KEGG   ORTHOLOGY: K09222
Entry
K09222                      KO                                     
Symbol
REST
Name
RE1-silencing transcription factor
Pathway
map04550  Signaling pathways regulating pluripotency of stem cells
map05016  Huntington disease
Disease
H00604  Deafness, autosomal dominant
H01250  Hereditary gingival fibromatosis
H02301  Nephroblastoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K09222  REST; RE1-silencing transcription factor
 09160 Human Diseases
  09164 Neurodegenerative disease
   05016 Huntington disease
    K09222  REST; RE1-silencing transcription factor
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09222  REST; RE1-silencing transcription factor
   03036 Chromosome and associated proteins
    K09222  REST; RE1-silencing transcription factor
Transcription factors [BR:ko03000]
 Eukaryotic type
  Zinc finger
   Cys2His2 others
    K09222  REST; RE1-silencing transcription factor
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Histone modification proteins
   HDAC complexes
    REST complex
     K09222  REST; RE1-silencing transcription factor
Genes
HSA: 5978(REST)
PTR: 471235(REST)
PPS: 100968041(REST)
GGO: 101143077(REST)
PON: 100449247(REST)
NLE: 100583285(REST)
HMH: 116467953(REST)
MCC: 100425257(REST)
MCF: 102116020(REST)
MTHB: 126955058
MNI: 105463564(REST)
CSAB: 103235636(REST)
CATY: 105575092(REST)
PANU: 101007427(REST)
TGE: 112624529(REST)
MLEU: 105552715(REST)
RRO: 104682704(REST)
RBB: 108513477(REST)
TFN: 117085569(REST)
PTEH: 111526476(REST)
CANG: 105508310(REST)
CJC: 100399762(REST)
SBQ: 101031593(REST)
CIMI: 108292389(REST)
CSYR: 103265209(REST)
MMUR: 105867870(REST)
LCAT: 123624106(REST)
PCOQ: 105807685(REST)
OGA: 100941288(REST)
MMU: 19712(Rest)
MCAL: 110294391(Rest)
MPAH: 110330594(Rest)
RNO: 83618(Rest)
MCOC: 116071321(Rest)
ANU: 117713111(Rest)
MUN: 110560331(Rest)
CGE: 100756480(Rest)
MAUA: 101829197(Rest)
PROB: 127232485(Rest)
MORG: 121460801(Rest)
MFOT: 126506422
AAMP: 119814381(Rest)
NGI: 103734374(Rest)
HGL: 101718905(Rest)
CPOC: 100729177(Rest)
CCAN: 109691663(Rest)
DORD: 105980282(Rest)
DSP: 122106774(Rest)
PLOP: 125364421(Rest)
NCAR: 124994664
MMMA: 107139256(Rest)
OCU: 100341801
OPI: 101533757(REST)
TUP: 102488680(REST)
GVR: 103594630(REST)
CFA: 100682666 482163(REST)
CLUD: 112652141(REST)
VVP: 112923703(REST)
VLG: 121473518(REST)
NPO: 129520498(REST)
AML: 100483588(REST)
UMR: 103672754(REST)
UAH: 113262528(REST)
UAR: 123804029(REST)
ELK: 111149307
LLV: 125093757
MPUF: 101691035(REST)
MNP: 132006620(REST)
MLK: 131823748(REST)
NVS: 122890154(REST)
ORO: 101384761(REST)
EJU: 114206780(REST)
ZCA: 113924784(REST)
MLX: 118010499(REST)
NSU: 110590822(REST)
LWW: 102749433(REST)
FCA: 101086719(REST)
PYU: 121035201(REST)
PCOO: 112858420(REST)
PBG: 122497300(REST)
LRUF: 124520215
PTG: 102949845(REST)
PPAD: 109278581(REST)
PUC: 125922753
AJU: 106971663
HHV: 120243036(REST)
BTA: 507148(RESTB) 615792(RESTA)
BBUB: 102396779(REST) 102398050
OAS: 101110593(REST) 101111099
SSC: 100520754(REST) 100621006
CFR: 102506327 102517836(REST)
VPC: 102526304 102538543(REST)
