KEGG ORTHOLOGY: K09189

ORTHOLOGY: K09189

Entry

K09189                      KO

Symbol

MLL5

Name

[histone H3]-lysine4 N-trimethyltransferase MLL5 [EC:2.1.1.354]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H02535

Neurodevelopmental disorder with dysmorphic facies

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K09189  MLL5; [histone H3]-lysine4 N-trimethyltransferase MLL5
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K09189  MLL5; [histone H3]-lysine4 N-trimethyltransferase MLL5
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K09189  MLL5; [histone H3]-lysine4 N-trimethyltransferase MLL5
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K09189  MLL5; [histone H3]-lysine4 N-trimethyltransferase MLL5

Other DBs

GO:

0042800

Genes

HSA:	55904(KMT2E)

PTR:	463640(KMT2E)

PPS:	100982828(KMT2E)

GGO:	101144971(KMT2E)

PON:	100173903(KMT2E)

NLE:	100600051(KMT2E)

HMH:	116814204(KMT2E)

MCC:	697233(KMT2E)

MCF:	101926094(KMT2E)

MTHB:

126949835

MNI:	105475332(KMT2E)

CSAB:

103226692(KMT2E)

CATY:

105583166(KMT2E)

PANU:

101010195(KMT2E)

TGE:	112621770(KMT2E)

MLEU:

105554094(KMT2E)

RRO:	104675848(KMT2E)

RBB:	108531292(KMT2E)

TFN:	117073230(KMT2E)

PTEH:

111526693(KMT2E)

CANG:

105501710(KMT2E)

CJC:	100389921(KMT2E)

SBQ:	101033099(KMT2E)

CIMI:

108287696(KMT2E)

CSYR:

103274301(KMT2E)

MMUR:

105861339(KMT2E)

LCAT:

123647293(KMT2E)

PCOQ:

105815198(KMT2E)

OGA:	100954551(KMT2E)

MMU:	69188(Kmt2e)

MCAL:

110294014(Kmt2e)

MPAH:

110313856(Kmt2e)

RNO:	311968(Kmt2e)

MCOC:

116097528(Kmt2e)

ANU:	117720383(Kmt2e)

MUN:	110552814(Kmt2e)

CGE:	100756731(Kmt2e)

MAUA:

101824199(Kmt2e)

PROB:

127214400(Kmt2e)

PLEU:

114681829(Kmt2e)

MORG:

121434635 121459125(Kmt2e)

MFOT:

126500117

AAMP:

119803796(Kmt2e)

NGI:	103732191(Kmt2e)

HGL:	101712321(Kmt2e)

CPOC:

100722538(Kmt2e)

CCAN:

109684282(Kmt2e)

DORD:

105999650(Kmt2e)

DSP:	122111781(Kmt2e)

PLOP:

125346903(Kmt2e)

NCAR:

124990995

MMMA:

107144560(Kmt2e)

OCU:

100353840

OPI:	101518647(KMT2E)

TUP:	102483069(KMT2E)

GVR:	103586689(KMT2E)

CFA:	475895(KMT2E)

CLUD:

112661448(KMT2E)

VVP:	112925373(KMT2E)

VLG:	121471496(KMT2E)

NPO:	129494321(KMT2E)

AML:	100468393(KMT2E)

UMR:	103674714(KMT2E)

UAH:	113258804(KMT2E)

UAR:	123789383(KMT2E)

ELK:

111155211

LLV:

125081229

MPUF:

101688015(KMT2E)

MNP:	132016019(KMT2E)

MLK:	131829267(KMT2E)

NVS:	122904727(KMT2E)

ORO:	101362332(KMT2E)

EJU:	114221922(KMT2E)

ZCA:	113911901(KMT2E)

MLX:	118020644(KMT2E)

NSU:	110574278(KMT2E)

LWW:	102736062(KMT2E)

FCA:	101084945(KMT2E)

PYU:	121028858(KMT2E)

PCOO:

112867066(KMT2E)

PBG:	122487770(KMT2E)

PVIV:

125147999(KMT2E)

LRUF:

124524290

PTG:	102949117(KMT2E)

PPAD:

109268101(KMT2E)

PUC:

125930780

AJU:

106978485

HHV:	120243583(KMT2E)

BTA:	539121(KMT2E)

BOM:	102281278(KMT2E)

BIU:	109557366(KMT2E)

BBUB:

102398212(KMT2E)

BBIS:

104989687(KMT2E)

CHX:	102169548(KMT2E)

OAS:	101121766(KMT2E)

BTAX:

128046444(KMT2E)

ODA:	120878163(KMT2E)

CCAD:

122438292(KMT2E)

MBEZ:

129552374(KMT2E)

SSC:	100628131(KMT2E)

CFR:	102514543(KMT2E)

CBAI:

105062412(KMT2E)

CDK:	105093021(KMT2E)

VPC:	102536134(KMT2E)

BACU:

103002011(KMT2E)

BMUS:

118900473(KMT2E)

LVE:	103074842(KMT2E)

OOR:	101285642(KMT2E)

DLE:	111164613(KMT2E)

PCAD:

102980726(KMT2E)

PSIU:

116759805(KMT2E)

NASI:

112407436(KMT2E)

ECB:	100058928(KMT2E)

EPZ:	103560579(KMT2E)

EAI:	106825187(KMT2E)

MYB:	102246410(KMT2E)

MYD:	102758785(KMT2E)

MMYO:

118666018(KMT2E)

MLF:	102420403(KMT2E)

PKL:	118714393(KMT2E)

EFUS:

103293529(KMT2E)

MNA:	107542284(KMT2E)

DRO:	112303206(KMT2E)

SHON:

118994425(KMT2E)

AJM:	119063552(KMT2E)

PDIC:

114507268(KMT2E)

PHAS:

123811826(KMT2E)

MMF:	118620490(KMT2E)

PPAM:

129063476(KMT2E)

HAI:	109392049(KMT2E)

RFQ:	117012250(KMT2E)

PALE:

102888384(KMT2E)

PGIG:

120591655(KMT2E)

PVP:	105300340(KMT2E)

RAY:	107511501(KMT2E)

MJV:	108398623(KMT2E)

TOD:	119245069(KMT2E)

SARA:

101541405(KMT2E)

SETR:

126022074(KMT2E)

LAV:	100671071(KMT2E)

TMU:

101357397

ETF:	101651153(KMT2E)

DNM:	101443711(KMT2E)

MDO:	100018480(KMT2E)

GAS:	123249354(KMT2E)

SHR:	100922144(KMT2E)

AFZ:

127538133

PCW:	110206991(KMT2E)

OAA:	100077208(KMT2E)

GGA:	417712(KMT2E)

PCOC:

116230863(KMT2E)

MGP:	100545555(KMT2E)

CJO:	107325180(KMT2E)

TPAI:

128079545(KMT2E)

LMUT:

125692210(KMT2E)

NMEL:

110392363(KMT2E)

APLA:

101805084(KMT2E)

ACYG:

106043274(KMT2E)

CATA:

118249529(KMT2E)

AFUL:

116501490(KMT2E)

TGU:	100226399(KMT2E)

LSR:	110472726(KMT2E)

SCAN:

103813524(KMT2E)

PMOA:

120509257(KMT2E)

OTC:	121336375(KMT2E)

PRUF:

121357414(KMT2E)

GFR:	102045471(KMT2E)

FAB:	101812878(KMT2E)

OMA:	130248653(KMT2E)

PHI:	102108338(KMT2E)

PMAJ:

107204272(KMT2E)

CCAE:

111923252(KMT2E)

CCW:	104686872(KMT2E)

CBRC:

103623419(KMT2E)

ETL:	114060528(KMT2E)

ZAB:	102066708(KMT2E)

ACHL:

103805653(KMT2E)

SVG:	106848840(KMT2E)

MMEA:

130572663(KMT2E)

HRT:	120751397(KMT2E)

FPG:	101919912(KMT2E)

FCH:	102047542(KMT2E)

CLV:	102088903(KMT2E)

EGZ:	104128583(KMT2E)

NNI:	104010731(KMT2E)

PCRI:

104034948(KMT2E)

PLET:

104626408(KMT2E)

EHS:	104505919(KMT2E)

PCAO:

104047173(KMT2E)

ACUN:

113490163(KMT2E)

TALA:

104361303(KMT2E)

PADL:

103920580(KMT2E)

AFOR:

103906976(KMT2E)

ACHC:

115341062(KMT2E)

HALD:

104319785(KMT2E)

HLE:	104840156(KMT2E)

AGEN:

126044473

GCL:

127026814

CCRI:

104168454(KMT2E)

CSTI:

104558096(KMT2E)

CMAC:

104478959(KMT2E)

MUI:	104537048(KMT2E)

FGA:	104080339(KMT2E)

GSTE:

104263967

LDI:	104343329(KMT2E)

MNB:	103770762(KMT2E)

OHA:	104328750(KMT2E)

SHAB:

115605050(KMT2E)

DPUB:

104307867(KMT2E)

PGUU:

104461520(KMT2E)

ACAR:

104518615(KMT2E)

CPEA:

104394278(KMT2E)

AVIT:

104273424(KMT2E)

CVF:	104285138(KMT2E)

RTD:	128904181(KMT2E)

CUCA:

104056073(KMT2E)

TEO:	104372793(KMT2E)

BRHI:

104490852(KMT2E)

AAM:	106485892(KMT2E)

AROW:

112962650(KMT2E)

NPD:	112953335(KMT2E)

TGT:

104570786

DNE:	112981749(KMT2E)

SCAM:

104140582(KMT2E)

ASN:	102375642(KMT2E)

AMJ:	102560388(KMT2E)

CPOO:

109315734(KMT2E)

GGN:	109292146(KMT2E)

PSS:	102454598(KMT2E)

CMY:	102933355(KMT2E)

CCAY:

125630438(KMT2E)

DCC:	119855274(KMT2E)

CPIC:

101935009(KMT2E)

TST:	117875197(KMT2E)

CABI:

116828853(KMT2E)

MRV:	120392458(KMT2E)

ACS:	100553183(kmt2e)

ASAO:

132776559(KMT2E)

PVT:	110080953(KMT2E)

SUND:

121931651(KMT2E)

PBI:	103051962(KMT2E)

PMUR:

107298635(KMT2E)

CTIG:

120313722(KMT2E)

TSR:	106543655(KMT2E)

PGUT:

117675207(KMT2E)

APRI:

131201678(KMT2E)

PTEX:

113436879(KMT2E)

NSS:	113418372(KMT2E)

VKO:	123019961(KMT2E)

PMUA:

114605818(KMT2E)

PRAF:

128422350(KMT2E)

ZVI:	118091298(KMT2E)

HCG:	128327966(KMT2E)

GJA:	107113725(KMT2E)

STOW:

125434309(KMT2E)

EMC:	129335378(KMT2E)

XLA:	108711190(kmt2e.L) 108713071(kmt2e.S)

XTR:	779539(kmt2e)

NPR:	108795231(KMT2E)

RTEM:

120931759(KMT2E)

BBUF:

120982437(KMT2E)

BGAR:

122927872(KMT2E)

MUO:	115478814(KMT2E)

GSH:	117367034(KMT2E)

DRE:	325395(kmt2e)

SRX:	107710662 107755882

SANH:

107680023(kmt2e) 107694189

SGH:	107590817 107590964

CCAR:

109066408 109066409

CAUA:

113048205 113061806

CGIB:

127956623 127973055

PTET:

122343261(kmt2e)

LROH:

127163812(kmt2e)

OMC:	131538635(kmt2e)

PPRM:

120476920(kmt2e)

RKG:	130082666(kmt2e)

MAMB:

125245495(kmt2e)

CIDE:

127510796

MASI:

127435394 127436493

TROS:

130547852(kmt2e)

TDW:	130421504(kmt2e)

MANU:

129432309(kmt2e)

IPU:

108279641

IFU:	128622996(kmt2e)

PHYP:

113523882(kmt2e)

SMEO:

124401164(kmt2e)

TFD:	113651867(kmt2e)

TVC:	132858628(kmt2e)

AMEX:

103038810(kmt2e)

CMAO:

118812318(kmt2e)

EEE:	113569424(kmt2e)

CHAR:

105909605(kmt2e) 116224043

TRU:	101076756(kmt2e)

TFS:	130519095(kmt2e)

TNG:	GSTEN00021508G001

LCO:	104925314(kmt2e)

NCC:	104950113(kmt2e)

TBEN:

117484886(kmt2e)

CGOB:

115028240(kmt2e)

PGEO:

117468384(kmt2e)

GACU:

117559172(kmt2e)

EMAC:

134879091(kmt2e)

ELY:	117249611(kmt2e)

EFO:	125882665(kmt2e)

PLEP:

121961373(kmt2e)

SLUC:

116060181(kmt2e)

ECRA:

117938968(kmt2e)

ESP:	116673276(kmt2e)

PFLV:

114550568(kmt2e)

GAT:	120818322(kmt2e)

PPUG:

119210331(kmt2e)

AFB:	129112782(kmt2e)

CLUM:

117725970(kmt2e)

PSWI:

130200813(kmt2e)

MSAM:

119918232(kmt2e)

SCHU:

122871308(kmt2e)

CUD:	121505652(kmt2e)

ALAT:

119032432(kmt2e)

MZE:	101483461(kmt2e)

ONL:	100699588(kmt2e)

OAU:	116334675(kmt2e)

OLA:	101162568(kmt2e)

OML:	112155842(kmt2e)

CSAI:

133424477(kmt2e)

XMA:	102233159(kmt2e)

XCO:	114160652(kmt2e)

XHE:	116736574(kmt2e)

PRET:

103459296(kmt2e)

PFOR:

103140276(kmt2e)

PLAI:

106957544(kmt2e)

PMEI:

106924679(kmt2e)

GAF:	122826612(kmt2e)

PPRL:

129351546(kmt2e)

CVG:	107095902(kmt2e)

CTUL:

119791153(kmt2e)

GMU:	124882897(kmt2e)

NFU:	107386366(kmt2e)

KMR:	108233216(kmt2e)

ALIM:

106514822(kmt2e)

NWH:	119428195(kmt2e)

AOCE:

111569065(kmt2e)

MCEP:

125000051(kmt2e)

CSEM:

103382716(kmt2e)

POV:	109643621(kmt2e)

SSEN:

122766654(kmt2e)

HHIP:

117757178(kmt2e)

HSP:	118101325(kmt2e)

SMAU:

118286000(kmt2e)

LCF:

108886201

SDU:	111224728(kmt2e)

SLAL:

111660020(kmt2e)

XGL:	120799113(kmt2e)

HCQ:	109530075(kmt2e)

SSCV:

125992144

SBIA:

133493738(kmt2e)

PEE:	133396899(kmt2e)

PTAO:

133471831(kmt2e)

BPEC:

110161381(kmt2e)

MALB:

109969716(kmt2e)

BSPL:

114861452(kmt2e)

SJO:	128385260(kmt2e)

SASA:

106576014 106609379

STRU:

115180212(kmt2e) 115197978

OTW:	112217205(kmt2e) 112267824

OMY:	110490479(kmt2e) 110501025

OGO:	123994441 124014611

ONE:

115132988

OKI:	109864517 109885967

OKE:	118377779 118380705

SNH:	120031905(kmt2e) 120049120

CCLU:

121579219(kmt2e)

ELS:	105023447(kmt2e)

SFM:	108918760 108931426

PKI:	111851208(kmt2e) 111857810

AANG:

118218848 118231711(kmt2e)

LOC:	102694752(kmt2e)

PSPA:

121317956 121319159

ARUT:

117415540 117419831(kmt2e)

PSEX:

120539610(kmt2e)

LCM:	102349988(KMT2E)

CMK:	103176975(kmt2e)

RTP:	109916977(kmt2e)

CPLA:

122561751(kmt2e)

HOC:	132826706(kmt2e)

LERI:

129707817(kmt2e)

PMRN:

116942478(KMT2E)

LRJ:	133349350(KMT2E)

BFO:

BBEL:

CIN:

SPU:

LPIC:

APLC:

AAG:

AALB:

CQU:	CpipJ_CPIJ005719

CPII:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:

DPA:

SOY:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_209930

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM494030

FOC:

TPAL:

ZNE:

DMK:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

HAZT:

EAF:

LSM:

PPOI:

RSAN:

VDE:

VJA:

PTEP:

LOA:	LOAG_17683

TSP:

Tsp_08530

HRO:	HELRODRAFT_182558

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

MMER:

OBI:

OSN:

LAK:

SMM:	Smp_161010

SHX:	MS3_00007773

OVI:	T265_13393

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

TAD:	TRIADDRAFT_61865

AQU:

105313876

» show all

Reference

PMID:14718661

Authors

Deng LW, Chiu I, Strominger JL

Title

MLL 5 protein forms intranuclear foci, and overexpression inhibits cell cycle progression.

Journal

Proc Natl Acad Sci U S A 101:757-62 (2004)
DOI:10.1073/pnas.2036345100

Sequence

[hsa:55904]

Reference

PMID:20236313

Authors

Ansari KI, Mandal SS

Title

Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.

Journal

FEBS J 277:1790-804 (2010)
DOI:10.1111/j.1742-4658.2010.07606.x

ORTHOLOGY: K09188

Entry

K09188                      KO

Symbol

MLL3

Name

[histone H3]-lysine4 N-trimethyltransferase MLL3 [EC:2.1.1.354]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00907

Kleefstra syndrome

H02434

Diffuse large B-cell lymphoma, not otherwise specified

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K09188  MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K09188  MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K09188  MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K09188  MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3
   HMT complexes
    MLL3/MLL4 complex
     K09188  MLL3; [histone H3]-lysine4 N-trimethyltransferase MLL3

Other DBs

GO:

0042800

Genes

HSA:	58508(KMT2C)

PTR:	463875(KMT2C)

PPS:	100992231(KMT2C)

GGO:	101134599(KMT2C)

PON:	100450852(KMT2C)

NLE:	100607151(KMT2C)

HMH:	116814558(KMT2C)

MCC:	716753(KMT2C)

MCF:	102128002(KMT2C)

MTHB:

126951568

MNI:	105474928(KMT2C)

CSAB:

103227268(KMT2C)

CATY:

105584763(KMT2C)

PANU:

101009836(KMT2C)

TGE:	112620339(KMT2C)

MLEU:

105542682(KMT2C)

RRO:	104678716(KMT2C)

RBB:	108523124(KMT2C)

TFN:	117072766(KMT2C)

PTEH:

111551529(KMT2C)

CANG:

105511352(KMT2C)

CJC:	100401397(KMT2C)

SBQ:	101043552(KMT2C)

CIMI:

108297195(KMT2C)

CSYR:

103256120(KMT2C)

MMUR:

105883198(KMT2C)

LCAT:

123647436(KMT2C)

PCOQ:

105824618(KMT2C)

OGA:	100940723(KMT2C)

MMU:	231051(Kmt2c)

MCAL:

110295273(Kmt2c)

MPAH:

110316198(Kmt2c)

RNO:	502710(Kmt2c)

MCOC:

116097574(Kmt2c)

ANU:	117720401(Kmt2c)

MUN:	110564205(Kmt2c)

CGE:	100767367(Kmt2c)

MAUA:

101836405(Kmt2c)

PROB:

127235790(Kmt2c)

PLEU:

114700061(Kmt2c)

MORG:

121439912(Kmt2c)

MFOT:

126489435

AAMP:

119808500(Kmt2c)

NGI:	103745326(Kmt2c)

HGL:	101698170(Kmt2c)

CPOC:

100715884(Kmt2c)

CCAN:

109685268(Kmt2c)

DORD:

105993844(Kmt2c)

DSP:	122105863(Kmt2c)

PLOP:

125347338(Kmt2c)

NCAR:

124990225

MMMA:

107148917(Kmt2c)

OCU:

100353688

OPI:	101518895(KMT2C)

TUP:	102479012(KMT2C)

GVR:	103599133(KMT2C)

CFA:	611094(KMT2C)

CLUD:

112663328(KMT2C)

VVP:	112916198(KMT2C)

VLG:	121489565(KMT2C)

NPO:	129515919(KMT2C)

AML:	100465228(KMT2C)

UMR:	103660985(KMT2C)

UAH:	113241427(KMT2C)

UAR:	123788754(KMT2C)

ELK:

111154508

LLV:

125081365

MPUF:

101678014(KMT2C)

MNP:	132015545(KMT2C)

MLK:	131829967(KMT2C)

NVS:	122905221(KMT2C)

ORO:	101365628(KMT2C)

EJU:	114197990(KMT2C)

ZCA:	113911401(KMT2C)

MLX:	118026826(KMT2C)

NSU:	110582776(KMT2C)

LWW:	102733195(KMT2C)

FCA:	101084095(KMT2C)

PYU:	121022936(KMT2C)

PCOO:

112866516(KMT2C)

PBG:	122488553(KMT2C)

PVIV:

125160093(KMT2C)

LRUF:

124524239

PTG:	102964154(KMT2C)

PPAD:

109252401(KMT2C)

PUC:

125930941

AJU:

106984461

HHV:	120230926(KMT2C)

BTA:	789336(KMT2C)

BOM:	102267186(KMT2C)

BIU:	109558041(KMT2C)

BBUB:

102396938(KMT2C)

BBIS:

105001180(KMT2C)

CHX:	102181925(KMT2C)

OAS:	101115617(KMT2C)

BTAX:

128046722(KMT2C)

ODA:	120877744(KMT2C)

CCAD:

122438891(KMT2C)

MBEZ:

129552800(KMT2C)

SSC:	100514805(KMT2C)

CFR:	102507730(KMT2C)

CBAI:

105067032(KMT2C)

CDK:	105098689(KMT2C)

VPC:	102534434(KMT2C)

BACU:

103004433(KMT2C)

BMUS:

118900623(KMT2C)

LVE:	103078348(KMT2C)

OOR:	101288516(KMT2C)

DLE:	111176572(KMT2C)

PCAD:

102988929(KMT2C)

PSIU:

116759441(KMT2C)

NASI:

112395773(KMT2C)

ECB:	100064812(KMT2C)

EPZ:	103553137(KMT2C)

EAI:	106823334(KMT2C)

MYB:	102246704(KMT2C)

MYD:	102759674(KMT2C)

MMYO:

118679443(KMT2C)

MLF:	102425917(KMT2C)

PKL:	118704757(KMT2C)

EFUS:

103301773(KMT2C)

MNA:	107524895(KMT2C)

DRO:	112308262(KMT2C)

SHON:

118975535(KMT2C)

AJM:	119039227(KMT2C)

PDIC:

114507487(KMT2C)

PHAS:

123817942(KMT2C)

MMF:	118619604(KMT2C)

PPAM:

129086736(KMT2C)

HAI:	109389650(KMT2C)

RFQ:	117018143(KMT2C)

PALE:

102897550(KMT2C)

PGIG:

120601517(KMT2C)

PVP:	105303780(KMT2C)

RAY:	107520298(KMT2C)

MJV:	108397889(KMT2C)

TOD:	119249083(KMT2C)

SARA:

101549683(KMT2C)

SETR:

126026291(KMT2C)

LAV:	100673765(KMT2C)

TMU:

101349940

ETF:	101664543(KMT2C)

DNM:	101426108(KMT2C)

MDO:	100019161(KMT2C)

GAS:	123249858(KMT2C)

SHR:	100920575(KMT2C)

AFZ:

127564250

PCW:	110223876(KMT2C)

OAA:	100074286(KMT2C)

GGA:	420437(KMT2C)

PCOC:

116238267(KMT2C)

MGP:	100545169(KMT2C)

CJO:	107308762(KMT2C)

TPAI:

128085371(KMT2C)

LMUT:

125696177(KMT2C)

NMEL:

110393789(KMT2C)

APLA:

101796266(KMT2C)

ACYG:

106046952(KMT2C)

CATA:

118251781(KMT2C)

AFUL:

116485841(KMT2C)

TGU:	100227193(KMT2C)

LSR:	110484559(KMT2C)

SCAN:

103813061(KMT2C)

PMOA:

120499797(KMT2C)

OTC:	121337901(KMT2C)

PRUF:

121363768(KMT2C)

GFR:	102031396(KMT2C)

FAB:	101806346(KMT2C)

OMA:	130250007(KMT2C)

PHI:	102099277(KMT2C)

PMAJ:

107216349(KMT2C)

CCAE:

111925501(KMT2C)

CCW:	104686428(KMT2C)

CBRC:

103623953(KMT2C)

ETL:	114062389(KMT2C)

ZAB:	102063460(KMT2C)

ACHL:

103801933(KMT2C)

SVG:	106851591(KMT2C)

MMEA:

130573147(KMT2C)

HRT:	120762620(KMT2C)

