KEGG   ORTHOLOGY: K08852Help
Entry
K08852                      KO                                     

Name
ERN1
Definition
serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]
Pathway
ko04140  Autophagy - animal
ko04141  Protein processing in endoplasmic reticulum
ko04210  Apoptosis
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko05010  Alzheimer disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K08852  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K08852  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
  09143 Cell growth and death
   04210 Apoptosis
    K08852  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
 09160 Human Diseases
  09164 Neurodegenerative diseases
   05010 Alzheimer disease
    K08852  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
  09167 Endocrine and metabolic diseases
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K08852  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08852  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08852  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.26  Endoribonucleases producing 5'-phosphomonoesters
    3.1.26.-  
     K08852  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  IRE family
   K08852  ERN1; serine/threonine-protein kinase/endoribonuclease IRE1
BRITE hierarchy
Genes
HSA: 2081(ERN1)
PTR: 454769(ERN1)
PPS: 100975737(ERN1)
GGO: 101133025(ERN1)
PON: 100456324(ERN1)
NLE: 100606427(ERN1)
MCC: 717751(ERN1)
MCF: 102116193(ERN1)
CSAB: 103243204(ERN1)
RRO: 104675499(ERN1)
RBB: 108536259(ERN1)
CJC: 100414862(ERN1)
SBQ: 101028157(ERN1)
MMU: 78943(Ern1)
RNO: 498013(Ern1)
CGE: 100750680(Ern1)
NGI: 103744745(Ern1)
HGL: 101714734(Ern1)
OCU: 100357346(ERN1)
TUP: 102491971(ERN1)
CFA: 610766(ERN1)
AML: 100474476(ERN1)
UMR: 103665903(ERN1)
ORO: 101371113(ERN1)
FCA: 101084148(ERN1)
PTG: 102955540(ERN1)
AJU: 106978670(ERN1)
BTA: 112442685(ERN1)
BOM: 102275172(ERN1)
BIU: 109574052(ERN1)
PHD: 102331716(ERN1)
CHX: 102173038(ERN1)
OAS: 101102746(ERN1)
SSC: 100510978(ERN1)
CFR: 102518977(ERN1)
CDK: 105092320(ERN1)
BACU: 103016780(ERN1)
LVE: 103088377(ERN1)
OOR: 101288419(ERN1)
ECB: 100064339(ERN1)
EPZ: 103549771(ERN1)
EAI: 106835569(ERN1)
MYB: 102243225(ERN1)
MYD: 102773882(ERN1)
HAI: 109380320(ERN1)
RSS: 109440208 109448052(ERN1)
PALE: 102888330(ERN1)
LAV: 100668197(ERN1)
TMU: 101352446
MDO: 100026418(ERN1)
SHR: 100935398(ERN1)
OAA: 100079980(ERN1)
GGA: 417414(ERN1) 771230(ERN2)
MGP: 100539722(ERN2) 100543580(ERN1)
CJO: 107320692(ERN2) 107322004(ERN1)
APLA: 101800310(ERN2) 101801189(ERN1)
ACYG: 106034606(ERN1) 106046018(ERN2)
TGU: 100224514(ERN2) 100232717(ERN1)
SCAN: 103817561(ERN2) 103819783(ERN1)
GFR: 102037392(ERN1) 102042914(ERN2)
FAB: 101805946(ERN1) 101811924(ERN2)
PHI: 102103505(ERN1) 102106238(ERN2)
PMAJ: 107211358(ERN2) 107212393(ERN1)
CCAE: 111936204(ERN2) 111937407(ERN1)
CCW: 104684731(ERN2) 104694246(ERN1)
FPG: 101912358(ERN2) 101916090(ERN1)
FCH: 102046501(ERN2) 102054971(ERN1)
CLV: 102089185(ERN2) 102098781(ERN1)
EGZ: 104123760(ERN1) 104134548(ERN2)
NNI: 104014306(ERN1) 104015282(ERN2)
ACUN: 113485918(ERN2) 113486954(ERN1)
AAM: 106486197(ERN2) 106493134(ERN1)
ASN: 102370398(ERN2) 102388413(ERN1)
