONECUT1)

CDK:	105086830(ONECUT1)

VPC:	102525613(ONECUT1)

BACU:

103003567(ONECUT1)

BMUS:

118890411(ONECUT1)

LVE:	103090061(ONECUT1)

OOR:	101290246(ONECUT1)

DLE:	111177631(ONECUT1)

PCAD:

102994558(ONECUT1)

PSIU:

116749616(ONECUT1)

NASI:

112405796(ONECUT1)

ECB:	100069457(ONECUT1)

EPZ:	103548462(ONECUT1)

EAI:	106837149(ONECUT1)

MYB:	102241830(ONECUT1)

MYD:	102764214(ONECUT1)

MMYO:

118652098(ONECUT1)

MLF:	102440464(ONECUT1)

PKL:	118720963(ONECUT1)

EFUS:

103287441(ONECUT1)

MNA:	107546555(ONECUT1)

DRO:	112311998(ONECUT1)

SHON:

118992643(ONECUT1)

AJM:	119065529(ONECUT1)

PDIC:

114492689(ONECUT1)

PHAS:

123808499(ONECUT1)

MMF:	118615492(ONECUT1)

PPAM:

129064236(ONECUT1)

HAI:	109395014(ONECUT1)

RFQ:	117023878(ONECUT1)

PALE:

102880367(ONECUT1)

PGIG:

120623079(ONECUT1)

PVP:	105288762(ONECUT1)

RAY:	107515161(ONECUT1)

MJV:	108385301(ONECUT1)

TOD:	119237931(ONECUT1)

SARA:

101540871(ONECUT1)

SETR:

126002076(ONECUT1)

LAV:	100676371(ONECUT1)

TMU:

101354428

ETF:	101660478(ONECUT1)

DNM:	101419708(ONECUT1)

MDO:	100026501(ONECUT1)

GAS:	123235991(ONECUT1)

SHR:	100932222(ONECUT1)

AFZ:

127551169

PCW:	110204894(ONECUT1)

TVP:	118859061(ONECUT1)

OAA:	114813801(ONECUT1)

GGA:	107054176(ONECUT1)

PCOC:

116244678(ONECUT1)

CJO:	107318788(ONECUT1)

TPAI:

128075378(ONECUT1)

LMUT:

125698485(ONECUT1)

NMEL:

110403972(ONECUT1)

APLA:

101793784(ONECUT1)

ACYG:

106033616(ONECUT1)

CATA:

118251668(ONECUT1)

AFUL:

116493570(ONECUT1)

TGU:	100227378(ONECUT1)

LSR:	110474216(ONECUT1)

SCAN:

103816184(ONECUT1)

PMOA:

120509156(ONECUT1)

OTC:	121343579(ONECUT1)

PRUF:

121354519(ONECUT1)

GFR:	102041900(ONECUT1)

FAB:	101809064(ONECUT1)

OMA:	130257389(ONECUT1)

PHI:	102113987(ONECUT1)

PMAJ:

107209576(ONECUT1)

CCAE:

111944743(ONECUT1)

CCW:	120410550(ONECUT1)

CBRC:

103621317(ONECUT1)

ETL:	114057154(ONECUT1)

ZLE:	135452086(ONECUT1)

SVG:	106851839(ONECUT1)

MMEA:

130577019(ONECUT1)

HRT:	120758930(ONECUT1)

FPG:	101912935(ONECUT1)

FCH:	102056706(ONECUT1)

CLV:	102090739(ONECUT1)

EGZ:	104130781(ONECUT1)

NNI:	104017271(ONECUT1)

TALA:

116959153(ONECUT1)

PADL:

103922771(ONECUT1)

AFOR:

103896598(ONECUT1)

ACHC:

115341904(ONECUT1)

HLE:	104834475(ONECUT1)

AGEN:

126043862

GCL:

127020798

CSTI:

104549341(ONECUT1)

MNB:

103772474

OHA:	104334626(ONECUT1)

SHAB:

115613269(ONECUT1)

DPUB:

104305586(ONECUT1)

CPEA:

104385910(ONECUT1)

AVIT:

104281218(ONECUT1)

CVF:	104287103(ONECUT1)

RTD:	128915286(ONECUT1)

CUCA:

104055247(ONECUT1)

TEO:

104380892

AAM:	106496444(ONECUT1)

AROW:

112963514(ONECUT1) 112972518

NPD:	112952835(ONECUT1)

TGT:	104572164(ONECUT1)

DNE:	112985838(ONECUT1)

SCAM:

104148416(ONECUT1)

ASN:	102380290 102383017(ONECUT1)

AMJ:	102565075 106736804(ONECUT1)

CPOO:

109309261(ONECUT1)

GGN:	109288368(ONECUT1)

PSS:	102447491(ONECUT1) 102461102

CMY:	102937140 102940869(ONECUT1)

CCAY:

125626044 125644125(ONECUT1)

DCC:	119847904 119863054(ONECUT1)

CPIC:

101937837 101951168(ONECUT1)

TST:	117869841 117884191(ONECUT1)

CABI:

116817648 116834516(ONECUT1)

MRV:	120372762(ONECUT1) 120390502

ACS:

100561530

PVT:	110074585(ONECUT1)

SUND:

121915018 121934012(ONECUT1)

PBI:	103056551 103066165(ONECUT1)

PMUR:

107283139(ONECUT1) 107292902

CTIG:

120306528(ONECUT1) 120317007

TSR:	106542867(ONECUT1)

PGUT:

117661068(ONECUT1) 117670138

APRI:

131184672(ONECUT1) 131186548

PTEX:

113442402(ONECUT1) 113452503 113452504

NSS:	113421626(ONECUT1) 113425704

VKO:	123027783(ONECUT1) 123032889

PMUA:

114584813(ONECUT1) 114587120

PRAF:

128401804(ONECUT1) 128403857

ZVI:	118093060(ONECUT1)

HCG:	128335035(ONECUT1) 128337244

GJA:

107120545

STOW:

125424692(ONECUT1) 125441251

EMC:	129342602 129345776(ONECUT1)

XLA:	108699342 108700338(onecut1.2.S) 108711382(onecut1.L) 108712923

XTR:	100101763(onecut1) 100488409(onecut1.2)

NPR:	108789802 108804350(ONECUT1)

RTEM:

120920705 120931357(ONECUT1)

BBUF:

120982254 120985794(ONECUT1)

BGAR:

122922226 122929646(ONECUT1)

MUO:	115457464 115459413(ONECUT1)

GSH:	117348698(ONECUT1) 117349919

DRE:	246225(onecutl) 393545(onecut1)

SRX:	107712763 107732477 107741751 107746960

SANH:

107663311 107676486 107689849 107704258

SGH:	107574330 107598011

CCAR:

109056408 109078549 109078553 109088810

CAUA:

113059152 113061817 113116108 113118556

CGIB:

127933974 127975149 127976985 128030610

PTET:

122361078(onecutl) 122362469(onecut1)

LROH:

127178600(onecutl) 127180661(onecut1)

OMC:	131521517(onecutl) 131524100(onecut1)

PPRM:

120484667(onecutl) 120485864(onecut1)

RKG:	130069290(onecutl) 130089416(onecut1)

MAMB:

125243014(onecutl) 125254522(onecut1)

CIDE:

127496724 127500210

MASI:

127417031 127452788 127454175 127456107

TROS:

130558095(onecutl) 130563161(onecut1)

TDW:	130432805(onecutl) 130435356(onecut1)

MANU:

129419878(onecut1) 129448282(onecutl)

IPU:	108264470 108268128(onecutl)

IFU:	128607101 128610350(onecutl)

PHYP:

113533947 113534827(onecut1)

SMEO:

124384140(onecutl) 124395419(onecut1)

TFD:	113644725(onecutl) 113651537(onecut1)

TVC:	132845311(onecutl) 132851491(onecut1)

TRN:	134310794(onecutl) 134323344(onecut1)

