KEGG   ORTHOLOGY: K08844
Entry
K08844                      KO                                     

Name
LRRK2
Definition
leucine-rich repeat kinase 2 [EC:2.7.11.1]
Pathway
ko05012  Parkinson disease
ko05022  Pathways of neurodegeneration - multiple diseases
Disease
H00057  Parkinson disease
H00066  Lewy body dementia (LBD)
H01600  Parkinsonian syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K08844  LRRK2; leucine-rich repeat kinase 2
   05022 Pathways of neurodegeneration - multiple diseases
    K08844  LRRK2; leucine-rich repeat kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08844  LRRK2; leucine-rich repeat kinase 2
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K08844  LRRK2; leucine-rich repeat kinase 2
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K08844  LRRK2; leucine-rich repeat kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08844  LRRK2; leucine-rich repeat kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  LRRK family
   K08844  LRRK2; leucine-rich repeat kinase 2
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K08844  LRRK2; leucine-rich repeat kinase 2
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K08844  LRRK2; leucine-rich repeat kinase 2
Genes
HSA: 120892(LRRK2)
PTR: 745893(LRRK2)
PPS: 100991115(LRRK2)
GGO: 101129744(LRRK2)
PON: 100440374(LRRK2)
NLE: 100582066(LRRK2)
MCC: 697930(LRRK2)
MCF: 102126106(LRRK2)
CSAB: 103238159(LRRK2)
RRO: 104664577(LRRK2)
RBB: 108538682(LRRK2)
CJC: 100412740(LRRK2)
SBQ: 101046501(LRRK2)
MMU: 66725(Lrrk2)
MCAL: 110310364(Lrrk2)
MPAH: 110334545(Lrrk2)
RNO: 300160(Lrrk2)
MUN: 110541861(Lrrk2)
CGE: 100768191(Lrrk2)
NGI: 103731296(Lrrk2)
HGL: 101708809(Lrrk2)
CCAN: 109700877(Lrrk2)
OCU: 100343394(LRRK2)
TUP: 102479879(LRRK2)
CFA: 486608(LRRK2)
VVP: 112921054(LRRK2)
AML: 100466511(LRRK2)
UMR: 103675581(LRRK2)
UAH: 113257729(LRRK2)
ORO: 101382328(LRRK2)
ELK: 111161332
FCA: 101096157(LRRK2)
PTG: 102957332(LRRK2)
PPAD: 109268830(LRRK2)
AJU: 106986899(LRRK2)
BTA: 535652(LRRK2)
BOM: 102267844(LRRK2)
BIU: 109559216(LRRK2)
BBUB: 102391863(LRRK2)
CHX: 102188019(LRRK2)
OAS: 101111447(LRRK2)
SSC: 780403(LRRK2)
CFR: 102505769(LRRK2)
CDK: 105089274(LRRK2)
BACU: 103007107(LRRK2)
LVE: 103070824
OOR: 101273162(LRRK2)
DLE: 111174109(LRRK2)
PCAD: 102989961(LRRK2)
ECB: 100052935(LRRK2)
EPZ: 103551980(LRRK2)
EAI: 106822491(LRRK2)
MYB: 102257573(LRRK2)
MYD: 102770006(LRRK2)
MNA: 107528359(LRRK2)
HAI: 109376683(LRRK2)
DRO: 112318354(LRRK2)
PALE: 102880438(LRRK2)
RAY: 107514208(LRRK2)
MJV: 108393528(LRRK2)
