KEGG ORTHOLOGY: K08285

ORTHOLOGY: K08285

Entry

K08285                      KO

Symbol

TRIM18, MID1

Name

midline 1 [EC:2.3.2.27]

Pathway

map04120

Ubiquitin mediated proteolysis

Disease

H00583

Opitz-GBBB syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K08285  TRIM18, MID1; midline 1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K08285  TRIM18, MID1; midline 1
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K08285  TRIM18, MID1; midline 1
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRIM/RBCC proteins
    K08285  TRIM18, MID1; midline 1

Genes

HSA:	4281(MID1)

PTR:	741750(MID1)

PPS:	100970390(MID1)

GGO:	101147859(MID1)

PON:	100174199(MID1)

NLE:	100579343(MID1)

HMH:	116811511(MID1)

MCC:	709683(MID1)

MCF:	102130085(MID1)

MTHB:

126946663

MNI:	105478113(MID1)

CSAB:

103231585(MID1)

CATY:

105574731(MID1)

PANU:

101015249(MID1)

TGE:	112615624(MID1)

MLEU:

105529646(MID1)

RRO:	104653797(MID1)

RBB:	108519345(MID1)

TFN:	117077367(MID1)

PTEH:

111531478(MID1)

CANG:

105518061(MID1)

CJC:	100389533(MID1)

SBQ:	101030143(MID1)

CIMI:

108290188(MID1)

CSYR:

103270861(MID1)

MMUR:

105882448(MID1)

LCAT:

123628683(MID1)

PCOQ:

105820357(MID1)

OGA:	100961438(MID1)

MMU:	17318(Mid1)

MPAH:

110313293(Mid1)

RNO:	54252(Mid1)

MCOC:

116090702(Mid1)

ANU:	117693976(Mid1)

MUN:	110563993(Mid1)

CGE:	100758489(Mid1)

MAUA:

101836114(Mid1)

PROB:

127214466(Mid1)

PLEU:

114704612(Mid1)

MORG:

121443080 121444458

MFOT:

126487945

AAMP:

119804660(Mid1)

NGI:	103749977(Mid1)

HGL:	101701977(Mid1)

CPOC:

100716416(Mid1)

DORD:

105997673(Mid1)

DSP:	122108553(Mid1)

PLOP:

125343360(Mid1)

NCAR:

124972374

MMMA:

107144222(Mid1)

TUP:	102491156(MID1)

GVR:	103589307(MID1)

CFA:	491737(MID1)

CLUD:

112652687(MID1)

VVP:	112932373(MID1)

VLG:	121482852(MID1)

NPO:	129518522(MID1)

UMR:	103668093(MID1)

UAH:	113240741(MID1)

ELK:

111157160

LLV:

125091921

MPUF:

101680593(MID1)

MNP:	132007827(MID1)

MLK:	131821146(MID1)

NVS:	122897654(MID1)

ORO:	101380716(MID1)

EJU:	114218093(MID1)

ZCA:	113931252(MID1)

MLX:	118026701(MID1)

NSU:	110575158(MID1)

FCA:	101085021(MID1)

PYU:	121025179(MID1)

PCOO:

112871612(MID1)

PBG:	122477216(MID1)

PVIV:

125157320(MID1)

LRUF:

124509637

PTG:	102966170(MID1)

PPAD:

109248280(MID1)

PUC:

125931468

AJU:

106971044

HHV:	120233137(MID1)

BTA:	534604(MID1)

BOM:	102268511(MID1)

BIU:	109555198(MID1)

BBUB:

102414408(MID1)

CHX:	102174822(MID1)

OAS:	101117818(MID1)

BTAX:

128070101(MID1)

ODA:	120882462(MID1)

CCAD:

122434728(MID1)

MBEZ:

129564120(MID1)

SSC:	100524415(MID1)

CBAI:

105077746(MID1)

CDK:	105100695(MID1)

VPC:	102526318(MID1)

BACU:

103013073(MID1)

BMUS:

118888795(MID1)

LVE:	103085610(MID1)

OOR:	101283464(MID1)

DLE:	111167232(MID1)

PCAD:

102979162(MID1)

PSIU:

116747642(MID1)

NASI:

112407636(MID1)

ECB:	100049999(MID1)

EAI:	106840187(MID1)

MYB:	102240796(MID1)

MYD:	102773634(MID1)

MMYO:

118653973(MID1)

MLF:	102423733(MID1)

PKL:	118708936(MID1)

EFUS:

103299734(MID1)

MNA:	107536024(MID1)

DRO:	112313345(MID1)

SHON:

118993307(MID1)

AJM:	119058356(MID1)

PDIC:

114504633(MID1)

PHAS:

123830032(MID1)

MMF:	118636399(MID1)

PPAM:

129076894(MID1)

HAI:	109387383(MID1)

RFQ:	117027820(MID1)

PALE:

102897002(MID1)

PGIG:

120611599(MID1)

PVP:	105293975(MID1)