FPG:	101917176(KMT2C)

FCH:	102047191(KMT2C)

CLV:	102097963(KMT2C)

EGZ:	104130998(KMT2C)

NNI:	104014894(KMT2C)

PCRI:

104027327(KMT2C)

PLET:

104618442(KMT2C)

EHS:	104516448(KMT2C)

PCAO:

104052968

ACUN:

113477175(KMT2C)

TALA:

104366519(KMT2C)

PADL:

103915639(KMT2C)

AFOR:

103905987(KMT2C)

ACHC:

115338945(KMT2C)

HALD:

104310581(KMT2C)

HLE:	104843220(KMT2C)

AGEN:

126038035

GCL:

127012902

CCRI:

104166867

CSTI:

104559749(KMT2C)

CMAC:

104483667

MUI:

104543461

BREG:

104636206(KMT2C)

FGA:

104084400

GSTE:

104263057(KMT2C)

LDI:	104347215(KMT2C)

MNB:	103777989(KMT2C)

OHA:	104337194(KMT2C)

NNT:

104412482

SHAB:

115604961(KMT2C)

DPUB:

104297846(KMT2C)

PGUU:

104461173(KMT2C)

ACAR:

104524952

CPEA:

104396186(KMT2C)

AVIT:

104281017

CVF:	104288042(KMT2C)

RTD:	128906189(KMT2C)

CUCA:

104057025(KMT2C)

TEO:	104383327(KMT2C)

BRHI:

104489768(KMT2C)

AAM:	106485306(KMT2C)

AROW:

112978282(KMT2C)

NPD:	112958121(KMT2C)

TGT:

104569024

DNE:	112981377(KMT2C)

SCAM:

104148877(KMT2C)

ASN:	102379342(KMT2C)

AMJ:	102567474(KMT2C)

CPOO:

109306813(KMT2C)

GGN:	109291225(KMT2C)

PSS:	102459016(KMT2C)

CMY:	102948345(KMT2C)

CCAY:

125631222(KMT2C)

DCC:	119850915(KMT2C)

CPIC:

101953918(KMT2C)

TST:	117872024(KMT2C)

CABI:

116817570(KMT2C)

MRV:	120399324(KMT2C)

ACS:	100556055(kmt2c)

ASAO:

132778987(KMT2C)

PVT:	110071916(KMT2C)

SUND:

121934860(KMT2C)

PBI:

103049419

PMUR:

107303312(KMT2C)

CTIG:

120310214(KMT2C)

TSR:	106556966(KMT2C)

PGUT:

117654789(KMT2C)

APRI:

131198738(KMT2C)

PTEX:

113448992(KMT2C)

NSS:	113419523(KMT2C)

VKO:	123020648(KMT2C)

PMUA:

114607001(KMT2C)

PRAF:

128424424(KMT2C)

ZVI:	118091856(KMT2C)

HCG:	128329288(KMT2C)

GJA:	107123162(KMT2C)

STOW:

125440642(KMT2C)

EMC:	129337741(KMT2C)

XLA:	108718730(kmt2c.L) 108719820(kmt2c.S)

XTR:	100486829(kmt2c)

NPR:	108784343(KMT2C)

RTEM:

120940104(KMT2C)

BBUF:

121002685(KMT2C)

BGAR:

122937808(KMT2C)

MUO:	115466811(KMT2C)

GSH:	117354332(KMT2C)

DRE:	560793(kmt2ca) 568162(kmt2cb)

SRX:	107709778 107711680 107727489 107755698

SANH:

107655805 107664649 107671648 107693534

SGH:	107550009 107557235 107559353 107593836

CCAR:

109050388 109050390 109110986

CAUA:

113038829 113042173(kmt2c) 113046088 113066129

CGIB:

127946125 127950906 128013513 128025086

PTET:

122326787(kmt2cb) 122329988(kmt2ca)

LROH:

127155696(kmt2ca) 127182659(kmt2cb)

OMC:	131530621(kmt2cb) 131533335(kmt2ca)

PPRM:

120475849(kmt2ca) 120482955(kmt2cb)

RKG:	130084410(kmt2ca) 130096489(kmt2cb)

MAMB:

125252002(kmt2cb) 125257560(kmt2ca)

CIDE:

127505482 127506478

MASI:

127431841 127434229 127441623 127442645

TROS:

130551101(kmt2ca) 130553892(kmt2cb)

TDW:	130413552(kmt2ca) 130418290(kmt2cb)

MANU:

129425713(kmt2ca) 129442742(kmt2cb)

IPU:	108267465(kmt2cb) 108272993(kmt2ca)

IFU:	128607693(kmt2ca) 128609781(kmt2cb)

PHYP:

113540030 113545405(kmt2c)

SMEO:

124383970(kmt2ca) 124387745(kmt2cb)

TFD:	113640089(kmt2cb) 113656630(kmt2ca)

TVC:	132845514(kmt2ca) 132848202(kmt2cb)

AMEX:

103033881 103041268

CMAO:

118815568(kmt2ca) 118826193(kmt2cb)

EEE:	113570107 113589795

CHAR:

105889223(kmt2ca) 105891315(kmt2cb)

TRU:	101071853 101075083 105419488

TFS:	130513811 130539415(kmt2cb)

TNG:	GSTEN00025312G001 GSTEN00028349G001

LCO:	104918307 104938105

NCC:	104957667(kmt2c)

TBEN:

117488269(kmt2cb)

CGOB:

115021962(kmt2c)

PGEO:

117462421(kmt2cb)

GACU:

117558315(kmt2cb)

EMAC:

134865840(kmt2cb) 134883941

ELY:	117263913(kmt2cb) 117264300

EFO:	125881947 125901664(kmt2cb)

PLEP:

121951133(kmt2cb)

SLUC:

116046070(kmt2cb) 116057843(kmt2ca) 118494350

ECRA:

117954862(kmt2cb)

ESP:	116699448(kmt2c)

PFLV:

114548971 114565863

GAT:	120812052 120815682(kmt2cb)

PPUG:

119198388 119209337(kmt2cb)

AFB:	129089370(kmt2cb) 129111059

CLUM:

117746087(kmt2cb) 117749363

PSWI:

130197523(kmt2cb)

MSAM:

119897280 119902079(kmt2cb)

SCHU:

122866515(kmt2ca) 122887055(kmt2cb)

CUD:	121520025(kmt2cb) 121527127

ALAT:

119008407(kmt2ca) 119011051(kmt2cb)

MZE:	101465418 101481911

ONL:	100692488 100710717

OAU:	116316974 116336523(kmt2ca)

OLA:	101162786 101171448

OML:	112147812(kmt2cb) 112151375

CSAI:

133423495 133452734(kmt2cb)

XMA:	102216709 102222583(kmt2c)

XCO:	114136765 114145996(kmt2c)

XHE:	116711590 116721167

PRET:

103460165(kmt2c) 103479582

PFOR:

103143029 103156870(kmt2c)

PLAI:

106937609(kmt2c) 106949143

PMEI:

106919800(kmt2c) 106934157

GAF:	122823930(kmt2ca) 122841199(kmt2cb)

PPRL:

129356909 129361937(kmt2cb)

CVG:	107083362(kmt2c) 107101949

CTUL:

119782752 119795676(kmt2cb)

GMU:	124858406(kmt2ca) 124869701(kmt2cb)

NFU:	107374212 107383945(kmt2c)

KMR:	108239632(kmt2cb) 108251294

ALIM:

106534057(kmt2c) 106534301 106535402

NWH:	119415074(kmt2cb) 119426464

AOCE:

111563576 111570146(kmt2c)

MCEP:

124995447 125010715(kmt2cb)

CSEM:

103377343(kmt2c) 103396169

POV:	109639815(kmt2c) 109644301

SSEN:

122758698 122778117

HHIP:

117753901 117777677(kmt2cb)

HSP:	118098932 118118312(kmt2cb)

SMAU:

118291461 118310357(kmt2cb)

LCF:	108883444(kmt2cb) 108890120

SDU:	111236883 111238975

SLAL:

111651182 111670500(kmt2c)

XGL:	120789866 120799116(kmt2cb)

HCQ:	109521240 109526300

SSCV:

125984481 125985779

SBIA:

133492394 133510581(kmt2cb)

PEE:	133396356 133412044(kmt2cb)

PTAO:

133470583 133488838(kmt2cb)

BPEC:

110159445 110166930

MALB:

109957735 109974986(kmt2c)

BSPL:

114844982(kmt2cb) 114853983

SJO:	128369146(kmt2cb)

SASA:

106569192 106579599 106590429 106599252

STRU:

115150500 115157103 115169671 115195273

OTW:	112226861 112232703 112233554 112260547

OMY:	110490933 110508653 110530401 110535292

OGO:	123990418(kmt2ca) 124010018 124040486 124041794

ONE:	115103015 115104488 115114491 115130171

OKI:	109871531 109875158 109899297 109909640

OKE:	118361750(kmt2ca) 118370518 118395216 118402033

SALP:

111953862 111956861 111957019 111973505 111979462

SNH:	120019822 120027884(kmt2ca) 120050620 120055304

CCLU:

121535290 121549477 121568683 121581316

ELS:	105019052 105019546

SFM:	108931734(kmt2c) 108937588

PKI:	111845839 111851671(kmt2c)

AANG:

118226485(kmt2ca) 118234703

LOC:	102682648(kmt2c)

PSPA:

121310091 121314053

ARUT:

117394699 117400327 117966669

PSEX:

120529948(kmt2ca)

LCM:	102347272(KMT2C)

CMK:

103189435

CPLA:

122550327(kmt2ca)

HOC:	132815844(kmt2ca)

LERI:

129714455(kmt2ca)

BFO:	118403620 118403621

BBEL:

CIN:

SCLV:

SPU:

APLC:

SKO:

DME:	Dmel_CG3848(trr)

DER:

6555719

DSE:

6616046

DSI:	Dsimw501_GD16408(Dsim_GD16408)

DYA:	Dyak_GE16999

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI21761

DAZ:

DNV:

DHE:

BDR:

AOQ:

TDA:	119678846 119679409

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ011192 CpipJ_CPIJ011193

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:	105148205 105148261

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:

DPA:

SOY:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_208927

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

API:	100159693 100571907

DNX:	107162062 107162063

AGS:

RMD:

BTAB:

CLEC:

HHAL:

PHU:	Phum_PHUM411800

FOC:

113206615

TPAL:

117649666

ZNE:	110838850 110838870

CSEC:

111873928

FCD:

110850681

DPX:	DAPPUDRAFT_51465

DMK:

PVM:

PJA:

PCHN:

HAME:

PCLA:

PTRU:

LSM:

PPOI:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

PTEP:

CEL:	CELE_T12D8.1(set-16)

CBR:	CBG_18244(Cbr-set-16)

CRQ:	GCK72_010339

NAI:	NECAME_02467

LOA:	LOAG_17819

LGI:	LOTGIDRAFT_215812

PCAN:

112558293 112558303

BGT:	106050290 106050292

GAE:

HRF:

HRJ:

MYI:

PMAX:

OBI:

OSN:

LAK:	106170103 106176161

SMM:	Smp_070170 Smp_138030

SHX:	MS3_00007489(KMT2D)

OVI:	T265_12021 T265_12618 T265_13605

EGL:	EGR_00975 EGR_08154

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

CME:	CYME_CMD005C

GSL:	Gasu_28030

CCP:	CHC_T00005548001

SRE:	PTSG_07559

DFA:

DFA_05766

» show all

Reference

PMID:11891048

Authors

Ruault M, Brun ME, Ventura M, Roizes G, De Sario A

Title

MLL3, a new human member of the TRX/MLL gene family, maps to 7q36, a chromosome region frequently deleted in myeloid leukaemia.

Journal

Gene 284:73-81 (2002)
DOI:10.1016/S0378-1119(02)00392-X

Sequence

[hsa:58508]

Reference

PMID:20236313

Authors

Ansari KI, Mandal SS

Title

Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.

Journal

FEBS J 277:1790-804 (2010)
DOI:10.1111/j.1742-4658.2010.07606.x

Reference

PMID:17500065

Authors

Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K

Title

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

Journal

J Biol Chem 282:20395-406 (2007)
DOI:10.1074/jbc.M701574200

Sequence

[hsa:58508]

ORTHOLOGY: K11419

Entry

K11419                      KO

Symbol

SUV39H, CLR4

Name

[histone H3]-lysine9 N-trimethyltransferase SUV39H [EC:2.1.1.355]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11419  SUV39H, CLR4; [histone H3]-lysine9 N-trimethyltransferase SUV39H
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11419  SUV39H, CLR4; [histone H3]-lysine9 N-trimethyltransferase SUV39H
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.355  [histone H3]-lysine9 N-trimethyltransferase
     K11419  SUV39H, CLR4; [histone H3]-lysine9 N-trimethyltransferase SUV39H
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11419  SUV39H, CLR4; [histone H3]-lysine9 N-trimethyltransferase SUV39H
  Heterochromatin formation proteins
   Other heterochromatin formation proteins
    K11419  SUV39H, CLR4; [histone H3]-lysine9 N-trimethyltransferase SUV39H

Other DBs

GO:

0046974

Genes

HSA:	6839(SUV39H1) 79723(SUV39H2)

PTR:	107971148(SUV39H1) 466014(SUV39H2)

PPS:	100977497(SUV39H1) 100982469(SUV39H2)

GGO:	101126338(SUV39H2) 101146540(SUV39H1)

PON:	100172621(SUV39H1) 100436926(SUV39H2)

NLE:	100591032(SUV39H2) 100598636(SUV39H1)

HMH:	116470963(SUV39H2) 116811661(SUV39H1)

MCC:	697378(SUV39H2) 711040(SUV39H1)

MCF:	102123944 102134179(SUV39H1) 102136014(SUV39H2)

MTHB:

126945594 126962370

MNI:	105490642(SUV39H2) 105493901(SUV39H1)

CSAB:

103231938(SUV39H1) 103237926(SUV39H2)

CATY:

105573130(SUV39H1) 105583853(SUV39H2) 105598847

PANU:

101002260(SUV39H2) 101003206 101007672(SUV39H1)

TGE:	112604683 112616406(SUV39H1) 112631347(SUV39H2)

MLEU:

105530542(SUV39H2) 105547724(SUV39H1)

RRO:	104660660(SUV39H1) 104664471(SUV39H2)

RBB:	108517467(SUV39H1) 108531071(SUV39H2)

TFN:	117062164 117078273(SUV39H1) 117082672(SUV39H2)

PTEH:

111528202 111535700(SUV39H1) 111550038(SUV39H2)

CANG:

105506196(SUV39H2) 105515012(SUV39H1) 105519677

CJC:	100401369(SUV39H1) 100401513(SUV39H2)

SBQ:	101040475(SUV39H2) 101052197(SUV39H1)

CIMI:

108300896(SUV39H1) 108305252(SUV39H2)

CSYR:

103254226(SUV39H1) 103267726(SUV39H2)

MMUR:

105856353(SUV39H2) 105856376(SUV39H1) 105871464

LCAT:

123625405(SUV39H2) 123628362(SUV39H1)

PCOQ:

105816777(SUV39H1) 105823671(SUV39H2)

OGA:	100954282(SUV39H2) 100956539(SUV39H1)

MMU:	20937(Suv39h1) 64707(Suv39h2)

MCAL:

110287176(Suv39h1) 110289296(Suv39h2)

MPAH:

110313347(Suv39h1) 110333642(Suv39h2)

RNO:	302553(Suv39h1) 364785(Suv39h2)

MCOC:

116068177(Suv39h1) 116082667(Suv39h2)

ANU:	117694599(Suv39h1) 117714230(Suv39h2)

MUN:	110554698(Suv39h2) 110561991(Suv39h1)

CGE:	100755145(Suv39h2) 100764568(Suv39h1)

MAUA:

101838624(Suv39h1) 101844757(Suv39h2)

PROB:

127237547(Suv39h2)

PLEU:

114686373 114701015 114701306(Suv39h1) 114710826(Suv39h2)

MORG:

121432621(Suv39h2) 121442585 121442661

MFOT:

126506760 126512880

AAMP:

119805158(Suv39h1) 119816729(Suv39h2)

NGI:	103735184(Suv39h2) 103741644(Suv39h1)

HGL:	101701917(Suv39h2) 101706867(Suv39h1)

CPOC:

100728513(Suv39h2) 100731248(Suv39h1)

CCAN:

109691500(Suv39h2) 109701207(Suv39h1)

DORD:

105984374(Suv39h2) 105997867(Suv39h1) 106000651

DSP:	122098810(Suv39h1) 122113286(Suv39h2) 122120623

PLOP:

125343311(Suv39h1) 125343986 125366781(Suv39h2)

NCAR:

124961476 124971891

MMMA:

107140435(Suv39h2) 107159818(Suv39h1)

OCU:	100354725 100358024

OPI:	101516403(SUV39H2) 101529760 101533574(SUV39H1)

TUP:	102468719(SUV39H1) 102472765

GVR:	103589452(SUV39H1) 103602806(SUV39H2)

CFA:	477995(SUV39H2) 491868(SUV39H1)

CLUD:

112658894(SUV39H2) 112673138(SUV39H1)

VVP:	112907242(SUV39H1) 112933120(SUV39H2)

VLG:	121482956(SUV39H1) 121497217(SUV39H2)

NPO:	129514028(SUV39H2) 129517744(SUV39H1)

AML:	100469547(SUV39H2) 100472595(SUV39H1)

UMR:	103664189(SUV39H2) 103669105(SUV39H1)

UAH:	113241391(SUV39H2) 113265922(SUV39H1)

UAR:	123785960(SUV39H2) 123790887(SUV39H1)

ELK:	111150521 111155595

LLV:	125091942 125107523

MPUF:

101675209(SUV39H1) 101693651(SUV39H2)

MNP:	132006848(SUV39H1) 132020152(SUV39H2)

MLK:	131820762(SUV39H1) 131838248(SUV39H2)

NVS:	122892395(SUV39H2) 122896983(SUV39H1)

ORO:	101374258(SUV39H2) 101381146(SUV39H1)

EJU:	114210177 114216775(SUV39H1) 114217278(SUV39H2)

ZCA:	113921911(SUV39H2) 113925008 113930896(SUV39H1)

MLX:	118010050(SUV39H1) 118021560(SUV39H2)

NSU:	110570881(SUV39H1) 110586530(SUV39H2)

LWW:	102732476(SUV39H2) 102734674(SUV39H1)

FCA:	101083571(SUV39H1) 101099218(SUV39H2)

PYU:	121014778(SUV39H2) 121025917(SUV39H1)

PCOO:

112867563(SUV39H2) 112870989(SUV39H1)

PBG:	122473257(SUV39H2) 122477943(SUV39H1)

PVIV:

125157596(SUV39H1) 125170198(SUV39H2)

LRUF:

124502538 124509510

PTG:	102950897(SUV39H1) 102963752(SUV39H2)

PPAD:

109248069(SUV39H1) 109273698(SUV39H2)

PUC:	125918609 125931659

AJU:	106970864 106971016

HHV:	120221011(SUV39H1) 120236934(SUV39H2)

BTA:	523047(SUV39H1) 536936(SUV39H2)

BOM:	102264756(SUV39H2) 102271191(SUV39H1)

BIU:	109567973(SUV39H2)

BBUB:

102401546(SUV39H1) 102415169(SUV39H2)

BBIS:

105003032(SUV39H2)

CHX:	102174919(SUV39H1) 102176621(SUV39H2)

OAS:	101110031(SUV39H1) 101116417(SUV39H2)

BTAX:

128058674(SUV39H2) 128069954(SUV39H1)

ODA:	120869586(SUV39H2) 120882096(SUV39H1)

CCAD:

122434492(SUV39H1) 122448086(SUV39H2) 122453800

MBEZ:

129539286 129558220(SUV39H2) 129564331(SUV39H1)

SSC:	664651(SUV39H2) 767626(SUV39H1)

CFR:	102521199(SUV39H2)

CBAI:

105072449(SUV39H2) 105079433(SUV39H1)

CDK:	105103308(SUV39H1) 105104521(SUV39H2)

VPC:	102525580(SUV39H1) 102545741(SUV39H2)

BACU:

102999710(SUV39H2) 103005831(SUV39H1)

BMUS:

118889064(SUV39H1) 118889791(SUV39H2)

LVE:	103073919(SUV39H1) 103084616(SUV39H2)

OOR:	101279239(SUV39H2) 101289196(SUV39H1)

DLE:	111169525(SUV39H1) 111178089(SUV39H2)

PCAD:

102988226(SUV39H2) 102988363(SUV39H1)

PSIU:

116747305(SUV39H1) 116748760(SUV39H2)

NASI:

112395395(SUV39H2) 112415988(SUV39H1)

ECB:	100062108(SUV39H1) 100068891(SUV39H2)

EPZ:	103544360 103544897(SUV39H1) 103556824(SUV39H2)

EAI:	106827436(SUV39H1) 106840452(SUV39H2)

MYB:	102243180(SUV39H1) 102260054(SUV39H2)

MYD:	102757145(SUV39H2) 102763954(SUV39H1)

MMYO:

118653933(SUV39H1) 118655474(SUV39H2)

MLF:	102425465(SUV39H1) 102432659(SUV39H2)

PKL:	118731722(SUV39H2) 118731771(SUV39H1)

EFUS:

103292577(SUV39H2) 103301285(SUV39H1)

MNA:	107534821(SUV39H2) 107541392(SUV39H1)

DRO:	112320455(SUV39H2) 112322458(SUV39H1)

SHON:

118997120(SUV39H2) 118998320(SUV39H1)

AJM:	119046306(SUV39H2) 119059808(SUV39H1)

PDIC:

114492683(SUV39H2) 114504865(SUV39H1)

PHAS:

123831095(SUV39H2) 123832782(SUV39H1)

MMF:	118636303(SUV39H1) 118643229(SUV39H2)

PPAM:

129065126(SUV39H1) 129086670(SUV39H2)

HAI:	109374812(SUV39H1) 109393823(SUV39H2)

RFQ:	117019247(SUV39H2) 117027799(SUV39H1)

PALE:

102894853(SUV39H1) 102898400(SUV39H2)

PGIG:

120587091(SUV39H1) 120614623(SUV39H2)

PVP:	105291688(SUV39H2) 105310010(SUV39H1)

RAY:	107504834(SUV39H2) 107515026(SUV39H1)

MJV:	108397103(SUV39H2) 108408400(SUV39H1)

TOD:	119244708(SUV39H2) 119246174(SUV39H1)

SARA:

101537099(SUV39H2) 101551845(SUV39H1)

SETR:

125999218(SUV39H1) 126014500(SUV39H2)

LAV:	100653780(SUV39H1) 100674328(SUV39H2)

TMU:	101347009 101348006

ETF:	101642805(SUV39H1) 101650388(SUV39H2)

DNM:	101410810(SUV39H2) 101431137(SUV39H1)

MDO:	100014806(SUV39H2) 100018670(SUV39H1)

GAS:	123249577(SUV39H2) 123254217(SUV39H1)

SHR:	100922258(SUV39H1) 100933751(SUV39H2)

AFZ:	127538359 127542923

PCW:	110201087(SUV39H1) 110217388(SUV39H2)

OAA:	100084051(SUV39H1) 100085175(SUV39H2)

GGA:	112529927(SUV39H1) 426314(SUV39H2)

PCOC:

116226677(SUV39H2) 116240919(SUV39H1)

MGP:	100539540(SUV39H2) 100548070 104916314

CJO:	107307203(SUV39H1) 107319605(SUV39H2)

TPAI:

128079646(SUV39H2)

LMUT:

125701293(SUV39H2)

NMEL:

110391539(SUV39H1) 110392282(SUV39H2)

APLA:

101796000(SUV39H2)

ACYG:

106046190(SUV39H2)

CATA:

118249431(SUV39H2)

AFUL:

116501666(SUV39H1) 116502296(SUV39H2)

TGU:	100225827(SUV39H2)

LSR:	110470972(SUV39H2) 110481760(SUV39H1)

SCAN:

103813741(SUV39H2)

PMOA:

120508289(SUV39H1) 120509265(SUV39H2)

OTC:	121339649(SUV39H1) 121340539(SUV39H2)

PRUF:

121351466(SUV39H1) 121362326(SUV39H2)

GFR:	102031848(SUV39H2)

FAB:	101814584 101816158(SUV39H2)

OMA:	130248391(SUV39H2)

PHI:	102110616(SUV39H1) 102114300(SUV39H2)

PMAJ:

107204624(SUV39H2)

CCAE:

111923103(SUV39H2)

CCW:	104694491(SUV39H2)

CBRC:

103619827(SUV39H2)