AMEX:

103044517(onecutl) 103047808(onecut1)

CMAO:

118813520(onecutl) 118818043(onecut1)

EEE:	113575271 113592376(onecut1)

CHAR:

105889075(onecut1) 105891890(onecutl)

TRU:	101068977 101072750(onecut1)

TFS:	130521511(onecut1) 130532150(onecutl)

TNG:	GSTEN00011684G001 GSTEN00021465G001

LCO:	104923062(onecut1) 109138720

NCC:	104953691(onecut1) 104959116

TBEN:

117471306(onecut1) 117494893(onecutl)

CGOB:

115006460(onecut1) 115021398

PGEO:

117440367(onecut1)

GACU:

117558976(onecut1)

EMAC:

134862436(onecutl) 134863519(onecut1)

ELY:	117256553(onecut1) 117266343(onecutl)

EFO:	125881499(onecut1) 125892605(onecutl)

PLEP:

121944532(onecut1) 121945185(onecutl) 121945686

SLUC:

116037606(onecut1) 116049090(onecutl)

ECRA:

117946159(onecut1) 117946631(onecutl)

ESP:	116690355(onecut1) 116690787

PFLV:

114556816 114560994(onecut1)

GAT:	120810940(onecut1) 120811173(onecutl)

PPUG:

119196955(onecutl) 119197693(onecut1)

AFB:	129106223(onecut1) 129110239(onecutl)

CLUM:

117745699(onecutl) 117748761(onecut1)

PSWI:

130192751(onecut1) 130213032(onecutl)

MSAM:

119890188(onecut1) 119897016(onecutl)

SCHU:

122881355(onecut1) 122882283(onecutl)

CUD:	121513199(onecut1) 121514246(onecutl)

ALAT:

119006857(onecutl) 119018281(onecut1)

MZE:

101482175

ONL:	100705161 100706340(onecut1)

OAU:	116322846(onecut1) 116333465(onecutl)

OLA:	101165421 101168774(onecut1)

OML:	112136745(onecutl) 112161123(onecut1)

CSAI:

133441174(onecutl) 133464395(onecut1)

XMA:	102230581(onecut1) 102231119

XCO:	114138415 114143733(onecut1)

XHE:	116717910 116719067(onecut1)

PRET:

103462165(onecut1) 103477642

PFOR:

103135980(onecut1) 103156713

PLAI:

106949134 106952413(onecut1)

PMEI:

106916675(onecut1) 106920371

GAF:	122819600(onecut1) 122831314(onecutl)

PPRL:

129369575(onecut1) 129371045(onecutl)

CVG:	107085194(onecut1) 107086297

CTUL:

119781866(onecutl) 119794326(onecut1)

GMU:	124864107(onecutl) 124867392(onecut1)

NFU:	107374254 107379222

KMR:	108237389(onecut1) 108243192(onecutl)

ALIM:

106518986 106524064

NWH:	119409852(onecutl) 119430117(onecut1)

AOCE:

111562841(onecut1) 111571664

MCEP:

125005972(onecut1) 125015757

CSEM:

103379430(onecut1) 103388698

POV:	109624735(onecut1) 109625531 109633540

SSEN:

122772877(onecut1) 122774429(onecutl)

HHIP:

117759223(onecut1) 117776443(onecutl)

HSP:	118110592(onecut1) 118113338(onecutl)

PPLT:

128439860(onecut1) 128449965(onecutl)

SMAU:

118284856(onecutl) 118302025(onecut1)

LCF:	108876934 108883176(onecutl)

SDU:	111221845(onecut1) 111222454

SLAL:

111659116(onecut1) 111669216

XGL:	120784651(onecutl) 120793795(onecut1)

HCQ:	109509697 109514033

SSCV:

125967463 125974661

SBIA:

133497958(onecut1) 133501162(onecutl)

PEE:	133402122(onecutl) 133415546(onecut1)

PTAO:

133474224(onecut1) 133479665(onecutl)

BPEC:

110162664 110175263

MALB:

109955814(onecut1) 109968911

BSPL:

114843353(onecutl) 114852457(onecut1)

SJO:	128360123(onecut1) 128365723(onecutl)

SASA:

106562487 106580869 106605329

STRU:

115166985 115176786 115178891 115203336

OTW:	112222946 112237323 112244982 121838608(onecut1)

OMY:	110487220(onecutl) 110506775 110506779 110514668

OGO:	123997751 124006232 124033077 124033543(onecut1)

ONE:	115103947 115119556(onecut1) 115126087 115141060

OKI:	109881218 109882424 109901725 109908560

OKE:	118364446 118367490 118372191 118372192(onecut1)

SALP:

112079955

SNH:	120024883 120025199 120031630 120047167(onecutl)

CCLU:

121543124 121580020(onecut1)

ELS:	105012709 105022642(onecut1) 105031252

SFM:	108926708(onecut1) 108929035 108930362 108941875

PKI:	111838481 111844979 111846710 111860679

AANG:

118210145(onecutl) 118214883 118226957 118233312

LOC:	102686299 102693940(onecut1)

PSPA:

121294498 121299350 121307021(onecutl)

ARUT:

117395131 117427639 117429081 117965111 117965121

PSEX:

120517942(onecutl) 120539929(onecut1)

LCM:	102355130 102366156

CMK:	103189279(onecut1)

RTP:	109913563(onecut1)

CPLA:

122540990(onecut1)

HOC:	132834313(onecut1)

LERI:

129712572(onecut1) 129716405

PMRN:

116942201(ONECUT1)

LRJ:	133343899(ONECUT1)

CIN:	778970(hnf6)

SCLV:

120341226

SPU:	115917884 378468(hnf6)

APLC:

ARUN:

AJC:

SKO:

DME:	Dmel_CG1922(onecut)

DER:

6555856

DSE:

6619469

DSI:	Dsimw501_GD24376(Dsim_GD24376)

DYA:	Dyak_GE14509

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI14052

DAZ:

DNV:

DHE:

DVI:

BOD:

SCAC:

LCQ:

AGA:

ACOZ:

AARA:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ006386

CPII:

CNS:

BCOO:

AME:

ALAB:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

CFO:

FEX:

LHU:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:	103574465 106693567

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:

DPA:	109541137 125502593 125502594

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_214467

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CFEL:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

CLEC:

HHAL:

NLU:

HVI:

PHU:	Phum_PHUM228480

ZNE:

CSEC:

FCD:

PVM:

PJA:

PCHN:

PCLA:

EAF:

PPOI:

DSV:

RSAN:

RMP:

VJA:

DPTE:

DFR:	124489992 124497738

PTEP:

107437115 107451597

ABRU:

129958053 129976065

UDV:

129219075

SDM:	118185840 118199793

LPOL:

106460680 106463274 106473110 106475560

CBR:	CBG_07897 CBG_19824

NAI:	NECAME_06517

BMY:	BM_BM3512(Bma-ceh-38)

LOA:	LOAG_08712 LOAG_18692

TSP:

GAE:

MCAF:

MAEA:

OSN:

SMM:	Smp_013070

OVI:	T265_00751 T265_01147

EGL:

EGR_05040

LLON:

135492638

NVE:	116608206 5516956

EPA:

ATEN:

ADF:

AMIL:

SPIS:

Reference

PMID:8790352

Authors

Lemaigre FP, Durviaux SM, Truong O, Lannoy VJ, Hsuan JJ, Rousseau GG

Title

Hepatocyte nuclear factor 6, a transcription factor that contains a novel type of homeodomain and a single cut domain.

Journal

Proc Natl Acad Sci U S A 93:9460-4 (1996)
DOI:10.1073/pnas.93.18.9460

Sequence

[rno:25231]

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (4)   
   KEGG PATHWAY (4)   
Gene (1460)   
   KEGG GENES (771)   
   KEGG MGENES (215)   
   RefGene (472)   
   OC (2)   
Literature (1)   
   PubMed (1)   
All databases (1467)   

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