KEGG   ORTHOLOGY: K08333Help
Entry
K08333                      KO                                     

Name
PIK3R4, VPS15
Definition
phosphoinositide-3-kinase, regulatory subunit 4 [EC:2.7.11.1]
Pathway
ko04136  Autophagy - other
ko04138  Autophagy - yeast
ko04140  Autophagy - animal
ko04371  Apelin signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K08333  PIK3R4, VPS15; phosphoinositide-3-kinase, regulatory subunit 4
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K08333  PIK3R4, VPS15; phosphoinositide-3-kinase, regulatory subunit 4
   04138 Autophagy - yeast
    K08333  PIK3R4, VPS15; phosphoinositide-3-kinase, regulatory subunit 4
   04136 Autophagy - other
    K08333  PIK3R4, VPS15; phosphoinositide-3-kinase, regulatory subunit 4
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08333  PIK3R4, VPS15; phosphoinositide-3-kinase, regulatory subunit 4
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K08333  PIK3R4, VPS15; phosphoinositide-3-kinase, regulatory subunit 4
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08333  PIK3R4, VPS15; phosphoinositide-3-kinase, regulatory subunit 4
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  VPS15 family
   K08333  PIK3R4, VPS15; phosphoinositide-3-kinase, regulatory subunit 4
Membrane trafficking [BR:ko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K08333  PIK3R4, VPS15; phosphoinositide-3-kinase, regulatory subunit 4
 Autophagy
  Autophagosome formation proteins
   PI3K complex
    K08333  PIK3R4, VPS15; phosphoinositide-3-kinase, regulatory subunit 4
BRITE hierarchy
Other DBs
COG: COG0515 COG2319
Genes
HSA: 30849(PIK3R4)
PTR: 460692(PIK3R4)
PPS: 100968568(PIK3R4)
GGO: 101143072(PIK3R4)
PON: 100172860(PIK3R4)
NLE: 100603428(PIK3R4)
MCC: 718012(PIK3R4)
MCF: 102140446(PIK3R4)
CSAB: 103241695(PIK3R4)
RRO: 104675724(PIK3R4)
RBB: 108522247(PIK3R4)
CJC: 100413515(PIK3R4)
SBQ: 101052638(PIK3R4)
MMU: 75669(Pik3r4)
RNO: 363131(Pik3r4)
CGE: 100769548(Pik3r4)
NGI: 103727284(Pik3r4)
HGL: 101707122(Pik3r4)
OCU: 100343824(PIK3R4)
TUP: 102476949(PIK3R4)
CFA: 477064(PIK3R4)
AML: 100484642(PIK3R4)
UMR: 103679280(PIK3R4)
ORO: 101386847(PIK3R4)
FCA: 101091893(PIK3R4)
PTG: 102954950(PIK3R4)
AJU: 106971603(PIK3R4)
BTA: 507414(PIK3R4)
BOM: 102271813(PIK3R4)
BIU: 109561669(PIK3R4)
PHD: 102321683(PIK3R4)
SSC: 100516293(PIK3R4)
CFR: 102508821(PIK3R4)
CDK: 105088768(PIK3R4)
BACU: 102999939(PIK3R4)
LVE: 103070031(PIK3R4)
OOR: 101282029(PIK3R4)
ECB: 100052647(PIK3R4)
EPZ: 103550794(PIK3R4)
EAI: 106842752(PIK3R4)
MYB: 102252872(PIK3R4)