ETL:	114067551(SUV39H2)

ZAB:	102072951(SUV39H2)

ACHL:

103809755(SUV39H2)

SVG:	106857201(SUV39H2) 106863835(SUV39H1)

MMEA:

130573756(SUV39H2)

HRT:	120751545(SUV39H2)

FPG:	101912815(SUV39H2)

FCH:	102059458(SUV39H2)

CLV:	102098917(SUV39H2)

EGZ:	104132393(SUV39H2)

NNI:	104014630(SUV39H2)

PCRI:

104025251(SUV39H2)

PLET:

104621630(SUV39H2)

EHS:	104504052(SUV39H2)

PCAO:

104040081(SUV39H2)

ACUN:

113489768(SUV39H2)

TALA:

104358970(SUV39H2)

PADL:

103915032(SUV39H2)

AFOR:

103904163(SUV39H2)

ACHC:

115341481(SUV39H2)

HALD:

104311858(SUV39H2)

HLE:	104840187(SUV39H2)

AGEN:

126044433

GCL:	127013323 127028025

CCRI:

104165623(SUV39H2)

CSTI:

104554346(SUV39H2)

CMAC:

104474267(SUV39H2)

MUI:	104548728(SUV39H2)

BREG:

104630351(SUV39H2)

FGA:	104071424(SUV39H2)

GSTE:

104252364(SUV39H2)

LDI:	104351471(SUV39H2)

MNB:	103778373(SUV39H2)

OHA:	104337645(SUV39H2)

NNT:	104400243(SUV39H2)

SHAB:

115604906(SUV39H2) 115614601(SUV39H1)

DPUB:

104300079(SUV39H2)

PGUU:

104467057(SUV39H2)

ACAR:

104518833(SUV39H2)

CPEA:

104391931(SUV39H2)

AVIT:

104280300(SUV39H2)

CVF:	104284642(SUV39H2)

RTD:	128903193(SUV39H1) 128906894(SUV39H2)

CUCA:

104059191 104066427(SUV39H2)

TEO:	104370577(SUV39H2)

BRHI:

104494427(SUV39H2)

AAM:	106485143(SUV39H2)

AROW:

112978060(SUV39H2)

NPD:	112942367(SUV39H2)

TGT:	104569918(SUV39H2)

DNE:	112994764(SUV39H2)

SCAM:

104147717(SUV39H2)

ASN:	102375358(SUV39H2) 102378805(SUV39H1)

AMJ:	102558468(SUV39H1) 102563656(SUV39H2)

CPOO:

109315785(SUV39H2)

GGN:	109292195(SUV39H2)

PSS:	102454204(SUV39H2) 102462370(SUV39H1)

CMY:	102937045(SUV39H2) 102937831(SUV39H1)

CCAY:

125628293(SUV39H1) 125630502(SUV39H2)

DCC:	119846993(SUV39H1) 119850738(SUV39H2)

CPIC:

101945875(SUV39H2) 101951503(SUV39H1)

TST:	117874798(SUV39H2)

CABI:

116818898(SUV39H1) 116836408(SUV39H2)

MRV:	120388525(SUV39H1) 120395171(SUV39H2)

ACS:	100553897(suv39h1)

ASAO:

132767602(SUV39H1)

PVT:	110081193(SUV39H1)

SUND:

121922732(SUV39H1)

PBI:	103052540(SUV39H1)

PMUR:

107300048(SUV39H1)

CTIG:

120306632(SUV39H1)

TSR:	106546114(SUV39H1)

PGUT:

117675420(SUV39H1)

APRI:

131191629(SUV39H1)

PTEX:

113443263(SUV39H1)

NSS:	113417787(SUV39H1)

VKO:	123023976(SUV39H1)

PMUA:

114588136(SUV39H1)

PRAF:

128405041(SUV39H1)

ZVI:	118097686(SUV39H1)

HCG:	128343984(SUV39H1)

GJA:	107112843(SUV39H1)

STOW:

125429255(SUV39H1)

EMC:	129346140(SUV39H1)

XLA:	100037174(suv39h2.L) 108700299(suv39h1.S) 108713053(suv39h2.S) 431943(suv39h1.L)

XTR:	116408207 549262(suv39h2)

NPR:	108788266(SUV39H1) 108794066(SUV39H2)

RTEM:

120914074(SUV39H1) 120931719(SUV39H2)

BBUF:

120983221(SUV39H2) 121009587(SUV39H1)

BGAR:

122925399(SUV39H2) 122946834(SUV39H1)

MUO:	115462395(SUV39H1) 115478820(SUV39H2)

GSH:	117349866(SUV39H1) 117366471(SUV39H2)

DRE:	326906(suv39h1b) 445198(suv39h1a)

SRX:	107707679(suv39h1) 107711921 107731148

SANH:

107668084 107669636 107679310

SGH:	107549953 107550505 107571686 107591797

CCAR:

109050848 109068236 109082351

CAUA:

113080156 113093937 113107270 113107584 113107647

CGIB:

127963667 127963948 128018622

PTET:

122350199(suv39h1a) 122350205(suv39h1b)

LROH:

127169300(suv39h1a) 127170313(suv39h1b)

OMC:	131545270(suv39h1b) 131546077(suv39h1a)

PPRM:

120469056(suv39h1a) 120483495(suv39h1b)

RKG:	130094587(suv39h1b) 130094655(suv39h1a)

MAMB:

125279861(suv39h1b) 125280489(suv39h1a)

CIDE:

127516956 127518080

MASI:

127414501 127423831 127424355

TROS:

130568294(suv39h1b) 130568410(suv39h1a)

TDW:	130440295(suv39h1b) 130440297(suv39h1a)

MANU:

129413716(suv39h1b) 129414325(suv39h1a)

IPU:	108265282(suv39h1a) 108265881(suv39h1b)

IFU:	128607866(suv39h1a) 128607941(suv39h1b)

PHYP:

113534019 113540759

SMEO:

124399714(suv39h1a) 124399954(suv39h1b)

TFD:	113655884(suv39h1a) 113656002(suv39h1b)

TVC:	132853834(suv39h1a) 132853939(suv39h1b)

AMEX:

103040252 103041908

CMAO:

118812876(suv39h1a) 118813757(suv39h1b)

EEE:	113579097 113581117

CHAR:

105893664(suv39h1b) 105898965(suv39h1a)

TRU:	101070634 115249168

TFS:

130529445

TNG:	GSTEN00008490G001

LCO:	104932794(suv39h1)

NCC:	104953540(suv39h1)

TBEN:

117481505

CGOB:

115019085(suv39h1)

PGEO:

117448963 117449516

GACU:

117535476

EMAC:

134872286(suv39h1b)

ELY:

EFO:

PLEP:

SLUC:

ECRA:

ESP:	116693088(suv39h1)

PFLV:

114559282(suv39h1)

GAT:

PPUG:

AFB:

CLUM:

PSWI:

130199704(suv39h1b)

MSAM:

119904964

SCHU:

122882470

CUD:

121518164

ALAT:

119022825(suv39h1b)

MZE:	101475727(suv39h1)

ONL:	100693758(suv39h1)

OAU:	116311434 116317088

OLA:	101155408(suv39h1)

OML:

112140032

XMA:	102218201(suv39h1)

XCO:	114142201(suv39h1)

XHE:	116721277(suv39h1)

PRET:

103466971(suv39h1)

PFOR:

103154222(suv39h1)

PLAI:

106957137(suv39h1)

PMEI:

106928341(suv39h1)

GAF:	122820970 122837012

PPRL:

129371865(suv39h1b)

CVG:	107090999(suv39h1)

CTUL:

119786878

GMU:

124875741

NFU:	107390532(suv39h1)

KMR:

108231967

ALIM:

106527380(suv39h1)

NWH:

119416867

AOCE:

111588288(suv39h1)

MCEP:

125020725

CSEM:

103384853(suv39h1)

POV:	109630999(suv39h1)

SSEN:

122777668

HHIP:

117765148(suv39h1a)

HSP:

118111057

SMAU:

118317298

LCF:

108900517

SDU:	111219081(suv39h1)

SLAL:

111670830(suv39h1)

XGL:

120804350

HCQ:	109528227(suv39h1)

SSCV:

125988769

SBIA:

133511861(suv39h1a)

PEE:	133408196(suv39h1a)

PTAO:

133486514(suv39h1a)

BPEC:

110156027(suv39h1)

MALB:

109965296(suv39h1)

BSPL:

114859242(suv39h1b)

SJO:	128356886(suv39h1b)

SASA:

106566827 106567313 106572223 106572377

STRU:

115165747 115166297 115168254

OTW:	112215887 112216612 112222060

OMY:	110492276 110532480

OGO:	124022560 124031815 124045067

ONE:	115102224 115132021 115132329

OKI:	109869445 109907876 109908559

OKE:	118359742 118360846 118361267

SALP:

111966328 111966640 111976965

SNH:	120058874 120058957 120060725

CCLU:

121538205 121538517 121545532 121545663

ELS:	105013831(suv39h1) 105022372

SFM:	108934780(suv39h1)

PKI:	111847791(suv39h1)

AANG:

118208326(suv39h1a)

LOC:	102685370(suv39h1)

PSPA:

121328396

ARUT:

117401622 117404230

PSEX:

120542706

LCM:	102351913 102360554(SUV39H2)

CMK:

RTP:

CPLA:

HOC:

LERI:

PMRN:

116942370(SUV39H2)

LRJ:	133349470(SUV39H2)

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG43664(Su(var)3-9)

DAN:

DPO:

DPE:

DMN:

DWI:	6647325 6649359

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

HIS:

AARA:

AMER:

AFUN:

AMOU:

AALI:

AAG:

AALB:

CQU:	CpipJ_CPIJ019323

CPII:

120426320

CNS:

116347715

BCOO:

119066565 119075575 119078065 119080347

ACER:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

AGIF:

CCIN:

DSM:

NPT:

NFB:

NVG:

TCA:

DPA:

AGRG:

CSET:

AGB:

NVL:

APLN:

PPYR:

OTU:

MSEX:

DPL:	KGM_203219

BANY:

112043085 112047822

MJU:	123870125 123880531

NIQ:

VCD:

MCIX:

PRAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PGW:

CCRN:

API:	100161603(Su(var)3-9) 100161910 100165299 103309898

DNX:	107165795 107173978 107174002

AGS:	114131380 114131445

RMD:	113556537 113557531

ACOO:

126838163 126838549

DVT:	126894257 126897767

BTAB:

109035926 109038184

DCI:	103505434 103507862

CLEC:

106661131

MQU:

128991507

PHU:	Phum_PHUM423590

FOC:	113204601 113206980

TPAL:

ZNE:

CSEC:

BROR:

IEL:

FCD:	110848867 110850699

DPX:	DAPPUDRAFT_306854

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

MNZ:

HAZT:

EAF:

LSM:

PPOI:

DSV:

RSAN:

RMP:

VDE:	111243931 111246042

VJA:	111260615 111267950

CSCU:

111614908

PTEP:

107457147

ABRU:

129960866 129971436 129972293

UDV:

129221009

SDM:	118195474 118205485

LPOL:

106457344

NAI:	NECAME_05130 NECAME_06579

LOA:	LOAG_18944

TSP:

Tsp_05330

HRO:	HELRODRAFT_131923

LGI:	LOTGIDRAFT_134869

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:	111107127 111110608

CANU:

OED:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

SMM:	Smp_027300

SHX:	MS3_00007274

OVI:	T265_13777

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

AQU:	100640934 109585408

PVIR:

120678325

OLU:	OSTLU_25709(SDG3507)

OTA:	OT_ostta18g00210

BPG:	Bathy14g00980

MIS:	MICPUN_64853

MPP:	MICPUCDRAFT_54214(JGI:MicpuC2_54214)

NCR:	NCU04402(dim-5)

NTE:	NEUTE1DRAFT121214(NEUTE1DRAFT_121214)

SMP:	SMAC_07345

PAN:	PODANSg7447

PBEL:

PPSD:

PPSP:

PPSA:

TTT:	THITE_2114845

MTM:	MYCTH_2086155

MGR:

PPEI:

PGRI:

SSCK:

FGR:	FGSG_02778

FPU:	FPSE_10781

FPOA:

FPOAC1_002919(DIM5)

FVN:	FVRRES_03236

FVR:	FVEG_08911

FOX:	FOXG_10263

NHE:	NECHADRAFT_94199(SDG2104)

FFC:	NCS54_00791900

FMU:	J7337_005481(DIM5)

TRE:	TRIREDRAFT_111216

TRR:	M419DRAFT_89807

MAW:

MAJ:

PCHM:

CMT:

AMUS:

PLJ:	VFPFJ_03193

PTKZ:

JDV02_005401

VDA:	VDAG_07826

CHIG:

CH63R_00107

ELA:	UCREL1_2940

PFY:	PFICI_00682

SSL:	SS1G_01550

BFU:	BCIN_11g02360(BcDIM5)

MBE:

MBM_05751

PSCO:

LY89DRAFT_600648

GLZ:	GLAREA_08846

ANI:	ANIA_01170

AFM:	AFUA_1G11090

ACT:	ACLA_024460

NFI:	NFIA_014540

AOR:	AO090038000300

ANG:	An08g03380

AFV:	AFLA_008787

ALUC:

AKAW2_30689A

ACHE:

ACHE_30207S

APUU:

APUU_50577S

PCS:	N7525_003280

PDP:	PDIP_30370

POU:	POX_c04074

TMF:	EYB26_003001

TRG:	TRUGW13939_03059

CIM:	CIMG_06955

CPW:	CPC735_033270

URE:	UREG_05902

PBL:	PAAG_03011

PBN:	PADG_02881

ABE:

ARB_02816

TVE:

TRV_01916

AJE:	HCAG_01813

BGH:	BDBG_00259

PNO:	SNOG_14974

PTE:

PTT_11395

BZE:	COCCADRAFT_96085

BSC:	COCSADRAFT_123285

BOR:	COCMIDRAFT_92785

AALT:

CC77DRAFT_1060195

ARAB:

EKO05_0001435

ZTR:	MYCGRDRAFT_107709(SDG2411)

PFJ:	MYCFIDRAFT_149458

FFU:	CLAFUR5_00190 CLAFUR5_12582

CBET:

CB0940_00773

BCOM:

BAUCODRAFT_100172

NPA:	UCRNP2_4835

SPO:	SPBC428.08c(clr4)

SOM:	SOMG_05025(clr4)

CNE:

CNH00720

CNB:

CNBL0680

CNG:	CNAG_05404

CGI:	CGB_L0430W

CDEU:

CNBG_4448

TMS:	TREMEDRAFT_74418

TASA:

A1Q1_02905

TVS:	TRAVEDRAFT_112981 TRAVEDRAFT_55782

DSQ:	DICSQDRAFT_110205 DICSQDRAFT_51443

SHS:	STEHIDRAFT_168918

HIR:	HETIRDRAFT_319697

PSQ:	PUNSTDRAFT_54070 PUNSTDRAFT_80062

ADL:	AURDEDRAFT_114614 AURDEDRAFT_93052 AURDEDRAFT_93062

FME:	FOMMEDRAFT_167613 FOMMEDRAFT_20301

GTR:	GLOTRDRAFT_125040

LBC:	LACBIDRAFT_296206(SDG16210) LACBIDRAFT_300409(SDG16205)

CCI:	CC1G_12392

ABP:	AGABI1DRAFT108076(AGABI1DRAFT_108076) AGABI1DRAFT129982(AGABI1DRAFT_129982)

ABV:	AGABI2DRAFT146074(AGABI2DRAFT_146074) AGABI2DRAFT180791(AGABI2DRAFT_180791)

MRR:	Moror_11412 Moror_2531

E1B28_007567

SCM:	SCHCO_01174894(SCHCODRAFT_01174894)

CPUT:

CONPUDRAFT_117641 CONPUDRAFT_56532

SLA:	SERLADRAFT_391489 SERLADRAFT_468863

DPP:	DICPUDRAFT_55529

EHX:	EMIHUDRAFT_457456

NGR:	NAEGRDRAFT_51681

» show all

Reference

PMID:14765126

Authors

Ait-Si-Ali S, Guasconi V, Fritsch L, Yahi H, Sekhri R, Naguibneva I, Robin P, Cabon F, Polesskaya A, Harel-Bellan A

Title

A Suv39h-dependent mechanism for silencing S-phase genes in differentiating but not in cycling cells.

Journal

EMBO J 23:605-15 (2004)
DOI:10.1038/sj.emboj.7600074

Sequence

[hsa:6839 79723]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (8)   
   KEGG ENZYME (1)   
   KEGG REACTION (3)   
   KEGG RCLASS (4)   
Gene (3136)   
   KEGG GENES (1015)   
   KEGG MGENES (478)   
   RefGene (1620)   
   OC (23)   
Literature (1)   
   PubMed (1)   
All databases (3153)   

Download RDF

ORTHOLOGY: K14959

Entry

K14959                      KO

Symbol

MLL4

Name

[histone H3]-lysine4 N-trimethyltransferase MLL4 [EC:2.1.1.354]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00773

Autosomal dominant intellectual developmental disorder

H00831

Primary dystonia

H01613

Follicular lymphoma

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
   03036 Chromosome and associated proteins
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   CXXC CpG-binding proteins
    K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4
   HMT complexes
    MLL3/MLL4 complex
     K14959  MLL4; [histone H3]-lysine4 N-trimethyltransferase MLL4

Other DBs

GO:

0042800

Genes

HSA:	9757(KMT2B)

PTR:	455959(KMT2B)

PPS:	100979249(KMT2B)

GGO:	101139923(KMT2B)

PON:	100442005(KMT2B)

NLE:	100594433(KMT2B)

HMH:	116478917(KMT2B)

MCC:	718835(KMT2B)

MCF:	102115861(KMT2B)

MTHB:

126941879

MNI:	105495504(KMT2B)

CSAB:

103234531(KMT2B)

CATY:

105578189(KMT2B)

PANU:

101011413(KMT2B)

TGE:	112613055(KMT2B)

MLEU:

105543104(KMT2B)

RRO:	104667085(KMT2B)

RBB:	108512323(KMT2B)

TFN:	117092369(KMT2B)

PTEH:

111529937(KMT2B)

CANG:

105516695(KMT2B)

CJC:	100407541(KMT2B)

SBQ:	101034359(KMT2B)

CIMI:

108286344(KMT2B)

CSYR:

103249681(KMT2B)

MMUR:

105876915(KMT2B)

LCAT:

123624459(KMT2B)

PCOQ:

105816259(KMT2B)

OGA:	100941061(KMT2B)

MMU:	75410(Kmt2b)

MCAL:

110297666(Kmt2b)

MPAH:

110338314(Kmt2b)

RNO:	102550344(Kmt2b)

MCOC:

116101986(Kmt2b)

ANU:	117709080(Kmt2b)

MUN:	110550986(Kmt2b)

CGE:	100750575(Kmt2b)

MAUA:

101835352(Kmt2b)

PROB:

127238764(Kmt2b)

PLEU:

114681635(Kmt2b)

MORG:

121449315(Kmt2b)

MFOT:

126486716

AAMP:

119820602(Kmt2b)

NGI:	103729965(Kmt2b)

HGL:	101699273(Kmt2b)

CPOC:

100735175(Kmt2b)

CCAN:

109689598(Kmt2b)

DORD:

105993122(Kmt2b)

DSP:	122097464(Kmt2b)

PLOP:

125368349(Kmt2b)

NCAR:

124966333

MMMA:

107151676(Kmt2b)

OCU:

100353483

OPI:	101535318(KMT2B)

TUP:	102477772(KMT2B)

GVR:	103583372 103592831(KMT2B)

CFA:	100688666(KMT2B)

CLUD:

112643518(KMT2B)

VVP:	112928324(KMT2B)

VLG:	121484255(KMT2B)

NPO:	129499888(KMT2B)

AML:	100469094(KMT2B)

UMR:	103682560(KMT2B)

UAH:	113244759(KMT2B)

UAR:	123793892(KMT2B)

ELK:

111161417

LLV:

125088364

MPUF:

101685930(KMT2B)

MNP:	132005509(KMT2B)

MLK:	131818658(KMT2B)

NVS:	122911561(KMT2B)

ORO:	101370290(KMT2B)

EJU:	114224359(KMT2B)

ZCA:	113935548(KMT2B)

MLX:	118022788(KMT2B)

NSU:	110590086(KMT2B)

LWW:	102730782(KMT2B)

FCA:	101098760(KMT2B)

PYU:	121011346(KMT2B)

PCOO:

112851004(KMT2B)

PBG:	122495065(KMT2B)

PVIV:

125153519(KMT2B)

LRUF:

124511218

PTG:	102964982(KMT2B)

PPAD:

109251503(KMT2B)

PUC:	125918291 125918297

AJU:

106974745

HHV:	120243477(KMT2B)

BTA:	785776(KMT2B)

BOM:	102269320(KMT2B)

BIU:	109572325(KMT2B)

BBIS:

104995419(KMT2B)

CHX:	102172292(KMT2B)

OAS:	101104086(KMT2B)

BTAX:

128062799(KMT2B)

ODA:	120872497(KMT2B)

CCAD:

122421375(KMT2B)

MBEZ:

129546059(KMT2B)

SSC:	100520742(KMT2B)

CFR:	102520520(KMT2B)

CBAI:

105065102(KMT2B)

CDK:

105088051

VPC:	102538562(KMT2B)

BACU:

103015601(KMT2B)

BMUS:

118884797(KMT2B)

LVE:	103073652(KMT2B)

OOR:	101276223(KMT2B)

DLE:	111181136(KMT2B)

PCAD:

102987727(KMT2B)

PSIU:

116744553(KMT2B)

NASI:

112392388(KMT2B)

ECB:	100059802(KMT2B)

EPZ:	103566091(KMT2B)

EAI:	106829152(KMT2B)

MYB:	102259087(KMT2B)

MYD:	102771251(KMT2B)

MMYO:

118674717(KMT2B)

MLF:	102433699(KMT2B)

PKL:	118720655(KMT2B)

EFUS:

103284776(KMT2B)

MNA:	107543372(KMT2B)

DRO:	112320053(KMT2B)

SHON:

118982549(KMT2B)

AJM:	119044204(KMT2B)

PDIC:

114511083(KMT2B)

PHAS:

123823661(KMT2B)

MMF:	118638673(KMT2B)

PPAM:

129083195(KMT2B)

HAI:	109372008(KMT2B)

RFQ:	117034916(KMT2B)

PALE:

102881431(KMT2B)

PGIG:

120592489(KMT2B)

PVP:	105306647(KMT2B)

RAY:	107497624(KMT2B)

MJV:	108401519(KMT2B)

TOD:	119250148(KMT2B)

SARA:

101537418(KMT2B)

SETR:

126027579(KMT2B)

LAV:	100669611(KMT2B)

TMU:

101345928

ETF:	101656752(KMT2B)

DNM:	101413650(KMT2B)

MDO:	100617561(KMT2B)

GAS:

123256611

SHR:	100927672(KMT2B)

AFZ:

127556061

PCW:	110201341(KMT2B)

OAA:	103165316(KMT2B)

ASN:	102382195(KMT2B)

CMY:	102931937(KMT2B)

CCAY:

125625630(KMT2B)

DCC:	119847681(KMT2B)

CPIC:

101950574(KMT2B)

TST:	117869515(KMT2B)

CABI:

116839067(KMT2B)

MRV:	120390254(KMT2B)

ACS:	100556600(kmt2b)

ASAO:

132780295(KMT2B)

PVT:	110089900(KMT2B)

SUND:

121915298(KMT2B)

PBI:	103058696(KMT2B)

PMUR:

107287999(KMT2B)

CTIG:

120300040(KMT2B)

TSR:	106550780(KMT2B)

PGUT:

117669309(KMT2B)

APRI:

131204277(KMT2B)

PTEX:

113437418(KMT2B)

NSS:	113419887(KMT2B)

VKO:	123025799(KMT2B)

PMUA:

114603572(KMT2B)

PRAF:

128418584(KMT2B)

ZVI:	118085945(KMT2B)

HCG:	128332572(KMT2B)

GJA:	107108169(KMT2B)

STOW:

125434769(KMT2B)

EMC:	129343103(KMT2B)

XLA:	108696880 108697287

XTR:	100144721(kmt2b)

NPR:	108799776(KMT2B)

RTEM:

120916238(KMT2B)

BBUF:

120993856(KMT2B)

BGAR:

122929120(KMT2B)

MUO:	115476211(KMT2B)

GSH:	117369214(KMT2B)

DRE:	560856(kmt2ba) 566825(kmt2bb)

SRX:	107724085 107739503 107745205 107747652

SANH:

107665484 107675870 107693264 107701550

SGH:	107571391(kmt2b) 107585719 107589473 107599517

CCAR:

109085861 109103645 109112389

CAUA:

113061939 113061940 113062164 113069211 113077794 113099189 113099201 113114935 113120015

CGIB:

127935245 127973165 127979018 128028980

PTET:

122323526(kmt2ba) 122358939(kmt2bb)

LROH:

127157412(kmt2bb) 127182023(kmt2ba)

OMC:	131520426(kmt2bb) 131525286(kmt2ba)

PPRM:

120478822(kmt2bb) 120483374(kmt2ba)

RKG:	130070691(kmt2bb) 130070833(kmt2ba)

MAMB:

125248738 125275959(kmt2ba)

CIDE:

127495955 127501701

MASI:

127421184 127422178 127425593 127429839

TROS:

130564368(kmt2bb) 130566892(kmt2ba)

TDW:	130415530(kmt2ba) 130428110(kmt2bb)

MANU:

129438380(kmt2bb) 129454902(kmt2ba)

IPU:	108272954(kmt2ba) 108277672(kmt2bb)

IFU:	128615464(kmt2ba) 128621843(kmt2bb)

PHYP:

113535181 113539221(kmt2b)

SMEO:

124381839(kmt2ba) 124394710(kmt2bb)

TFD:	113641273(kmt2ba) 113642372(kmt2bb)

TVC:	132842880(kmt2ba) 132858299(kmt2bb)

AMEX:

103022217(kmt2b) 103024771

CMAO:

118803799(kmt2bb) 118805983(kmt2ba)

EEE:	113572597 113586392(kmt2b)

CHAR:

105901266(kmt2bb) 105902047(kmt2ba)

TRU:	101064190 101073293(kmt2b) 115251849

TFS:	130518561(kmt2ba) 130532714(kmt2bb)

TNG:	GSTEN00032527G001

LCO:	104927558 104932361(kmt2b)

NCC:	104960690 104961389(kmt2b)

TBEN:

117477555(kmt2ba) 117480290(kmt2bb)

CGOB:

115016046 115021110(kmt2b)

PGEO:

117455559(kmt2ba) 117460876(kmt2bb)

GACU:

117542674(kmt2ba) 117553899(kmt2bb)

EMAC:

134861535(kmt2bb) 134874859

ELY:	117263326(kmt2ba) 117266030(kmt2bb)

EFO:	125893714(kmt2bb) 125904405(kmt2ba)

PLEP:

121946079(kmt2bb) 121957413(kmt2ba)

SLUC:

116047504(kmt2ba) 116049332(kmt2bb)

ECRA:

117946883(kmt2bb) 117956541(kmt2ba)

ESP:	116690992(kmt2b) 116701633

PFLV:

114556540(kmt2b) 114567833

GAT:	120811149(kmt2bb) 120826849(kmt2ba)

PPUG:

119197459(kmt2bb) 119218734(kmt2ba)

AFB:	129097316 129110093(kmt2bb)

CLUM:

117739150(kmt2ba) 117745348(kmt2bb)

PSWI:

130193257 130213312(kmt2bb)

MSAM:

119898296(kmt2bb) 119907919(kmt2ba)

SCHU:

122864889(kmt2ba) 122881423(kmt2bb)

CUD:	121512979(kmt2bb) 121524572(kmt2ba)

ALAT:

119005807(kmt2bb) 119016569(kmt2ba)

MZE:	101467874 101481309(kmt2b)

ONL:	100689867 100700132(kmt2b)

OAU:	116319815(kmt2bb) 116320047(kmt2ba)

OLA:	101157226 101174945(kmt2b)

OML:	112143279(kmt2bb) 112162480(kmt2ba)

CSAI:

133428222(kmt2bb) 133461414(kmt2ba)

XMA:	102222844 102229737(kmt2b)

XCO:	114142152(kmt2b) 114156616

XHE:	116713912(kmt2b) 116730674

PRET:

103472504 103478519(kmt2b)

PFOR:

103143107(kmt2b) 103146865

PLAI:

106945874(kmt2b) 106960535

PMEI:

106919951 106928418(kmt2b)

GAF:	122831339(kmt2bb) 122843072(kmt2ba)

PPRL:

129371385(kmt2bb) 129374949

CVG:	107086122(kmt2b) 107101115

CTUL:

119775533(kmt2bb) 119779627

GMU:	124864459(kmt2bb) 124879104

NFU:	107372442(kmt2b) 107394636

KMR:	108240680(kmt2ba) 108241999(kmt2bb)

ALIM:

106517704(kmt2b) 106537143

NWH:	119409464(kmt2bb) 119425834(kmt2ba)

AOCE:

111571387 111577070(kmt2b)

MCEP:

125015742(kmt2bb) 125020556

CSEM:

103388508(kmt2b) 103394161

POV:	109633105(kmt2b) 109638782

SSEN:

122774538(kmt2bb) 122786593(kmt2ba)

HHIP:

117770576 117776549(kmt2bb)

HSP:	118113601(kmt2bb) 118124314(kmt2ba)

SMAU:

118291930(kmt2ba) 118300255(kmt2bb)

LCF:	108888836 108890658(kmt2bb)

SDU:	111223127 111234049(kmt2b)

SLAL:

111657578 111664979(kmt2b)

XGL:	120783762(kmt2bb) 120786435(kmt2ba)

HCQ:	109514546 109525616(kmt2b)

SSCV:

125975503 125987183

SBIA:

133499114(kmt2ba) 133500576(kmt2bb)

PEE:	133396134 133401744(kmt2bb)

PTAO:

133471228(kmt2ba) 133479257(kmt2bb)

BPEC:

110161138 110171497(kmt2b)

MALB:

109971699(kmt2b) 109973928

BSPL:

114843364(kmt2bb) 114866253(kmt2ba)

SJO:	128366747(kmt2bb) 128374749(kmt2ba)

SASA:

106570121 106577926 106588247 106594944 106605615

STRU:

115164151 115173397 115176084 115177337

OTW:	112226731 112230014 112246968 112264909

OMY:	110487656 110496098 110510370 110538034

OGO:	123998007 124005299 124012097 124043698

ONE:	115101452 115128277 115131800 115140822

OKI:	109900891 109901820 109903796 109907621

OKE:	118367807 118373824 118398340 118399190

SALP:

111955007 111955466 111958933 111964605

SNH:	120022385 120026748 120030911 120047222

CCLU:

121556964 121571388 121585346 121586284

ELS:	105007527 105019114(kmt2b)

SFM:	108930328(kmt2b)

PKI:	111833696(kmt2b) 111839650

AANG:

118212590(kmt2bb) 118233860

LOC:	102692171(kmt2b)

PSPA:

121299031(kmt2bb) 121304193

ARUT:

117434041(kmt2bb) 117971976 117971978

HOC:

CGLO:

CSET:

AGB:

FCD:

DMK:

PJA:

PCLA:

EAF:

PPOI:

EGL:

NVE:	5501691 5502141

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

AQU:

Reference

PMID:17707229

Authors

Demers C, Chaturvedi CP, Ranish JA, Juban G, Lai P, Morle F, Aebersold R, Dilworth FJ, Groudine M, Brand M

Title

Activator-mediated recruitment of the MLL2 methyltransferase complex to the beta-globin locus.

Journal

Mol Cell 27:573-84 (2007)
DOI:10.1016/j.molcel.2007.06.022

Sequence

[hsa:9757]

Reference

PMID:17500065

Authors

Cho YW, Hong T, Hong S, Guo H, Yu H, Kim D, Guszczynski T, Dressler GR, Copeland TD, Kalkum M, Ge K

Title

PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

Journal

J Biol Chem 282:20395-406 (2007)
DOI:10.1074/jbc.M701574200

Sequence

[hsa:9757]

ORTHOLOGY: K06101

Entry

K06101                      KO

Symbol

ASH1L

Name

[histone H3]-lysine4 N-trimethyltransferase ASH1L [EC:2.1.1.354]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00773

Autosomal dominant intellectual developmental disorder

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K06101  ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K06101  ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K06101  ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K06101  ASH1L; [histone H3]-lysine4 N-trimethyltransferase ASH1L

Other DBs

GO:

0042800

Genes

HSA:	55870(ASH1L)

PTR:	107971434(ASH1L)

PPS:	100979709(ASH1L)

GGO:	101134264(ASH1L)

NLE:	100580011(ASH1L)

HMH:	116469304(ASH1L)

MCC:	717778(ASH1L)

MCF:	101867084(ASH1L)

MTHB:

126932888

MNI:	105498260(ASH1L)

CSAB:

103223879(ASH1L)

CATY:

105593539(ASH1L)

PANU:

101019457(ASH1L)

TGE:	112621576(ASH1L)

MLEU:

105544859(ASH1L)

RRO:	104659604(ASH1L)

RBB:	108526806(ASH1L)

TFN:	117074556(ASH1L)

PTEH:

111543765(ASH1L)

CANG:

105502046(ASH1L)

CJC:	100393607(ASH1L)

SBQ:	101046051(ASH1L)

CIMI:

108297159(ASH1L)

CSYR:

103255836(ASH1L)

MMUR:

105873156(ASH1L)

LCAT:

123634072(ASH1L)

PCOQ:

105821867(ASH1L)

OGA:	100954638(ASH1L)

MMU:	192195(Ash1l)

MCAL:

110291461(Ash1l)

MPAH:

110320636(Ash1l)

RNO:	310638(Ash1l)

MCOC:

116093147(Ash1l)

ANU:	117707081(Ash1l)

MUN:	110548961(Ash1l)

CGE:	100754103(Ash1l)

MAUA:

101823215(Ash1l)

PROB:

127232663(Ash1l)

PLEU:

114707881(Ash1l)

MORG:

121450522(Ash1l)

MFOT:

126516121

AAMP:

119800836(Ash1l)

NGI:	103750808(Ash1l)

HGL:	101723836(Ash1l)

CPOC:

100717586(Ash1l)

CCAN:

109688014(Ash1l)

DORD:

105984904(Ash1l)

DSP:	122109545(Ash1l)

PLOP:

125359696(Ash1l)

NCAR:

124994959

MMMA:

107156714(Ash1l)

OCU:

100354541

OPI:	101535854(ASH1L)

TUP:	102469443(ASH1L)

GVR:	103603651(ASH1L)

CFA:	480128(ASH1L)

CLUD:

112648925(ASH1L)

VVP:	112918925(ASH1L)

VLG:	121485278(ASH1L)

NPO:	129508576(ASH1L)

AML:	100474237(ASH1L)

UMR:	103668369(ASH1L)

UAH:	113245266(ASH1L)

UAR:	123783381(ASH1L)

ELK:

111138933

LLV:

125085470

MPUF:

101692156(ASH1L)

MNP:	132025893(ASH1L)

MLK:	131815219(ASH1L)

NVS:	122918271(ASH1L)

ORO:	101362745(ASH1L)

EJU:	114198572(ASH1L)

ZCA:	113933287(ASH1L)

MLX:	118013887(ASH1L)

NSU:	110573557(ASH1L)

LWW:	102729035(ASH1L)

FCA:	101086114(ASH1L)

PYU:	121015632(ASH1L)

PCOO:

112851746(ASH1L)

PBG:	122476171(ASH1L)

PVIV:

125155107(ASH1L)

LRUF:

124521683

PTG:	102969379(ASH1L)

PPAD:

109256230(ASH1L)

PUC:

125925697

AJU:

106981535

HHV:	120244733(ASH1L)

BTA:	540563(ASH1L)

BOM:	102275046(ASH1L)

BIU:	109553548(ASH1L)

BBUB:

102415367(ASH1L)

BBIS:

104987397(ASH1L)

CHX:	102185413(ASH1L)

OAS:	101119775(ASH1L)

BTAX:

128044530(ASH1L)

ODA:	120855721(ASH1L)

CCAD:

122432434(ASH1L)

MBEZ:

129541286(ASH1L)

SSC:	100155920(ASH1L)

CFR:	102510601(ASH1L)

CBAI:

105068149(ASH1L)

CDK:	105088782(ASH1L)

VPC:	102541092(ASH1L)

BACU:

103015822(ASH1L)

BMUS:

118883966(ASH1L)

LVE:	103087473(ASH1L)

OOR:	101288541(ASH1L)

DLE:	111167169(ASH1L)

PCAD:

102993773(ASH1L)

PSIU:

116749029(ASH1L)

NASI:

112401717(ASH1L)

ECB:	100057386(ASH1L)

EPZ:	103548807 103552840

EAI:	106828486(ASH1L)

MYB:	102256394(ASH1L)

MYD:	102764796(ASH1L)

MMYO:

118673205(ASH1L)

MLF:	102422609(ASH1L)

PKL:	118721618(ASH1L)

EFUS:

103298888(ASH1L)

MNA:	107543779(ASH1L)

DRO:	112316914(ASH1L)

SHON:

118990223(ASH1L)

AJM:	119039727(ASH1L)

PDIC:

114489233(ASH1L)

PHAS:

123804317(ASH1L)

MMF:	118637054(ASH1L)

PPAM:

129062300(ASH1L)

HAI:	109393386(ASH1L)

RFQ:	117014381(ASH1L)

PALE:

102888124(ASH1L)

PGIG:

120592114(ASH1L)

PVP:	105296438(ASH1L)

RAY:	107521457(ASH1L)

MJV:	108407349(ASH1L)

TOD:	119235659(ASH1L)

SARA:

101536883(ASH1L)

SETR:

126020683(ASH1L)

LAV:	100668468(ASH1L)

TMU:

101348724

ETF:	101640320(ASH1L)

DNM:	101437622(ASH1L)

MDO:	100017118(ASH1L)

GAS:	123247906(ASH1L)

SHR:	100931585(ASH1L)

AFZ:

127559804

PCW:	110211945(ASH1L)

OAA:	103168045(ASH1L)

GGA:	425064(ASH1L)

PCOC:

116240863(ASH1L)

MGP:	100539732(ASH1L)

CJO:	107324503(ASH1L)

TPAI:

128092065(ASH1L)

LMUT:

125685860(ASH1L)

NMEL:

110387902(ASH1L)

APLA:

119713747(ASH1L)

ACYG:

106048498(ASH1L)

CATA:

118258443(ASH1L)

AFUL:

116499662(ASH1L)

TGU:	100229714(ASH1L)

LSR:	110471483(ASH1L)

SCAN:

103823951(ASH1L)

PMOA:

120498930(ASH1L)

OTC:	121332147(ASH1L)

PRUF:

121352178(ASH1L)

GFR:	102042927(ASH1L)

FAB:	101819907(ASH1L)

OMA:	130263172(ASH1L)

PHI:	102113028(ASH1L)

PMAJ:

107214568(ASH1L)

CCAE:

111939443(ASH1L)

CBRC:

103611269(ASH1L)

ETL:	114069574(ASH1L)

SVG:	106861120(ASH1L)

MMEA:

130586867(ASH1L)

HRT:	120764150(ASH1L)

FPG:	101913546(ASH1L)

FCH:	102056587(ASH1L)

CLV:	102090928(ASH1L)

EGZ:	104134854(ASH1L)

NNI:	104020487(ASH1L)

PCRI:

104034316

EHS:	104504530(ASH1L)

ACUN:

113488743(ASH1L)

TALA:

104365486(ASH1L)

PADL:

103913294(ASH1L)

AFOR:

103894959(ASH1L)

ACHC:

115346307(ASH1L)

HALD:

104311829(ASH1L)

HLE:	104829641(ASH1L)

AGEN:

126040631

GCL:

127027048

CCRI:

104156176

CSTI:

104554497(ASH1L)

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:	104341118(ASH1L)

MNB:	103776047(ASH1L)

OHA:	104329765(ASH1L)

NNT:	104406553(ASH1L)

SHAB:

115602803(ASH1L)

DPUB:

104310254(ASH1L)

PGUU:

104460694

CPEA:

104387244(ASH1L)

AVIT:

104280494

CVF:	104294109(ASH1L)

RTD:	128901143(ASH1L)

CUCA:

104057090(ASH1L)

BRHI:

104492230

AAM:	106494341(ASH1L)

AROW:

112978246(ASH1L)

NPD:	112952957(ASH1L)

TGT:	104565882(ASH1L)

DNE:	112992196(ASH1L)

SCAM:

104139355(ASH1L)

ASN:	102372997(ASH1L)

AMJ:	102571713(ASH1L)

CPOO:

109324810(ASH1L)

GGN:	109305142(ASH1L)

PSS:	102448117(ASH1L)

CMY:	102943662(ASH1L)

CCAY:

125626207(ASH1L)

DCC:	119848004(ASH1L)

CPIC:

101942050(ASH1L)

TST:	117888659(ASH1L)

CABI:

116817234(ASH1L)

MRV:	120390221(ASH1L)

ACS:	100563888(ash1l)

ASAO:

132764246(ASH1L)

PVT:	110081037(ASH1L)

SUND:

121916058(ASH1L)

PBI:	103060233(ASH1L)

PMUR:

107297020(ASH1L)

CTIG:

120317174(ASH1L)

TSR:

106538172

PGUT:

117658860(ASH1L)

APRI:

131186393(ASH1L)

PTEX:

113446585(ASH1L)

NSS:	113426974(ASH1L)

VKO:	123032623(ASH1L)

PMUA:

114586229(ASH1L)

PRAF:

128403918(ASH1L)

ZVI:	118076583(ASH1L)

HCG:	128336928(ASH1L)

GJA:	107119617(ASH1L)

STOW:

125441054(ASH1L)

EMC:	129339539(ASH1L)

XLA:	108699167 108700623

XTR:	108645568(ash1l)

NPR:	108794233(ASH1L)

RTEM:

120920770(ASH1L)

MUO:	115456952(ASH1L)

GSH:	117350090(ASH1L)

DRE:	563799(ash1l)

SRX:	107707165 107724081 107739498 107743194

SANH:

107656475 107673015 107685579 107693346

SGH:	107589474 107596620 107598430 107599509

CCAR:

109111952

CAUA:

113059914 113116331 113120006

CGIB:

127934925 127979019

PTET:

122323584(ash1l)

LROH:

127181447(ash1l)

OMC:	131525287(ash1l)

PPRM:

120483798(ash1l) 120484714

RKG:	130070828(ash1l)

MAMB:

125244159 125275540(ash1l)

CIDE:

127500630

MASI:

127420966 127425594

TROS:

130566565(ash1l)

TDW:	130415758(ash1l)

MANU:

129455335(ash1l)

IPU:	108267029 108272684(ash1l)

IFU:	128615239(ash1l)

PHYP:

113535206 113542280(ash1l)

SMEO:

124381860(ash1l) 124385197

TFD:	113641274(ash1l) 113644404

TVC:	132842875(ash1l)

AMEX:

103022779 103036607

CMAO:

118805977(ash1l)

EEE:	113570594 113572615

CHAR:

105901435(ash1l) 105906726

TRU:	101065064 101078475

TFS:	130518819(ash1l) 130532300

TNG:	GSTEN00032567G001

LCO:	104929091 104934663

NCC:	104942643 104958848(ash1l)

TBEN:

117477916(ash1l) 117480263

CGOB:

115015423

PGEO:

117455328(ash1l) 117461084

GACU:

117540997 117542568(ash1l)

EMAC:

134861400 134874850(ash1l)

ELY:	117263128(ash1l) 117265713

EFO:	125892769 125904401(ash1l)

PLEP:

121945149 121957926(ash1l)

SLUC:

116047314(ash1l) 116049571

ECRA:

117946694 117956323(ash1l)

ESP:	116691354 116701264

PFLV:

114557800(ash1l) 114567637

GAT:	120825936(ash1l)

PPUG:

119197439 119218735(ash1l)

AFB:	129097038(ash1l) 129109105

CLUM:

117738591(ash1l) 117745551

PSWI:

130199528(ash1l) 130212726

MSAM:

119897568 119908147(ash1l)

SCHU:

122864341(ash1l) 122882158

CUD:	121513663 121524306(ash1l)

ALAT:

119005927 119014819(ash1l)

MZE:	101465538 101472002

ONL:	100706567(ash1l) 100707110

OAU:	116315704 116319419(ash1l)

OLA:	101156847(ash1l) 101161417

OML:	112143321 112162542(ash1l)

CSAI:

133432525 133461347(ash1l)

XMA:	102219717 102229525(ash1l)

XCO:	114141764(ash1l) 114156414

XHE:	116717078(ash1l) 116730665

PRET:

103472762 103478185(ash1l)

PFOR:

103140776(ash1l) 103144472

PLAI:

106938021 106954688 106964214

PMEI:

106917899(ash1l) 106918176

GAF:	122830959 122843303(ash1l)

PPRL:

129371196 129374981(ash1l)

CVG:	107084057 107088414(ash1l)

CTUL:

119779602(ash1l) 119783008

GMU:	124865811 124879004(ash1l)

NFU:	107379592(ash1l) 107394561

KMR:	108240202(ash1l) 108241069

ALIM:

106520872 106531577(ash1l)

NWH:	119409732 119425388(ash1l)

AOCE:

111570477

MCEP:

125016431 125019564(ash1l)

CSEM:

103388251(ash1l) 103394569

POV:	109633377 109639158

SSEN:

122774591 122786837(ash1l)

HHIP:

117770539(ash1l)

HSP:	118113702 118125034(ash1l)

SMAU:

118291884(ash1l) 118299741

LCF:	108885923 108888847

SDU:	111223036 111230135(ash1l)

SLAL:

111652181(ash1l) 111657636

XGL:	120783754 120786127(ash1l)

HCQ:	109513128 109521050(ash1l)

SSCV:

125986976

SBIA:

133500492 133504115(ash1l)

PEE:	133395365(ash1l) 133401323

PTAO:

133471177(ash1l) 133479435

BPEC:

110163006(ash1l) 110167402

MALB:

109951508 109964099(ash1l)

BSPL:

114843444 114865435(ash1l)

SJO:	128366440 128373753(ash1l)

SASA:

106570093 106588182 106605880(ash1l)

STRU:

115173287 115176059

OTW:	112229989 112266640

OMY:	110487650 110496012(ash1l) 110520799 110520835

OGO:	123998200 124013137 124043678

ONE:	115128210 115131772

OKI:	109882336 109882341 109903805 109907687

OKE:	118379684 118383326 118398364 118399115

SALP:

111955046 112070639

SNH:	120026898(ash1l) 120041142 120047244 120048866

CCLU:

121571414(ash1l) 121586317

ELS:	105006914 105024439

SFM:	108925420(ash1l)

PKI:	111840856(ash1l) 111858202

AANG:

118234224(ash1l) 118236528

PSPA:

121306919

ARUT:

117395225 117969039

PSEX:

120537978(ash1l)

LCM:	102367246(ASH1L)

CPLA:

122544720(ash1l)

HOC:	132805626(ash1l)

LERI:

129715786

PMRN:

116942143 116954923(ASH1L)

LRJ:	133342177(ASH1L) 133343620

BFO:

BBEL:

CIN:

SCLV:

SPU:

APLC:

SKO:

DME:	Dmel_CG8887(ash1)

DER:

6545341

DSI:	Dsimw501_GD12268(Dsim_GD12268)

DYA:	Dyak_GE22484

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI13513

DAZ:

DNV:

DHE:

CCAT:

BOD:

BDR:

AOQ:

TDA:

MDE:	101901319 131805647

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

CLON:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ001202 CpipJ_CPIJ001203

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

AROA:

TCA:

DPA:

SOY:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_208029

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:	119839737 119839791

CCRC:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

CCRN:

API:

DNX:

AGS:

RMD:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM244720

FOC:

TPAL:

ZNE:

CSEC:

BROR:

FCD:

DMK:

PVM:	113819372 113819373

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

HAZT:

PPOI:

DSV:

RMP:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

SDM:

CEL:	CELE_T12F5.4(lin-59)

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

MMER:

OBI:

OSN:

LAK:

PPA:	PAS_chr1-1_0102

YLI:	YALI0D21684g

NCR:	NCU01932(set-3)

NTE:	NEUTE1DRAFT125465(NEUTE1DRAFT_125465)

SMP:	SMAC_05383

PAN:	PODANSg050

PBEL:

PPSD:

PPSP:

PPSA:

TTT:	THITE_2111453

MTM:	MYCTH_2298281

CTHR:

MGR:

PPEI:

PGRI:

TMN:	UCRPA7_7438

SSCK:

SPSK_05820

FGR:	FGSG_08916

FPU:	FPSE_08917

FPOA:

FPOAC1_005073

FVN:	FVRRES_05596

FVR:	FVEG_02520

FOX:	FOXG_03647

NHE:	NECHADRAFT_123121(SDG2103)

FFC:	NCS54_00437800

FKR:	NCS57_00444500

FMU:	J7337_008861

TRE:	TRIREDRAFT_59359

TRR:	M419DRAFT_75768

MAW:

MAJ:

PCHM:

CMT:

AMUS:

PLJ:	VFPFJ_02950

PTKZ:

JDV02_008304

VAL:	VDBG_01967

VDA:	VDAG_10334

CFJ:	CFIO01_08009

CLUP:

CLUP02_14796

CHIG:

CH63R_09988

SAPO:

SAPIO_CDS5211

ELA:	UCREL1_654

PFY:	PFICI_02813

SSL:	SS1G_04018

BFU:	BCIN_01g02240

MBE:

MBM_00593

PSCO:

LY89DRAFT_691849

GLZ:	GLAREA_11975

ANI:	ANIA_04764

AFM:	AFUA_3G06480

ACT:	ACLA_034430

NFI:	NFIA_070790

AOR:	AO090020000101

ANG:	An11g09860

AFV:	AFLA_010555

PCS:	N7525_009200

PDP:	PDIP_00750

POU:	POX_g09054

TMF:	EYB26_008952

TRG:	TRUGW13939_11162

CIM:	CIMG_00441

CPW:	CPC735_057720

URE:	UREG_00487

PBL:	PAAG_05913

PBN:	PADG_06078

ABE:

ARB_07287

TVE:

TRV_02019

AJE:	HCAG_01200

BGH:	BDBG_06685

ARAB:

EKO05_0004468

ZTR:	MYCGRDRAFT_97419

FFU:	CLAFUR5_14562

CBET:

CB0940_05501

BCOM:

BAUCODRAFT_402857

NPA:	UCRNP2_7239

TML:	GSTUM_00002654001

TASA:

A1Q1_02180

UMA:	UMAG_00400

PFP:	PFL1_06302

PGR:	PGTG_16563

SRE:	PTSG_04178

» show all

Reference

PMID:21239497

Authors

An S, Yeo KJ, Jeon YH, Song JJ

Title

Crystal structure of the human histone methyltransferase ASH1L catalytic domain and its implications for the regulatory mechanism.