LVE: 103078260(REST) 103090669
DLE: 111169240(REST) 111169295
PSIU: 116754328(REST) 116754783
ECB: 100058152(REST)
EPZ: 103556481(REST)
EAI: 106841687(REST)
MYB: 102261820(REST)
MYD: 102755535(REST)
MMYO: 118669148(REST)
MLF: 102435343(REST)
PKL: 118706111(REST)
EFUS: 103285053(REST)
MNA: 107533240(REST)
DRO: 112322213(REST)
SHON: 118978573(REST)
AJM: 119061643(REST)
PDIC: 114492845(REST)
PHAS: 123815689(REST)
MMF: 118627506(REST)
PPAM: 129065532(REST)
HAI: 109394382(REST)
RFQ: 117022365(REST)
PALE: 102879115(REST)
PGIG: 120588111(REST)
PVP: 105293757(REST)
RAY: 107517714(REST)
MJV: 108387770(REST)
TOD: 119260657(REST)
SARA: 101551510(REST)
LAV: 100659269(REST)
TMU: 101345477
ETF: 101647109(REST)
DNM: 101433509(REST)
MDO: 100016000(REST)
GAS: 123251263(REST)
SHR: 100921808(REST)
AFZ: 127539922
PCW: 110200152(REST)
OAA: 100078457(REST)
GGA: 422623(REST)
PCOC: 116231143(REST)
MGP: 100549206(REST)
CJO: 107313403(REST)
TPAI: 128080603(REST)
LMUT: 125692585(REST)
NMEL: 110399054(REST)
APLA: 101791754(REST)
ACYG: 106046092(REST)
CATA: 118247341(REST)
AFUL: 116488744(REST)
TGU: 100228357(REST)
LSR: 110471704(REST)
SCAN: 103825985(REST)
PMOA: 120502716(REST)
OTC: 121348411(REST)
PRUF: 121360218(REST)
GFR: 102031873(REST)
FAB: 101814797(REST)
OMA: 130252510(REST)
PHI: 102099605(REST)
PMAJ: 107203260(REST)
CCAE: 111927808(REST)
CCW: 104697147(REST)
CBRC: 103617346(REST)
ETL: 114065781(REST)
ZAB: 102074943(REST)
ACHL: 103808367(REST)
SVG: 106860444(REST)
MMEA: 130579653(REST)
HRT: 120752812(REST)
FPG: 101911619(REST)
FCH: 102054905(REST)
CLV: 102087713(REST)
EGZ: 104122668(REST)
NNI: 104021209(REST)
PCRI: 104031607(REST)
PLET: 104622406(REST)
EHS: 104502924(REST)
PCAO: 104046951(REST)
ACUN: 113479642(REST)
TALA: 104366110(REST)
PADL: 103921756(REST)
AFOR: 103902264(REST)
ACHC: 115342737(REST)
HALD: 104314050(REST)
HLE: 104843293(REST)
AGEN: 126044628
GCL: 127015745
CCRI: 104165217(REST)
CSTI: 104549774(REST)
CMAC: 104477352(REST)
MUI: 104533534(REST)
BREG: 104629401(REST)
FGA: 104075593(REST)
GSTE: 104258812(REST)
LDI: 104350003(REST)
MNB: 103769602(REST)
OHA: 104331693(REST)
NNT: 104404393(REST)
SHAB: 115610936(REST)
DPUB: 104298085(REST)
PGUU: 104470156(REST)
ACAR: 104517876(REST)
CPEA: 104387177(REST)
AVIT: 104267678(REST)
CVF: 104294108(REST)
RTD: 128910160(REST)
CUCA: 104064987(REST)
TEO: 104369889(REST)
BRHI: 104488061(REST)
AAM: 106495841(REST)
AROW: 112973799(REST)
NPD: 112953428(REST)
TGT: 104580659(REST)
DNE: 112989310(REST)
SCAM: 104149853(REST)
ASN: 102378229(REST)
AMJ: 102565143(REST)
CPOO: 109309455(REST)
GGN: 109301254(REST)
PSS: 102445246(REST)
CMY: 102941140(REST)
CCAY: 125635319(REST)
DCC: 119854715(REST)
CPIC: 101947249(REST)
TST: 117877739(REST)
CABI: 116826337(REST)
MRV: 120406520(REST)
ACS: 100564403(rest)
ASAO: 132767579(REST)
PVT: 110091002(REST)
SUND: 121922122(REST)
PBI: 103055825(REST)
CTIG: 120308760(REST)
TSR: 106550815(REST)
PGUT: 117661754(REST)
APRI: 131191578(REST)
PTEX: 113444076(REST)
NSS: 113426104(REST)
VKO: 123017488(REST)
PMUA: 114587605(REST)
PRAF: 128405281(REST)
ZVI: 118075429(REST)
HCG: 128345146(REST)
