KEGG   ORTHOLOGY: K09095Help
Entry
K09095                      KO                                     

Name
HIF2A, EPAS1
Definition
hypoxia-inducible factor 2 alpha
Pathway
ko05200  Pathways in cancer
ko05211  Renal cell carcinoma
Disease
H00236  Congenital polycythemia
H01510  Malignant paraganglioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09161 Cancers: Overview
   05200 Pathways in cancer
    K09095  HIF2A, EPAS1; hypoxia-inducible factor 2 alpha
  09162 Cancers: Specific types
   05211 Renal cell carcinoma
    K09095  HIF2A, EPAS1; hypoxia-inducible factor 2 alpha
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09095  HIF2A, EPAS1; hypoxia-inducible factor 2 alpha
   04131 Membrane trafficking
    K09095  HIF2A, EPAS1; hypoxia-inducible factor 2 alpha
Transcription factors [BR:ko03000]
 Eukaryotic Type
  Basic helix-loop-helix (bHLH)
   Factors with PAS domain
    K09095  HIF2A, EPAS1; hypoxia-inducible factor 2 alpha
Membrane trafficking [BR:ko04131]
 Autophagy
  Pexophagy
   Other pexophagy associated proteins
    K09095  HIF2A, EPAS1; hypoxia-inducible factor 2 alpha
BRITE hierarchy
Genes
HSA: 2034(EPAS1)
PTR: 459204(EPAS1)
PPS: 100975248(EPAS1)
GGO: 109024921 109025170
PON: 100439667(EPAS1)
NLE: 100606638(EPAS1)
MCC: 714641(EPAS1)
MCF: 102124613(EPAS1)
CSAB: 103220342(EPAS1)
RRO: 104663183(EPAS1)
RBB: 108522497(EPAS1)
CJC: 100396711(EPAS1)
SBQ: 101052563(EPAS1)
MMU: 13819(Epas1)
RNO: 29452(Epas1)
CGE: 100771160(Epas1)
NGI: 103725756(Epas1)
HGL: 101701434(Epas1)
CCAN: 109698638(Epas1)
OCU: 100348809(EPAS1)
TUP: 102500928(EPAS1)
CFA: 474578(EPAS1)
AML: 100476273(EPAS1)
UMR: 103671227(EPAS1)
ORO: 101362839(EPAS1)
FCA: 101085621(EPAS1)
PTG: 102956746(EPAS1)
AJU: 106977230(EPAS1)
BTA: 282711(EPAS1)
BOM: 102267223(EPAS1)
BIU: 109566045(EPAS1)
PHD: 102327225(EPAS1)
CHX: 102180230(EPAS1)
OAS: 443286(EPAS1)
SSC: 100037272(EPAS1)
CFR: 102517299(EPAS1)
CDK: 105103582(EPAS1)
BACU: 103005217(EPAS1)
LVE: 103084980(EPAS1)
OOR: 101276152(EPAS1)
ECB: 100068622(EPAS1)
EPZ: 103553101(EPAS1)
EAI: 106826102(EPAS1)
MYB: 102257697(EPAS1)
MYD: 102754977(EPAS1)
HAI: 109389904(EPAS1)
RSS: 109456358(EPAS1)
PALE: 102894133(EPAS1)
LAV: 100655103(EPAS1)
TMU: 101356007
MDO: 100033364(EPAS1)
SHR: 100921392(EPAS1)
OAA: 100091752(EPAS1)
GGA: 395596(EPAS1)
MGP: 100543912(EPAS1)
CJO: 107311161(EPAS1)
APLA: 101796345(EPAS1)
ACYG: 106029792(EPAS1)
TGU: 100220014(EPAS1)
SCAN: 103821514(EPAS1)
GFR: 102035773(EPAS1)
FAB: 101815524(EPAS1)
PHI: 102103672(EPAS1)
PMAJ: 107201722(EPAS1)
CCAE: 111927604(EPAS1)
CCW: 104685690(EPAS1)
FPG: 101916819(EPAS1)
FCH: 102048705(EPAS1)
CLV: 102096505(EPAS1)
EGZ: 104123429(EPAS1)
NNI: 104019730(EPAS1)
ACUN: 113478428(EPAS1)
AAM: 106485447(EPAS1)
ASN: 102375013(EPAS1)
AMJ: 102564804(EPAS1)
PSS: 102453156(EPAS1)
CMY: 102935901(EPAS1)
CPIC: 101951793(EPAS1)
ACS: 100551891(epas1)
PVT: 110080749(EPAS1)
PBI: 103055479(EPAS1)
PMUR: 107287860(EPAS1)
GJA: 107110986(EPAS1)
XLA: 443990(epas1.S) 444145(epas1.L)
XTR: 448117(epas1)
NPR: 108804502(EPAS1)
DRE: 555192(epas1b)
PHYP: 113527215 113542372(epas1)
AMEX: 103026643(epas1) 103036701
LCO: 104922402(epas1) 104936228
NCC: 104951026(epas1)
MZE: 101473138 101486512(epas1)
OLA: 101168496(epas1) 101172602
XMA: 102218651 102227739(epas1)
NFU: 107376137 107387754(epas1)
KMR: 108247260(epas1) 108250231
LCF: 108872873 108882791(epas1)
SDU: 111220260(epas1) 111223860
HCQ: 109510069 109530160(epas1)
BPEC: 110162854
MALB: 109963058(epas1) 109963808
SASA: 106589722(epas1) 106611028
OTW: 112224583(epas1) 112260055
SALP: 111968049(epas1) 112073362
ELS: 105021253(epas1)
SFM: 108942753(epas1)
LCM: 102354477 102357464(EPAS1)
CMK: 103180815(epas1)
APLC: 110983203
EPA: 110235754
AQU: 105312385
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9000051
  Authors
Tian H, McKnight SL, Russell DW
  Title
Endothelial PAS domain protein 1 (EPAS1), a transcription factor selectively expressed in endothelial cells.
  Journal
Genes Dev 11:72-82 (1997)
DOI:10.1101/gad.11.1.72
  Sequence
[hsa:2034]
Reference
  Authors
Walter KM, Schonenberger MJ, Trotzmuller M, Horn M, Elsasser HP, Moser AB, Lucas MS, Schwarz T, Gerber PA, Faust PL, Moch H, Kofeler HC, Krek W, Kovacs WJ
  Title
Hif-2alpha promotes degradation of mammalian peroxisomes by selective autophagy.
  Journal
Cell Metab 20:882-97 (2014)
DOI:10.1016/j.cmet.2014.09.017
  Sequence
[hsa:2034]

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