KEGG   ORTHOLOGY: K08857
Entry
K08857                      KO                                     

Name
NEK1_4_5
Definition
NIMA (never in mitosis gene a)-related kinase 1/4/5 [EC:2.7.11.1]
Disease
H00511  Short rib-polydactyly syndrome
H02157  Short-rib thoracic dysplasia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08857  NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K08857  NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5
   03400 DNA repair and recombination proteins
    K08857  NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08857  NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  NEK family
   K08857  NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Other cilium assembly proteins
    K08857  NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  Check point factors
   Other check point factors
    K08857  NEK1_4_5; NIMA (never in mitosis gene a)-related kinase 1/4/5
Genes
HSA: 341676(NEK5) 4750(NEK1) 6787(NEK4)
PTR: 460434(NEK4) 471345(NEK1) 745999(NEK5)
PPS: 100973939(NEK5) 100981661(NEK4) 100990642(NEK1)
GGO: 101125530(NEK5) 101139519(NEK4) 101144675(NEK1)
PON: 100173731(NEK4) 100436374(NEK1)
NLE: 100581109(NEK1) 100586441(NEK4) 100605118(NEK5)
MCC: 694345(NEK1) 695646(NEK4) 713960(NEK5)
MCF: 102114802(NEK5) 102115637(NEK1) 102130430(NEK4)
CSAB: 103214473(NEK5) 103227744(NEK4) 103236516(NEK1)
RRO: 104653858(NEK5) 104662876(NEK1) 104663694(NEK4)
RBB: 108519338(NEK5) 108522327(NEK4) 108522850(NEK1)
CJC: 100394078(NEK4) 100394930(NEK1)
SBQ: 101029557(NEK5) 101037612 101051138(NEK1)
MMU: 18004(Nek1) 23955(Nek4) 330721(Nek5)
MCAL: 110299782(Nek1) 110300147(Nek5) 110309470(Nek4)
MPAH: 110325412(Nek4) 110336318(Nek1) 110336903(Nek5)
RNO: 290705(Nek1) 306252(Nek4) 685440(Nek5)
CGE: 100752822(Nek5) 100759305(Nek1) 100761888(Nek4)
NGI: 103727139(Nek1) 103745482(Nek5) 103749012(Nek4)
HGL: 101696587(Nek4) 101703746(Nek1) 101711997(Nek5)
CCAN: 109676479(Nek5) 109686883(Nek1) 109693725(Nek4)
OCU: 100345120(NEK5) 100346687(NEK1) 100349662(NEK4)
TUP: 102489588 102491616(NEK4) 102491752(NEK5)
CFA: 100683905(NEK5) 476591(NEK4) 486058(NEK1)
VVP: 112910267(NEK4) 112934153(NEK1)
AML: 100472594(NEK5) 100482924(NEK4) 100483504(NEK1)
UMR: 103658148(NEK1) 103674753(NEK4) 103677632(NEK5)
ORO: 101363457(NEK4) 101364240(NEK1) 101364387(NEK5)
FCA: 101093171(NEK4) 101094016(NEK1) 101097612(NEK5)
PTG: 102952900(NEK1) 102956539(NEK5) 102963755(NEK4)
PPAD: 109247910(NEK4) 109262434(NEK1) 109265997(NEK5)
AJU: 106972660 106976517(NEK1) 106987000(NEK4)
BTA: 100138147(NEK5) 511455(NEK4) 534671(NEK1)
BOM: 102271510(NEK1) 102277016(NEK4) 102287387(NEK5)
BIU: 109562754(NEK1) 109566748(NEK5) 109576014(NEK4)
BBUB: 102389575 102391455(NEK1) 102403947(NEK4)
CHX: 102179611(NEK4) 102183800(NEK5) 102189122(NEK1)
OAS: 101107110(NEK5) 101110544(NEK4) 101114757(NEK1)
SSC: 100156672(NEK5) 100520589(NEK1) 106504146(NEK4)
CFR: 102510287(NEK5) 102512886(NEK4) 102517527(NEK1)
CDK: 105090995(NEK5) 105093308(NEK4) 105101615(NEK1)
BACU: 103003275(NEK5) 103016859(NEK1) 103020484
LVE: 103077466(NEK1) 103089687(NEK5) 103091092(NEK4)
OOR: 101276787(NEK1) 101284485(NEK4) 101285789(NEK5)
DLE: 111174295(NEK4) 111175280 111185341(NEK1)