RAY:	107508372(MID1)

MJV:	108401468(MID1)

TOD:	119246351(MID1)

SARA:

101553001(MID1)

SETR:

125998714(MID1)

LAV:	100667991(MID1)

TMU:

101350845

ETF:	101639027(MID1)

DNM:	101425840(MID1)

MDO:	100018227(MID1)

GAS:	123242551(MID1)

SHR:	100925173(MID1)

AFZ:

127553648

PCW:	110221538(MID1)

OAA:	100082209(MID1)

GGA:	373920(MID1)

PCOC:

116230759(MID1)

MGP:	100544167(MID1)

CJO:	107325797(MID1)

TPAI:

128071830(MID1)

LMUT:

125696001(MID1)

NMEL:

110405413(MID1)

APLA:

101796423(MID1)

ACYG:

106042568(MID1)

CATA:

118245810(MID1)

AFUL:

116492344(MID1)

TGU:	100230380(MID1)

LSR:	110469216(MID1)

SCAN:

103815803(MID1)

PMOA:

120504706(MID1)

OTC:	121342256(MID1)

PRUF:

121356263(MID1)

GFR:	102040330(MID1)

FAB:	101821567(MID1)

OMA:	130255659(MID1)

PHI:	102103044(MID1)

PMAJ:

107210341(MID1)

CCAE:

111922807(MID1)

CCW:	104686143(MID1)

CBRC:

103617579(MID1)

ETL:	114060629(MID1)

ZAB:	102061384(MID1)

ACHL:

103798673

SVG:	106856808(MID1)

MMEA:

130588762(MID1)

HRT:	120749328(MID1)

FPG:	101922750(MID1)

FCH:	102053970(MID1)

CLV:	102083555(MID1)

EGZ:	104132985(MID1)

NNI:	104022553(MID1)

PCRI:

PLET:

EHS:

PCAO:

ACUN:

TALA:

104363951(MID1)

PADL:

103924801(MID1)

AFOR:

103906019(MID1)

ACHC:

115334571(MID1)

HALD:

104322416

HLE:	104840571(MID1)

AGEN:

GCL:

CCRI:

CSTI:

CMAC:

MUI:

BREG:

GSTE:

LDI:

MNB:

OHA:	104337536(MID1)

NNT:

104404510

SHAB:

115604136(MID1)

DPUB:

104297067(MID1)

PGUU:

104464583

ACAR:

104523949(MID1)

CPEA:

104394988(MID1)

AVIT:

104271110

CVF:	104287271(MID1)

RTD:	128910473(MID1)

CUCA:

104054884(MID1)

TEO:

104374470

BRHI:

104493889

AAM:	106491602(MID1)

AROW:

112972837(MID1)

NPD:	112954051(MID1)

TGT:

104577508

DNE:	112993386(MID1)

SCAM:

104149814(MID1)

ASN:	102374310(MID1)

AMJ:	102576737(MID1)

CPOO:

109306080(MID1)

GGN:	109302740(MID1)

PSS:	102449757(MID1)

CMY:	102935002(MID1)

CCAY:

125641115(MID1)

DCC:	119850063(MID1)

CPIC:

101948450(MID1)

TST:	117869995(MID1)

CABI:

116824458(MID1)

MRV:	120385354(MID1)

ACS:	100556113(mid1)

ASAO:

132771662(MID1)

PVT:	110075474(MID1)

SUND:

121925524(MID1)

PBI:	103051810(MID1)

PMUR:

107288529(MID1)

CTIG:

120297181(MID1)

TSR:	106551541(MID1)

PGUT:

117676199(MID1)

APRI:

131199167(MID1)

PTEX:

113445163(MID1)

NSS:	113411697(MID1)

VKO:	123024509(MID1)

PMUA:

114596297(MID1)

PRAF:

128413217(MID1)

ZVI:	118084709(MID1)

HCG:	128350260(MID1)

GJA:	107120436(MID1)

STOW:

125431334(MID1)

EMC:	129326750(MID1)

XLA:	100463496(mid1.L) 108709429(mid1.S)

XTR:	448651(mid1)

NPR:	108784643(MID1)

RTEM:

120927450(MID1)

BBUF:

120994892(MID1)

BGAR:

122943304(MID1)

MUO:	115469199(MID1)

GSH:	117362519(MID1)

DRE:	100330952(mid1)

SRX:

107707569

SANH:

107679943 107691263

SGH:	107563871(mid1) 107564314

CCAR:

109096447

CAUA:

113108211

CGIB:

127964777

PTET:

122333113(mid1)

LROH:

127171260(mid1)

OMC:	131547428(mid1)

PPRM:

120479165(mid1)

RKG:	130072538(mid1)

MAMB:

125270866(mid1)

CIDE:

127519000

MASI:

127446981 127448245

TROS:

130555381(mid1)

TDW:	130427283(mid1)

MANU:

129451963(mid1)

IPU:

108258982

IFU:	128602247(mid1)

PHYP:

113537591(mid1)

