KEGG ORTHOLOGY: K08654

ORTHOLOGY: K08654

Entry

K08654                      KO

Symbol

PCSK5

Name

proprotein convertase subtilisin/kexin type 5 [EC:3.4.21.-]

Brite

KEGG Orthology (KO) [BR:ko00001]
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K08654  PCSK5; proprotein convertase subtilisin/kexin type 5
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts
    K08654  PCSK5; proprotein convertase subtilisin/kexin type 5
Enzymes [BR:ko01000]
3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.-
     K08654  PCSK5; proprotein convertase subtilisin/kexin type 5
Peptidases and inhibitors [BR:ko01002]
Serine peptidases
  Family S8: subtilisin family
   K08654  PCSK5; proprotein convertase subtilisin/kexin type 5
Chaperones and folding catalysts [BR:ko03110]
Intramolecular chaperones
  Subtilisin family
   K08654  PCSK5; proprotein convertase subtilisin/kexin type 5

Genes

HSA:	5125(PCSK5)

PTR:	464533(PCSK5)

PPS:	100969356(PCSK5)

GGO:	101142785(PCSK5)

PON:	100451865(PCSK5)

NLE:	100589851(PCSK5)

MCC:	704428(PCSK5)

MCF:	101867285(PCSK5)

CSAB:

103219608(PCSK5)

CATY:

105584199(PCSK5)

PANU:

101020523(PCSK5)

TGE:	112608430(PCSK5)

RRO:	104682187(PCSK5)

RBB:	108542650(PCSK5)

TFN:	117098450(PCSK5)

PTEH:

111543363(PCSK5)

CJC:	100399969(PCSK5)

SBQ:	101050594(PCSK5)

CSYR:

103276920(PCSK5)

MMUR:

105868703(PCSK5)

OGA:	100942654(PCSK5)

MMU:	18552(Pcsk5)

MCAL:

110285424(Pcsk5)

MPAH:

110338648(Pcsk5)

RNO:	116548(Pcsk5)

MCOC:

116103634(Pcsk5)

MUN:	110557755 110561810 110565455

CGE:

100762283

PLEU:

114696920(Pcsk5)

HGL:	101711492(Pcsk5)

CPOC:

100729657(Pcsk5)

CCAN:

109697156

DORD:

105987193(Pcsk5)

DSP:	122095106(Pcsk5)

NCAR:

124964584

OCU:	100338956(PCSK5)

OPI:	101535556(PCSK5)

TUP:	102475750(PCSK5)

CFA:	484160(PCSK5)

VVP:	112922097(PCSK5)

VLG:	121484820(PCSK5)

AML:	100482021(PCSK5)

UMR:	103663349(PCSK5)

UAH:	113269839(PCSK5)

UAR:	123781497(PCSK5)

ELK:

111153546

LLV:

125083272

MPUF:

101671492(PCSK5)

ORO:	101362414(PCSK5)

EJU:	114201579(PCSK5)

ZCA:	113934648(PCSK5)

MLX:	118026277(PCSK5)

FCA:	101096422(PCSK5)

PYU:	121013539(PCSK5)

PBG:	122474467(PCSK5)

PTG:	102961274(PCSK5)

PPAD:

109275375(PCSK5)

AJU:	106982976(PCSK5)

HHV:	120238447(PCSK5)

BTA:	528098(PCSK5)

BOM:	102285425(PCSK5)

BIU:	109562969(PCSK5)

BBUB:

102391145(PCSK5)

CHX:	102187133(PCSK5)

OAS:	101121570 114112975

ODA:	120874750(PCSK5)

CCAD:

122453215(PCSK5)

SSC:	100519237(PCSK5)

CFR:	102509281(PCSK5)

CBAI:

105067286(PCSK5)

CDK:	105087403(PCSK5)

VPC:	102537833(PCSK5)

BACU:

103002573(PCSK5)

LVE:	103084489(PCSK5)