MYD: 102769127(PIK3R4)
HAI: 109374379(PIK3R4)
RSS: 109444508(PIK3R4)
PALE: 102892160(PIK3R4)
LAV: 100665644(PIK3R4)
TMU: 101345725
MDO: 100023836(PIK3R4)
SHR: 100919089(PIK3R4)
OAA: 100080711(PIK3R4)
GGA: 428449(PIK3R4)
MGP: 100551310(PIK3R4)
CJO: 107309336(PIK3R4)
APLA: 101790933(PIK3R4)
ACYG: 106046659(PIK3R4)
TGU: 100221598(PIK3R4)
SCAN: 103812965(PIK3R4)
GFR: 102033444(PIK3R4)
FAB: 101807431(PIK3R4)
PHI: 102100776(PIK3R4)
PMAJ: 107200638(PIK3R4)
CCAE: 111923539(PIK3R4)
CCW: 104689019(PIK3R4)
FPG: 101911885(PIK3R4)
FCH: 102055902(PIK3R4)
CLV: 102088807(PIK3R4)
EGZ: 104127528(PIK3R4)
NNI: 104018476(PIK3R4)
ACUN: 113476692(PIK3R4)
AAM: 106491226(PIK3R4)
ASN: 102371712(PIK3R4)
AMJ: 102569602(PIK3R4)
PSS: 102454205(PIK3R4)
CMY: 102939377(PIK3R4)
CPIC: 101947697(PIK3R4)
ACS: 100559866(pik3r4)
PVT: 110086128(PIK3R4)
PBI: 103065413(PIK3R4)
PMUR: 107286065(PIK3R4)
GJA: 107122693(PIK3R4)
XLA: 108718957(pik3r4.L) 399407(pik3r4.S)
XTR: 779618(pik3r4)
NPR: 108795806(PIK3R4)
DRE: 564088(pik3r4)
IPU: 108270867(pik3r4)
PHYP: 113526733(pik3r4)
AMEX: 103025076(pik3r4)
TRU: 101074703(pik3r4)
LCO: 104938551(pik3r4)
NCC: 104954447(pik3r4)
MZE: 101487246(pik3r4)
XMA: 102221088(pik3r4)
PRET: 103477487(pik3r4)
NFU: 107379028(pik3r4)
CSEM: 103388091(pik3r4)
LCF: 108881848(pik3r4)
SDU: 111233666(pik3r4)
HCQ: 109512176(pik3r4)
BPEC: 110162516(pik3r4) 110175111
MALB: 109970105(pik3r4)
OTW: 112222485(pik3r4)
ELS: 105031039(pik3r4)
SFM: 108937332(pik3r4)
LCM: 102349203(PIK3R4)
CMK: 103176250(pik3r4)
CIN: 100186582
APLC: 110977764
SKO: 100368721
DME: Dmel_CG9746(Vps15)
DER: 6552416
DPE: 6595287
DSI: Dsimw501_GD20813(Dsim_GD20813)
DWI: 6649900
MDE: 101900784
AAG: 5576461
AME: 726562
BIM: 100740987
BTER: 100649679
SOC: 105197070
MPHA: 105835445
AEC: 105147479
ACEP: 105619662
PBAR: 105429912
HST: 105180889
DQU: 106744008
CFO: 105258125
LHU: 105679188
PGC: 109860013
OBO: 105276974
PCF: 106791560
NVI: 100119152
MDL: 103569908
TCA: 659265
DPA: 109540179
NVL: 108559129
BMOR: 101740636
PMAC: 106714673
PRAP: 110996778
HAW: 110382898
TNL: 113494260
PXY: 105395854
DNX: 107164438
CLEC: 106672596
ZNE: 110834890
FCD: 110847410
TUT: 107364013
DPTE: 113798818
CEL: CELE_ZK930.1(vps-15)
CBR: CBG02750
BMY: Bm1_22785
TSP: Tsp_09181
CRG: 105320190
MYI: 110457796
OBI: 106873538
LAK: 106164475
EGL: EGR_08702
EPA: 110237217
PDAM: 113682510
SPIS: 111329190
HMG: 100208429
ATH: AT4G29380(VPS15)
CRB: 17877662
BRP: 103853623
BOE: 106305100
THJ: 104814595
CPAP: 110812416
CIT: 102606643
TCC: 18588496
GRA: 105767583
GAB: 108486275
DZI: 111303158
EGR: 104438212