LAV: 100675822(LRRK2)
TMU: 101360352
MDO: 100019429(LRRK2)
SHR: 100914746(LRRK2)
PCW: 110199010(LRRK2)
OAA: 100080785(LRRK2)
GGA: 427844(LRRK2)
MGP: 100548936(LRRK2)
CJO: 107307980(LRRK2)
NMEL: 110392392(LRRK2)
APLA: 101799033(LRRK2)
ACYG: 106042027(LRRK2)
TGU: 100230190(LRRK2)
LSR: 110475185(LRRK2)
SCAN: 103813716(LRRK2)
GFR: 102035180(LRRK2)
FAB: 101807426(LRRK2)
PHI: 102105175(LRRK2)
PMAJ: 107204228(LRRK2)
CCAE: 111923010(LRRK2)
CCW: 104686859(LRRK2)
ETL: 114060564(LRRK2)
FPG: 101912937(LRRK2)
FCH: 102053602(LRRK2)
CLV: 102096289(LRRK2)
EGZ: 104123793(LRRK2)
NNI: 104010796(LRRK2)
ACUN: 113487676(LRRK2)
PADL: 103917271(LRRK2)
AAM: 106487733(LRRK2)
ASN: 102372165(LRRK2)
AMJ: 102569017(LRRK2)
PSS: 102462745(LRRK2)
CMY: 102935365(LRRK2)
CPIC: 103307567(LRRK2)
ACS: 100555929(lrrk2)
PVT: 110080790(LRRK2)
PBI: 103054138(LRRK2)
PMUR: 107303316(LRRK2)
PMUA: 114605058(LRRK2)
GJA: 107119907(LRRK2)
XLA: 445832(lrrk2.L)
XTR: 100145062(lrrk2)
NPR: 108783840(LRRK2)
DRE: 559366(lrrk2)
CCAR: 109050968
IPU: 108274736(lrrk2)
PHYP: 113529688(lrrk2)
AMEX: 103037394(lrrk2)
EEE: 113573141(lrrk2)
TRU: 101065896(lrrk2)
LCO: 104922606(lrrk2)
MZE: 101468617(lrrk2)
ONL: 100693798(lrrk2)
OLA: 101155093(lrrk2)
XMA: 102223156(lrrk2)
XCO: 114136420(lrrk2)
PRET: 103465740(lrrk2)
CVG: 107102890(lrrk2)
NFU: 107388331(lrrk2)
KMR: 108244226(lrrk2)
ALIM: 106526120(lrrk2)
AOCE: 111582490(lrrk2)
CSEM: 103379674(lrrk2)
POV: 109624654(lrrk2)
LCF: 108880868(lrrk2)
SDU: 111222523(lrrk2)
SLAL: 111672161(lrrk2)
HCQ: 109530852(lrrk2)
BPEC: 110168304(lrrk2)
MALB: 109956385(lrrk2)
SASA: 106561594(lrrk2)
OTW: 112218871(lrrk2)
SALP: 111962739
ELS: 105026420(lrrk2)
SFM: 108927228(lrrk2)
PKI: 111853401(lrrk2)
LCM: 102365848(LRRK2)
CMK: 103189557(lrrk2)
RTP: 109938857(lrrk2)
BFO: 118416238
CIN: 101243223
SPU: 581823
APLC: 110983101
OBI: 106869154
LAK: 106175217
NVE: 5508612
EPA: 110236932
ADF: 107348398
AMIL: 114963646
SPIS: 111326220
DDI: DDB_G0269250(pats1)
DPP: DICPUDRAFT_159478(pats1)
DFA: DFA_03616 DFA_06290(pats1)
 » show all
Reference
  Authors
Zimprich A, Biskup S, Leitner P, Lichtner P, Farrer M, Lincoln S, Kachergus J, Hulihan M, Uitti RJ, Calne DB, Stoessl AJ, Pfeiffer RF, Patenge N, Carbajal IC, Vieregge P, Asmus F, Muller-Myhsok B, Dickson DW, Meitinger T, Strom TM, Wszolek ZK, Gasser T
  Title
Mutations in LRRK2 cause autosomal-dominant parkinsonism with pleomorphic pathology.
  Journal
Neuron 44:601-7 (2004)
DOI:10.1016/j.neuron.2004.11.005
  Sequence
[hsa:120892]

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