KEGG   ORTHOLOGY: K09186Help
Entry
K09186                      KO                                     

Name
MLL1
Definition
histone-lysine N-methyltransferase MLL1 [EC:2.1.1.43]
Pathway
ko00310  Lysine degradation
ko04934  Cushing's syndrome
ko05202  Transcriptional misregulation in cancer
Disease
H00001  B lymphoblastic leukemia/lymphoma
H00002  T lymphoblastic leukemia/lymphoma
H01879  Wiedemann-Steiner syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 Metabolism
  Amino acid metabolism
   00310 Lysine degradation
    K09186  MLL1; histone-lysine N-methyltransferase MLL1
 Human Diseases
  Cancers
   05202 Transcriptional misregulation in cancers
    K09186  MLL1; histone-lysine N-methyltransferase MLL1
  Endocrine and metabolic diseases
   04934 Cushing's syndrome
    K09186  MLL1; histone-lysine N-methyltransferase MLL1
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.43  histone-lysine N-methyltransferase
     K09186  MLL1; histone-lysine N-methyltransferase MLL1
Transcription factors [BR:ko03000]
 Eukaryotic Type
  Zinc finger
   Cys4 Trithorax
    K09186  MLL1; histone-lysine N-methyltransferase MLL1
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K09186  MLL1; histone-lysine N-methyltransferase MLL1
   HMT complexes
    MLL-HCF complex
     K09186  MLL1; histone-lysine N-methyltransferase MLL1
BRITE hierarchy
Other DBs
RN: R03875 R03938 R04866 R04867
GO: 0042800
Genes
HSA: 4297(KMT2A)
PTR: 451587(KMT2A)
PPS: 100984332(KMT2A)
GGO: 101129366(KMT2A)
PON: 100441102(KMT2A)
NLE: 100604245(KMT2A)
MCC: 705511(KMT2A)
MCF: 101866311(KMT2A)
CSAB: 103248594(KMT2A)
RRO: 104665589(KMT2A)
RBB: 108536375(KMT2A)
CJC: 100391138(KMT2A)
SBQ: 101029847(KMT2A)
MMU: 214162(Kmt2a)
RNO: 315606(Kmt2a)
CGE: 100760424(Kmt2a)
NGI: 103748298(Kmt2a)
HGL: 101716671(Kmt2a)
CCAN: 109689973(Kmt2a)
OCU: 100339782 100353733(KMT2A)
TUP: 102473382(KMT2A)
CFA: 479417(KMT2A)
AML: 100484220(KMT2A)
UMR: 103662507(KMT2A)
ORO: 101363392 101363669(KMT2A)
FCA: 101090288(KMT2A)
PTG: 102956940(KMT2A)
AJU: 106966460(KMT2A)
BTA: 508330(KMT2A)
BOM: 102280025(KMT2A)
BIU: 109569413(KMT2A)
PHD: 102332319(KMT2A)
CHX: 102169033(KMT2A)
OAS: 101101916(KMT2A)
SSC: 100623006(KMT2A)
CFR: 102517824(KMT2A)
CDK: 105090168(KMT2A)
BACU: 103014183(KMT2A)
LVE: 103068531(KMT2A)
OOR: 101278571(KMT2A)
ECB: 100071238(KMT2A)
EPZ: 103546689(KMT2A)
EAI: 106840333(KMT2A)
MYB: 102246785(KMT2A)
MYD: 102766910(KMT2A) 107182758
HAI: 109385301(KMT2A)
RSS: 109437195(KMT2A)
PALE: 102893336(KMT2A)
LAV: 100653681(KMT2A)
TMU: 101351964
MDO: 100031440(KMT2A)
SHR: 100924557(KMT2A)
OAA: 100086068(KMT2A)
GGA: 414897(KMT2A)
MGP: 100540662(KMT2A)
CJO: 107324133(KMT2A)
APLA: 101797321(KMT2A) 106020297
ACYG: 106039772(KMT2A)
TGU: 100231049(KMT2A)
GFR: 102036439(KMT2A)
FAB: 101813917(KMT2A)
PHI: 102103515(KMT2A)
PMAJ: 107214385(KMT2A)
CCW: 104692048(KMT2A)
FPG: 101922729(KMT2A)
FCH: 102059401(KMT2A)
CLV: 102084453(KMT2A)
EGZ: 104135361(KMT2A)
AAM: 106485191(KMT2A)
ASN: 102385246(KMT2A)
AMJ: 102572253(KMT2A)
PSS: 102463628(KMT2A)
CMY: 102941272(KMT2A)
CPIC: 101941687(KMT2A)
ACS: 100560745(kmt2a)
PVT: 110079453(KMT2A)
PBI: 103065152 103067762(KMT2A)
GJA: 107112539(KMT2A)
XTR: 100135006(kmt2a)
NPR: 108794984(KMT2A)
DRE: 557048(kmt2a)
IPU: 108277661(kmt2a)
AMEX: 103035686
TRU: 101079297(kmt2a)
LCO: 104936774(kmt2a)
MZE: 101478918(kmt2a)
OLA: 101171020(kmt2a)
XMA: 102233842(kmt2a)
PRET: 103474566(kmt2a)
NFU: 107380358(kmt2a)
CSEM: 103378141(kmt2a)
LCF: 108886384(kmt2a)
HCQ: 109529394(kmt2a)
BPEC: 110154093(kmt2a)
SASA: 106612477(kmt2a)
ELS: 105011706(kmt2a)
LCM: 102357046(KMT2A)
CMK: 103180354(kmt2a)
CIN: 100180972
SPU: 579728
APLC: 110983880
DME: Dmel_CG8651(trx)
DSI: Dsimw501_GD20433(Dsim_GD20433)
DVI: Dvir_GJ22599(Dvir_trx)
MDE: 101896996
AAG: 5573555
AME: 408716(trx)
BIM: 100748492
BTER: 100646252
SOC: 105197865
AEC: 105145559
ACEP: 105626604
PBAR: 105422098
HST: 105191719
CFO: 105251303
LHU: 105668075
PGC: 109854362
TCA: 658843(trithorax)
DPA: 109540960
NVL: 108569866
BMOR: 101742231
PMAC: 106715470
PRAP: 110992468
PXY: 105383381
DNX: 107167618
ZNE: 110832202
CRG: 105347805
MYI: 110462400
OBI: 106883428
SHX: MS3_01195
ADF: 107345259
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Avdic V, Zhang P, Lanouette S, Groulx A, Tremblay V, Brunzelle J, Couture JF
  Title
Structural and biochemical insights into MLL1 core complex assembly.
  Journal
Structure 19:101-8 (2011)
DOI:10.1016/j.str.2010.09.022
  Sequence
[hsa:4297]
Reference
  Authors
Ansari KI, Mandal SS
  Title
Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.
  Journal
FEBS J 277:1790-804 (2010)
DOI:10.1111/j.1742-4658.2010.07606.x
Reference
PMID:8703835
  Authors
Nilson I, Lochner K, Siegler G, Greil J, Beck JD, Fey GH, Marschalek R
  Title
Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias.
  Journal
Br J Haematol 93:966-72 (1996)
  Sequence
[hsa:4297]

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