KEGG   ORTHOLOGY: K09188Help
Entry
K09188                      KO                                     

Name
MLL3
Definition
histone-lysine N-methyltransferase MLL3 [EC:2.1.1.43]
Pathway
ko00310  Lysine degradation
Disease
H00907  Kleefstra syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K09188  MLL3; histone-lysine N-methyltransferase MLL3
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09188  MLL3; histone-lysine N-methyltransferase MLL3
   03036 Chromosome and associated proteins
    K09188  MLL3; histone-lysine N-methyltransferase MLL3
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.43  histone-lysine N-methyltransferase
     K09188  MLL3; histone-lysine N-methyltransferase MLL3
Transcription factors [BR:ko03000]
 Eukaryotic Type
  Zinc finger
   Cys4 Trithorax
    K09188  MLL3; histone-lysine N-methyltransferase MLL3
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic Type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K09188  MLL3; histone-lysine N-methyltransferase MLL3
   HMT complexes
    MLL3/MLL4 complex
     K09188  MLL3; histone-lysine N-methyltransferase MLL3
BRITE hierarchy
Other DBs
RN: R03875 R03938 R04866 R04867
GO: 0042800
Genes
HSA: 58508(KMT2C)
PTR: 463875(KMT2C)
PPS: 100992231(KMT2C)
GGO: 101134599(KMT2C)
PON: 100444736
NLE: 100607151(KMT2C)
MCC: 716753(KMT2C)
MCF: 102128002(KMT2C)
CSAB: 103227268(KMT2C)
RRO: 104678716(KMT2C)
RBB: 108523124(KMT2C)
CJC: 100401397(KMT2C)
SBQ: 101043552(KMT2C)
MMU: 231051(Kmt2c)
RNO: 502710(Kmt2c)
CGE: 100767367(Kmt2c)
NGI: 103745326(Kmt2c)
HGL: 101698170(Kmt2c)
CCAN: 109685268(Kmt2c) 109695167
OCU: 100353688(KMT2C)
TUP: 102479012(KMT2C)
CFA: 611094(KMT2C)
AML: 100465228(KMT2C)
UMR: 103660985(KMT2C)
ORO: 101365628(KMT2C)
FCA: 101084095(KMT2C)
PTG: 102964154(KMT2C)
AJU: 106984461(KMT2C)
BTA: 789336(KMT2C)
BOM: 102267186(KMT2C)
BIU: 109558041(KMT2C)
PHD: 102317507(KMT2C)
CHX: 102181925(KMT2C)
OAS: 101115617(KMT2C)
SSC: 100514805(KMT2C)
CFR: 102507730(KMT2C)
CDK: 105098689(KMT2C)
BACU: 103004433(KMT2C)
LVE: 103078348(KMT2C)
OOR: 101288516(KMT2C)
ECB: 100064812(KMT2C)
EPZ: 103553137(KMT2C)
EAI: 106823334(KMT2C)
MYB: 102246704(KMT2C)
MYD: 102759674(KMT2C)
HAI: 109389650(KMT2C)
RSS: 109435154(KMT2C)
PALE: 102897550(KMT2C)
LAV: 100673765(KMT2C)
TMU: 101349940
MDO: 100019161(KMT2C)
SHR: 100920575(KMT2C)
OAA: 100074286(KMT2C)
GGA: 420437(KMT2C)
MGP: 100545169(KMT2C)
CJO: 107308762(KMT2C)
APLA: 101796266(KMT2C)
ACYG: 106046952(KMT2C)
TGU: 100227193(KMT2C)
GFR: 102031396(KMT2C)
FAB: 101806346(KMT2C)
PHI: 102099277(KMT2C)
PMAJ: 107216349(KMT2C)
CCW: 104686428(KMT2C)
FPG: 101917176(KMT2C)
FCH: 102047191(KMT2C)
CLV: 102097963(KMT2C)
EGZ: 104130998(KMT2C)
AAM: 106485306(KMT2C)
ASN: 102379342(KMT2C)
AMJ: 102567474(KMT2C)
PSS: 102459016(KMT2C)
CMY: 102948345(KMT2C)
CPIC: 101953918(KMT2C)
ACS: 100556055(kmt2c)
PVT: 110071916(KMT2C)
PBI: 103049419
GJA: 107123156 107123162(KMT2C)
XTR: 100486829(kmt2c)
NPR: 108784343(KMT2C)
DRE: 560793(kmt2ca)
IPU: 108267465 108272993(kmt2c)
LCO: 104918307(kmt2c) 104938105
XMA: 102216709 102222583(kmt2c)
PRET: 103460165(kmt2c) 103479582
NFU: 107374212 107383945(kmt2c)
CSEM: 103377343(kmt2c) 103396169
SFM: 108931734(kmt2c) 108937588
LCM: 102347272(KMT2C)
CMK: 103189435(kmt2c) 103189436
CIN: 778537(alr-like)
SPU: 591084
APLC: 110988546
DME: Dmel_CG3848(trr)
DSI: Dsimw501_GD16408(Dsim_GD16408)
MDE: 101890357
AAG: 5566444
AME: 411466
BIM: 100745609
BTER: 100646364
SOC: 105197366
PBAR: 105433546
HST: 105192566
CFO: 105254099
LHU: 105673337
PGC: 109857124
NVI: 100120205(Trr)
TCA: 658776
NVL: 108559353
BMOR: 101736107
PMAC: 106719608
PRAP: 110995177
FCD: 110850681
TUT: 107366040
CEL: CELE_T12D8.1(set-16)
CBR: CBG18244(Cbr-set-16)
BMY: Bm1_21795
TSP: Tsp_02214
CRG: 105330921
MYI: 110460322
EPA: 110245624
HMG: 100209023
DFA: DFA_05766
SPAR: SPRG_20781
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Ruault M, Brun ME, Ventura M, Roizes G, De Sario A
  Title
MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia.
  Journal
Gene 284:73-81 (2002)
DOI:10.1016/S0378-1119(02)00392-X
  Sequence
[hsa:58508]
Reference
  Authors
Ansari KI, Mandal SS
  Title
Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.
  Journal
FEBS J 277:1790-804 (2010)
DOI:10.1111/j.1742-4658.2010.07606.x
Reference
  Authors
Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K
  Title
PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.
  Journal
J Biol Chem 282:20395-406 (2007)
DOI:10.1074/jbc.M701574200
  Sequence
[hsa:58508]

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