KEGG ORTHOLOGY: K08619

ORTHOLOGY: K08619

Entry

K08619                      KO

Symbol

ADAMTS3

Name

a disintegrin and metalloproteinase with thrombospondin motifs 3 [EC:3.4.24.-]

Disease

H02169

Hennekam lymphangiectasia-lymphedema syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K08619  ADAMTS3; a disintegrin and metalloproteinase with thrombospondin motifs 3
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.24  Metalloendopeptidases
    3.4.24.-
     K08619  ADAMTS3; a disintegrin and metalloproteinase with thrombospondin motifs 3
Peptidases and inhibitors [BR:ko01002]
Metallo peptidases
  Family M12: astacin/adamalysin family
   K08619  ADAMTS3; a disintegrin and metalloproteinase with thrombospondin motifs 3

Genes

HSA:	9508(ADAMTS3)

PTR:	461267(ADAMTS3)

PPS:	100994048(ADAMTS3)

GGO:	101126736(ADAMTS3)

PON:	100433249(ADAMTS3)

NLE:	100582603(ADAMTS3)

MCC:	705473(ADAMTS3)

MCF:	102133798(ADAMTS3)

CSAB:

103235768(ADAMTS3)

CATY:

105596218(ADAMTS3)

PANU:

101003137(ADAMTS3)

TGE:	112624896(ADAMTS3)

RRO:	104678797(ADAMTS3)

RBB:	108523452(ADAMTS3)

TFN:

117084903

PTEH:

111524910(ADAMTS3)

CJC:	100393613(ADAMTS3)

SBQ:	101047699(ADAMTS3)

CSYR:

103274045(ADAMTS3)

MMUR:

105860363(ADAMTS3)

OGA:	100948780(ADAMTS3)

MMU:	330119(Adamts3)

MCAL:

110294518(Adamts3)

MPAH:

110330467(Adamts3)

RNO:	305253(Adamts3)

MCOC:

116071463(Adamts3)

MUN:	110562904(Adamts3)

CGE:	100758325(Adamts3)

PLEU:

114705899(Adamts3)

NGI:	103735052(Adamts3)

HGL:	101701511(Adamts3)

CPOC:

100728969(Adamts3)

CCAN:

109676537(Adamts3)

DORD:

105988508(Adamts3)

DSP:	122106859(Adamts3)

NCAR:

124994523

OCU:	100355810(ADAMTS3)

OPI:	101516381(ADAMTS3)

TUP:	102501465(ADAMTS3)

CFA:	482192(ADAMTS3)

VVP:	112909237(ADAMTS3)

VLG:	121472615(ADAMTS3)

AML:	100467704(ADAMTS3)

UMR:	103665300(ADAMTS3)

UAH:	113263289(ADAMTS3)

UAR:	123786965(ADAMTS3)

ELK:

111149093

LLV:

125093807

MPUF:

101681475(ADAMTS3)

ORO:	101362083(ADAMTS3)

EJU:	114206712(ADAMTS3)

ZCA:	113925685(ADAMTS3)

MLX:	118010465(ADAMTS3)

FCA:	101095822(ADAMTS3)

PYU:	121034599(ADAMTS3)

PBG:	122478816(ADAMTS3)

PTG:	102950599(ADAMTS3)

PPAD:

109277944(ADAMTS3)

AJU:	106982070(ADAMTS3)

HHV:	120231073(ADAMTS3)

BTA:	534082(ADAMTS3)

BOM:	102269830(ADAMTS3)

BIU:	109560561(ADAMTS3)

BBUB:

102411211(ADAMTS3)

CHX:	102180478(ADAMTS3)

OAS:	101102903(ADAMTS3)

ODA:	120861420(ADAMTS3)

CCAD:

122428502(ADAMTS3)

SSC:	100524818(ADAMTS3)

CFR:	102504021(ADAMTS3)

CBAI:

105080392(ADAMTS3)

CDK:	105091252(ADAMTS3)

VPC:	102530487(ADAMTS3)

BACU:

103016578(ADAMTS3)

LVE:	103088554(ADAMTS3)

OOR:	101280876(ADAMTS3)

DLE:	111187586(ADAMTS3)

PCAD:

102977824(ADAMTS3)

PSIU:

116754683(ADAMTS3)

ECB:

100050106

EPZ:	103556189(ADAMTS3)

EAI:	106835104(ADAMTS3)

MYB:	102239056(ADAMTS3)

MYD:	102769044(ADAMTS3)

MMYO:

118668813(ADAMTS3)

MLF:	102432647(ADAMTS3)

MNA:	107532634(ADAMTS3)

PKL:	118705462(ADAMTS3)

HAI:	109394830(ADAMTS3)

DRO:	112319974(ADAMTS3)

SHON:

118999097(ADAMTS3)

AJM:	119052840(ADAMTS3)

PDIC:

114492567(ADAMTS3)

PHAS:

123831222(ADAMTS3)

MMF:	118641708(ADAMTS3)

RFQ:	117022647(ADAMTS3)

PALE:

102890984(ADAMTS3)

PGIG:

120588183(ADAMTS3)

PVP:	105292332(ADAMTS3)

RAY:	107504019(ADAMTS3)

MJV:	108397012(ADAMTS3) 108400905

TOD:	119260213(ADAMTS3)

SARA:

101547896(ADAMTS3)

LAV:	100666756(ADAMTS3)

TMU:

101360169

DNM:	101422584(ADAMTS3)

MDO:	100023421(ADAMTS3)

GAS:	123252193(ADAMTS3)

SHR:	100935069(ADAMTS3)

PCW:	110209805(ADAMTS3)

OAA:	100080834(ADAMTS3)

GGA:	428760(ADAMTS3)

PCOC:

116231183(ADAMTS3)

MGP:	100544650(ADAMTS3)

CJO:	107313467(ADAMTS3)

NMEL:

110398810(ADAMTS3)

APLA:

101801056(ADAMTS3)

ACYG:

106041897(ADAMTS3)

AFUL:

116488806(ADAMTS3)

TGU:	100226131(ADAMTS3)

LSR:	110470140(ADAMTS3)

SCAN:

103823466(ADAMTS3)

PMOA:

120498813(ADAMTS3)

OTC:	121348185(ADAMTS3)

PRUF:

121349366(ADAMTS3)

GFR:	102032909(ADAMTS3)

FAB:	101818237(ADAMTS3)

PHI:	102106581(ADAMTS3)

PMAJ:

107202880(ADAMTS3)

CCAE:

111929444(ADAMTS3)

CCW:	120409894(ADAMTS3)

ETL:	114068040(ADAMTS3)

ZAB:	102070615(ADAMTS3)

FPG:	101910604(ADAMTS3)

FCH:	102051125(ADAMTS3)

CLV:	102091722(ADAMTS3)

EGZ:	104124677(ADAMTS3)

NNI:	104015859(ADAMTS3)

ACUN:

113479661(ADAMTS3)

TALA:

104363510(ADAMTS3)

PADL:

103917693(ADAMTS3)

ACHC:

115342162(ADAMTS3)

AAM:	106491805(ADAMTS3)

AROW:

112977620(ADAMTS3)

NPD:	112950077(ADAMTS3)

DNE:

112994285

ASN:	102381376(ADAMTS3)

AMJ:	106736907(ADAMTS3)

CPOO:

109309308(ADAMTS3)

GGN:	109297143(ADAMTS3)

PSS:	102456642(ADAMTS3)

CMY:	102935768(ADAMTS3)

CPIC:

101951627(ADAMTS3)

TST:	117877981(ADAMTS3)

CABI:

116817715(ADAMTS3)

MRV:	120406103(ADAMTS3)

ACS:	100559595(adamts3)

PVT:	110088681(ADAMTS3)

SUND:

121932044(ADAMTS3)

PBI:	103047996(ADAMTS3)

PMUR:

107291823(ADAMTS3)

PGUT:

117673653(ADAMTS3)

VKO:	123022853(ADAMTS3)

PMUA:

114604182(ADAMTS3)

ZVI:	118079075(ADAMTS3)

GJA:	107111377(ADAMTS3)

XLA:	108706770(adamts3.S) 108719631(adamts3.L)

XTR:	100498276(adamts3)

NPR:	108798630(ADAMTS3)