OOR:	101290400(PCSK5)

DLE:	111174583(PCSK5)

PCAD:

102979227(PCSK5)

PSIU:

116755380(PCSK5)

ECB:	100063740(PCSK5)

EPZ:	103548070(PCSK5)

EAI:	106827811(PCSK5)

MYB:	102239087(PCSK5)

MYD:	102756643(PCSK5)

MMYO:

118667442(PCSK5)

MLF:	102422159(PCSK5)

MNA:	107544911(PCSK5)

PKL:	118716470(PCSK5)

HAI:	109375139(PCSK5)

DRO:	112299473(PCSK5)

SHON:

118976051(PCSK5)

AJM:	119045575(PCSK5)

PDIC:

114504577(PCSK5)

PHAS:

123819763(PCSK5)

MMF:	118629492(PCSK5)

RFQ:	117031982(PCSK5)

PALE:

102897606(PCSK5)

PGIG:

120587043(PCSK5)

PVP:	105303998(PCSK5)

RAY:	107501187(PCSK5)

MJV:	108399493(PCSK5)

TOD:	119232971(PCSK5)

SARA:

101540488(PCSK5)

LAV:	100658661(PCSK5)

TMU:

101348628

DNM:	101426292(PCSK5)

MDO:	100019619(PCSK5)

GAS:	123249545(PCSK5)

SHR:	100915833(PCSK5)

PCW:	110223165(PCSK5)

OAA:	100075612(PCSK5)

GGA:	395456(PCSK5)

PCOC:

116234686(PCSK5)

MGP:

104916661

CJO:	107306216(PCSK5)

NMEL:

110389799(PCSK5)

APLA:

113840369(PCSK5) 113840370

ACYG:

106044141 106044163

AFUL:

116500519(PCSK5)

TGU:	100219573(PCSK5)

LSR:	110476513(PCSK5)

SCAN:

103821058(PCSK5)

PMOA:

120507061(PCSK5)

OTC:	121345369(PCSK5)

PRUF:

121365366(PCSK5)

GFR:	102031889(PCSK5)

FAB:	101806590(PCSK5)

PHI:	102105826(PCSK5)

PMAJ:

107216063(PCSK5)

CCAE:

111941541

CCW:	104685287(PCSK5)

ETL:	114054833 114058708(PCSK5)

ZAB:	102061391(PCSK5)

FPG:	101916041(PCSK5)

FCH:	102059251(PCSK5)

CLV:	102095742(PCSK5)

EGZ:	104123828(PCSK5)

NNI:	104008679 104011396(PCSK5) 104012734

ACUN:

113490110(PCSK5)

TALA:

104360003(PCSK5)

PADL:

103920430(PCSK5)

ACHC:

115336728(PCSK5) 121232763

AROW:

112965406(PCSK5)

NPD:	112958197(PCSK5)

DNE:	112983247(PCSK5)

ASN:	102384120(PCSK5)

AMJ:	102571816(PCSK5)

CPOO:

109323408(PCSK5)

GGN:	109297580(PCSK5)

PSS:	102449743(PCSK5)

CMY:	102941966(PCSK5)

CPIC:

101952958(PCSK5)

TST:	117878966(PCSK5)

CABI:

116821606(PCSK5)

MRV:	120407890(PCSK5)

ACS:

100561221

PVT:	110076008(PCSK5)

SUND:

121922643(PCSK5)

PBI:	103049483 103068036

PMUR:

107286164(PCSK5)

TSR:	106538301 106553532

PGUT:

117661429(PCSK5)

VKO:	123031239(PCSK5)

PMUA:

114606309(PCSK5)

ZVI:	118076850(PCSK5)

GJA:	107108742(PCSK5)

XLA:	446297(pcsk5.S) 495940(pcsk5.L)

XTR:	779961(pcsk5)

NPR:	108788486(PCSK5)

RTEM:

120943028(PCSK5)

BBUF:

120989143(PCSK5)

BGAR:

122923177(PCSK5)

DRE:	559556(pcsk5b) 571235(pcsk5a)

SRX:	107723238 107723482 107728213 107730328 107740995

SANH:

107684380 107691579 107691788 107702857 107702858

SGH:	107548272 107565122 107596014 107600598

CCAR:

109053363 109085719

CAUA:

113049842 113070709 113070711 113107353

IPU:	108260017(pcsk5a) 108265616(pcsk5b)

PHYP:

113531433 113533614(pcsk5)

SMEO:

124378739(pcsk5a) 124400458(pcsk5b)

TFD:	113640924(pcsk5a) 113656044(pcsk5b)

AMEX:

103025246(pcsk5) 103028782

EEE:	113567651 113586942

TRU:	101066227(pcsk5) 101069826 115247494

TNG:	GSTEN00012944G001 GSTEN00014471G001 GSTEN00029416G001

LCO:	104920282(pcsk5) 104922480

NCC:	104952308(pcsk5)

CGOB:

115013226(pcsk5) 115017048

ELY:	117252142(pcsk5b) 117269442(pcsk5a)

PLEP:

121944136(pcsk5b) 121959702(pcsk5a)

SLUC:

116056724(pcsk5b) 116062861(pcsk5a)

ECRA:

117945527(pcsk5b) 117959576(pcsk5a)

PFLV:

114555204(pcsk5) 114571243

GAT:	120830492(pcsk5b) 120831434(pcsk5a)

PPUG:

119224777(pcsk5b) 119226685(pcsk5a)

MSAM:

119891359(pcsk5b) 119914982(pcsk5a)

CUD:	121509417 121509418(pcsk5b) 121524825(pcsk5a)

MZE:	101478025 101480927(pcsk5)

ONL:	100696025(pcsk5) 100696905

OAU:	116331858(pcsk5a) 116332447(pcsk5b)

OLA:	101160179 101170192(pcsk5)

OML:	112148291(pcsk5b) 112163034(pcsk5a)

XMA:	102217319(pcsk5) 102223283

XCO:	114149302 114154270

XHE:	116724331 116729595(pcsk5)

PRET:

103470243(pcsk5) 103473507

PFOR:

103135353(pcsk5) 103155145

PLAI:

106951459(pcsk5) 106954514

PMEI:

106912391 106924504(pcsk5)

GAF:	122819449(pcsk5a) 122828757(pcsk5b)

CVG:	107087280 107087281(pcsk5) 107088991

CTUL:

119776508(pcsk5a) 119790142(pcsk5b)

GMU:	124872652(pcsk5a) 124877590(pcsk5b)

NFU:	107394002(pcsk5) 107395526

KMR:	108231026(pcsk5a) 108234552(pcsk5b) 108234553

ALIM:

106516254 106523787(pcsk5)

NWH:	119413948(pcsk5b) 119424499(pcsk5a)

AOCE:

111576634(pcsk5) 111587832

CSEM:

103390426 103397177 103397520

POV:	109626060 109638143(pcsk5)

SSEN:

122758639(pcsk5a) 122769621(pcsk5b)

HHIP:

117768420(pcsk5b) 117771865(pcsk5a)

LCF:	108874103 108878089(pcsk5)

SDU:	111230780 111230885(pcsk5) 111239889

SLAL:

111656779 111658215

XGL:	120804810(pcsk5b) 120804941 120806705(pcsk5a)

HCQ:	109514183(pcsk5) 109527928

BPEC:

110157503 110162080(pcsk5)

MALB:

109961533 109961554(pcsk5) 109972346

SASA:

106562014 106580081 106585692(pcsk5)

OTW:	112215066(pcsk5a) 112249450(pcsk5b) 112263262

OMY:	110522949(pcsk5a) 110525391(pcsk5b) 110535788

OGO:	124034533(pcsk5b) 124036070 124048621(pcsk5a)