Journal

J Biol Chem 286:8369-74 (2011)
DOI:10.1074/jbc.M110.203380

Sequence

[hsa:55870]

ORTHOLOGY: K11433

Entry

K11433                      KO

Symbol

SETMAR

Name

[histone H3]-lysine36 N-dimethyltransferase SETMAR [EC:2.1.1.357]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11433  SETMAR; [histone H3]-lysine36 N-dimethyltransferase SETMAR
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11433  SETMAR; [histone H3]-lysine36 N-dimethyltransferase SETMAR
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.357  [histone H3]-lysine36 N-dimethyltransferase
     K11433  SETMAR; [histone H3]-lysine36 N-dimethyltransferase SETMAR
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11433  SETMAR; [histone H3]-lysine36 N-dimethyltransferase SETMAR

Other DBs

GO:

0046975

Genes

HSA:	6419(SETMAR)

PTR:	107976692 470738

PPS:	100986203 106635114

GGO:

PON:

NLE:

HMH:

MCC:

MCF:

MTHB:

MNI:

CSAB:

103227932(SETMAR)

CATY:

PANU:

TGE:

MLEU:

RRO:

RBB:

TFN:

PTEH:

CANG:

CJC:	100385401(SETMAR)

SBQ:

CIMI:

CSYR:

MMUR:

LCAT:

123620130 123623024 123623351 123625917

PCOQ:

105812204 105815349

OGA:

100949203

MMU:	74729(Setmar)

MCAL:

110296632

MPAH:

110317184

RNO:	500281(Setmar)

MCOC:

ANU:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

NGI:

HGL:	101704237(Setmar)

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

OCU:

OPI:

TUP:	102469064(SETMAR) 102476876 102502765

GVR:

103606123

CFA:	476549(SETMAR)

CLUD:

VVP:

VLG:

NPO:

AML:

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:

PYU:

PCOO:

PBG:

PVIV:

LRUF:

PTG:	102964395(SETMAR)

PPAD:

PUC:

AJU:

HHV:

BTA:	511299(SETMAR) 534913

BOM:	102265377 102268256(SETMAR)

BIU:	109563294 109566704(NUDT15) 109576394

BBUB:

102410920 112580666 123465037

BBIS:

104984974 104991586

CHX:	102177756 102189632

OAS:	101110273(SETMAR) 101122242

BTAX:

128046342 128053878

ODA:	120867663 120869845 120883034(NUDT15)

CCAD:

MBEZ:

SSC:

CFR:

CBAI:

CDK:

VPC:

BACU:

103008807(SETMAR)

BMUS:

118904491

LVE:	103084286(SETMAR)

OOR:

101278000

DLE:

111174172

PCAD:

102987462

PSIU:

116743077(NUDT15) 116762922

NASI:

ECB:

EPZ:

EAI:

MYB:	102261854(SETMAR)

MYD:	102761804(SETMAR)

MMYO:

MLF:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:	109383953 109395803

RFQ:	117023401 117036110 117036888

PALE:

PGIG:

RAY:

MJV:

TOD:

SARA:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:	100022449(SETMAR)

GAS:

SHR:

AFZ:

PCW:

OAA:

GGA:	101747682(SETMAR)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

APLA:

101794070 106020314 119712998

ACYG:

CATA:

AFUL:

TGU:

LSR:

SCAN:

PMOA:

OTC:

PRUF:

GFR:	102034588(SETMAR)

FAB:

OMA:

PHI:

PMAJ:

CCAE:

CCW:

CBRC:

ETL:

ACHL:

SVG:

MMEA:

HRT:

FPG:

FCH:

CLV:

EGZ:

NNI:

PCRI:

PLET:

EHS:

PCAO:

ACUN:

TALA:

PADL:

AFOR:

ACHC:

HALD:

HLE:

GCL:

CCRI:

CSTI:

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:

OHA:

NNT:

SHAB:

DPUB:

PGUU:

ACAR:

CPEA:

AVIT:

CVF:

RTD:

CUCA:

TEO:

BRHI:

AAM:

NPD:

TGT:

DNE:

SCAM:

ASN:

AMJ:	102562146(SETMAR)

CPOO:

GGN:

PSS:

CMY:

CCAY:

DCC:

CPIC:

TST:

CABI:

MRV:

ACS:

ASAO:

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:

HCG:

GJA:

STOW:

EMC:

XLA:	108714624(setmar.L)

XTR:	100135741(setmar)

NPR:

RTEM:

BBUF:

BGAR:

MUO:

GSH:	117347655 117348239 117352047

DRE:	564575(setmar)

SRX:

SANH:

SGH:

CCAR:

CAUA:

CGIB:

PTET:

122354450(setmar)

LROH:

127172697(setmar)

OMC:	131549442(setmar)

PPRM:

120480285(setmar)

RKG:	130083527(setmar)

MAMB:

125257094(setmar)

CIDE:

127522252

MASI:

127428338

TROS:

130571223(setmar)

TDW:	130410351(setmar)

MANU:

129428154(setmar)

IPU:	108281008(setmar)

IFU:	128624755(setmar)

PHYP:

113539644

SMEO:

124402048(setmar)

TFD:	113648571(setmar)

TVC:	132837730(setmar)

AMEX:

103031955

CMAO:

118799728(setmar)

EEE:

113578936

CHAR:

105909948(setmar)

TRU:

101063240

TFS:	130524542(setmar)

TNG:	GSTEN00014092G001

LCO:

104921972

NCC:

104943860

TBEN:

117475579(setmar)

CGOB:

115008438

PGEO:

117447169(setmar)

GACU:

117543782(setmar)

EMAC:

134883205(setmar)

ELY:	117256668(setmar)

EFO:	125892033(setmar)

PLEP:

121950561(setmar)

SLUC:

116036381(setmar)

ECRA:

117942927(setmar)

ESP:

116687334

PFLV:

114554360

GAT:	120835792(setmar)

PPUG:

119229398(setmar)

AFB:	129106221(setmar)

CLUM:

117731529(setmar)

PSWI:

130208380(setmar)

MSAM:

119886668(setmar)

SCHU:

122865825(setmar)

CUD:	121507156(setmar)

ALAT:

119020382(setmar)

MZE:	101468986 101470671 112435269

ONL:	100698471 109194411

OAU:	116313939(setmar) 116324713

OLA:

101172575

OML:	112145419(setmar)

CSAI:

133449521(setmar)

XMA:

102227344

XCO:

114135919

XHE:	116711098 116711148

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122833724(setmar)

PPRL:

129358555(setmar)

CVG:

107082340

CTUL:

119783611(setmar)

GMU:	124857023(setmar)

NFU:

107385794

KMR:	108244389(setmar)

ALIM:

106527164

NWH:	119412308(setmar)

AOCE:

111569667

MCEP:

125006147(setmar)

CSEM:

103386617

POV:

109629044

SSEN:

122767748(setmar)

HHIP:

117761989(setmar)

HSP:	118105497(setmar)

SMAU:

118309098(setmar)

LCF:	108898863(setmar)

SDU:

111221954

SLAL:

111653186

XGL:	120783415(setmar)

HCQ:

109521469

SSCV:

125977362

SBIA:

133506980(setmar)

PEE:	133408800(setmar)

PTAO:

133483992(setmar)

BPEC:

110170182

MALB:

109956250

BSPL:

114856082(setmar)

SJO:	128355831(setmar)

SASA:

106565748

STRU:

115207562

OTW:	112220135(setmar)

OMY:	110494587(setmar)

OGO:

ONE:

OKI:

OKE:

SALP:

SNH:

CCLU:

ELS:

SFM:

PKI:

AANG:

118210629(setmar)

LOC:

102698683

PSPA:

121297738(setmar)

ARUT:

117411731 117412151

PSEX:

120519381(setmar)

LCM:	102366478(SETMAR)

CMK:	103174199(setmar)

RTP:	109915044(setmar)

CPLA:

122559174(setmar)

HOC:	132822389(setmar)

LERI:

129704555(setmar)

PMRN:

116952266

LRJ:	133340031 133355605

BFO:

118416000

BBEL:

109470348 109476894

SCLV:

120335967

SPU:	115918289 577608

LPIC:

APLC:

AJC:

SKO:

DME:	Dmel_CG4565(CG4565)

DER:

6551945

DSI:	Dsimw501_GD18718(Dsim_GD18718)

DYA:	Dyak_GE26056

DSR:

110191434

DPO:

4802104

DPE:

6592004

DMN:	108153915 117193386

DWI:

6650959

DGR:

116805413

DMO:	Dmoj_GI25725

DAZ:

108608863

DNV:

115563961

CCAT:

101459896 110117737

BOD:	106618602 106626200 118681743

BDR:	105226258 125777334 125780345

RZE:	108373991 108374757 108375023

AOQ:	129238340 129238343 129240685 129242024 129247401 129247474 129248875

TDA:	119664576 119671575 119679791 119679792 119681360 119689601

LCQ:

111678638

LSQ:

119616288

GFS:	119635702 119636982 119638394 119639426 119639645 119642163

ECOE:

129939592 129945384

CLON:

129616040

HIS:	119647174 119650444 119650974 119651091 119653955 119658203

AAG:

110680195

CPII:

120421079

CNS:	116347030 116349981 116351281

BCOO:

119073306

AME:	102653839 727429

ACER:

107993903

ALAB:

122717054

ADR:

116186078

BIM:	100745893 105681569

BBIF:

117210246 117215847 117216969

BVK:	117236420 117242138

BVAN:

117154423 117159442

BTER:

100642822 100643865 100650396 105666228

BAFF:

126925391

BPYO:

122569836 122576214 122577352

BPAS:

132910549 132915001

FVI:

122538723

CCAL:

108631204 108632805 113465043

OBB:	114876621 114879807 114880462 114880468 114881526

OLG:	117606541 117606736 117608874

MGEN:

117218387 117219666 117223255 117223293 117227029

NMEA:

116425992

CGIG:

122400229 122400568 122401791 122402146 122403457 122404085

SOC:	105199735 105200558 105206723 113005314 120356899 120357001 120357042 120357123 120357352 120357353 120357379 120357749 120357757 120358089 120359076 120359356 120359488 120359706 120359772

MPHA:

105829261 105836795

AEC:	105143020 105144375 105144447 105145136 105145190 105145213 105146071 105148333 105150513 105150661 105151756 105152146 105153683 105154791 105155021 105155023 105155059

ACEP:

105617360 105617912 105620443 105620816 105621020 105622129 105622148 105623384 105623436 105624618 105625548 105626998

PBAR:

105423644 105425110 105433874

VEM:	105557270 105557616 105559419 105564983 105565306 105567926 105569501

FEX:	115238654 115240491 115241982 115245419

LHU:	105668985 105670104 105679235

PGC:	109851850 109854283 109855380 109857709 109858047 109860103 109860369 109861607 109862068 109862076 109862277 109862287 109862392 109862449 109862508 109862698

PCF:	106785835 106785849 106788346 106789818 106790185 106792900 106793308

VPS:

122634119

VVE:	124947000 124947041 124947151 124947152 124947190 124947428 124948495 124949419 124950643 124953553 124954005 124954177 124954435 124954864 124955256 124957223 124957232 124957235 124957413

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

NPT:

NFB:

NVG:

AROA:

TCA:	103312148 103312422

DPA:

109543945

SOY:

115881972

AGRG:

126736201 126747060

ATD:	109596568 109605261 126264503 126264504

CSET:

123306363 123309237 123309458 123310929 123312974 123322578

AGB:	108905687 108917874 111691447 111691609

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_204281

BANY:

112058459

MJU:	123864812 123870301 123878948

VCD:	124533386 124538267 124542459 124542577 124543855

MCIX:

123653341 123653775 123655826 123659376 123659897 123660183 123660995 123662445 123665526 123666948 123667239 123667451 123668413

PMAC:

106710178 106712261 106712638

PPOT:

PXU:

PBX:

PNAP:

ZCE:

LSIN:

AAGE:

HAW:

HZE:

TNL:	113492782 113500822

SLIU:

OFU:

PXY:

PGW:

CFEL:

113365451 113369727 113376139 113377543 113380536 113380537 113380710 113381127 113388462 113390987

CCRN:

123290502 123294711

API:

103308507

DNX:

107164244

AGS:	114119746 114126764

RMD:

113550875

ACOO:

126843462

DVT:	126895120 126901310 126903279

CLEC:

106673172 106674070

NLU:

111063886

HVI:	124355764 124358213 124361052 124361283 124365413 124369412 124369686

MQU:	128995624 129003756

PHU:	Phum_PHUM017920 Phum_PHUM451270

FOC:

113210062

TPAL:

117646297

CSEC:

111862560 111866148 111867895 111871520 111872930

SGRE:

126279104

BROR:

134527326 134534539

IEL:	124163633 124172494 124172499

DPX:	DAPPUDRAFT_41537

PTRU:

123502627 123504894 123510352

HAZT:

108669686

EAF:

111708508

LSM:

121124763

TCF:	131883305 131883376

DSV:	119444005 119461862

RSAN:

119395708

RMP:

119174104

TUT:	107361489 107362200 107369797 107370800

DPTE:

113792769 113793716

PTEP:

107439732 107455943 122274084

ABRU:

129957352 129959850 129962573 129962807 129963558 129968796 129972507

SDM:	118184061 118184665 118186126 118188170 118188825 118195628 118196274 118197157 118198544 118201072 118201362 118201730 118201755

LPOL:

106463061 106467041 106470675 106477886

PMEO:

129594651 129598493

CEL:	CELE_Y41D4B.12(set-23)

CBR:	CBG_13569(Cbr-set-23) CBG_27765

CRQ:	GCK72_016338

NAI:	NECAME_07501 NECAME_11050 NECAME_11052 NECAME_11055

LOA:	LOAG_08272

TSP:

Tsp_06031

HRO:	HELRODRAFT_112743

LGI:	LOTGIDRAFT_116536

PVUL:

PCAN:

BGT:

GAE:

HRF:	124116190 124122492 124145874

HRJ:

124270171

CRG:	105328549 117683214 117683215 117683216

CVN:	111106265 111107192

CANU:

128159805 128169190 128169191 128169192 128169211 128169971 128176869

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

132716513 132718124 132719006 132725569 132738971 132740493 132741673 132749212 132755551 132756739

OBI:	106870859 106878480 128247041

OSN:	115214769 115220815 115223783

LAK:	106157374 106160141

SMM:	Smp_043580

SHX:	MS3_00009171

OVI:	T265_15266

NVE:

EPA:

ATEN:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:	100211437 100212228 101235118 101235548 101236072 101236192 101236419 101240986 101241807 105846639 124817115

HSY:

130641307

TAD:	TRIADDRAFT_26103

AQU:	105315653 109584904

ATH:	AT3G03750(SDG20)

ALY:

9320476

CRB:

17891553

CSAT:

104744471 104764005

EUS:	EUTSA_v10021023mg

BRP:

103855179

BNA:	111212671 125587866

BOE:

106295242

RSZ:	108861953 130495029

THJ:

104827255

CPAP:

110807781

CIT:

102611687

CIC:	CICLE_v10020754mg

PVY:

MINC:

TCC:

GRA:

GHI:	107913635 121209838

GAB:

HSYR:

DZI:

EGR:

GMX:

GSJ:

PVU:	PHAVU_004G072800g

VRA:

VAR:

VUN:

VUM:

CCAJ:

APRC:

MTR:

TPRA:

CAM:

PSAT:

VVO:

LJA:	Lj0g3v0172449.1(Lj0g3v0172449.1) Lj0g3v0172449.2(Lj0g3v0172449.2) Lj2g3v1436870.1(Lj2g3v1436870.1)

ADU:

107471979

AIP:

107623701

AHF:	112716830 112782298

LANG:

109336425

PCIN:

129319054

QSA:	O6P43_009907

FVE:	101295388 101299745

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:

MSYL:

PXB:	103942863 103956251

ZJU:

MNT:

CSAV:

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

JCU:

HBR:

MESC:

POP:

PEU:

PALZ:

JRE:

CILL:

CAVE:

QSU:

QLO:	115970399 115977244

TWL:

VVI:

VRI:

SLY:

SPEN:

SOT:

SSTN:

SDUL:

CANN:

LBB:

NTA:	107795654 107796520

NSY:

NTO:

NAU:

INI:

ITR:

SIND:

OEU:

EGT:

SSPL:

121760753 121792294 121796946

SMIL:

SHIS:

APAN:

HAN:

ECAD:

LSV:

CCAV:

DCR:

CSIN:

RVL:

AEW:

BVG:

SOE:

CQI:	110721162 110739872

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

OSA:

DOSA:

Os01t0772150-00(Os01g0772150)

OBR:

OGL:

BDI:

ATS:

TDC:	119269159 119277148

TAES:

123062201 123070938 123079321

TUA:

LPER:

LRD:

SBI:

ZMA:

SITA:

SVS:

PVIR:

PHAI:

PDA:

EGU:

MUS:

ZOF:	121969461 122027553

DCT:

PEQ:

AOF:

MSIN:

NCOL:

ATR:

SMO:	SELMODRAFT_129885 SELMODRAFT_166928

PPP:

112295395

CRE:	CHLRE_17g702451v5

MNG:	MNEG_12904

CSL:	COCSUDRAFT_14893

CVR:	CHLNCDRAFT_137958

APRO:

F751_2187

MPP:	MICPUCDRAFT_68459(JGI:MicpuC2_68459)

CNE:

CNH00900

CNB:

CNBL0850

CNG:	CNAG_05423

CGI:	CGB_L0600C

CDEU:

CNBG_4431

TMS:	TREMEDRAFT_74707

MBR:	MONBRDRAFT_26549 MONBRDRAFT_30554

ACAN:

ACA1_320950

PSOJ:

PHYSODRAFT_408331

SPAR:

SPRG_10825 SPRG_15023

NGR:	NAEGRDRAFT_72003

» show all

Reference

PMID:17403897

Authors

Miskey C, Papp B, Mates L, Sinzelle L, Keller H, Izsvak Z, Ivics Z

Title

The ancient mariner sails again: transposition of the human Hsmar1 element by a reconstructed transposase and activities of the SETMAR protein on transposon ends.

Journal

Mol Cell Biol 27:4589-600 (2007)
DOI:10.1128/MCB.02027-06

Sequence

[hsa:6419]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (4)   
   KEGG PATHWAY (4)   
Chemical reaction (6)   
   KEGG ENZYME (1)   
   KEGG REACTION (2)   
   KEGG RCLASS (3)   
Gene (2001)   
   KEGG GENES (1374)   
   KEGG MGENES (54)   
   RefGene (526)   
   OC (47)   
Literature (1)   
   PubMed (1)   
All databases (2016)   

Download RDF

ORTHOLOGY: K09187

Entry

K09187                      KO

Symbol

MLL2, ALR

Name

[histone H3]-lysine4 N-trimethyltransferase MLL2 [EC:2.1.1.354]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

map04934

Cushing syndrome

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00570

Kabuki syndrome

H01613

Follicular lymphoma

H02434

Diffuse large B-cell lymphoma, not otherwise specified

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K09187  MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2
09160 Human Diseases
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K09187  MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K09187  MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K09187  MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K09187  MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2
   HMT complexes
    MLL-HCF complex
     K09187  MLL2, ALR; [histone H3]-lysine4 N-trimethyltransferase MLL2

Other DBs

GO:

0042800

Genes

HSA:	8085(KMT2D)

PTR:	100610362(KMT2D)

PPS:	100995808(KMT2D)

GGO:	101144774(KMT2D)

PON:	100441715(KMT2D)

NLE:	100586637(KMT2D)

HMH:	116461666(KMT2D)

MCC:	710795(KMT2D)

MCF:	102123773(KMT2D)

MTHB:

126930146

MNI:	105492887(KMT2D)

CSAB:

103238253(KMT2D)

CATY:

105580395(KMT2D)

PANU:

101013975(KMT2D)

TGE:	112634043(KMT2D)

MLEU:

105544907(KMT2D)

RRO:	104679726(KMT2D)

RBB:	108543918(KMT2D)

TFN:	117090180(KMT2D)

PTEH:

111542040(KMT2D)

CANG:

105507638(KMT2D)

CJC:	100408425(KMT2D)

SBQ:	101037539(KMT2D)

CIMI:

108316029(KMT2D)

CSYR:

103273452(KMT2D)

MMUR:

105869278(KMT2D)

LCAT:

123640430(KMT2D)

PCOQ:

105817625(KMT2D)

OGA:	100944849(KMT2D)

MMU:	381022(Kmt2d)

MCAL:

110310214(Kmt2d)

MPAH:

110334561(Kmt2d)

RNO:	100362634(Kmt2d)

MCOC:

116079206(Kmt2d)

ANU:	117719408(Kmt2d)

MUN:	110547438(Kmt2d)

CGE:	100765465(Kmt2d)

MAUA:

101839981(Kmt2d)

PROB:

127226039(Kmt2d)

PLEU:

114708576(Kmt2d)

MORG:

121441441(Kmt2d)

MFOT:

126493757

AAMP:

119824034(Kmt2d)

NGI:	103750570(Kmt2d)

HGL:	101718411(Kmt2d)

CPOC:

100728357(Kmt2d)

CCAN:

109694824(Kmt2d)

DORD:

105987518(Kmt2d)

DSP:	122106312(Kmt2d)

PLOP:

125365227(Kmt2d)

NCAR:

124984039

MMMA:

107148596(Kmt2d)

OCU:

100357052

OPI:	101525881(KMT2D)

TUP:	102480722(KMT2D)

GVR:	103588851(KMT2D)

CFA:	486558(KMT2D)

CLUD:

112678280(KMT2D)

VVP:	112921101(KMT2D)

VLG:	121480058(KMT2D)

NPO:	129517321(KMT2D)

AML:	100479447(KMT2D)

UMR:	103675622(KMT2D)

UAH:	113257661(KMT2D)

UAR:	123794786(KMT2D)

ELK:

111157787

LLV:

125107080

MPUF:

101672336(KMT2D)

MNP:	132019637(KMT2D)

MLK:	131838809(KMT2D)

NVS:	122891630(KMT2D)

ORO:	101369213(KMT2D)

EJU:	114225810(KMT2D)

ZCA:	113921953(KMT2D)

MLX:	118008878(KMT2D)

NSU:	110593565(KMT2D)

LWW:	102742632(KMT2D)

FCA:	101095268(KMT2D)

PYU:	121038633(KMT2D)

PCOO:

112867498(KMT2D)

PBG:	122472347(KMT2D)

PVIV:

125169640(KMT2D)

LRUF:

124501541

PTG:	102962859(KMT2D)

PPAD:

109249058(KMT2D)