RTEM:

120915573(ADAMTS3)

BBUF:

120989802(ADAMTS3)

BGAR:

122944580(ADAMTS3)

DRE:	102467218(adamts3)

SRX:	107719190 107755736

SANH:

107681286 107700077(adamts3)

SGH:	107557615 107558022 107575494

CCAR:

109046935

CAUA:

113049212 113079115

PPRM:

120461719(adamts3)

IPU:	108255965(adamts3)

PHYP:

113537165(adamts3)

SMEO:

124380784(adamts3)

TFD:	113637671(adamts3)

AMEX:

103043359(adamts3)

EEE:	113589057(adamts3)

TRU:	101063312(adamts3)

TNG:	GSTEN00028560G001

LCO:	104923469(adamts3)

CGOB:

115013462(adamts3)

ELY:	117252869(adamts3)

PLEP:

121944308(adamts3)

SLUC:

116054121(adamts3)

ECRA:

117944556(adamts3)

PFLV:

114555642

GAT:	120830986(adamts3)

PPUG:

119224819(adamts3)

MSAM:

119892279(adamts3)

CUD:	121510492(adamts3)

MZE:	101479253(adamts3) 112433495

ONL:	100699019(adamts3)

OAU:	116333378(adamts3)

OLA:

101167013

OML:	112136425(adamts3)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:

CVG:

CTUL:

119791903(adamts3)

GMU:	124877797(adamts3)

NFU:	107386095(adamts3)

KMR:	108241873(adamts3)

ALIM:

106531469

AOCE:

111580542

CSEM:

103397812

SSEN:

122769447(adamts3) 122769448

HHIP:

117768004(adamts3)

LCF:

108878409

SDU:	111236849(adamts3)

SLAL:

111660878(adamts3)

XGL:	120805412(adamts3)

HCQ:

109519561

BPEC:

110153445(adamts3)

MALB:

109951326(adamts3)

SASA:

106570999

OTW:	112238733(adamts3)

OMY:	110529238(adamts3)

OGO:	124034975(adamts3)

ELS:

105027426

SFM:	108938376(adamts3)

PKI:	111848578(adamts3)

AANG:

118206708(adamts3) 118212487

LOC:	102696749(adamts3)

PSPA:

121300201 121317269

ARUT:

117403608 117403920

LCM:	102363046(ADAMTS3)

CMK:	103182120(adamts3)

RTP:	109931399(adamts3)

BFO:

BBEL:

CIN:

SCLV:

SPU:	579423 588716

APLC:

SKO:

AME:

ALAB:

BIM:

BTER:

CCAL:

OBB:

NMEA:

MDL:

CCIN:

TCA:

DPA:

NVL:

BMOR:

692529(Adamts-1)

BMAN:

MSEX:

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

HAW:

TNL:

SLIU:

OFU:

ZNE:

PVM:

PJA:

PCHN:

HAME:

PCLA:

PTRU:

HAZT:

EAF:

CSCU:

GAE:

HRF:

HRJ:

CRG:	105319380 105319381

OBI:

106867989

OSN:

115231387

SMM:	Smp_146730

NVE:

XEN:

HMG:

Reference

PMID:15987500

Authors

Jones GC, Riley GP

Title

ADAMTS proteinases: a multi-domain, multi-functional family with roles in extracellular matrix turnover and arthritis.

Journal

Arthritis Res Ther 7:160-9 (2005)
DOI:10.1186/ar1783

Reference

PMID:28985353

Authors

Brouillard P, Dupont L, Helaers R, Coulie R, Tiller GE, Peeden J, Colige A, Vikkula M

Title

Loss of ADAMTS3 activity causes Hennekam lymphangiectasia-lymphedema syndrome 3.

Journal

Hum Mol Genet 26:4095-4104 (2017)
DOI:10.1093/hmg/ddx297

Sequence

[hsa:9508]

All links

Ontology (3)   
   KEGG BRITE (3)   
Disease (1)   
   KEGG DISEASE (1)   
Gene (1381)   
   KEGG GENES (309)   
   KEGG MGENES (219)   
   RefGene (842)   
   OC (11)   
Literature (2)   
   PubMed (2)   
All databases (1387)   

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