AMJ: 102572344(ERN2) 106736761(ERN1)
CMY: 102931380 102933241(ERN1)
CPIC: 101941243(ERN1) 101943085(ERN2)
ACS: 100558581(ern2) 100566768(ern1)
PVT: 110073407(ERN1)
PBI: 103052502 103060161(ERN2) 103062073(ERN1)
PMUR: 107284852(ERN1)
XLA: 108701211(ern1.L) 108701627(ern2.L) 108702862(ern1.S) 444075(ern2.S)
XTR: 779732(ern2)
NPR: 108790768(ERN2) 108801893(ERN1)
DRE: 567021(ern2)
IPU: 108258664(ern2) 108278270(ern1)
PHYP: 113524239 113528209(ern1) 113535782(ern2)
NFU: 107376527(ern1) 107388775
KMR: 108230211 108239231(ern1)
HCQ: 109511384 109522743(ern1)
BPEC: 110166443(ern1) 110167591
MALB: 109968226 109971528(ern1)
SFM: 108927413(ern2) 108938732 108940180(ern1)
LCM: 102352244(ERN2) 102363303(ERN1)
CMK: 103175740(ern1) 103186624(ern2)
CIN: 100178253
SPU: 105442135
APLC: 110986031
SKO: 102809207
DME: Dmel_CG4583(Ire1)
DER: 6553832
DPE: 6594645
DSI: Dsimw501_GD20099(Dsim_GD20099)
DWI: 6649410
AAG: 5574668
AME: 408501
BIM: 100747935
BTER: 100647594
SOC: 105206286
MPHA: 105835918
ACEP: 105621969
PBAR: 105422728
HST: 105191732
DQU: 106742574
CFO: 105250660
LHU: 105670652
PGC: 109860126
OBO: 105282800
PCF: 106793657
NVI: 100124019
MDL: 103575372
TCA: 658142
DPA: 109544543
NVL: 108569258
PMAC: 106718241
HAW: 110371337
PXY: 105381209
API: 100164567
DNX: 107162936
CLEC: 106663854
ZNE: 110837643
TUT: 107369906
DPTE: 113790048
CEL: CELE_C41C4.4(ire-1)
CBR: CBG13333(Cbr-ire-1)
BMY: Bm1_25785
TSP: Tsp_03028
CRG: 105321014
MYI: 110466943
OBI: 106874141
SHX: MS3_01418
PDAM: 113671430
HMG: 100198901
ATH: AT2G17520(IRE1A)
BRP: 103874122
VAR: 108343424
LJA: Lj2g3v1589600.1(Lj2g3v1589600.1) Lj2g3v1599840.1(Lj2g3v1599840.1) Lj4g3v1330210.1(Lj4g3v1330210.1)
LANG: 109350196
NNU: 104603792
OSA: 4343198
DOSA: Os07t0471000-01(Os07g0471000)
OBR: 102713479
BDI: 100833665
ATS: 109750659(LOC109750659)
SBI: 8077273
SITA: 101783039
PDA: 103704928
EGU: 105042748
DCT: 110114002
PEQ: 110037720
AOF: 109836599
MIS: MICPUN_100424(IRE1)
SCE: YHR079C(IRE1)
ERC: Ecym_8164
KMX: KLMA_50358(IRE1)
NCS: NCAS_0H01740(NCAS0H01740)
NDI: NDAI_0C01890(NDAI0C01890)
TPF: TPHA_0H01470(TPHA0H01470)
TBL: TBLA_0A03220(TBLA0A03220)
TDL: TDEL_0E02600(TDEL0E02600)
KAF: KAFR_0D04760(KAFR0D04760)
CAL: CAALFM_C107970CA(IRE1)
CAUR: QG37_03494
SLB: AWJ20_3345(IRE1)
NCR: NCU02202(stk-14)
NTE: NEUTE1DRAFT148210(NEUTE1DRAFT_148210)
MGR: MGG_15988
SSCK: SPSK_01381
TRE: TRIREDRAFT_45242(ire1)
MAW: MAC_05911
MAJ: MAA_07884
CMT: CCM_06835
BFU: BCIN_01g02660(Bcire1)
MBE: MBM_08307
ANI: AN0235.2
ANG: ANI_1_848014(An01g06550)
ABE: ARB_07150
TVE: TRV_07737
PTE: PTT_08190
SPO: SPAC167.01(ire1)
CNE: CNB01690
CNB: CNBB4040
ABP: AGABI1DRAFT60620(AGABI1DRAFT_60620)
ABV: AGABI2DRAFT37330(AGABI2DRAFT_37330)
MGL: MGL_2052
DDI: DDB_G0267650(ireA)
DFA: DFA_00609(irlE) DFA_01673(irlD) DFA_06636(ireA) DFA_11591(irlB-2)
EHI: EHI_068350(61.t00012) EHI_075540(253.t00012)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Liu CY, Xu Z, Kaufman RJ
  Title
Structure and intermolecular interactions of the luminal dimerization domain of human IRE1alpha.
  Journal
J Biol Chem 278:17680-7 (2003)
DOI:10.1074/jbc.M300418200
  Sequence
[hsa:2081]

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