PCAD: 102976069(NEK4) 102981544(NEK1)
ECB: 100051545(NEK4) 100052593(NEK5) 100061302(NEK1)
EAI: 106821749(NEK4) 106837700(NEK5) 106848465(NEK1)
MYB: 102249725(NEK4) 102259171(NEK1) 102263040(NEK5)
MYD: 102758129(NEK1) 102764427(NEK5) 102767708(NEK4)
MNA: 107527523(NEK1) 107534940(NEK4) 107537545(NEK5)
HAI: 109373882(NEK4) 109394921(NEK1) 109396765(NEK5)
DRO: 112301182(NEK4) 112312199(NEK5) 112312457(NEK1)
PALE: 102888550(NEK1) 102893235 102894766(NEK4)
RAY: 107498570(NEK4) 107503293(NEK5) 107512541(NEK1)
MJV: 108408411(NEK4)
LAV: 100661998(NEK4) 100665709(NEK1) 100677745(NEK5)
MDO: 100020318(NEK4) 100021205(NEK1) 100028128(NEK5)
SHR: 100917015(NEK1) 100928958(NEK4)
PCW: 110196651(NEK5) 110197531(NEK4) 110215969(NEK1)
OAA: 100077133(NEK1) 100082611(NEK5) 100092385(NEK4)
GGA: 415900(NEK4) 418881(NEK5) 422433(NEK1)
MGP: 100539213(NEK4) 100540479(NEK1) 100541238
CJO: 107308186(NEK5) 107313003(NEK1) 107319539(NEK4)
NMEL: 110388050(NEK5) 110398892(NEK1) 110404835(NEK4)
APLA: 101795060(NEK5) 101797316(NEK4) 101804085(NEK1)
ACYG: 106032343(NEK1) 106035100 106042839(NEK4)
TGU: 100222015(NEK4) 100222443(NEK5) 100229879(NEK1)
LSR: 110468586(NEK5) 110472340(NEK4) 110483752(NEK1)
SCAN: 103816977(NEK4) 103826217(NEK1) 103827384(NEK5)
GFR: 102034206(NEK1) 102038725(NEK5) 102045571(NEK4)
FAB: 101808886(NEK5) 101814798(NEK1) 101816073(NEK4)
PHI: 102099195(NEK5) 102101142(NEK1) 102110829(NEK4)
PMAJ: 107202862(NEK1) 107208037(NEK5) 107210212(NEK4)
CCAE: 111927900(NEK1) 111935171(NEK4) 111945569
CCW: 104683227(NEK4) 104689945(NEK5) 104690539(NEK1)
ETL: 114059568 114061292(NEK4) 114064973(NEK1)
FPG: 101911989(NEK1) 101916543(NEK5) 101923813(NEK4)
FCH: 102050035(NEK1) 102051609(NEK4) 102056741(NEK5)
CLV: 102086210(NEK5) 102089264(NEK1) 102093212
EGZ: 104123118(NEK1) 104126685(NEK4) 104129676(NEK5)
NNI: 104008705(NEK4) 104010942(NEK5) 104021367(NEK1)
ACUN: 113479128(NEK1) 113482713(NEK5) 113485038(NEK4)
PADL: 103913475(NEK5) 103915094(NEK4) 103922554(NEK1)
AAM: 106482187(NEK4) 106484010(NEK1) 106489228(NEK5)
ASN: 102370320(NEK4) 102386517(NEK1) 102388857
AMJ: 102559950(NEK4) 102561351(NEK1) 102574416(NEK5)
PSS: 102444868(NEK1) 102445572(NEK5) 102454391(NEK4)
CMY: 102937442(NEK5) 102942101(NEK1) 102947290(NEK4)
CPIC: 101940071(NEK1) 101944066(NEK5) 101947554(NEK4)
ACS: 100552798(nek1) 100558250(nek5) 100560174(nek4)
PVT: 110076146(NEK5) 110080625(NEK4) 110085374(NEK1)
PBI: 103055048(NEK1) 103062506 103063229(NEK5)
TSR: 106539383(NEK1) 106549050(NEK5) 106551071(NEK4)
PMUA: 114591594(NEK4) 114593599 114603843(NEK1)
GJA: 107114670(NEK1) 107121776(NEK4) 107125619
XLA: 108699026(nek1.L) 108706631(nek1.S) 108708675(nek5.L) 414527(nek4.S)
XTR: 100036653(nek1) 100497645(nek5) 780225(nek4)
NPR: 108787016(NEK5) 108789893(NEK1) 108791872(NEK4)
DRE: 393987(nek4) 556002(nek1) 557131(si:ch211-285c6.3) 791193(si:ch211-285c6.2)
IPU: 108260678(nek1) 108266669
PHYP: 113524663(nek5) 113529077(nek1) 113539594(nek4)
AMEX: 103028272(nek1) 103028530 103043005(nek4)
EEE: 113583900(nek4) 113588971(nek1) 113592181(nek5)
TRU: 101071067(nek1) 101079247(nek4)
LCO: 104919071(nek1) 104932286 104939100(nek5) 104940452(nek4)
NCC: 104943005(nek4)
