KEGG ORTHOLOGY: K08731

ORTHOLOGY: K08731

Entry

K08731                      KO

Symbol

BIRC5

Name

baculoviral IAP repeat-containing protein 5

Pathway

map01524

Platinum drug resistance

map04210

Apoptosis

map04215

Apoptosis - multiple species

map04390

Hippo signaling pathway

map05161

Hepatitis B

map05200

Pathways in cancer

map05207

Chemical carcinogenesis - receptor activation

map05210

Colorectal cancer

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04390 Hippo signaling pathway
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
   04215 Apoptosis - multiple species
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
   05207 Chemical carcinogenesis - receptor activation
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
  09162 Cancer: specific types
   05210 Colorectal cancer
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
  09172 Infectious disease: viral
   05161 Hepatitis B
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K08731  BIRC5; baculoviral IAP repeat-containing protein 5
Peptidases and inhibitors [BR:ko01002]
Peptidase inhibitors
  Family I32: IAP family
   K08731  BIRC5; baculoviral IAP repeat-containing protein 5
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Centromeric chromatin formation proteins
   Kinetochore proteins
    CPC (chromosomal passenger complex)
     K08731  BIRC5; baculoviral IAP repeat-containing protein 5

Other DBs

GO:

0043027

Genes

HSA:	332(BIRC5)

PTR:	455276(BIRC5)

PPS:	100980532(BIRC5)

GGO:	101152864(BIRC5)

PON:	100172652(BIRC5)

NLE:	100598415(BIRC5)

HMH:	116483979(BIRC5)

MCC:	709565(BIRC5)

MCF:	102120307(BIRC5) 102133017

MTHB:

126939275 126963345

MNI:	105469239(BIRC5)

CSAB:

103243654(BIRC5)

CATY:

105577651(BIRC5)

PANU:

101006161(BIRC5)

TGE:	112610215(BIRC5) 112631442

MLEU:

105537660 105545796(BIRC5)

RRO:	104659300(BIRC5)

RBB:	108534183(BIRC5)

TFN:	117066766(BIRC5)

PTEH:

111542352(BIRC5)

CANG:

105521103(BIRC5)

CJC:	100398121(BIRC5)

SBQ:	101046847(BIRC5)

CIMI:

108281839 108301749(BIRC5)

CSYR:

103262808(BIRC5)

MMUR:

105866736(BIRC5)

LCAT:

123650645(BIRC5)

PCOQ:

105824013(BIRC5)

OGA:	100961291(BIRC5)

MMU:	11799(Birc5)

MCAL:

110305684(Birc5)

MPAH:

110332414(Birc5)

RNO:	64041(Birc5)

MCOC:

116078576(Birc5)

ANU:	117711130(Birc5)

MUN:	110550569(Birc5)

CGE:	100769162 118237651(Birc5)

MAUA:

101828099(Birc5)

PROB:

127219827(Birc5)

PLEU:

114708968(Birc5)

MORG:

121436269(Birc5)

MFOT:

126500289

AAMP:

119812960(Birc5)

NGI:	103747285(Birc5)

HGL:	101703201(Birc5)

CPOC:

100527953(Birc5)

CCAN:

109683144(Birc5)

DORD:

106003260(Birc5)

DSP:	122096602(Birc5) 122097907

PLOP:

125365370(Birc5)

NCAR:

124980708

OCU:

103346801

OPI:	101522332(BIRC5)

TUP:	102487370(BIRC5)

GVR:	103595967(BIRC5)

CFA:	442936(BIRC5)

VVP:	112920853(BIRC5)

AML:	100475314(BIRC5)

UMR:	103665963(BIRC5)

UAH:	113244569(BIRC5)

UAR:	123803023(BIRC5)

ELK:

111160341

LLV:

125086892

MPUF:

101676477(BIRC5)

MNP:	132003502(BIRC5)

NVS:	122905937(BIRC5)

ORO:	101363894(BIRC5)

EJU:	114216173(BIRC5)

ZCA:	113908303(BIRC5)

MLX:	118024214(BIRC5)

NSU:	110572500(BIRC5)

