Entry |
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Symbol |
MLL1
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Name |
[histone H3]-lysine4 N-trimethyltransferase MLL1 [EC: 2.1.1.354]
|
Pathway |
map05202 | Transcriptional misregulation in cancer |
|
Reaction |
R04866 | S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase |
R04867 | S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase |
|
Disease |
H00001 | B-cell acute lymphoblastic leukemia |
H00002 | T-cell acute lymphoblastic leukemia |
H01879 | Wiedemann-Steiner syndrome |
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Brite |
KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
K09186 MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
09160 Human Diseases
09161 Cancer: overview
05202 Transcriptional misregulation in cancer
K09186 MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
09167 Endocrine and metabolic disease
04934 Cushing syndrome
K09186 MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03000 Transcription factors
K09186 MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
03036 Chromosome and associated proteins
K09186 MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
Enzymes [BR:ko01000]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.354 [histone H3]-lysine4 N-trimethyltransferase
K09186 MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
Transcription factors [BR:ko03000]
Eukaryotic type
Zinc finger
CXXC CpG-binding proteins
K09186 MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
K09186 MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
HMT complexes
MLL-HCF complex
K09186 MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
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Other DBs |
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Genes |
» show all
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Reference |
|
Authors |
Avdic V, Zhang P, Lanouette S, Groulx A, Tremblay V, Brunzelle J, Couture JF |
Title |
Structural and biochemical insights into MLL1 core complex assembly. |
Journal |
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Sequence |
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Reference |
|
Authors |
Ansari KI, Mandal SS |
Title |
Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing. |
Journal |
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Reference |
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Authors |
Nilson I, Lochner K, Siegler G, Greil J, Beck JD, Fey GH, Marschalek R |
Title |
Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias. |
Journal |
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Sequence |
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