PUC:

125919016

AJU:

106969329

HHV:	120223002(KMT2D)

BTA:	506805(KMT2D)

BOM:	102268887(KMT2D)

BIU:	109559148(KMT2D)

BBUB:

102401706(KMT2D)

BBIS:

105001687(KMT2D)

CHX:	102168698(KMT2D)

OAS:	101120741(KMT2D)

BTAX:

128048807(KMT2D)

ODA:	120858214 120861279

CCAD:

122427655(KMT2D)

MBEZ:

129536737(KMT2D)

SSC:	110260656(KMT2D)

CFR:	102515223(KMT2D)

CBAI:

105076349(KMT2D)

CDK:	105103813(KMT2D)

VPC:	102536075(KMT2D)

BACU:

103004413(KMT2D)

BMUS:

118902460(KMT2D)

LVE:	103082116(KMT2D)

OOR:	101269640(KMT2D)

DLE:	111174034(KMT2D)

PCAD:

102981848(KMT2D)

PSIU:

116760790(KMT2D)

NASI:

112394312(KMT2D)

ECB:	100058932(KMT2D)

EPZ:	103552202(KMT2D)

EAI:	106836860(KMT2D)

MYB:	102244965(KMT2D)

MYD:	102762410(KMT2D)

MMYO:

118650974(KMT2D)

MLF:	102434400(KMT2D)

PKL:	118730318(KMT2D)

EFUS:

129149802(KMT2D)

MNA:	107528109(KMT2D)

DRO:	112318232(KMT2D)

SHON:

118976513(KMT2D)

AJM:	119042258(KMT2D)

PDIC:

114512768(KMT2D)

PHAS:

123813126(KMT2D)

MMF:	118624157(KMT2D)

PPAM:

129084875(KMT2D)

HAI:	109393224(KMT2D)

RFQ:	117028056(KMT2D)

PALE:

102888593(KMT2D)

PGIG:

120618206(KMT2D)

PVP:	105297532(KMT2D)

RAY:	107514237(KMT2D)

MJV:	108383409(KMT2D)

TOD:	119247884(KMT2D)

SARA:

101556381(KMT2D)

SETR:

126022449(KMT2D)

LAV:	100670013(KMT2D)

TMU:

101353099

ETF:	101652640(KMT2D)

DNM:	101443835(KMT2D)

MDO:	103099827(KMT2D)

GAS:	123250244(KMT2D)

SHR:	100928575(KMT2D)

AFZ:

127538052

PCW:	110194047(KMT2D)

GGA:	425846(KMT2D)

PCOC:

116239278(KMT2D)

MGP:

104915798

CJO:	107325738(KMT2D)

TPAI:

128074181(KMT2D)

LMUT:

125685519(KMT2D)

NMEL:

110389135(KMT2D)

APLA:

119715282(KMT2D)

ACYG:

106047718(KMT2D)

CATA:

118261349(KMT2D)

AFUL:

116499959(KMT2D)

TGU:	100226907(KMT2D)

LSR:	110480395(KMT2D)

SCAN:

103824625(KMT2D)

PMOA:

120499503(KMT2D)

OTC:	121334290(KMT2D)

PRUF:

121356323(KMT2D)

FAB:	101818086(KMT2D)

OMA:	130265671(KMT2D)

PHI:	102100454(KMT2D)

PMAJ:

107198594(KMT2D)

CBRC:

103611912(KMT2D)

SVG:	106862663(KMT2D)

MMEA:

130584132(KMT2D)

HRT:	120764441(KMT2D)

TALA:

116963045(KMT2D)

ACHC:

115350939(KMT2D)

HLE:	104831179(KMT2D)

AGEN:

126046316

SHAB:

115618585(KMT2D)

CVF:	104284814(KMT2D)

RTD:	128901209(KMT2D)

CUCA:

104055021(KMT2D)

AROW:

112960842(KMT2D)

NPD:	112954231(KMT2D)

DNE:	112996078(KMT2D)

ASN:	102373099(KMT2D)

CPOO:

109323545(KMT2D)

GGN:	109305426(KMT2D)

CMY:	102944171(KMT2D)

CCAY:

125627479(KMT2D)

DCC:	119845758(KMT2D)

CPIC:

101934288(KMT2D)

TST:	117888986(KMT2D)

CABI:

116827822(KMT2D)

MRV:	120390931(KMT2D)

ACS:	100554175(kmt2d)

ASAO:

132768219(KMT2D)

PVT:	110075080(KMT2D)

SUND:

121922468(KMT2D)

PMUR:

107286389(KMT2D)

CTIG:

120306148(KMT2D)

PGUT:

117662873(KMT2D)

APRI:

131189511(KMT2D)

VKO:	123033085(KMT2D)

PMUA:

114587663

PRAF:

128407190

ZVI:	118079598(KMT2D)

HCG:	128342849(KMT2D)

GJA:	107105838(KMT2D)

STOW:

125428034(KMT2D)

EMC:	129346200(KMT2D)

XLA:	108708548(kmt2d.L) 108708990(kmt2d.S)

XTR:	100494109(kmt2d)

NPR:	108791395(KMT2D)

RTEM:

120929576(KMT2D)

BBUF:

120995961(KMT2D)

BGAR:

122930564(KMT2D)

MUO:	115465933(KMT2D)

GSH:

117357250

DRE:	100536523(kmt2d)

SRX:	107708781(kmt2d) 107716211

SANH:

107681934 107695802

SGH:	107563643 107570495(kmt2d)

CAUA:

113065480 113070551

CGIB:

127945167 128011063

PTET:

122328571 122329050(kmt2d)

LROH:

127154390(kmt2d)

OMC:	131531604(kmt2d)

PPRM:

120463585(kmt2d)

RKG:	130073522(kmt2d)

MAMB:

125259813(kmt2d)

MASI:

127418716 127419740

TROS:

130545175(kmt2d)

TDW:	130409817(kmt2d)

MANU:

129430804(kmt2d)

IPU:	108275851(kmt2d)

IFU:	128619792(kmt2d)

PHYP:

113530648(kmt2d)

TFD:	113658175(kmt2d)

TVC:	132861885(kmt2d)

AMEX:

103042576(kmt2d)

CMAO:

118822997(kmt2d)

EEE:	113584431(kmt2d)

CHAR:

105897331(kmt2d)

TRU:	101062458(kmt2d)

TFS:	130529879(kmt2d)

TNG:	GSTEN00028083G001

LCO:	104932523(kmt2d)

NCC:	104956939(kmt2d)

TBEN:

117494251(kmt2d)

CGOB:

115010606(kmt2d)

PGEO:

117449483(kmt2d)

GACU:

117542045(kmt2d)

EMAC:

134870678(kmt2d)

ELY:	117258597(kmt2d)

EFO:	125891096(kmt2d)

PLEP:

121946657(kmt2d)

SLUC:

116038913(kmt2d)

ECRA:

117947742(kmt2d)

ESP:	116692906(kmt2d)

PFLV:

114559193(kmt2d)

GAT:	120829072(kmt2d)

PPUG:

119206538

AFB:	129100258(kmt2d)

CLUM:

117733633(kmt2d)

PSWI:

130199076(kmt2d)

MSAM:

119887711 119919297(kmt2d)

SCHU:

122883461(kmt2d)

CUD:	121517403(kmt2d)

ALAT:

119023106(kmt2d)

MZE:	101486529(kmt2d)

ONL:	100706752(kmt2d)

OAU:	116325808(kmt2d)

OLA:	101172242(kmt2d)

OML:	112159276(kmt2d)

CSAI:

133457186(kmt2d)

XMA:	102237866(kmt2d)

XCO:	114140852(kmt2d)

XHE:	116727224(kmt2d)

PRET:

103467355(kmt2d)

PFOR:

103141131(kmt2d)

PLAI:

106959285(kmt2d)

PMEI:

106921544(kmt2d)

GAF:	122828614(kmt2d)

PPRL:

129372510(kmt2d)

CVG:	107086766(kmt2d)

CTUL:

119781989(kmt2d)

GMU:	124866846(kmt2d)

NFU:	107390885(kmt2d)

KMR:	108235223(kmt2d)

ALIM:

106524867(kmt2d)

NWH:	119417622(kmt2d)

AOCE:

111577439(kmt2d)

MCEP:

125019949(kmt2d)

CSEM:

103385102(kmt2d)

POV:	109630747(kmt2d)

SSEN:

122777068(kmt2d)

HHIP:

117764077(kmt2d)

HSP:	118110520(kmt2d)

SMAU:

118316365(kmt2d)

LCF:

108876442

SDU:	111219023(kmt2d)

SLAL:

111668971(kmt2d)

XGL:	120804417(kmt2d)

HCQ:	109531346(kmt2d)

SSCV:

125989448

SBIA:

133505432(kmt2d)

PEE:	133402236(kmt2d)

PTAO:

133478443(kmt2d)

BPEC:

110164958(kmt2d)

MALB:

109968659(kmt2d)

BSPL:

114858181(kmt2d)

SJO:	128356814(kmt2d)

SASA:

106567046(kmt2d) 106572669

STRU:

115165500 115167836(kmt2d)

OTW:	112221704(kmt2d) 112247360

OMY:	110491964(kmt2d) 110532701

OGO:	124032266 124046095(kmt2d)

ONE:	115102572(kmt2d) 115132488

OKI:	109869140(kmt2d) 109878425

OKE:	118360113(kmt2d) 118360673

SALP:

111966806 111976311

SNH:	120059601 120061017

CCLU:

121537893 121546498

ELS:	105013562(kmt2d)

SFM:

108939256

PKI:

111860624

AANG:

118207247(kmt2d) 118211876

LOC:	102683854(kmt2d)

PSPA:

121308967(kmt2d)

ARUT:

117401082 117967100

LCM:	102354014(KMT2D)

HOC:	132805781(kmt2d)

LERI:

129714725(kmt2d)

TAD:	TRIADDRAFT_62004

» show all

Reference

PMID:20808952

Authors

Andreu-Vieyra CV, Chen R, Agno JE, Glaser S, Anastassiadis K, Stewart AF, Matzuk MM

Title

MLL2 is required in oocytes for bulk histone 3 lysine 4 trimethylation and transcriptional silencing.

Journal

PLoS Biol 8:e1000453 (2010)
DOI:10.1371/journal.pbio.1000453

Sequence

[hsa:8085] [mmu:381022]

Reference

PMID:20236313

Authors

Ansari KI, Mandal SS

Title

Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.

Journal

FEBS J 277:1790-804 (2010)
DOI:10.1111/j.1742-4658.2010.07606.x

Reference

PMID:9247308

Authors

Prasad R, Zhadanov AB, Sedkov Y, Bullrich F, Druck T, Rallapalli R, Yano T, Alder H, Croce CM, Huebner K, Mazo A, Canaani E

Title

Structure and expression pattern of human ALR, a novel gene with strong homology to ALL-1 involved in acute leukemia and to Drosophila trithorax.

Journal

Oncogene 15:549-60 (1997)
DOI:10.1038/sj.onc.1201211

Sequence

[hsa:8085]

ORTHOLOGY: K09186

Entry

K09186                      KO

Symbol

MLL1

Name

[histone H3]-lysine4 N-trimethyltransferase MLL1 [EC:2.1.1.354]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

map04934

Cushing syndrome

map05202

Transcriptional misregulation in cancer

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00001

B-cell acute lymphoblastic leukemia

H00002

T-cell acute lymphoblastic leukemia

H01879

Wiedemann-Steiner syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
   03036 Chromosome and associated proteins
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
Transcription factors [BR:ko03000]
Eukaryotic type
  Zinc finger
   CXXC CpG-binding proteins
    K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1
   HMT complexes
    MLL-HCF complex
     K09186  MLL1; [histone H3]-lysine4 N-trimethyltransferase MLL1

Other DBs

GO:

0042800

Genes

HSA:	4297(KMT2A)

PTR:	451587(KMT2A)

PPS:	100984332(KMT2A)

GGO:	101129366(KMT2A)

PON:	100441102(KMT2A)

NLE:	100604245(KMT2A)

HMH:	116477013(KMT2A)

MCC:	705511(KMT2A)

MCF:	101866311(KMT2A)

MTHB:

126936036

MNI:	105476407(KMT2A)

CSAB:

103248594(KMT2A)

CATY:

105582478(KMT2A)

PANU:

101019707(KMT2A)

TGE:	112606639(KMT2A)

MLEU:

105528288(KMT2A)

RRO:	104665589(KMT2A)

RBB:	108536375(KMT2A)

TFN:	117081434(KMT2A)

PTEH:

111540209(KMT2A)

CANG:

105501211(KMT2A)

CJC:	100391138(KMT2A)

SBQ:	101029847(KMT2A)

CIMI:

108300601(KMT2A)

CSYR:

103265207(KMT2A)

MMUR:

105876097(KMT2A)

LCAT:

123641515(KMT2A)

PCOQ:

105819233(KMT2A)

OGA:	100960499(KMT2A)

MMU:	214162(Kmt2a)

MCAL:

110301786(Kmt2a)

MPAH:

110327485(Kmt2a)

RNO:	315606(Kmt2a)

MCOC:

116073930(Kmt2a)

ANU:	117698937(Kmt2a)

MUN:	110549115(Kmt2a)

CGE:	100760424(Kmt2a)

MAUA:

101829158(Kmt2a)

PROB:

127231612(Kmt2a)

PLEU:

114691187(Kmt2a)

MORG:

121438253(Kmt2a)

MFOT:

126510029

AAMP:

119809915(Kmt2a)

NGI:	103748298(Kmt2a)

HGL:	101716671(Kmt2a)

CPOC:

100727230(Kmt2a)

CCAN:

109689973(Kmt2a)

DORD:

105980771(Kmt2a)

DSP:	122110350(Kmt2a)

PLOP:

125349620(Kmt2a)

NCAR:

124958853

MMMA:

107145668(Kmt2a)

OCU:

100353733

OPI:	101530610(KMT2A)

TUP:	102473382(KMT2A)

GVR:	103592282(KMT2A)

CFA:	479417(KMT2A)

CLUD:

112671243(KMT2A)

VVP:	112920160(KMT2A)

VLG:	121499474(KMT2A)

NPO:	129496993(KMT2A)

AML:	100484220(KMT2A)

UMR:	103662507(KMT2A)

UAH:	113259992(KMT2A)

UAR:	123792623(KMT2A)

ELK:

111153928

LLV:

125080181

MPUF:

101677851(KMT2A)

MNP:	132027434(KMT2A)

MLK:	131836642(KMT2A)

NVS:	122912328(KMT2A)

ORO:	101363669(KMT2A)

EJU:	114211262(KMT2A)

ZCA:	113915195(KMT2A)

MLX:	118013279(KMT2A)

NSU:	110586354(KMT2A)

LWW:	102734687(KMT2A)

FCA:	101090288(KMT2A)

PYU:	121035470(KMT2A)

PCOO:

112865847(KMT2A)

PBG:	122483027(KMT2A)

PVIV:

125176515(KMT2A)

LRUF:

124504766

PTG:	102956940(KMT2A)

PPAD:

109278556(KMT2A)

PUC:

125909145

AJU:

106966460

HHV:	120230018(KMT2A)

BTA:	508330(KMT2A)

BOM:	102280025(KMT2A)

BIU:	109569413(KMT2A)

BBUB:

102401126(KMT2A)

BBIS:

104981499(KMT2A)

CHX:	102169033(KMT2A)

OAS:	101101916(KMT2A)

BTAX:

128060105(KMT2A)

ODA:	120876324(KMT2A)

CCAD:

122449209(KMT2A)

MBEZ:

129554385(KMT2A)

SSC:	100623006(KMT2A)

CFR:	102517824(KMT2A)

CBAI:

105067814(KMT2A)

CDK:	105090168(KMT2A)

VPC:	102533506(KMT2A)

BACU:

103014183(KMT2A)

BMUS:

118899217(KMT2A)

LVE:	103068531(KMT2A)

OOR:	101278571(KMT2A)

DLE:	111166868(KMT2A)

PSIU:

116758514(KMT2A)

NASI:

112403956(KMT2A)

ECB:	100071238(KMT2A)

EPZ:	103546689(KMT2A)

EAI:	106840333(KMT2A)

MMYO:

118664230(KMT2A)

MLF:	102438683(KMT2A)

PKL:	118710551(KMT2A)

EFUS:

103293817(KMT2A)

DRO:	112314381(KMT2A)

SHON:

118994753(KMT2A)

AJM:	119050761(KMT2A)

PDIC:

114498625(KMT2A)

PHAS:

123818140(KMT2A)

MMF:	118629080(KMT2A)

PPAM:

129085933(KMT2A)

HAI:	109385301(KMT2A)

RFQ:	117030043(KMT2A)

PGIG:

120622054(KMT2A)

PVP:	105310196(KMT2A)

RAY:	107502258(KMT2A)

MJV:	108384991(KMT2A)

TOD:	119240728(KMT2A)

SARA:

101546445(KMT2A)

SETR:

126015812(KMT2A)

LAV:	100653681(KMT2A)

TMU:

101351964

ETF:	101655592(KMT2A)

DNM:	101421357(KMT2A)

MDO:	100031440(KMT2A)

GAS:	123242101(KMT2A)

SHR:	100924557(KMT2A)

PCW:	110207193(KMT2A)

OAA:	100086068(KMT2A)

GGA:	414897(KMT2A)

PCOC:

116233137(KMT2A)

MGP:	100540662(KMT2A)

CJO:	107324133(KMT2A)

TPAI:

128087482(KMT2A)

LMUT:

125703648(KMT2A)

NMEL:

110387546(KMT2A)

APLA:

101797321(KMT2A)

ACYG:

106039772(KMT2A)

CATA:

118252552(KMT2A)

AFUL:

116497834(KMT2A)

TGU:	100231049(KMT2A)

LSR:	110470458(KMT2A)

SCAN:

103822784(KMT2A)

PMOA:

120508316(KMT2A)

OTC:	121340745(KMT2A)

PRUF:

121348548(KMT2A)

GFR:	102036439(KMT2A)

FAB:	101813917(KMT2A)

OMA:	130262575(KMT2A)

PHI:	102103515(KMT2A)

PMAJ:

107214385(KMT2A)

CCAE:

111939213(KMT2A)

CCW:	104692048(KMT2A)

CBRC:

103618527(KMT2A)

ETL:	114056306(KMT2A)

ZAB:	102071495(KMT2A)

ACHL:

103803311(KMT2A)

SVG:	106858174(KMT2A)

MMEA:

130581108(KMT2A)

HRT:	120762671(KMT2A)

FPG:	101922729(KMT2A)

FCH:	102059401(KMT2A)

CLV:	102084453(KMT2A)

EGZ:	104135361(KMT2A)

NNI:	104016208(KMT2A)

PCRI:

104031628

PLET:

104627680

PCAO:

104051828

ACUN:

113488577(KMT2A)

TALA:

104359457(KMT2A)

PADL:

103916551(KMT2A)

AFOR:

103894085(KMT2A)

ACHC:

115344881(KMT2A)

HALD:

104316581

HLE:	104836373(KMT2A)

AGEN:

126038415

GCL:

127025791

CCRI:

104158728(KMT2A)

CSTI:

CMAC:

MUI:

BREG:

FGA:

GSTE:

LDI:

MNB:

OHA:	104338074(KMT2A)

NNT:

104406956

SHAB:

115616428(KMT2A)

DPUB:

104307283(KMT2A)

PGUU:

104462652

ACAR:

104527626

CPEA:

104398655(KMT2A)

AVIT:

104279618

CVF:	104296092(KMT2A)

RTD:	128918752(KMT2A)

TEO:

104377302

BRHI:

104499796(KMT2A)

AAM:	106485191(KMT2A)

AROW:

112962037(KMT2A)

NPD:	112948101(KMT2A)

TGT:	104580926(KMT2A)

DNE:	112991639(KMT2A)

SCAM:

104140985(KMT2A)

ASN:	102385246(KMT2A)

AMJ:	102572253(KMT2A)

CPOO:

109315397(KMT2A)

GGN:	109293959(KMT2A)

PSS:	102463628(KMT2A)

CMY:	102941272(KMT2A)

CCAY:

125625353(KMT2A)

DCC:	119846728(KMT2A)

CPIC:

101941687(KMT2A)

TST:	117868628(KMT2A)

CABI:

116822931(KMT2A)

MRV:	120375573(KMT2A)

ACS:	100560745(kmt2a)

ASAO:

132782442(KMT2A)

SUND:

121935627(KMT2A)

PBI:	103067762(KMT2A)

PMUR:

107284778(KMT2A)

CTIG:

120307243(KMT2A)

PGUT:

117670190(KMT2A)

APRI:

131203834(KMT2A)

PTEX:

113441927(KMT2A)

NSS:	113420873(KMT2A)

VKO:	123020231(KMT2A)

PMUA:

114585722(KMT2A)

PRAF:

128403173(KMT2A)

ZVI:	118096807(KMT2A)

HCG:	128333633(KMT2A)

GJA:	107112539(KMT2A)

STOW:

125441702(KMT2A)

EMC:	129342610(KMT2A)

XLA:	108696457 108705229(kmt2a.S)

XTR:	100135006(kmt2a)

NPR:	108794984(KMT2A)

RTEM:

120915166(KMT2A)

BBUF:

120995916(KMT2A)

BGAR:

122935504(KMT2A)

MUO:	115481502(KMT2A)

GSH:	117347268(KMT2A)

DRE:	557048(kmt2a)

SRX:	107718271 107743706

SANH:

107683818 107690455

SGH:	107585544 107601691

CCAR:

109103211

CAUA:

113058440 113115076

CGIB:

127972680 128029223

PTET:

122358751(kmt2a)

LROH:

127176714(kmt2a)

OMC:	131554129(kmt2a)

PPRM:

120478575(kmt2a)

RKG:	130096738(kmt2a)

MAMB:

125249738(kmt2a)

MASI:

127421727 127429777

TROS:

130564365(kmt2a)

TDW:	130428963(kmt2a)

MANU:

129437998(kmt2a)

IPU:

108277661

IFU:	128620982(kmt2a)

PHYP:

113533005(kmt2a)

SMEO:

124394449(kmt2a)

TFD:	113660479(kmt2a)

TVC:	132857686(kmt2a)

AMEX:

103035686

CMAO:

118800792(kmt2a)

EEE:	113579441(kmt2a)

CHAR:

105893748(kmt2a)

TRU:	101079297(kmt2a)

TFS:	130535396(kmt2a)

TNG:	GSTEN00035709G001

LCO:	104936774(kmt2a)

TBEN:

117470424(kmt2a)

CGOB:

115018265(kmt2a)

PGEO:

117457455(kmt2a)

GACU:

117552304(kmt2a)

EMAC:

134879878(kmt2a)

ELY:	117260183(kmt2a)

EFO:	125888606(kmt2a)

PLEP:

121942999(kmt2a)

SLUC:

116047987(kmt2a)

ECRA:

117938109(kmt2a)

ESP:	116671708(kmt2a)

PFLV:

114549562(kmt2a)

GAT:	120809005(kmt2a)

PPUG:

119227019(kmt2a)

AFB:	129092493(kmt2a)

CLUM:

117741232(kmt2a)

PSWI:

130210992(kmt2a)

MSAM:

119882412(kmt2a)

SCHU:

122878580(kmt2a)

CUD:	121520197(kmt2a)

ALAT:

119032097(kmt2a)

MZE:	101478918(kmt2a)

ONL:	100700211(kmt2a)

OAU:	116328181(kmt2a)

OLA:	101171020(kmt2a)

OML:	112149217(kmt2a)

CSAI:

133441738(kmt2a)

XMA:	102233842(kmt2a)

XCO:	114133379(kmt2a)

XHE:	116708135(kmt2a)

PRET:

103474566(kmt2a)

PFOR:

103155206(kmt2a)

PLAI:

106957246(kmt2a)

PMEI:

106908737(kmt2a)

GAF:	122833182(kmt2a)

PPRL:

129358723(kmt2a)

CVG:	107088316(kmt2a)

CTUL:

119782827(kmt2a)

GMU:	124883798(kmt2a)

NFU:	107380358(kmt2a)

KMR:	108246035(kmt2a)

ALIM:

106533989(kmt2a)

NWH:	119410864 119410869(kmt2a)

AOCE:

111584353

MCEP:

125013317(kmt2a)

CSEM:

103378141(kmt2a)

POV:	109630237(kmt2a)

SSEN:

122760603(kmt2a)

HHIP:

117772370(kmt2a)

HSP:	118105801(kmt2a)

SMAU:

118299902(kmt2a)

LCF:

108886384

SDU:	111228034(kmt2a)

SLAL:

111650938(kmt2a)

XGL:	120791877(kmt2a)

HCQ:	109529394(kmt2a)

SSCV:

125972871

SBIA:

133505393(kmt2a)

PEE:	133405558(kmt2a)

PTAO:

133482808(kmt2a)

BPEC:

110154093(kmt2a)

MALB:

109960262(kmt2a)

BSPL:

114867615(kmt2a)

SJO:	128359941(kmt2a)

SASA:

106612477(kmt2a)

STRU:

115162944 115205898

OTW:	112244682 112266726

OMY:	110503544 110507387(kmt2a)

OGO:	124006249 124018147

ONE:	115137115 115141498

OKI:	109905387 109908869

OKE:	118386248 118397094(kmt2a)

SALP:

111949850 111960556

SNH:	120018423(kmt2a) 120029128

CCLU:

121560747 121567356

ELS:	105011706(kmt2a)

SFM:	108936191(kmt2a)

PKI:	111846253(kmt2a)

AANG:

118209436 118236776

LOC:	102694582(kmt2a)

PSPA:

121309421(kmt2a)

ARUT:

117397194 117962449

PSEX:

120536063(kmt2a)

LCM:	102357046(KMT2A)

CPLA:

122540591(kmt2a)

HOC:	132829694(kmt2a)

LERI:

129712254(kmt2a)

CIN:

100180972

SCLV:

120325631

SPU:

579728

DME:	Dmel_CG8651(trx)

DER:

6552649

DSE:

6606415

DSI:	Dsimw501_GD20433(Dsim_GD20433)

DYA:	Dyak_GE26459

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI24532

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

AOQ:

TDA:

SCAC:

LCQ:

LSQ:

GFS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ013972

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

CCAL:

MGEN:

NMEA:

CGIG:

PCF:

PFUC:

VPS:

VCRB:

VVE:

FAS:

DAM:

AGIF:

CCIN:

TCA:	658843(trithorax)

SOY:

LDC:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_212487

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

HHAL:

PHU:	Phum_PHUM079870

FOC:

TPAL:

PCHN:

HAME:

PCLA:

PTRU:

DSV:

RSAN:

RMP:

VDE:

VJA:

SDM:

BGT:

GAE:

HRF:

HRJ:

CRG:

PMAX:

MMER:

OSN:

XEN:

TAD:	TRIADDRAFT_50258

» show all

Reference

PMID:21220120

Authors

Avdic V, Zhang P, Lanouette S, Groulx A, Tremblay V, Brunzelle J, Couture JF

Title

Structural and biochemical insights into MLL1 core complex assembly.