ONL: 100695804(nek1) 100697929(nek4) 100698951(nek5) 109196662
OLA: 101160722(nek1) 101162253 101169778(nek4)
XMA: 102219862(nek1) 102225044(nek5) 102230022(nek4) 102230438
XCO: 114135537(nek4) 114139705 114148161(nek5) 114151345(nek1)
CVG: 107090125(nek5) 107103657(nek4) 107103729(nek1)
NFU: 107376214 107385574(nek4) 107389589(nek5) 107396568(nek1)
ALIM: 106526070(nek1) 106527757(nek5) 106534017(nek4)
AOCE: 111566405(nek1) 111570835 111587422(nek4)
CSEM: 103386146(nek4) 103391509(nek5) 103398921(nek1)
POV: 109625849(nek1) 109628882(nek4)
HCQ: 109515100(nek1) 109519337(nek5) 109522630(nek4)
BPEC: 110154880(nek1) 110162963(nek5) 110168405(nek4)
MALB: 109956038(nek4) 109962096(nek1) 109972591(nek5)
LCM: 102347554(NEK5) 102350772(NEK4) 102367432(NEK1)
CMK: 103177169 103186328(nek1) 103188767(nek4)
RTP: 109919878(nek4) 109932445(nek5) 109933404 109935032(nek1)
SKO: 100366844
ZNE: 110833256
AQU: 100639181
ATH: AT1G54510(NEK1) AT3G04810(NEK2) AT3G12200(Nek7) AT3G20860(NEK5) AT3G44200(NEK6) AT3G63280(NEK4) AT5G28290(NEK3)
LJA: Lj0g3v0066389.1(Lj0g3v0066389.1) Lj0g3v0066389.2(Lj0g3v0066389.2) Lj0g3v0200839.1(Lj0g3v0200839.1) Lj0g3v0250989.1(Lj0g3v0250989.1) Lj0g3v0250989.2(Lj0g3v0250989.2) Lj1g3v4446980.1(Lj1g3v4446980.1) Lj1g3v4446980.2(Lj1g3v4446980.2) Lj3g3v1339050.2(Lj3g3v1339050.2) Lj5g3v1003590.1(Lj5g3v1003590.1)
DOSA: Os02t0590800-00(Os02g0590800) Os03t0636800-01(Os03g0636800) Os05t0440800-01(Os05g0440800) Os07t0176600-01(Os07g0176600)
ATS: 109743851(LOC109743851) 109744177(LOC109744177) 109748667(LOC109748667) 109756555(LOC109756555) 109781444(LOC109781444) 109784913(LOC109784913)
PPP: 112279091
PCB: PCHAS_124110(PC000234.00.0)
SMIN: v1.2.000143.t1(symbB.v1.2.000143.t1) v1.2.000530.t1(symbB.v1.2.000530.t1) v1.2.006977.t1(symbB.v1.2.006977.t1) v1.2.012484.t1(symbB.v1.2.012484.t1) v1.2.013139.t1(symbB.v1.2.013139.t1) v1.2.013647.t1(symbB.v1.2.013647.t1) v1.2.019906.t1(symbB.v1.2.019906.t1) v1.2.025880.t1(symbB.v1.2.025880.t1) v1.2.030100.t1(symbB.v1.2.030100.t1) v1.2.030155.t1(symbB.v1.2.030155.t1) v1.2.031111.t1(symbB.v1.2.031111.t1) v1.2.031698.t1(symbB.v1.2.031698.t1) v1.2.032085.t1(symbB.v1.2.032085.t1) v1.2.032085.t2(symbB.v1.2.032085.t2) v1.2.035856.t1(symbB.v1.2.035856.t1) v1.2.037791.t1(symbB.v1.2.037791.t1) v1.2.039050.t1(symbB.v1.2.039050.t1)
TCR: 506851.10
 » show all
Reference
  Authors
Thiel C, Kessler K, Giessl A, Dimmler A, Shalev SA, von der Haar S, Zenker M, Zahnleiter D, Stoss H, Beinder E, Abou Jamra R, Ekici AB, Schroder-Kress N, Aigner T, Kirchner T, Reis A, Brandstatter JH, Rauch A
  Title
NEK1 mutations cause short-rib polydactyly syndrome type majewski.
  Journal
Am J Hum Genet 88:106-14 (2011)
DOI:10.1016/j.ajhg.2010.12.004
  Sequence
[hsa:4750]
Reference
PMID:8208544
  Authors
Levedakou EN, He M, Baptist EW, Craven RJ, Cance WG, Welcsh PL, Simmons A, Naylor SL, Leach RJ, Lewis TB, et al.
  Title
Two novel human serine/threonine kinases with homologies to the cell cycle regulating Xenopus MO15, and NIMA kinases: cloning and characterization of their expression pattern.
  Journal
Oncogene 9:1977-88 (1994)
  Sequence
[hsa:6787]

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