KEGG   ORTHOLOGY: K09408Help
Entry
K09408                      KO                                     

Name
FOXO3
Definition
forkhead box protein O3
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04062  Chemokine signaling pathway
ko04068  FoxO signaling pathway
ko04137  Mitophagy - animal
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04212  Longevity regulating pathway - worm
ko04213  Longevity regulating pathway - multiple species
ko04218  Cellular senescence
ko04722  Neurotrophin signaling pathway
ko04917  Prolactin signaling pathway
ko05213  Endometrial cancer
ko05223  Non-small cell lung cancer
Module
M00676  PI3K-Akt signaling
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04068 FoxO signaling pathway
    K09408  FOXO3; forkhead box protein O3
   04151 PI3K-Akt signaling pathway
    K09408  FOXO3; forkhead box protein O3
   04152 AMPK signaling pathway
    K09408  FOXO3; forkhead box protein O3
 Cellular Processes
  Transport and catabolism
   04137 Mitophagy - animal
    K09408  FOXO3; forkhead box protein O3
  Cell growth and death
   04218 Cellular senescence
    K09408  FOXO3; forkhead box protein O3
 Organismal Systems
  Immune system
   04062 Chemokine signaling pathway
    K09408  FOXO3; forkhead box protein O3
  Endocrine system
   04917 Prolactin signaling pathway
    K09408  FOXO3; forkhead box protein O3
  Nervous system
   04722 Neurotrophin signaling pathway
    K09408  FOXO3; forkhead box protein O3
  Aging
   04211 Longevity regulating pathway - mammal
    K09408  FOXO3; forkhead box protein O3
   04212 Longevity regulating pathway - worm
    K09408  FOXO3; forkhead box protein O3
   04213 Longevity regulating pathway - multiple species
    K09408  FOXO3; forkhead box protein O3
 Human Diseases
  Cancers
   05213 Endometrial cancer
    K09408  FOXO3; forkhead box protein O3
   05223 Non-small cell lung cancer
    K09408  FOXO3; forkhead box protein O3
  Drug resistance
   01521 EGFR tyrosine kinase inhibitor resistance
    K09408  FOXO3; forkhead box protein O3
KEGG modules [BR:ko00002]
 Functional set
  Cellular processes
   Cell signaling
    M00676  PI3K-Akt signaling
     K09408  FOXO3; forkhead box protein O3
Transcription factors [BR:ko03000]
 Eukaryotic Type
  Helix-turn-helix
   Fork head/winged helix other regulators
    K09408  FOXO3; forkhead box protein O3
BRITE hierarchy
Genes
HSA: 2309(FOXO3)
PTR: 462921(FOXO3)
PPS: 100976373(FOXO3)
GGO: 101153605(FOXO3)
PON: 100451077(FOXO3)
NLE: 100600519(FOXO3)
MCC: 700731(FOXO3)
MCF: 101925779(FOXO3)
CSAB: 103240621(FOXO3)
RRO: 104677475(FOXO3)
RBB: 108533814(FOXO3)
CJC: 100406446(FOXO3)
SBQ: 101039948(FOXO3)
MMU: 56484(Foxo3)
RNO: 294515(Foxo3)
CGE: 100770315(Foxo3)
NGI: 103749566(Foxo3)
HGL: 101699251(Foxo3)
CCAN: 109700754(Foxo3)
OCU: 100343573(FOXO3)
TUP: 102479628(FOXO3)
CFA: 481954(FOXO3)
AML: 100480992(FOXO3)
UMR: 103675835(FOXO3)