LWW:	102731151(BIRC5)

FCA:	493835(BIRC5)

PYU:	121017987(BIRC5)

PCOO:

112864535(BIRC5)

PBG:	122486155(BIRC5)

LRUF:

124513356

PTG:	102950505(BIRC5)

PPAD:

109276862(BIRC5)

PUC:

125926304

AJU:

106981916

HHV:	120228299(BIRC5)

BTA:	414925(BIRC5)

BOM:	102275014(BIRC5)

BIU:	109574440(BIRC5)

BBUB:

102396201(BIRC5) 123334696

BBIS:

105000397(BIRC5)

CHX:	102180077(BIRC5)

OAS:	101123390(BIRC5)

BTAX:

128065504(BIRC5)

ODA:	120866827(BIRC5)

CCAD:

122437556(BIRC5)

MBEZ:

129544663(BIRC5)

SSC:	397266(BIRC5)

CFR:	102511273(BIRC5)

CBAI:

105065598(BIRC5)

CDK:	105092156(BIRC5)

VPC:	102543682(BIRC5)

BACU:

103012250(BIRC5)

LVE:	103072055(BIRC5)

OOR:	101284595(BIRC5)

DLE:	111182765(BIRC5)

PCAD:

102977574(BIRC5)

PSIU:

116745382(BIRC5) 116747138

NASI:

112404902 112410443(BIRC5)

ECB:	100050808(BIRC5)

EPZ:	103554048(BIRC5)

EAI:	106845247(BIRC5)

MYB:	102241862 102247286

MYD:	102765549 102766681(BIRC5)

MMYO:

118664013 118671120(BIRC5)

MLF:	102427260 102439527(BIRC5)

MNA:	107532046(BIRC5)

PKL:	118704572(BIRC5) 118713057

EFUS:

103291033 103298251(BIRC5)

HAI:	109383622(BIRC5)

DRO:	112298801(BIRC5) 112302993

SHON:

118999731(BIRC5)

AJM:	119058668(BIRC5)

PDIC:

114490782 114503458(BIRC5)

PHAS:

123816756(BIRC5) 123826954

MMF:	118634154(BIRC5)

RFQ:	117014004(BIRC5)

PPAM:

129086565(BIRC5)

PALE:

102888083(BIRC5)

PGIG:

120600298(BIRC5)

PVP:	105293400(BIRC5)

RAY:	107510062(BIRC5)

MJV:	108407801(BIRC5)

TOD:	119232055(BIRC5)

SARA:

101543114(BIRC5)

LAV:	100671026(BIRC5)

TMU:

101348672

ETF:	115872347(BIRC5)

DNM:

101420644

MDO:	100031079(BIRC5)

GAS:	123231659 123245520(BIRC5)

SHR:	100934619(BIRC5)

AFZ:

127560698

PCW:	110193934(BIRC5)

OAA:	100087013(BIRC5)

GGA:	374078(BIRC5) 768589

PCOC:

116231736 116233942

MGP:	104911642(BIRC5)

CJO:	107310923(BIRC5) 107316337

TPAI:

128075530(BIRC5) 128077107

LMUT:

125689724(BIRC5) 125696997

NMEL:

110395353(BIRC5) 110400323

APLA:

106017805 113843115(BIRC5)

ACYG:

106039984 106044728(BIRC5)

CATA:

118254691(BIRC5)

AFUL:

116488102(BIRC5)

TGU:	100229685 100232531(BIRC5)

LSR:	110475823 110484624

SCAN:

103814531 103819217

PMOA:

120506157(BIRC5) 120511613

OTC:	121335493 121346373(BIRC5)

PRUF:

121356434 121365308

GFR:	102034875(BIRC5)

FAB:	101808801 101810543(BIRC5)

OMA:	130250754(BIRC5) 130255644

PHI:	102101400 102111696

PMAJ:

107202602 107207386

CCAE:

111921972 111931948

CCW:	104693747 120411781

CBRC:

103612385(BIRC5)

ETL:	114066244 114069101

ZAB:	102070072 106629467

ACHL:

103801622 103808632

SVG:	106855089 106857292

MMEA:

130580484 130581310

HRT:	120750759(BIRC5) 120755093

FPG:	101915727(BIRC5)

FCH:	102049312(BIRC5) 114016184

CLV:	102092273 102095218(BIRC5)

EHS:

104505795

TALA:

104362357(BIRC5) 116965818

ACHC:

115342697 115350343(BIRC5)

HLE:	104838180(BIRC5)

AGEN:

126038379 126052763

GCL:	127014262 127018727

CCRI:

104160455(BIRC5)

CSTI:

104562851(BIRC5)

CMAC:

104482202(BIRC5)

MUI:	104535197(BIRC5)

BREG:

104633063(BIRC5)

FGA:	104071044(BIRC5)

GSTE:

104252066(BIRC5)

LDI:	104350775 104352846(BIRC5)

MNB:	103777974(BIRC5)

SHAB:

115608111 115613995

DPUB:

104305315(BIRC5)

CPEA:

104397439(BIRC5)

AVIT:

104276125(BIRC5)

RTD:	128907766(BIRC5) 128912697

CUCA:

104060753(BIRC5)

TEO:	104382815(BIRC5)

AAM:	106492420 106494127(BIRC5)

AROW:

112977479(BIRC5)

NPD:	112949336(BIRC5) 112954743

TGT:

104579984

DNE:	112983647 112985534(BIRC5)

ASN:	102380435(BIRC5) 106722454

AMJ:	102573002(BIRC5) 106737667(BIRC5B)

CPOO:

109316178(BIRC5) 109322733

GGN:	109296656(BIRC5) 109301862

CMY:	102938634 119567431

CCAY:

125633344(BIRC5) 125644483

DCC:	119853650(BIRC5) 119863151

CPIC:

101941733(BIRC5) 101942470

TST:	117874187(BIRC5)

CABI:

116834050(BIRC5)

MRV:	120374360 120400223(BIRC5)

ACS:	100561388 100566215(birc5)

PVT:	110087327 110090465(BIRC5)

SUND:

121919573 121922797(BIRC5)

PBI:	103064357(BIRC5)

PMUR:

107290052(BIRC5) 107291928

CTIG:

120308685(BIRC5) 120313094

TSR:	106547391(BIRC5)

PGUT:

117663025(BIRC5) 117672809

APRI:

131189926 131189927 131190548 131200937

PTEX:

113433987 113436961(BIRC5)

NSS:	113411905(BIRC5) 113412395

VKO:	123018177(BIRC5) 123024299

PMUA:

114585314 114589289(BIRC5)

PRAF:

128399356 128407357(BIRC5)

ZVI:	118079728(BIRC5) 118084290

HCG:	128346907(BIRC5)

GJA:	107115319(BIRC5) 107117947

STOW:

125426211 125427673(BIRC5)

EMC:	129323596 129328660(BIRC5)

XLA:	394382(birc5.S) 398418(birc5.L) 398454(birc5l.L) 735055(birc5l.S)

XTR:	733532(birc5) 733575(birc5l)

NPR:	108800977 108801438

RTEM:

120919626(BIRC5) 120929382

BBUF:

120993933 121004207(BIRC5)

BGAR:

122933331(BIRC5)

MUO:	115465068 115472381 115473575

GSH:	117356405 117367596(BIRC5)

DRE:	246726(birc5b) 373110(birc5a)

SRX:	107708796 107716091 107722191 107755428

SANH:

107681933 107684154 107690959 107695794

SGH:	107571769 107581679 107586566

CCAR:

109046380 109048546 109064084 109066312

CAUA:

113041763 113055953 113099920 113111694

CGIB:

128011948 128025426

PTET:

122329060(birc5b) 122355665(birc5a)

LROH:

127154962(birc5b) 127174287(birc5a)

OMC:	131532327(birc5b) 131551238(birc5a)

PPRM:

120463253(birc5b) 120474830(birc5a)

MAMB:

125255063(birc5a) 125260700(birc5b)

CIDE:

127523877

MASI:

127420145 127423063 127427456

TROS:

130545189(birc5b) 130569065(birc5a)

MANU:

129421567(birc5a) 129430623(birc5b)

IPU:	108273465(birc5a) 108274059 108275580(birc5b)

IFU:	128617388(birc5a) 128619822(birc5b) 128625553

PHYP:

113527276 113528386(birc5) 113530836

SMEO:

124388671(birc5a) 124397005

TFD:	113638908(birc5a) 113639462 113658080(birc5b)

AMEX:

103025428(birc5) 111192978 111194016

CMAO:

118809371(birc5a) 118821318 118822764(birc5b)

EEE:	113571426 113577672 113590300

CHAR:

105897314(birc5b) 105908581(birc5a) 105908958

TRU:	101062741 101064682

TFS:	130527993(birc5a) 130529998(birc5b)

TNG:	GSTEN00024148G001 GSTEN00028102G001

LCO:	104918068 104932614

NCC:	104954876 104956851

CGOB:

115010664 115024964

ELY:	117247561(birc5a) 117258637(birc5b)

EFO:	125880727(birc5a) 125891615(birc5b)

PLEP:

121947308(birc5b) 121958815(birc5a)

SLUC:

116038379(birc5b) 116044330(birc5a)

ECRA:

117937202(birc5a) 117947803(birc5b)

ESP:	116670939 116692326

PFLV:

114548056 114559116

GAT:	120818922(birc5a) 120829133(birc5b)

PPUG:

119213327(birc5a) 119222677(birc5b)

AFB:	129091600(birc5a) 129100316(birc5b)

CLUM:

117733821(birc5b) 117748663(birc5a)

MSAM:

119887883 119906056(birc5b) 119916083(birc5a)

SCHU:

122867699(birc5a) 122883037(birc5b)

CUD:	121517049(birc5b) 121527871(birc5a)

ALAT:

119010198(birc5a) 119023040(birc5b)

MZE:	101481959 101485763

ONL:	100709346 100709661

OAU:	116320167(birc5a) 116325877(birc5b)

OLA:	101155061 101168459

OML:	112154285(birc5a) 112158719(birc5b)

XMA:	102218059 102224158

XCO:	114151496 114158857

XHE:	116711217 116726670

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122823709(birc5a) 122827657 122833711 122833717 122833745

CVG:	107086758 107099875

CTUL:

119782245(birc5b) 119793258(birc5a)

GMU:	124872919(birc5b) 124875496(birc5a)

NFU:	107388179 107390640

KMR:	108237147(birc5a) 108244583(birc5b)

ALIM:

106522649 106528792

NWH:	119416924(birc5b) 119423391(birc5a)

AOCE:

111585891 111587248

MCEP:

125022987(birc5a)

CSEM:

103382361 103385084(survivin)

POV:	109627178 109630673

SSEN:

122759397(birc5a) 122777130(birc5b)

HHIP:

117752713(birc5a) 117765022(birc5b)

HSP:	118101071(birc5a) 118111255(birc5b)

LCF:	108876532(birc5b) 108880779(birc5a)

SDU:	111219265 111220232

SLAL:

111668900 111672046

XGL:	120794443(birc5a) 120804111(birc5b)

HCQ:	109516568 109531332

SSCV:

125989062 125991153

BPEC:

110159670 110164468

MALB:

109969183 109971546

BSPL:

114846480(birc5a) 114859194(birc5b)

SASA:

106572692 106610005(birc5)

STRU:

115152911(birc5) 115165488

OTW:	112216626(birc5b) 112259586(birc5a)

OMY:	110502934(birc5a) 110532707(birc5b) 118939474

OGO:	124023136(birc5b) 124038582(birc5a)

ONE:	115112869(birc5) 115124792

OKI:	109900053(birc5) 109908605

OKE:	118377015(birc5b) 118377721(birc5a)

SALP:

111966102 111978782(birc5)

SNH:	120045725(birc5a) 120059587(birc5b)

CCLU:

121537396(birc5b) 121577642(birc5a)

ELS:	105013536 105031550

SFM:	108924792(birc5) 108939213

PKI:	111848326(birc5) 111853929

AANG:

118207533(birc5b) 118216302 118218170

LOC:	102690217(birc5) 102696960

PSPA:

121295344(birc5a) 121308868(birc5b)

ARUT:

117400943(birc5b) 117424092(birc5a)

PSEX:

120517963(birc5a) 120526745(birc5b)

LCM:	102346472 102348297(BIRC5)

CMK:	103175557(birc5a)

RTP:	109938723(birc5)

CPLA:

122540557 122562224(birc5a)

LERI:

129708229(birc5a) 129709585 129712476

BFO:

BBEL:

CIN:

SCLV:

SPU:

APLC:

AJC:

SKO:

DME:	Dmel_CG12265(Det)

DER:

6552326

DSE:

6616779

DSI:	Dsimw501_GD19147(Dsim_GD19147)

DYA:	Dyak_GE10116

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI24770

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

RZE:

TDA:	119677668 119684329

MDE:

SCAC:

LCQ:

LSQ:

ECOE:

HIS:

AGA:	AgaP_AGAP008420(IAP5)

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ006694

CPII:

CNS:

BCOO:

AME:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

FVI:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

BMOR:

100302609(Iap2)

BMAN:

114248076

MSEX:

115449461

DPL:	KGM_201142

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

PGW:

CCRN:

API:	100159292(Det) 100569400

DNX:

AGS:

RMD:

ACOO:

BTAB:

DCI:	103508457 103516527 103522644 103523747

CLEC:

106664242

HHAL:

106689514

NLU:	111052464 120350633 120352145

HVI:

FOC:

TPAL:

ZNE:

CSEC:

IEL:

FCD:

DPX:	DAPPUDRAFT_307098

DMK:

DPZ:

PVM:

PJA:

PCHN:

HAME:

PCLA:

CQD:

PTRU:

ESN:

HAZT:

EAF:

LSM:

PPOI:

119113400 119113401 119114302

DSV:	119431547 119437413 119440115 119440135 119441998

RSAN:

119387565

RMP:	119159703 119159704 119162094

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

UDV:	129216989 129233718

SDM:

118192059

LPOL:

111083946

CEL:	CELE_C50B8.2(bir-2) CELE_T27F2.3(bir-1)

CBR:	CBG_11537(Cbr-bir-2) CBG_23296(Cbr-bir-1)

CRQ:	GCK72_018078 GCK72_018601 GCK72_019406 GCK72_019455

BMY:	BM_BM8420(Bm8420)

LOA:	LOAG_04028

TSP:

Tsp_10804

LGI:	LOTGIDRAFT_125617 LOTGIDRAFT_229109

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

RPHI:

DPOL:

OBI:

LAK:

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

TAD:	TRIADDRAFT_56224

AQU:	100634627 100635173

TDC:

119359119

PCHM:

VFPPC_17662

SHS:	STEHIDRAFT_65375

GTR:	GLOTRDRAFT_63085

CPUT:

CONPUDRAFT_54433

EIN:	Eint_050680

EHE:	EHEL_050740

ERO:	EROM_050670

NCE:	NCER_100918

GTT:	GUITHDRAFT_107595

NGR:	NAEGRDRAFT_61105

» show all

Reference

PMID:16534789

Authors

Fangusaro JR, Caldas H, Jiang Y, Altura RA

Title

Survivin: an inhibitor of apoptosis in pediatric cancer.

Journal

Pediatr Blood Cancer 47:4-13 (2006)
DOI:10.1002/pbc.20805

Reference

PMID:9256286

Authors

Ambrosini G, Adida C, Altieri DC

Title

A novel anti-apoptosis gene, survivin, expressed in cancer and lymphoma.

Journal

Nat Med 3:917-21 (1997)
DOI:10.1038/nm0897-917

Sequence

[hsa:332]

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Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (16)   
   KEGG PATHWAY (16)   
Drug (3)   
   KEGG DRUG (3)   
Gene (1708)   
   KEGG GENES (813)   
   KEGG MGENES (17)   
   RefGene (869)   
   OC (9)   
Literature (2)   
   PubMed (2)   
All databases (1733)   

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