ONE:	115111358 115126789 115139790

SALP:

111957470 111962819 111974527

SNH:	120025624 120051211(pcsk5b) 120063087

ELS:	105014466(pcsk5) 105027940

SFM:	108938578(pcsk5)

PKI:	111839318(pcsk5)

AANG:

118206630(pcsk5b) 118212216

LOC:	102690988(pcsk5)

PSPA:

121299199 121318956

ARUT:

117409381 117421292

LCM:

102361626

CMK:	103182388(pcsk5b)

RTP:

109928201

BFO:	118431777 118432114

BBEL:

CIN:

SCLV:

SPU:

APLC:

SKO:

DER:

DSI:	Dsimw501_GD17282(Dsim_Fur2)

DYA:	Dyak_GE17268(Dyak_Fur2)

DSR:

110181665

DPO:	Dpse_GA15057

DPE:

6599354

DMN:

108158126

DWI:

6648841

DMO:	Dmoj_GI14460

DAZ:

DNV:

DHE:

DVI:

LCQ:

AGA:	AgaP_AGAP002915

ACOZ:

AARA:

AAG:

AALB:

CQU:	CpipJ_CPIJ015181

CPII:

AME:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

NVI:

CSOL:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:

ATD:

NVL:

BMOR:

BMAN:

MSEX:

115442728 115442759 119188416

DPL:	KGM_209563 KGM_215393

BANY:

112052316 112054245

PMAC:

106709159 106709186

PPOT:

106111660

PXU:	106119341 106119423

PRAP:

111003975 111004005

ZCE:	119839562 119839723

HAW:	110370406 110370407

TNL:	113503401 113503527

OFU:	114356341 114359782

PXY:	105385521 105393727

API:	100160882 100164716

DNX:	107161287 107163151

AGS:	114120060 114122374

RMD:	113550595 113551039

BTAB:

109035576

CLEC:

106662545 106674127

NLU:	111043758 111055043 111062025

PHU:	Phum_PHUM018560

ZNE:

110838933

CSEC:

111864742

FCD:

110842410

DPX:	DAPPUDRAFT_306585

PVM:

113824262

EAF:

111707127

ISC:	IscW_ISCW018863

TUT:

107372295

DPTE:

113792966

CSCU:

111623007

LGI:	LOTGIDRAFT_106119 LOTGIDRAFT_224835

PCAN:

112553735

GAE:

121380459

CRG:	105328548 105346967 109619720

MYI:	110441699 110441700 110449353 110453082 110461611

PMAX:

117317446

MMER:

123529657 123534732 123562916 123565983

LAK:

106178752

SMM:	Smp_144080

SHX:	MS3_0014934

OVI:	T265_06397

EGL:

EGR_00916

NVE:

5503300

EPA:	110241428 110253418

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

111326502 111326591 111334072

DGT:	114522472 114540557

XEN:

124459458

HMG:

101237189

TAD:	TRIADDRAFT_54612

AQU:

100637637

NCOL:

116268094 116268096

MBR:	MONBRDRAFT_14515 MONBRDRAFT_26825

SRE:	PTSG_00429 PTSG_05153

TET:

TTHERM_000009879 TTHERM_000043859 TTHERM_000053939 TTHERM_000059527 TTHERM_000077009 TTHERM_00009810 TTHERM_00009880 TTHERM_000115543 TTHERM_000115547 TTHERM_00014940 TTHERM_00014950 TTHERM_000194618 TTHERM_00030100 TTHERM_00030110 TTHERM_00030140 TTHERM_00030160 TTHERM_000304319 TTHERM_000304329 TTHERM_000344108 TTHERM_00037250 TTHERM_00037610 TTHERM_00037650 TTHERM_000411588 TTHERM_000417959 TTHERM_00045050 TTHERM_00046850 TTHERM_000478080 TTHERM_000527078 TTHERM_000527079 TTHERM_00058210 TTHERM_00058220 TTHERM_00059520 TTHERM_000629740 TTHERM_000647239 TTHERM_00069500 TTHERM_000706447 TTHERM_00070910 TTHERM_00077010 TTHERM_00077020 TTHERM_00077430 TTHERM_00092870 TTHERM_00093940 TTHERM_00100000 TTHERM_00100020 TTHERM_00100080 TTHERM_00101530 TTHERM_00102580 TTHERM_00115420 TTHERM_00115430 TTHERM_00115460 TTHERM_00115480 TTHERM_00115500 TTHERM_00115510 TTHERM_00115530 TTHERM_00115540 TTHERM_00116547 TTHERM_00117540 TTHERM_00129530 TTHERM_00129540 TTHERM_00129550 TTHERM_00129590 TTHERM_00129840 TTHERM_00133390 TTHERM_00136200 TTHERM_00160550 TTHERM_00189050 TTHERM_00191330 TTHERM_00191940 TTHERM_00194600 TTHERM_00194630 TTHERM_00215880 TTHERM_00220940 TTHERM_00222410 TTHERM_00223420 TTHERM_00224470 TTHERM_00224540 TTHERM_00227680 TTHERM_00270370 TTHERM_00273380 TTHERM_00274430 TTHERM_00283930 TTHERM_00283960 TTHERM_00283970 TTHERM_00298260 TTHERM_00298410 TTHERM_00300550 TTHERM_00304220 TTHERM_00304240 TTHERM_00304320 TTHERM_00313360 TTHERM_00313390 TTHERM_00318530 TTHERM_00323130 TTHERM_00344110 TTHERM_00344130 TTHERM_00348670 TTHERM_00395810 TTHERM_00417860 TTHERM_00417900 TTHERM_00417910 TTHERM_00417990 TTHERM_00418000 TTHERM_00423410 TTHERM_00424410 TTHERM_00424520 TTHERM_00424560 TTHERM_00425830 TTHERM_00427550 TTHERM_00492480 TTHERM_00519770 TTHERM_00540440 TTHERM_00541520 TTHERM_00541530 TTHERM_00541540 TTHERM_00541547 TTHERM_00541550 TTHERM_00543560 TTHERM_00543570 TTHERM_00543580 TTHERM_00559840 TTHERM_00581890 TTHERM_00586810 TTHERM_00599920 TTHERM_00621540 TTHERM_00629910 TTHERM_00633070 TTHERM_00637180 TTHERM_00643380 TTHERM_00647240 TTHERM_00655630 TTHERM_00678480 TTHERM_00678490 TTHERM_00707460 TTHERM_00707470 TTHERM_00709560 TTHERM_00777320 TTHERM_00787310 TTHERM_00787420 TTHERM_00895910 TTHERM_00941600 TTHERM_00941610 TTHERM_00942860 TTHERM_00951940 TTHERM_01006490 TTHERM_01006510 TTHERM_01006530 TTHERM_01144950 TTHERM_01212880 TTHERM_01267140 TTHERM_01321600 TTHERM_01358380 TTHERM_01419330 TTHERM_01520330 TTHERM_01545790

SMIN:

v1.2.003473.t1(symbB.v1.2.003473.t1) v1.2.024856.t1(symbB.v1.2.024856.t1) v1.2.037987.t1(symbB.v1.2.037987.t1)

» show all

Reference

PMID:20555025

Authors

Heng S, Paule S, Hardman B, Li Y, Singh H, Rainczuk A, Stephens AN, Nie G

Title

Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment.

Journal

Endocrinology 151:3909-17 (2010)
DOI:10.1210/en.2010-0326

Sequence

[hsa:5125]

All links

Ontology (4)   
   KEGG BRITE (4)   
Gene (5912)   
   KEGG GENES (751)   
   KEGG MGENES (501)   
   RefGene (4632)   
   OC (28)   
Literature (1)   
   PubMed (1)   
All databases (5917)   

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