SMEO:

124378019(mid1)

TFD:

113648947

TVC:	132839661(mid1)

AMEX:

103025901 103030906(mid1)

CMAO:

118798236 118811305(mid1)

EEE:	113578504(mid1)

CHAR:

105898087(mid1) 105902831

TRU:	101069053 101075355

TFS:	130522633 130529332(mid1)

TNG:	GSTEN00026080G001

LCO:	104928714 109136685

NCC:	104944396(mid1) 104947495

TBEN:

117481107(mid1) 117498881

CGOB:

115020080 115026761(mid1)

PGEO:

117459648 117466601(mid1)

GACU:

117544340(mid1) 117546722

EMAC:

134861052 134867564(mid1)

ELY:	117250077 117251141(mid1)

EFO:	125885151 125899261(mid1)

PLEP:

121949131(mid1) 121963002

SLUC:

116044553 116047552(mid1)

ECRA:

117939382 117952490(mid1)

ESP:	116673994 116698035

PFLV:

114550884 114564059

GAT:	120828768 120833743(mid1)

PPUG:

119215704 119229207(mid1)

AFB:	129104192(mid1) 129111781

CLUM:

117744143 117751031(mid1)

PSWI:

130204465 130204944(mid1)

MSAM:

119902217 119904156(mid1)

SCHU:

122872159 122885697(mid1)

CUD:	121506454 121522440(mid1)

ALAT:

119015521 119026416(mid1)

MZE:	101466449 101482248

ONL:	100692412 100711508

OAU:	116319315(mid1) 116328902

OLA:	101168755 101171810

OML:	112155520(mid1) 112160027

CSAI:

133424899 133445899(mid1)

XMA:	102229324 102235707

XCO:	114141125 114148002

XHE:	116716158 116722879

PRET:

103459105 103475959(mid1)

PFOR:

103134245 103141445(mid1)

PLAI:

106946168(mid1) 106954819

PMEI:

106917007(mid1)

GAF:	122827172 122840074(mid1)

PPRL:

129361419(mid1) 129379020

CVG:	107092128 107103808

CTUL:

119784483 119788803(mid1)

GMU:	124861591 124871483(mid1)

NFU:	107381064(mid1) 107389952

KMR:	108239704(mid1) 108244316

ALIM:

106521329(mid1) 106524740

NWH:	119419646(mid1) 119428837

AOCE:

111571707 111583411

MCEP:

125000943 125018180(mid1)

CSEM:

103389714(mid1) 103392028

POV:	109631190 109638900

SSEN:

122765020 122785654

HHIP:

117754888(mid1) 117777648

HSP:	118103516 118119763(mid1)

SMAU:

118312998 118320536(mid1)

LCF:	108891883 108901601(mid1)

SDU:	111218735 111222775

SLAL:

111646186 111662129

XGL:	120798277 120801440(mid1)

HCQ:	109515038 109531291

SSCV:

125973631 125988560

SBIA:

133495807 133512409(mid1)

PEE:	133410299 133410745(mid1)

PTAO:

133486816(mid1) 133489198

BPEC:

110153288 110173172

MALB:

109955790 109958097

BSPL:

114846272 114847131(mid1)

SJO:	128354155 128367874(mid1)

SASA:

106574413 106575281 106581913 106586808

STRU:

115155960 115161352 115179195 115196084

OTW:	112225282(mid1) 112243139 112253738 112266469

OMY:	110495818 110501400 110520618 110527438

OGO:	124008377 124011437 124043555 124044257

ONE:	115107706 115129741 115133023

OKI:	109870914 109871081 109890604 109906720

OKE:	118363800 118366705 118370252 118386089

SALP:

111959610 111970892 112067745 112068350

SNH:	120033446 120050486 120058531 120064359

CCLU:

121535969 121536461 121553068

ELS:	105018783 105020024

SFM:	108930164 108942215

PKI:

111855588

AANG:

118214515 118223425

LOC:	102692365(mid1)

PSPA:

121320645 121327922

ARUT:

117405155 117407287

PSEX:

120522884(mid1)

LCM:	102351326(MID1)

CMK:

103177517

CPLA:

122554975(mid1)

HOC:	132820984(mid1)

LERI:

129702856

PMRN:

116943675(MID1)

LRJ:	133349893(MID1)

» show all

Reference

PMID:11685209

Authors

Trockenbacher A, Suckow V, Foerster J, Winter J, Krauss S, Ropers HH, Schneider R, Schweiger S

Title

MID1, mutated in Opitz syndrome, encodes an ubiquitin ligase that targets phosphatase 2A for degradation.

Journal

Nat Genet 29:287-94 (2001)
DOI:10.1038/ng762

Sequence

[hsa:4281]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Disease (1)   
   KEGG DISEASE (1)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (1151)   
   KEGG GENES (489)   
   KEGG MGENES (211)   
   RefGene (444)   
   OC (7)   
Literature (1)   
   PubMed (1)   
All databases (1159)   

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