ORO: 101376741
FCA: 101081548(FOXO3)
PTG: 102961930(FOXO3)
AJU: 106986643(FOXO3)
BTA: 535530(FOXO3)
BOM: 102287014(FOXO3)
BIU: 109563845(FOXO3)
PHD: 102315499(FOXO3)
CHX: 102188676(FOXO3)
OAS: 100913151(FOXO3)
SSC: 733621(FOXO3)
CFR: 102513603(FOXO3)
CDK: 105097118(FOXO3)
BACU: 102999779(FOXO3)
LVE: 103084467(FOXO3)
OOR: 101288204(FOXO3)
ECB: 100066558(FOXO3)
EPZ: 103551216(FOXO3)
EAI: 106829766(FOXO3)
MYB: 102246728(FOXO3)
MYD: 102751393(FOXO3)
HAI: 109391421(FOXO3)
RSS: 109449094(FOXO3)
PALE: 102890472(FOXO3)
LAV: 100657588(FOXO3)
TMU: 101354741
MDO: 100021705(FOXO3)
SHR: 100917083(FOXO3)
OAA: 100080284(FOXO3)
GGA: 421769(FOXO3)
MGP: 100545873(FOXO3)
CJO: 107311812(FOXO3)
APLA: 101799850(FOXO3)
ACYG: 106032604(FOXO3)
TGU: 100217648(FOXO3)
GFR: 102034329(FOXO3)
FAB: 101810105(FOXO3)
PHI: 102100166(FOXO3)
PMAJ: 107201324(FOXO3)
CCW: 104691645(FOXO3)
FPG: 101911781(FOXO3)
FCH: 102052285(FOXO3)
CLV: 102095969(FOXO3)
EGZ: 104131578(FOXO3)
AAM: 106489614(FOXO3)
ASN: 102373584(FOXO3)
AMJ: 106737273(FOXO3)
PSS: 102455970(FOXO3)
CMY: 102942736(FOXO3)
CPIC: 101940984(FOXO3)
ACS: 100561938(foxo3)
PVT: 110083133(FOXO3)
PBI: 103053115(FOXO3) 103066631
GJA: 107105443(FOXO3)
XLA: 108717943(foxo3.S) 444992(foxo3.L)
XTR: 100125025(foxo3)
NPR: 108792872(FOXO3)
DRE: 30296(foxo3b) 494532(foxo3a)
IPU: 108270398 108279058(foxo3)
AMEX: 103022904(foxo3) 103026113
NCC: 104966138(foxo3)
OLA: 100301621(foxo3) 101155614
XMA: 102217263(foxo3) 102225439
NFU: 107377534(foxo3) 107391983
ELS: 105015400 105017479(foxo3)
SFM: 108920401(foxo3) 108921079
LCM: 102359675(FOXO3)
CMK: 103178343(foxo3)
CIN: 100186156(foxo)
APLC: 110974374
SKO: 100303473(foxO3)
DME: Dmel_CG3143(foxo)
DSI: Dsimw501_GD18943(Dsim_GD18943)
AAG: 5576867
AME: 727091(foxo)
BIM: 100745007
BTER: 100643217
SOC: 105196024
AEC: 105151192
ACEP: 105624987
PBAR: 105431952
HST: 105183293
CFO: 105254925
LHU: 105678422
PGC: 109856359
NVI: 100123890
TCA: 664090
DPA: 109540202
BMOR: 100529235(foxO)
PMAC: 106720323
PRAP: 111004181
API: 100168097
DNX: 107165145
FCD: 110859825
DPX: DAPPUDRAFT_109005(FOXO)
TUT: 107366353
CEL: CELE_R13H8.1(daf-16)
CBR: CBG12825(Cbr-daf-16)
BMY: Bm1_50095
TSP: Tsp_10373
CRG: 105318783
MYI: 110465698
OBI: 106882662
LAK: 106167332
HMG: 100202184
AQU: 109586425
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9479491
  Authors
Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC
  Title
Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.
  Journal
Genomics 47:187-99 (1998)
DOI:10.1006/geno.1997.5122
  Sequence
[hsa:2309]
Reference
  Authors
Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villen J, Becker EB, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK, Bonni A
  Title
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.
  Journal
Cell 125:987-1001 (2006)
DOI:10.1016/j.cell.2006.03.046
  Sequence
[hsa:2309]

DBGET integrated database retrieval system