Journal

Structure 19:101-8 (2011)
DOI:10.1016/j.str.2010.09.022

Sequence

[hsa:4297]

Reference

PMID:20236313

Authors

Ansari KI, Mandal SS

Title

Mixed lineage leukemia: roles in gene expression, hormone signaling and mRNA processing.

Journal

FEBS J 277:1790-804 (2010)
DOI:10.1111/j.1742-4658.2010.07606.x

Reference

PMID:8703835

Authors

Nilson I, Lochner K, Siegler G, Greil J, Beck JD, Fey GH, Marschalek R

Title

Exon/intron structure of the human ALL-1 (MLL) gene involved in translocations to chromosomal region 11q23 and acute leukaemias.

Journal

Br J Haematol 93:966-72 (1996)
DOI:10.1046/j.1365-2141.1996.d01-1748.x

Sequence

[hsa:4297]

ORTHOLOGY: K11423

Entry

K11423                      KO

Symbol

SETD2

Name

[histone H3]-lysine36 N-trimethyltransferase [EC:2.1.1.359]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H00773

Autosomal dominant intellectual developmental disorder

H02444

Luscan-Lumish syndrome

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11423  SETD2; [histone H3]-lysine36 N-trimethyltransferase
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11423  SETD2; [histone H3]-lysine36 N-trimethyltransferase
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.359  [histone H3]-lysine36 N-trimethyltransferase
     K11423  SETD2; [histone H3]-lysine36 N-trimethyltransferase
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11423  SETD2; [histone H3]-lysine36 N-trimethyltransferase

Other DBs

GO:

0046975

Genes

HSA:	29072(SETD2)

PTR:	460331(SETD2)

PPS:	100993006(SETD2)

GGO:	101132140(SETD2)

PON:	100433116(SETD2)

NLE:	100584442(SETD2)

HMH:	116473532(SETD2)

MCC:	711825(SETD2)

MCF:	102121581(SETD2)

MTHB:

126948577

MNI:

105480624

CSAB:

103227561(SETD2)

CATY:

105573623(SETD2)

PANU:

101026986(SETD2)

TGE:	112618523(SETD2)

MLEU:

105540477(SETD2)

RRO:	104671311(SETD2)

RBB:	108517641(SETD2)

TFN:	117080326(SETD2)

PTEH:

111555466(SETD2)

CANG:

105509827(SETD2)

CJC:	100411953(SETD2)

SBQ:	101034613(SETD2)

CIMI:

108305438(SETD2)

CSYR:

103273788(SETD2)

MMUR:

105874896(SETD2)

LCAT:

123623336(SETD2)

PCOQ:

105827280(SETD2)

OGA:	100950439(SETD2)

MMU:	235626(Setd2)

MCAL:

110301050(Setd2)

MPAH:

110328077(Setd2)

RNO:	316013(Setd2)

MCOC:

116072571(Setd2)

ANU:	117693276(Setd2)

MUN:	110554986(Setd2)

CGE:	100765637(Setd2)

MAUA:

101830442(Setd2)

PROB:

127235952(Setd2)

PLEU:

114705174(Setd2)

MORG:

121464185(Setd2)

MFOT:

126499805

AAMP:

119808984(Setd2)

NGI:	103732034(Setd2)

CPOC:

100719166(Setd2)

CCAN:

109689470(Setd2)

DORD:

105996211(Setd2)

DSP:	122126928(Setd2)

PLOP:

125342285(Setd2)

NCAR:

124969403

MMMA:

107145083(Setd2)

OCU:

100351499

OPI:	101516490(SETD2)

TUP:	102477917(SETD2)

GVR:	103591229(SETD2)

CFA:	476643(SETD2)

CLUD:

112666853(SETD2)

VVP:	112912390(SETD2)

VLG:	121494650(SETD2)

NPO:	129521732(SETD2)

AML:	100466135(SETD2)

UMR:	103675118(SETD2)

UAH:	113256807(SETD2)

UAR:	123779799(SETD2)

ELK:

111144347

LLV:

125081004

MPUF:

101681942(SETD2)

MNP:	132011261(SETD2)

MLK:	131823866(SETD2)

NVS:	122909482(SETD2)

ORO:	101365495(SETD2)

EJU:	114196503(SETD2)

ZCA:	113916609(SETD2)

MLX:	118005368(SETD2)

NSU:	110577582(SETD2)

LWW:	102727823(SETD2)

FCA:	101085029(SETD2)

PYU:	121026806 121026808

PCOO:

112852684(SETD2)

PBG:	122487199(SETD2)

PVIV:

125154219(SETD2)

LRUF:

124523532

PTG:	102955436(SETD2)

PPAD:

109247730(SETD2)

PUC:

125930654

AJU:

106969033

HHV:	120229315(SETD2)

BTA:	539860(SETD2)

BOM:	102266643(SETD2)

BIU:	109575988(SETD2)

BBUB:

102393639(SETD2)

BBIS:

105004686(SETD2)

CHX:	102183113(SETD2)

OAS:	101114649(SETD2)

BTAX:

128044432(SETD2)

ODA:	120868180(SETD2)

CCAD:

122424798(SETD2)

MBEZ:

129547776(SETD2)

SSC:	100623101(SETD2)

CFR:	102512396(SETD2)

CBAI:

105072880(SETD2)

CDK:	105103636(SETD2)

VPC:	102531919(SETD2)

BACU:

102997833(SETD2)

BMUS:

118903175(SETD2)

LVE:	103086894(SETD2)

OOR:	101269476 101280364(SETD2) 101282703 125961717

DLE:	111174450(SETD2)

PCAD:

112064944(SETD2)

PSIU:

116742461 116742477 116761205 116761609(SETD2) 116764505

NASI:

112403750(SETD2)

ECB:	100064888(SETD2)

EPZ:	103551032(SETD2)

EAI:	106823246(SETD2)

MYB:	102260404(SETD2)

MYD:	102758485(SETD2)

MMYO:

118668537(SETD2)

MLF:	102435793(SETD2)

PKL:	118714790(SETD2)

EFUS:

103299125(SETD2)

MNA:	107529409(SETD2)

DRO:	112309866(SETD2)

SHON:

118976190(SETD2)

AJM:	119037871(SETD2)

PDIC:

114501512(SETD2)

PHAS:

123830508(SETD2)

MMF:	118633365(SETD2)

PPAM:

129087631(SETD2)

HAI:	109376628(SETD2)

RFQ:	117036580(SETD2)

PALE:

102884085(SETD2)

PGIG:

120582282(SETD2)

PVP:	105302344(SETD2)

RAY:	107509112(SETD2)

MJV:	108400455(SETD2) 108401248 118966919

TOD:	119259277(SETD2)

SARA:

101550871(SETD2)

SETR:

126014003(SETD2)

LAV:	100655356(SETD2)

TMU:

101343139

ETF:	101642970(SETD2)

DNM:	101433648(SETD2)

MDO:	100024848(SETD2)

GAS:	123252909(SETD2)

SHR:	100931646(SETD2)

PCW:	110217008(SETD2)

OAA:	114816148(SETD2)

GGA:	420404(SETD2)

PCOC:

116238217(SETD2)

MGP:	100539457(SETD2)

CJO:	107308808(SETD2)

TPAI:

128087412(SETD2)

LMUT:

125695638(SETD2)

NMEL:

110393293(SETD2)

APLA:

113842604(SETD2)

ACYG:

106046805(SETD2)

CATA:

118251837(SETD2)

AFUL:

116486033(SETD2)

TGU:	100224614(SETD2)

LSR:	110476945(SETD2)

SCAN:

103813035(SETD2)

PMOA:

120510532(SETD2)

OTC:	121337966(SETD2)

PRUF:

121351804(SETD2)

GFR:	102039322(SETD2)

FAB:	101814785(SETD2)

OMA:	130249334(SETD2)

PHI:	102106397(SETD2)

PMAJ:

107215411(SETD2)

CCAE:

111925482(SETD2)

CCW:	104686490(SETD2)

CBRC:

103623957(SETD2)

ETL:	114070402(SETD2)

ZAB:	102070924(SETD2)

ACHL:

103808009(SETD2)

SVG:	106862800(SETD2)

MMEA:

130574556(SETD2)

HRT:	120754330(SETD2)

FPG:	101913975(SETD2)

FCH:	102053248(SETD2)

CLV:	102098192(SETD2)

EGZ:	104123260(SETD2)

NNI:	104019238(SETD2)

PCRI:

104035741(SETD2)

PLET:

104618506(SETD2)

EHS:	104510412(SETD2)

PCAO:

104043224(SETD2)

ACUN:

113476423(SETD2)

TALA:

104358172(SETD2)

PADL:

103916778(SETD2)

AFOR:

103903408(SETD2)

ACHC:

115338781(SETD2)

HALD:

104322327

HLE:	104829204(SETD2)

AGEN:

126038089

GCL:

127012720

CCRI:

104159334(SETD2)

CMAC:

104473045(SETD2)

MUI:	104544284(SETD2)

BREG:

104641398(SETD2)

FGA:	104082936(SETD2)

GSTE:

104255118

LDI:	104353735(SETD2)

OHA:	104332883(SETD2)

NNT:

104407506

SHAB:

115611158(SETD2)

DPUB:

104306779(SETD2)

PGUU:

104457667(SETD2)

ACAR:

104529664(SETD2)

CPEA:

104387994(SETD2)

AVIT:

104275817(SETD2)

CVF:	104289689(SETD2)

RTD:	128906101(SETD2)

CUCA:

104055045(SETD2)

TEO:	104378282(SETD2)

BRHI:

104493974(SETD2)

AROW:

112977399(SETD2)

NPD:	112947562 112951575

TGT:	104570962(SETD2)

DNE:	112992776(SETD2)

SCAM:

104150107(SETD2)

ASN:	102378063(SETD2)

AMJ:	102567964(SETD2)

CPOO:

109306447(SETD2)

GGN:	109291156(SETD2)

PSS:	102460966(SETD2)

CMY:	102947543(SETD2)

CCAY:

125631124(SETD2)

DCC:	119851175(SETD2)

CPIC:

101953039(SETD2)

TST:	117871919(SETD2)

CABI:

116819138(SETD2)

MRV:	120397709(SETD2)

ACS:	100559621(setd2)

ASAO:

132779047(SETD2)

PVT:	110069987(SETD2)

SUND:

121933414(SETD2)

PBI:	103055763(SETD2)

PMUR:

107286005(SETD2)

CTIG:

120319695(SETD2)

TSR:	106542655(SETD2)

PGUT:

117656347(SETD2)

APRI:

131196724(SETD2)

PTEX:

113452005(SETD2)

NSS:	113427149(SETD2)

VKO:	123020920(SETD2)

PMUA:

114607160(SETD2)

PRAF:

128423845(SETD2)

ZVI:	118091669(SETD2)

HCG:	128329599(SETD2)

GJA:	107120098(SETD2)

STOW:

125440838(SETD2)

EMC:	129338042(SETD2)

XLA:	108718681(setd2.L) 108719797(setd2.S)

XTR:	100492810(setd2)

RTEM:

120941687(SETD2)

BBUF:

121000811(SETD2)

BGAR:

122938723(SETD2)

MUO:	115465989(SETD2)

GSH:	117354403(SETD2)

DRE:	794199(setd2)

SRX:	107743179 107752833

SANH:

107673014 107685560

SGH:	107581536 107596709

CCAR:

109063165

CAUA:

113060209 113116306

CGIB:

127969714 127975534 128030804

PTET:

122360104(setd2)

LROH:

127178249(setd2)

OMC:	131521470(setd2)

PPRM:

120484453(setd2)

RKG:	130070181(setd2)

MAMB:

125243135(setd2)

CIDE:

127497709

MASI:

127454335

TROS:

130557516(setd2)

TDW:	130432613(setd2)

MANU:

129447809(setd2)

IPU:

108267177

IFU:	128608990(setd2)

PHYP:

113542507(setd2)

SMEO:

124384161(setd2)

TFD:	113644580(setd2)

TVC:	132845981(setd2)

AMEX:

103039344(setd2)

CMAO:

118825674(setd2)

EEE:	113570706(setd2)

TRU:	101076040(setd2)

TFS:	130532370(setd2)

TNG:	GSTEN00034080G001

LCO:	104940331(setd2)

NCC:	104948745(setd2) 104957630

TBEN:

117480208(setd2)

CGOB:

115021807(setd2)

PGEO:

117460444(setd2)

GACU:

117554101(setd2)

EMAC:

134861484(setd2)

ELY:	117265736(setd2)

EFO:	125893649(setd2)

PLEP:

121945864(setd2)

SLUC:

116049433(setd2)

ECRA:

117945702(setd2)

ESP:	116690678(setd2)

PFLV:

114557737(setd2)

GAT:	120810650(setd2)

PPUG:

119197772(setd2)

AFB:	129109168(setd2)

CLUM:

117745025(setd2)

PSWI:

130212725(setd2)

MSAM:

119897705(setd2)

SCHU:

122881330(setd2)

CUD:	121513186(setd2)

ALAT:

119006696(setd2)

MZE:	101471514(setd2)

ONL:	100689872(setd2)

OAU:	116325355(setd2)

OLA:	101163764(setd2)

OML:	112143951(setd2)

CSAI:

133430454(setd2)

XMA:	102216591(setd2)

XCO:	114141991(setd2)

XHE:	116717187(setd2)

PRET:

103478611(setd2)

PFOR:

103152270(setd2)

PLAI:

106939758(setd2)

PMEI:

106906609(setd2)

GAF:	122831473(setd2)

PPRL:

129371146(setd2)

CVG:	107081814(setd2)

CTUL:

119772867(setd2)

GMU:	124865731(setd2)

NFU:	107395695(setd2)

KMR:	108241998(setd2)

ALIM:

106534862

NWH:	119409449(setd2)

AOCE:

111572050(setd2)

MCEP:

125016073(setd2)

CSEM:

103388382(setd2)

POV:	109633212(setd2)

SSEN:

122774466(setd2)

HHIP:

117777387(setd2)

HSP:	118113301(setd2)

SMAU:

118308029(setd2)

LCF:

108891907

SDU:	111236791(setd2)

SLAL:

111652786(setd2)

XGL:	120783986(setd2)

HCQ:	109518019(setd2)

SSCV:

125975337

SBIA:

133500905(setd2)

PEE:	133401664(setd2)

PTAO:

133479116(setd2)

BPEC:

110171513(setd2)

MALB:

109967312(setd2)

BSPL:

114843737(setd2)

SJO:	128366082(setd2)

SASA:

106593284 106593288 106606040

STRU:

115187660 115187661

OTW:	112243644(setd2)

OMY:	110520688(setd2)

OGO:	124019594(setd2)

ONE:

115115571

OKI:

109882680

SALP:

112076057(setd2)

SNH:	120031365(setd2)

CCLU:

121542611(setd2) 121542806

ELS:	105018749(setd2)

SFM:	108927425(setd2)

PKI:	111850417(setd2)

AANG:

118228444(setd2)

LOC:	102690042 102692025(setd2)

PSPA:

121312967 121314673

ARUT:

117394754 117400236

PSEX:

120515800(setd2)

LCM:	102359121(SETD2)

CMK:	103190896(setd2)

CPLA:

122548953(setd2)

HOC:	132815050(setd2)

LERI:

129714861(setd2)

PMRN:

116940988(SETD2)

LRJ:	133344877(SETD2)

BFO:

BBEL:

SCLV:

SPU:

APLC:

SKO:

DME:	Dmel_CG1716(Set2)

DER:

6551019

DSE:

6618681

DSI:	Dsimw501_GD17127(Dsim_GD17127)

DYA:	Dyak_GE17076

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12297

DAZ:	108614554 108619464

DNV:	108652260 108656778

DHE:	111593003 111598712

DVI:	6623058 6631536

CCAT:

BOD:

MDE:

SCAC:

LCQ:

LSQ:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ005876

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:	109855296 109859218

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CCIN:

TCA:

DPA:

SOY:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

BANY:

PMAC:

PPOT:

PXU:

PRAP:

ZCE:

AAGE:

HZE:

TNL:

SLIU:

OFU:

PXY:

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM463920

FOC:

TPAL:

ZNE:

CSEC:

BROR:

FCD:

DPX:	DAPPUDRAFT_319776

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

MNZ:

HAZT:

EAF:

LSM:

DSV:

RSAN:

RMP:

TUT:

DPTE:

DFR:

CSCU:

ABRU:

BGT:

GAE:

HRF:

HRJ:

CRG:

PMAX:

OBI:

OSN:

NVE:

EPA:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

HMG:

Reference

PMID:16118227

Authors

Sun XJ, Wei J, Wu XY, Hu M, Wang L, Wang HH, Zhang QH, Chen SJ, Huang QH, Chen Z

Title

Identification and characterization of a novel human histone H3 lysine 36-specific methyltransferase.

Journal

J Biol Chem 280:35261-71 (2005)
DOI:10.1074/jbc.M504012200

Sequence

[hsa:29072]

ORTHOLOGY: K11422

Entry

K11422                      KO

Symbol

SETD1, SET1

Name

[histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:2.1.1.354]

Pathway

map00310

Lysine degradation

map01100

Metabolic pathways

Reaction

R03875

R04866

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

R04867

S-adenosyl-L-methionine:cytochrome-c-L-lysine N6-methyltransferase

Disease

H02463

Syndromic intellectual developmental disorder

H02535

Neurodevelopmental disorder with dysmorphic facies

H02696

Early-onset epilepsy

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09105 Amino acid metabolism
   00310 Lysine degradation
    K11422  SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11422  SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1
Enzymes [BR:ko01000]
2. Transferases
  2.1  Transferring one-carbon groups
   2.1.1  Methyltransferases
    2.1.1.354  [histone H3]-lysine4 N-trimethyltransferase
     K11422  SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1
Chromosome and associated proteins [BR:ko03036]
Eukaryotic type
  Histone modification proteins
   HMTs (histone methyltransferases)
    HKMTs (histone lysine methyltransferases)
     K11422  SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1
   HMT complexes
    COMPASS/SET1 complex
     K11422  SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1
    COMPASS/SET1 complex (yeast)
     K11422  SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1

Other DBs

GO:

0042800

Genes

HSA:	23067(SETD1B) 9739(SETD1A)

PTR:	468101(SETD1A) 473295(SETD1B)

PPS:	100972983(SETD1A) 100985657(SETD1B)

PON:	100432076(SETD1A) 100435324(SETD1B)

NLE:	100584028(SETD1B) 100602268(SETD1A)

HMH:	116471174(SETD1A) 116477776(SETD1B)

MCC:	703717(SETD1B) 712416(SETD1A)

MCF:	102123137(SETD1B) 102134166(SETD1A)

MTHB:

126930593 126944171

MNI:	105483007(SETD1A) 105494476(SETD1B)

CSAB:

103231168(SETD1A) 103239290(SETD1B)

CATY:

105590973(SETD1B) 105599378(SETD1A)

PANU:

101020341(SETD1A) 101023789(SETD1B)

TGE:	112614267(SETD1A) 112635333(SETD1B)

MLEU:

105528008(SETD1B) 105541460(SETD1A)

RRO:	104661596(SETD1A) 104666361(SETD1B)

RBB:	108523384(SETD1B) 108526582(SETD1A)

TFN:	117087676(SETD1A) 117089265(SETD1B)

PTEH:

111525679(SETD1A) 111538048(SETD1B)

CANG:

105505730(SETD1A) 105516393(SETD1B)

CJC:	100398610(SETD1B) 100415635(SETD1A)

SBQ:	101042903(SETD1A) 101045177(SETD1B)

CIMI:

108293904(SETD1A) 108315141(SETD1B)

CSYR:

103264403(SETD1A) 103266138(SETD1B)

MMUR:

105871051(SETD1A) 105880900(SETD1B)

LCAT:

123626072(SETD1B) 123632706(SETD1A)

PCOQ:

105823084(SETD1A) 105825690(SETD1B)

OGA:	100945599(SETD1A) 100958719 100961024(SETD1B)

MMU:	208043(Setd1b) 233904(Setd1a)

MCAL:

110295015(Setd1b) 110298244(Setd1a)

MPAH:

110312745(Setd1b) 110317687(Setd1a)

RNO:	100359816(Setd1b)

MCOC:

116068383(Setd1b) 116103030(Setd1a)

ANU:	117696415(Setd1a) 117697926(Setd1b)

MUN:	110545334(Setd1b) 110559774(Setd1a)

CGE:	100753294(Setd1b) 100753962(Setd1a)

MAUA:

101829014(Setd1b)

PROB:

127216087(Setd1b)

PLEU:

114704387(Setd1a) 114704545(Setd1b)

MORG:

121445946(Setd1b)

MFOT:

126504215

AAMP:

119823471(Setd1a) 119825033(Setd1b)

NGI:	103726333(Setd1a) 103739104(Setd1b)

HGL:	101702850(Setd1b) 101709197(Setd1a)

CPOC:

100714908(Setd1b) 100715930(Setd1a)

CCAN:

109682842(Setd1a) 109686401(Setd1b)

DORD:

105982177(Setd1a) 105990633(Setd1b)

DSP:	122096261(Setd1a) 122098518(Setd1b)

PLOP:

125340333(Setd1a) 125349152(Setd1b)

NCAR:

124970066 124990549

MMMA:

107146965(Setd1a) 107156350(Setd1b)

OCU:	100347618 100354139

OPI:	101518304(SETD1A) 101533528(SETD1B)

TUP:	102478405(SETD1A)

GVR:	103606160(SETD1B) 103609922(SETD1A)

CFA:	486257(SETD1B) 489916(SETD1A)

CLUD:

112640121(SETD1A) 112676504(SETD1B)

VVP:	112929256(SETD1A) 112935175(SETD1B)

VLG:	121475438(SETD1B) 121487211(SETD1A)

NPO:	129507853(SETD1B) 129520097(SETD1A)

AML:	100478541(SETD1B) 100482700(SETD1A)

UMR:	103657933(SETD1A) 103661268(SETD1B)

UAH:	113266937(SETD1B) 113267709(SETD1A)

UAR:	123779442(SETD1B) 123784667(SETD1A)

ELK:	111156373 111162294

LLV:	125081907 125091088

MPUF:

101676784(SETD1A) 101682975(SETD1B)

MNP:	132023125(SETD1B) 132026692(SETD1A)

MLK:	131811292(SETD1B) 131819356(SETD1A)

NVS:	122896122 122896125 122903042(SETD1B)

ORO:	101376995(SETD1A)

EJU:	114214467(SETD1A) 114219185(SETD1B)

ZCA:	113912965(SETD1B) 113933089(SETD1A)

MLX:	117999573(SETD1A) 118018434(SETD1B)

NSU:	110588211(SETD1B) 110589952(SETD1A)

LWW:	102746225(SETD1B) 102748564

FCA:	101091070(SETD1A) 101096419(SETD1B)

PYU:	121010353(SETD1B) 121022169(SETD1A)

PCOO:

112857241(SETD1A)

PBG:	122470187(SETD1B) 122471425(SETD1A)

PVIV:

125149038(SETD1B) 125154172(SETD1A)

LRUF:

124517826 124518311

PTG:	102969005(SETD1A) 102970685(SETD1B)

PPAD:

109258968(SETD1A) 109277797(SETD1B)

PUC:	125914205 125928103

AJU:	106967594 106979084

HHV:	120242216(SETD1A) 120243585(SETD1B)

BTA:	514102(SETD1B) 782887(SETD1A)

BOM:	102279495(SETD1A) 102280610(SETD1B)

BIU:	109570912(SETD1B) 109578511(SETD1A)

BBUB:

102393219(SETD1B) 102401677(SETD1A)

BBIS:

104986763(SETD1A) 104989678(SETD1B)

CHX:	102170478(SETD1A) 102179971(SETD1B)

OAS:	101103509(SETD1B) 101105467(SETD1A)

BTAX:

128062225(SETD1B) 128068443(SETD1A)

ODA:	120871020(SETD1B) 120877526(SETD1A)

CCAD:

122423872(SETD1B) 122432971(SETD1A)

MBEZ:

129542812(SETD1B) 129545547(SETD1A)

SSC:	100156137(SETD1B) 100511747(SETD1A)

CFR:	102509980(SETD1A) 102521372(SETD1B)

CBAI:

105080705(SETD1B) 105082875(SETD1A)

CDK:	105102557(SETD1B) 105102789(SETD1A)

VPC:	102525013(SETD1A) 102533681(SETD1B)

BACU:

103008957(SETD1A) 103010622(SETD1B)

BMUS:

118879821(SETD1B) 118881222(SETD1A)

LVE:	103077679(SETD1B) 103079757(SETD1A)

OOR:	101278914(SETD1B) 101283071(SETD1A)

DLE:	111182119(SETD1A) 111186875(SETD1B)

PCAD:

102977910(SETD1B) 102992941(SETD1A)

PSIU:

116738782(SETD1B) 116740357(SETD1A)

NASI:

112399257(SETD1A) 112408730(SETD1B)

ECB:	100063523(SETD1A) 100146430(SETD1B)

EPZ:	103541678(SETD1B) 103547270(SETD1A)

EAI:	106831838(SETD1A) 106842219(SETD1B)

MYB:	102253255(SETD1A) 102255512(SETD1B)

MYD:	102756071(SETD1A)

MMYO:

118656653(SETD1A) 118678406(SETD1B)

MLF:	102442931(SETD1A)

PKL:	118704848(SETD1A) 118725309(SETD1B)

EFUS:

103287230(SETD1B) 103296321(SETD1A)

MNA:	107540799(SETD1A) 107541833(SETD1B)

DRO:	112304818(SETD1A) 112310608(SETD1B)

SHON:

118991063(SETD1B)

AJM:	119041139(SETD1A) 119048615(SETD1B)

PDIC:

114509374(SETD1B) 114512730(SETD1A)

PHAS:

123820603(SETD1B) 123825564(SETD1A)

MMF:	118639802(SETD1B) 118642749(SETD1A)

PPAM:

129078017(SETD1A) 129087511(SETD1B)

HAI:	109374193(SETD1A) 109386061(SETD1B)

RFQ:	117017510(SETD1B) 117019889(SETD1A)

PALE:

102879153(SETD1B) 102884674(SETD1A)

PGIG:

120616066(SETD1B) 120620062(SETD1A)

PVP:	105289379(SETD1B) 105304517(SETD1A)

RAY:	107503985(SETD1A) 107515234(SETD1B)

MJV:	108385302(SETD1A) 108390371(SETD1B)

TOD:	119241716(SETD1A) 119245021(SETD1B)

SARA:

101545082(SETD1A) 101555815(SETD1B)

SETR:

126001027(SETD1B) 126030840(SETD1A)

LAV:	100662609(SETD1A) 100668488(SETD1B)

TMU:	101349124 101354370

ETF:	101660780(SETD1A) 101661209(SETD1B)

DNM:	101411688(SETD1B) 101430254(SETD1A)

MDO:	100013387(SETD1A) 100618514(SETD1B)

GAS:	123233557(SETD1A)

SHR:	100929291(SETD1A)

AFZ:	127545436 127562842

PCW:	110196787(SETD1B) 110223143(SETD1A)

OAA:	100074411(SETD1B) 100090957(SETD1A)

GGA:	416851(SETD1B)

PCOC:

116228609(SETD1B)

MGP:	100544670(SETD1B)

CJO:	107321274(SETD1B)

TPAI:

128084789(SETD1B)

LMUT:

125701628(SETD1B)

NMEL:

110406578(SETD1B)

APLA:

101803072(SETD1B)

ACYG:

106031413(SETD1B)

CATA:

118257585(SETD1B)

AFUL:

116496232(SETD1B)

TGU:	100225647(SETD1B)

LSR:	110471750(SETD1B)

SCAN:

103818319(SETD1B)

PMOA:

120509726(SETD1B)

OTC:	121338904(SETD1B)

PRUF:

121365177(SETD1B)

GFR:	102040049(SETD1B)

FAB:	101812652(SETD1B)

OMA:	130259859(SETD1B)

PHI:	102114734(SETD1B)

PMAJ:

107211664(SETD1B)

CCW:	104688830(SETD1B)

CBRC:

103616030(SETD1B)

ETL:	114055005(SETD1B)

ZAB:	102063205(SETD1B)

ACHL:

103797867(SETD1B)

SVG:	106852411(SETD1B)

MMEA:

130580359(SETD1B)

HRT:	120760602(SETD1B)

FPG:	101911864(SETD1B)

FCH:	102051296(SETD1B)

CLV:	102083945(SETD1B)

EGZ:	104122745(SETD1B)

NNI:	104020788(SETD1B)

PCRI:

104028829(SETD1B)

PLET:

104627930(SETD1B)

EHS:	104509211(SETD1B)

PCAO:

104046246(SETD1B)

ACUN:

113485968(SETD1B)

TALA:

104357553(SETD1B)

PADL:

103914561(SETD1B)

AFOR:

103902864(SETD1B)

ACHC:

115346137(SETD1B)

HALD:

104322588(SETD1B)

HLE:	104840889(SETD1B)

AGEN:

126040986

GCL:

127022697

CCRI:

104167027(SETD1B)

CSTI:

104558267

CMAC:

104484378

MUI:

104533896

BREG:

104629600(SETD1B)

FGA:	104079639(SETD1B)

GSTE:

104261514(SETD1B)

LDI:

104343025

MNB:

103770219

OHA:	104339361(SETD1B)

NNT:	104404373(SETD1B)

SHAB:

115614298(SETD1B)

DPUB:

104308403(SETD1B)

PGUU:

104468713(SETD1B)

ACAR:

104518583(SETD1B)

CPEA:

104389444(SETD1B)

AVIT:

104281140

CVF:	104282211(SETD1B)

RTD:	128917164(SETD1B)

CUCA:

104058823(SETD1B)

TEO:	104380420(SETD1B)

BRHI:

104500111(SETD1B)

AAM:	106495668(SETD1B)

AROW:

112962587(SETD1B)

NPD:	112949410(SETD1B)

TGT:	104578305(SETD1B)

DNE:	112991769(SETD1B)

SCAM:

104138886(SETD1B)

ASN:	102378568(SETD1B)

AMJ:	102574091(SETD1B) 102576444(SETD1A)

CPOO:

109312977(SETD1B)

GGN:	109290592(SETD1B)

PSS:	102448089(SETD1B)

CMY:	102934693(SETD1B) 102937004(SETD1A)

CCAY:

125623122(SETD1B) 125639094(SETD1A)

DCC:	119843486(SETD1B) 119856799(SETD1A)

CPIC:

101936901(SETD1A) 101939661(SETD1B)

TST:	117870265 117888012(SETD1B)

CABI:

116815510(SETD1A) 116836803(SETD1B)

MRV:	120386207(SETD1B) 120403295(SETD1A)

ACS:	103279564(setd1a)

ASAO:

132777736(SETD1A) 132781641(SETD1B)

PVT:	110086418(SETD1A)

SUND:

121916642(SETD1B) 121933310(SETD1A)

PBI:	103054534(SETD1A)

CTIG:

120302200(SETD1A) 120316755(SETD1B)

PGUT:

117666830(SETD1A) 117672218(SETD1B)

APRI:

131185725(SETD1B)

PTEX:

113448694(SETD1B) 113452159

NSS:	113424897(SETD1B)

VKO:	123019576(SETD1A) 123028714(SETD1B)

PMUA:

114582823(SETD1A)

PRAF:

128399355(SETD1A) 128404488(SETD1B)

ZVI:	118076323(SETD1B) 118094883(SETD1A)

HCG:	128329422(SETD1A)

GJA:	107106655(SETD1A)

STOW:

125442810(SETD1B) 125444539(SETD1A)

EMC:	129338613(SETD1A) 129341324(SETD1B)

XLA:	108703944(setd1a.L) 108705280(setd1a.S) 108716786(setd1b.L) 447454(setd1b.S)

XTR:	100487270(setd1a) 780106(setd1b)

NPR:	108787262(SETD1B) 108800988(SETD1A)

RTEM:

120933662(SETD1B) 120943008(SETD1A)

BBUF:

120988587(SETD1B) 121008361(SETD1A)

BGAR:

122924535(SETD1B) 122944789(SETD1A)

MUO:	115473844(SETD1A) 115480576(SETD1B)

GSH:	117361385(SETD1A) 117364226 117364645(SETD1B)

DRE:	556535(setd1a) 567970(setd1ba) 571274(setd1bb)

SRX:	107729457 107737760 107753154 107758578

SANH:

107658500 107658592 107659604 107669245 107689149 107689688

SGH:	107550568 107554121 107555095 107558115 107582993

CCAR:

109054791 109065597 109080175 109107633

CAUA:

113045528 113047154(setd1a) 113047180 113054558 113078041 113097050 113110255

CGIB:

127950214 127953796 127963529 127966568 128020707

PTET:

122336438(setd1a) 122350125(setd1bb) 122352610(setd1ba)

LROH:

127156198(setd1a) 127169181(setd1bb) 127172078(setd1ba)

OMC:	131538114(setd1a) 131545246(setd1bb) 131548075(setd1ba)

PPRM:

120474215(setd1ba) 120485487(setd1bb) 120489364(setd1a)

RKG:	130078096(setd1ba) 130088464(setd1a) 130102052(setd1bb)

MAMB:

125262333(setd1ba) 125277583(setd1a) 125280089(setd1bb)

CIDE:

127507469 127521933

MASI:

127415408 127432980 127433402 127450448 127452313

TROS:

130545699(setd1ba) 130561353(setd1a) 130568326(setd1bb)

TDW:	130412062(setd1ba) 130426845(setd1a) 130440017(setd1bb)

MANU:

129415041(setd1bb) 129436029(setd1a) 129446574(setd1ba)

IPU:	108265096(setd1bb) 108277000(setd1ba) 108280267

IFU:	128604168(setd1a) 128607319(setd1bb) 128620716(setd1ba)

PHYP:

113528616 113544030(setd1b) 113546023

SMEO:

124393411(setd1ba) 124396744(setd1a) 124399738(setd1bb)

TFD:	113635362(setd1a) 113639360(setd1ba) 113645820(setd1bb)

TVC:	132854228(setd1bb) 132861519(setd1a) 132863328(setd1ba)

AMEX:

103026160 103032383(setd1b) 103040137

CMAO:

118800494(setd1a) 118812860(setd1bb) 118824675(setd1ba)

EEE:	113580885 113588670 113589255

CHAR:

105889485(setd1ba) 105898764(setd1a)

TRU:

101071878

TFS:	130515280(setd1a) 130517033(setd1ba)

TNG:	GSTEN00017296G001 GSTEN00027808G001

LCO:	104930237(setd1a) 104931165

NCC:

104953386

TBEN:

117476722(setd1ba) 117492295(setd1a)

CGOB:

115012067 115016385

PGEO:

117450876(setd1a) 117456664(setd1ba)

GACU:

117548512(setd1a) 117558155(setd1ba)

EMAC:

134868298(setd1ba) 134878202(setd1a)

ELY:	117268078(setd1a) 117269643(setd1ba)

EFO:	125879848(setd1a) 125905720(setd1ba)

PLEP:

121956150(setd1a) 121959451(setd1ba)

SLUC:

116034957(setd1ba) 116063825(setd1a)

ECRA:

117958583(setd1a) 117959061(setd1ba)

ESP:	116703213(setd1a)

PFLV:

114570178 114570901(setd1b)

GAT:	120827549(setd1a) 120832108(setd1ba)

PPUG:

119220208(setd1a) 119226293(setd1ba)

AFB:	129098180(setd1a) 129102119(setd1ba)

CLUM:

117734502(setd1a) 117740988(setd1ba)

PSWI:

130188420(setd1a) 130205831(setd1ba)

MSAM:

119893620(setd1a) 119914572(setd1ba)

SCHU:

122865873(setd1ba) 122868800(setd1a)

CUD:	121524894(setd1ba) 121529292(setd1a)

ALAT:

119013716(setd1a) 119029523(setd1ba)

MZE:	101469655(setd1a) 101470643(setd1b)

ONL:	100692647 100694318(setd1a)

OAU:	116322482(setd1ba) 116328737(setd1a)

OLA:	101162384(setd1b) 101168786

OML:	112146211(setd1a) 112163127(setd1ba)

CSAI:

133422463(setd1a) 133455255(setd1ba)

XMA:	102225235(setd1b) 102234339

XCO:	114149871(setd1b) 114159965(setd1a)

XHE:	116724415(setd1b) 116735517(setd1a)

PRET:

103468931(setd1a) 103473729(setd1b)

PFOR:

103144989(setd1a) 103148866(setd1b)

PLAI:

106953546 106961097(setd1a) 106961351(setd1b)

PMEI:

106906014(setd1a) 106921080 106924260(setd1b)

GAF:	122821898(setd1a) 122847186(setd1ba)

PPRL:

129366299(setd1ba) 129373887(setd1a)

CVG:	107084799(setd1a) 107091290

CTUL:

119783331(setd1a) 119788941(setd1ba)

GMU:	124863082 124864576 124872561(setd1ba)

NFU:	107373342(setd1b) 107378515(setd1a)

KMR:	108232668(setd1ba) 108237760(setd1a)

ALIM:

106529534(setd1a) 106535557

NWH:	119421858(setd1a) 119425184(setd1ba)

AOCE:

111581839(setd1b) 111588889(setd1a)

MCEP:

124996358(setd1ba) 124997463(setd1a)

CSEM:

103390461 103392668(setd1a)

POV:	109626185 109634234(setd1a) 109644957

SSEN:

122758289(setd1ba) 122784967(setd1a)

HHIP:

117766827(setd1a) 117772255(setd1ba)

HSP:	118123874(setd1a) 118125992(setd1ba)

SMAU:

118285083(setd1ba) 118288668(setd1a)

LCF:	108879820 108880620(setd1a)

SDU:	111217531(setd1a) 111234229(setd1b)

SLAL:

111655176(setd1b) 111660529(setd1a)

XGL:	120805979(setd1ba) 120807354(setd1a)

HCQ:	109517174(setd1b) 109531597

SSCV:

125979699 125983463

SBIA:

133490972(setd1ba) 133513990(setd1a)

PEE:	133413415(setd1ba) 133414744(setd1a)

PTAO:

133465637(setd1a) 133489880(setd1ba)

BPEC:

110160594(setd1b) 110164423(setd1a)

MALB:

109951316(setd1b) 109963139

BSPL:

114860538(setd1a) 114866446(setd1ba)

SJO:	128380097(setd1ba)

SASA:

106564528(setd1b) 106585338 106585476 106601535

STRU:

115149174 115159411(setd1b) 115171516 115203755

OTW:	112219446(setd1ba) 112248372 112258963 112259260

OMY:	110485207(setd1a) 110523727 110525298 110537198 110538637

OGO:	123998987 123999068 124015385(setd1a) 124034391 124048812(setd1ba)

ONE:	115105818 115110761 115111191 115124735(setd1b)

OKI:	109868353(setd1b) 109873484 109878662 109892528 116375924

OKE:	118372568 118378068 118387666 118391389

SALP:

111961475(setd1b) 111974001 111980138

SNH:	120025981(setd1ba) 120034473 120040543 120045034

CCLU:

121568624 121573795 121582371 123491170

ELS:	105013001(setd1a) 105014918

SFM:	108921845(setd1b) 108922553

PKI:	111839212(setd1b) 111842099 111854094

AANG:

118206991 118212758 118216609(setd1a)

LOC:	102690392(setd1a) 102699109(setd1b)

PSPA:

121305207(setd1a) 121307737 121307751(setd1ba)

ARUT:

117398266(setd1a) 117428209 117973335

PSEX:

120540822

LCM:	102363172(SETD1B)

HOC:	132827128(setd1ba)

LERI:

129709397

BFO:	118411046 118425946

BBEL:

CIN:

SCLV:

SPU:

SKO:

DME:	Dmel_CG40351(Set1)

DER:

26527103

DSE:

6620474

DSI:	Dsimw501_GD11928(Dsim_GD11928)

DYA:	Dyak_GE25383

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI23985

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

BDR:

RZE:

AOQ:

TDA:

MDE:

SCAC:

LCQ:

LSQ:

ECOE:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AAG:

AALB:

CQU:	CpipJ_CPIJ013516

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

CCIN:

TCA:

DPA:

SOY:

AGRG:

ATD:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_207038

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

CFEL:

API:	100159159 100573227

DNX:

AGS:

RMD:

BTAB:

CLEC:

HHAL:

NLU:

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

DMK:	116931940 123477137

DPZ:

PVM:

PJA:

PCHN:

HAME:

PCLA:

CQD:

PTRU:

ESN:

HAZT:

EAF:

LSM:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

CSCU:

PTEP:

CEL:	CELE_C26E6.9(set-2)

CBR:

CBG_18192

CRQ:	GCK72_009980

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

CVN:

CANU:

OED:

MYI:

PMAX:

MCAF:

MMER:

RPHI:

OBI:

OSN:

LAK:

TAD:	TRIADDRAFT_32357

SCE:	YHR119W(SET1)

SEUB:

DI49_2524

SPAO:

SPAR_H01610

AGO:	AGOS_ABR136W

ERC:

Ecym_8199

KLA:	KLLA0_F24134g

KMX:	KLMA_60252(SET1)

LTH:	KLTH0B05280g

VPO:	Kpol_1048p18

ZRO:	ZYRO0G06446g

CGR:	CAGL0L12980g

NCS:	NCAS_0B07030(NCAS0B07030)

NDI:	NDAI_0B04360(NDAI0B04360)

TPF:	TPHA_0I01480(TPHA0I01480)

TBL:	TBLA_0C05500(TBLA0C05500)

TGB:	HG536_0D03100

TDL:	TDEL_0B05100(TDEL0B05100)

KAF:	KAFR_0F00700(KAFR0F00700)

KNG:	KNAG_0H03550(KNAG0H03550)

ZMK:	HG535_0A02610

PPA:	PAS_chr2-2_0494

DHA:	DEHA2F20834g

PIC:	PICST_32740(SET1)

PGU:	PGUG_00321

SPAA:

SPAPADRAFT_133304

LEL:	PVL30_001340(SET1)

CAL:	CAALFM_C100960CA(SET1)

CTP:	CTRG_04399

COT:	CORT_0B11090

CDU:	CD36_00910

CTEN:

CANTEDRAFT_128029

YLI:	YALI0B14883g

CLU:	CLUG_03935

CLUS:

A9F13_01g01903

CAUR:

CJI96_0004142

SLB:	AWJ20_608(SET1)

PKZ:	C5L36_0E00970

BNN:	FOA43_003623

BBRX:

BRETT_004481

OPA:	HPODL_02902

NCR:	NCU01206(set-1)

NTE:	NEUTE1DRAFT144212(NEUTE1DRAFT_144212)

SMP:	SMAC_07534

PAN:	PODANSg8424

PBEL:

QC761_206140(SET1)

PPSD:

QC762_206140(SET1)

PPSP:

QC763_206140(SET1)

PPSA:

QC764_206140(SET1)

TTT:	THITE_129744

MTM:	MYCTH_79077

CTHR:

MGR:

PPEI:

PGRI:

TMN:	UCRPA7_4938

SSCK:

SPSK_05816

FGR:	FGSG_07445

FPU:	FPSE_09407

FPOA:

FPOAC1_011239(SET1)

FVN:	FVRRES_12271

FVR:	FVEG_07811

FOX:	FOXG_01447

NHE:	NECHADRAFT_49470(SDG2101)

FFC:	NCS54_01123100

FKR:	NCS57_01113900

FMU:	J7337_003137(SET1)

TRE:	TRIREDRAFT_81925

TRR:	M419DRAFT_90299

MAW:

MAJ:

PCHM:

CMT:

AMUS:

PLJ:	VFPFJ_07734

PTKZ:

JDV02_005368(SET1)

VAL:	VDBG_04198

VDA:	VDAG_01423

CFJ:	CFIO01_10439

CLUP:

CLUP02_08272

CHIG:

CH63R_04383

SAPO:

SAPIO_CDS9661

ELA:	UCREL1_3105

PFY:	PFICI_07909

SSL:	SS1G_03070

BFU:	BCIN_06g06760(Bcset1)

MBE:

MBM_05396

PSCO:

LY89DRAFT_691442

GLZ:	GLAREA_05909

ANI:	ANIA_05795

AFM:	AFUA_6G06335

ACT:	ACLA_088100

NFI:	NFIA_051950

AOR:	AO090003000002

ANG:	An18g06840

AFV:	AFLA_001694

ALUC:

AKAW2_30966A(SET1)

ACHE:

ACHE_20429A(SET1)

APUU:

APUU_41186S(SET1)

PCS:	N7525_000090

PDP:	PDIP_68080

POU:	POX_e06511

TMF:	EYB26_003357

TRG:	TRUGW13939_09770

CIM:	CIMG_07257

CPW:	CPC735_000650

URE:	UREG_07821

PBL:	PAAG_00848

PBN:	PADG_03985

ABE:

ARB_00972

TVE:

TRV_00712

AJE:	HCAG_04084

BGH:	BDBG_01703

PNO:	SNOG_03803

PTE:

PTT_01686

BZE:	COCCADRAFT_699

BSC:	COCSADRAFT_162605

BOR:	COCMIDRAFT_9083

AALT:

CC77DRAFT_846141

ARAB:

EKO05_0008232

ZTR:	MYCGRDRAFT_10108(SDG2403)

PFJ:	MYCFIDRAFT_204567

FFU:	CLAFUR5_12482

CBET:

CB0940_11106

BCOM:

BAUCODRAFT_80239

NPA:	UCRNP2_10139

TML:	GSTUM_00009579001

SPO:	SPCC306.04c(set1)

SOM:	SOMG_04222(set1)

CNE:

CND03610

CNB:

CNBD2720

CNG:	CNAG_01243

CGI:	CGB_D6310C

CDEU:

CNBG_0809

PCO:	PHACADRAFT_142398

MRR:	Moror_10709

E1B28_006614

WIC:	J056_000219

UMA:	UMAG_02677

DDI:	DDB_G0289257(set1)

PTI:	PHATRDRAFT_15937

TPS:	THAPSDRAFT_35182

TVA:	TVAG_2v0765810

» show all

Reference

PMID:12670868

Authors

Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W

Title

Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.

Journal

Genes Dev 17:896-911 (2003)
DOI:10.1101/gad.252103

Sequence

[hsa:9739]

Reference

PMID:12845608

Authors

Boa S, Coert C, Patterton HG

Title

Saccharomyces cerevisiae Set1p is a methyltransferase specific for lysine 4 of histone H3 and is required for efficient gene expression.

Journal

Yeast 20:827-35 (2003)
DOI:10.1002/yea.995

Sequence

[sce:YHR119W]

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