GJA: 107106832(REST)
STOW: 125436234(REST)
EMC: 129334355(REST)
XLA: 373614(rest.S) 734238(rest.L)
XTR: 734016(rest)
RTEM: 120912027(REST)
BBUF: 120989636(REST)
BGAR: 122927806(REST)
MUO: 115463788 115463791(REST)
GSH: 117345995(REST)
DRE: 564772(rest)
SRX: 107750328 107751319(rest)
SGH: 107562372(rest) 107587061
PTET: 122357491(rest)
LROH: 127175809(rest)
OMC: 131553377(rest)
PPRM: 120460768(rest)
RKG: 130072483(rest)
MAMB: 125259105(rest)
CIDE: 127525657
TROS: 130563623(rest)
TDW: 130438169(rest)
MANU: 129421995(rest)
IPU: 108275113
IFU: 128623385(rest)
PHYP: 113539864(rest)
SMEO: 124397219(rest)
TFD: 113648374(rest)
TVC: 132861209(rest)
AMEX: 103034010(rest)
CMAO: 118821126(rest)
EEE: 113587934(rest)
CHAR: 105888599(rest)
TRU: 100216471(rest) 115246415
TFS: 130531443(rest)
LCO: 104936076(rest)
NCC: 104968113(rest)
TBEN: 117482569(rest)
EMAC: 134859603(rest)
ELY: 117269473(rest)
EFO: 125894366(rest)
PLEP: 121947939(rest)
SLUC: 116060259(rest)
ECRA: 117941476(rest)
PFLV: 114562962(rest)
GAT: 120817302(rest)
PPUG: 119211448(rest)
AFB: 129089932(rest)
CLUM: 117737598(rest)
PSWI: 130210582(rest)
MSAM: 119888326(rest)
SCHU: 122880512(rest)
CUD: 121516322(rest)
ALAT: 119007281(rest)
MZE: 101472807(rest)
ONL: 100693239(rest)
OAU: 116332058(rest)
OLA: 101171397(rest)
OML: 112153209(rest)
CSAI: 133446708(rest)
XMA: 102216701(rest)
XCO: 114139602(rest)
XHE: 116714589(rest)
PRET: 103471787(rest)
PFOR: 103155974(rest)
PLAI: 106958579
PMEI: 106922897
GAF: 122836754(rest)
CVG: 107082720(rest)
CTUL: 119784562(rest)
GMU: 124860125(rest)
NFU: 107381113(rest)
KMR: 108228877(rest)
ALIM: 106534158(rest)
NWH: 119408815(rest)
AOCE: 111570938(rest)
MCEP: 125008281(resT)
CSEM: 103390793(rest)
POV: 109645180
SSEN: 122778192(rest)
HHIP: 117769182(rest)
HSP: 118112099(rest)
SMAU: 118320055(rest)
LCF: 108885295
SDU: 111233497(rest)
SLAL: 111665592
XGL: 120785453(rest)
HCQ: 109508297(rest)
SSCV: 125979249
SBIA: 133508412(rest)
PEE: 133407967(rest)
PTAO: 133484614(rest)
BPEC: 110168020(rest)
MALB: 109951107(rest)
BSPL: 114864570(rest)
SJO: 128363281(rest)
CCLU: 121541947
ELS: 105007536(rest)
SFM: 108938792(rest)
PKI: 111848741(rest)
AANG: 118228272 118231894(rest)
LOC: 102693544(rest)
PSPA: 121294877(rest) 121323258
PSEX: 120532262(rest)
LCM: 102347070 102365460(REST)
CMK: 103182119(rest)
RTP: 125481013
CPLA: 122564880(rest)
HOC: 132825336(rest)
LERI: 129695584(rest)
BFO: 118413327
AGB: 108914438
LDC: 111517959
VJA: 111273738
 » show all
Reference
PMID:7697725
  Authors
Chong JA, Tapia-Ramirez J, Kim S, Toledo-Aral JJ, Zheng Y, Boutros MC, Altshuller YM, Frohman MA, Kraner SD, Mandel G
  Title
REST: a mammalian silencer protein that restricts sodium channel gene expression to neurons.
  Journal
Cell 80:949-57 (1995)
DOI:10.1016/0092-8674(95)90298-8
  Sequence
[hsa:5978]
Reference
PMID:8568247
  Authors
Scholl T, Stevens MB, Mahanta S, Strominger JL
  Title
A zinc finger protein that represses transcription of the human MHC class II gene, DPA.
  Journal
J Immunol 156:1448-57 (1996)
  Sequence
[hsa:5978]

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