VRA: 106771141
VAR: 108345607
LJA: Lj2g3v0878940.1(Lj2g3v0878940.1)
LANG: 109358303
FVE: 101313919
PPER: 18786270
PMUM: 103331028
PAVI: 110765995
MDM: 103408931
PXB: 103946111
ZJU: 107432821
CSV: 101221823
CMO: 103492269
MCHA: 111014479
CMAX: 111495183
CMOS: 111437970
CPEP: 111792573
RCU: 8265137
JCU: 105637831
HBR: 110655084
MESC: 110603076
POP: 7497628
VVI: 100256057
SLY: 101248472
SPEN: 107017746
SOT: 102588012
CANN: 107870164
NTA: 107792939(VPS15) 107796379
NSY: 104238928
NTO: 104106820
SIND: 105162037
HAN: 110928518
LSV: 111883846
DCR: 108199496
BVG: 104902316
SOE: 110791514
NNU: 104604470
OSA: 4331010
DOSA: Os02t0796700-01(Os02g0796700)
OBR: 102708417
BDI: 100829300
ATS: 109749815(LOC109749815)
SBI: 8084642
SITA: 101785421
PDA: 103724252
EGU: 105060219
MUS: 103983927
DCT: 110104298
PEQ: 110023313
AOF: 109819959
ATR: 18434819
APRO: F751_2108
SCE: YBR097W(VPS15)
ERC: Ecym_3487
KMX: KLMA_70326(VPS15)
NCS: NCAS_0I01210(NCAS0I01210)
NDI: NDAI_0A07790(NDAI0A07790)
TPF: TPHA_0A03700(TPHA0A03700)
TBL: TBLA_0A06660(TBLA0A06660)
TDL: TDEL_0C04810(TDEL0C04810)
KAF: KAFR_0G01670(KAFR0G01670)
CAL: CAALFM_C601190CA(VPS15)
CAUR: QG37_07498
SLB: AWJ20_407(VPS15)
NCR: NCU06626(stk-45)
NTE: NEUTE1DRAFT59882(NEUTE1DRAFT_59882)
MGR: MGG_06100
SSCK: SPSK_03847
MAW: MAC_06749
MAJ: MAA_01153
CMT: CCM_03014
MBE: MBM_00840
ANI: AN0576.2
ANG: ANI_1_1068074(An08g07540)
PBL: PAAG_11780(PAAG_03956)
PBN: PADG_11604(PADG_03446)
ABE: ARB_06332
TVE: TRV_01419
PNO: SNOG_14090(SNOG_14089)
PTE: PTT_03995
SPO: SPBC119.07(ppk19)
CNE: CNK01680
CNB: CNBK1860
ABP: AGABI1DRAFT121500(AGABI1DRAFT_121500)
ABV: AGABI2DRAFT187673(AGABI2DRAFT_187673)
MGL: MGL_4028
DDI: DDB_G0282627(vps15)
DFA: DFA_00907(vps15)
EHI: EHI_044190(120.t00016)
SPAR: SPRG_04931
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8999962
  Authors
Panaretou C, Domin J, Cockcroft S, Waterfield MD
  Title
Characterization of p150, an adaptor protein for the human phosphatidylinositol (PtdIns) 3-kinase. Substrate presentation by phosphatidylinositol transfer protein to the p150.Ptdins 3-kinase complex.
  Journal
J Biol Chem 272:2477-85 (1997)
DOI:10.1074/jbc.272.4.2477
  Sequence
[hsa:30849]
Reference
  Authors
Thoresen SB, Pedersen NM, Liestol K, Stenmark H
  Title
A phosphatidylinositol 3-kinase class III sub-complex containing VPS15, VPS34, Beclin 1, UVRAG and BIF-1 regulates cytokinesis and degradative endocytic traffic.
  Journal
Exp Cell Res 316:3368-78 (2010)
DOI:10.1016/j.yexcr.2010.07.008
  Sequence
[hsa:30849]

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