KEGG   ORTHOLOGY: K08893Help
Entry
K08893                      KO                                     

Name
HCK
Definition
hemopoietic cell kinase [EC:2.7.10.2]
Pathway
ko04062  Chemokine signaling pathway
ko04666  Fc gamma R-mediated phagocytosis
ko05130  Pathogenic Escherichia coli infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K08893  HCK; hemopoietic cell kinase
   04062 Chemokine signaling pathway
    K08893  HCK; hemopoietic cell kinase
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K08893  HCK; hemopoietic cell kinase
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K08893  HCK; hemopoietic cell kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08893  HCK; hemopoietic cell kinase
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K08893  HCK; hemopoietic cell kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K08893  HCK; hemopoietic cell kinase
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  SRC family
   K08893  HCK; hemopoietic cell kinase
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K08893  HCK; hemopoietic cell kinase
BRITE hierarchy
Other DBs
GO: 0004715
Genes
HSA: 3055(HCK)
PTR: 458163(HCK)
PPS: 100975763(HCK)
GGO: 101149280(HCK)
PON: 100455620(HCK)
NLE: 100587780(HCK)
MCC: 715723(HCK)
MCF: 102115729(HCK)
CSAB: 103248155(HCK)
RRO: 104653712(HCK)
RBB: 108524139(HCK)
CJC: 100389637(HCK)
SBQ: 101032860(HCK)
MMU: 15162(Hck)
MCAL: 110309091(Hck)
MPAH: 110317518(Hck)
RNO: 25734(Hck)
MUN: 110550096(Hck)
CGE: 100773315(Hck)
NGI: 103731073(Hck)
HGL: 101709222(Hck)
CCAN: 109691761(Hck)
OCU: 100343961(HCK)
TUP: 102491330(HCK)
CFA: 485828(HCK)
VVP: 112909929(HCK)
AML: 100468494(HCK)
UMR: 103674340(HCK)
UAH: 113258471(HCK)
ORO: 101383723(HCK)
ELK: 111141509
FCA: 101101207(HCK)
PTG: 102953452(HCK)
PPAD: 109272582(HCK)
AJU: 106974647(HCK)
BTA: 280814(HCK)
BOM: 102274987(HCK)
BIU: 109567352(HCK)
BBUB: 102410643(HCK)
CHX: 102183977(HCK)
OAS: 101113167(HCK)
SSC: 100526085(HCK)
CFR: 102507677(HCK)
CDK: 105100829(HCK)
BACU: 103015546(HCK)
LVE: 103078130(HCK)
OOR: 101288667(HCK)
DLE: 111184309(HCK) 111184310
PCAD: 102977689(HCK)
ECB: 100068557(HCK)
EPZ: 103554273(HCK)
EAI: 106833726(HCK)
MYB: 102256952(HCK)
MYD: 102756136(HCK)
MNA: 107527783(HCK)
HAI: 109384426(HCK)
DRO: 112303915(HCK)
PALE: 102890019(HCK)
RAY: 107512878(HCK)
MJV: 108397287(HCK)
LAV: 100660288(HCK)
TMU: 101344005
MDO: 100010539(HCK)
SHR: 100913992(HCK)
PCW: 110211423(HCK)
OAA: 100085668(HCK)
GGA: 419280(HCK)
MGP: 100543739(HCK)
CJO: 107323072(HCK)
NMEL: 110408000(HCK)
APLA: 101792612(HCK)
ACYG: 106047123(HCK)
TGU: 100220059(HCK)
LSR: 110469018(HCK)
SCAN: 103818665(HCK)
GFR: 102036877(HCK)
FAB: 101812195(HCK)
PHI: 102101716(HCK)
PMAJ: 107213469(HCK)
CCAE: 111943147(HCK)
CCW: 104687710(HCK)
ETL: 114063045(HCK)
FPG: 101910593(HCK)
FCH: 102055899(HCK)
CLV: 102096776(HCK)
EGZ: 104127632(HCK)
NNI: 104018316(HCK)
ACUN: 113487683(HCK)
PADL: 103912489(HCK)
AAM: 106497371(HCK)
ASN: 102368801(HCK)
AMJ: 106737579(HCK)
PSS: 106732490(HCK)
CMY: 102941333(HCK)
CPIC: 101948814(HCK)
ACS: 100557519(hck)
PVT: 110086725(HCK)
PBI: 103054220(HCK)
PMUR: 107299503(HCK)
PMUA: 114599837(HCK)
GJA: 107123021(HCK)
XLA: 373700(hck.L)
XTR: 548439(hck)
NPR: 108786954(HCK)
DRE: 101885596(hck)
SGH: 107558239(hck) 107559464
IPU: 108275896(hck)
PHYP: 113530620(hck)
AMEX: 103036768(hck)
EEE: 113575473(hck)
TRU: 101067815(hck)
LCO: 104933734(hck)
MZE: 101483358(hck)
ONL: 100699435(hck)
OLA: 101163900(hck)
XMA: 102216930(hck)
XCO: 114145598(hck)
PRET: 103466927(hck)
CVG: 107098932
NFU: 107386929
KMR: 108246117(hck)
ALIM: 106523041(hck)
AOCE: 111570488(hck)
CSEM: 103384757(hck)
POV: 109630933(hck)
LCF: 108885037(hck)
SDU: 111237026(hck)
SLAL: 111651844
HCQ: 109511820(hck)
BPEC: 110169150(hck)
MALB: 109969986(hck)
SASA: 100136375(hck) 106572127
SALP: 111976955(hck) 112068453
ELS: 105013770
SFM: 108925655(hck) 108926451
LCM: 102352014
CMK: 103172176(hck)
RTP: 109911600(hck)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9407116
  Authors
Warmuth M, Bergmann M, Priess A, Hauslmann K, Emmerich B, Hallek M
  Title
The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr.
  Journal
J Biol Chem 272:33260-70 (1997)
DOI:10.1074/jbc.272.52.33260
Reference
PMID:3496523
  Authors
Quintrell N, Lebo R, Varmus H, Bishop JM, Pettenati MJ, Le Beau MM, Diaz MO, Rowley JD
  Title
Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.
  Journal
Mol Cell Biol 7:2267-75 (1987)
DOI:10.1128/MCB.7.6.2267
  Sequence
[hsa:3055]

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