KEGG   ORTHOLOGY: K08765Help
Entry
K08765                      KO                                     

Name
CPT1A
Definition
carnitine O-palmitoyltransferase 1, liver isoform [EC:2.3.1.21]
Pathway
ko00071  Fatty acid degradation
ko01212  Fatty acid metabolism
ko03320  PPAR signaling pathway
ko04152  AMPK signaling pathway
ko04714  Thermogenesis
ko04920  Adipocytokine signaling pathway
ko04922  Glucagon signaling pathway
ko04931  Insulin resistance
Disease
H00525  Disorders of mitochondrial fatty-acid oxidation
H01981  Carnitine palmitoyltransferase I deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K08765  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform
 09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    K08765  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform
 09150 Organismal Systems
  09152 Endocrine system
   04922 Glucagon signaling pathway
    K08765  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform
   04920 Adipocytokine signaling pathway
    K08765  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform
   03320 PPAR signaling pathway
    K08765  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform
  09159 Environmental adaptation
   04714 Thermogenesis
    K08765  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform
 09160 Human Diseases
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K08765  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03029 Mitochondrial biogenesis
    K08765  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.21  carnitine O-palmitoyltransferase
     K08765  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform
Mitochondrial biogenesis [BR:ko03029]
 Mitochondrial quality control factors
  Regulator of mitochondrial biogenesis
   Other regulator of mitochondrial biogenesis
    K08765  CPT1A; carnitine O-palmitoyltransferase 1, liver isoform
BRITE hierarchy
Other DBs
RN: R01923
GO: 0004095
Genes
HSA: 1374(CPT1A)
PTR: 451382(CPT1A)
PON: 100446735(CPT1A)
MCC: 709837(CPT1A)
MMU: 12894(Cpt1a)
RNO: 25757(Cpt1a)
CFA: 403583(CPT1A)
AML: 100482719(CPT1A)
BTA: 506812(CPT1A)
SSC: 399527(CPT1A)
ECB: 100009716(CPT1A)
MDO: 100012915(CPT1A)
OAA: 100081561(CPT1A)
GGA: 423118(CPT1A)
MGP: 100549362(CPT1A)
TGU: 100226785(CPT1A)
XLA: 108713843 108715191 379393(cpt1a.L)
XTR: 100135089(cpt1al) 100490391(cpt1a)
DRE: 100333227 558088(cpt1aa) 560000(cpt1ab)
DME: Dmel_CG12891(whd)
AAG: 5566521
AME: 550695
NVI: 100121693
CEL: CELE_Y46G5A.17(cpt-1)
CBR: CBG07886(Cbr-cpt-1)
BMY: Bm1_02015
HMG: 100206022(cpt1a) 100212546(cpt1a)
TCR: 507211.10
MMI: MMAR_0691
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7892212
  Authors
Britton CH, Schultz RA, Zhang B, Esser V, Foster DW, McGarry JD
  Title
Human liver mitochondrial carnitine palmitoyltransferase I: characterization of its cDNA and chromosomal localization and partial analysis of the gene.
  Journal
Proc Natl Acad Sci U S A 92:1984-8 (1995)
DOI:10.1073/pnas.92.6.1984
  Sequence
[hsa:1374]
Reference
  Authors
Prip-Buus C, Thuillier L, Abadi N, Prasad C, Dilling L, Klasing J, Demaugre F, Greenberg CR, Haworth JC, Droin V, Kadhom N, Gobin S, Kamoun P, Girard J, Bonnefont JP
  Title
Molecular and enzymatic characterization of a unique carnitine palmitoyltransferase 1A mutation in the Hutterite community.
  Journal
Mol Genet Metab 73:46-54 (2001)
DOI:10.1006/mgme.2001.3176

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