KEGG   ORTHOLOGY: K10165
Entry
K10165                      KO                                     

Name
NOD2, CARD15
Definition
nucleotide-binding oligomerization domain-containing protein 2
Pathway
ko04621  NOD-like receptor signaling pathway
ko04668  TNF signaling pathway
ko05152  Tuberculosis
ko05321  Inflammatory bowel disease
Disease
H00285  Blau syndrome
H00286  Crohn disease
H01227  Inflammatory bowel disease (IBD)
H01309  Sarcoidosis, early-onset
H01358  Atopic dermatitis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K10165  NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K10165  NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K10165  NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2
  09163 Immune disease
   05321 Inflammatory bowel disease
    K10165  NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04054 Pattern recognition receptors
    K10165  NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2
Pattern recognition receptors [BR:ko04054]
 Cytoplasmic pattern recognition receptors
  NOD-like receptors
   K10165  NOD2, CARD15; nucleotide-binding oligomerization domain-containing protein 2
Genes
HSA: 64127(NOD2)
PTR: 454083(NOD2)
PPS: 100986116(NOD2)
GGO: 101129872(NOD2)
PON: 100440517(NOD2)
NLE: 100590851(NOD2)
MCC: 695542(NOD2)
MCF: 102129800(NOD2)
CSAB: 103232735(NOD2)
RRO: 104672572(NOD2)
RBB: 108536321(NOD2)
CJC: 100414962(NOD2)
SBQ: 101034571(NOD2)
MMU: 257632(Nod2)
MCAL: 110300637(Nod2)
MPAH: 110337641(Nod2)
RNO: 291912(Nod2)
MUN: 110560783(Nod2)
CGE: 100759694(Nod2)
NGI: 103730124(Nod2)
HGL: 101709371(Nod2)
CCAN: 109701706(Nod2)
OCU: 100356594(NOD2)
TUP: 102497846(NOD2) 102500527
CFA: 487286(NOD2)
VVP: 112929606(NOD2)
AML: 100469482(NOD2)
UMR: 103673911(NOD2)
UAH: 113252225(NOD2)
ORO: 101374813(NOD2)
ELK: 111157341
FCA: 101096863(NOD2)
PTG: 102972059(NOD2)
PPAD: 109270946(NOD2)
AJU: 106977676(NOD2)
BTA: 444867(NOD2)
BOM: 102265346(NOD2)
BIU: 109572753(NOD2)
BBUB: 102390227(NOD2)
CHX: 102186424(NOD2)
OAS: 780465(NOD2)
SSC: 100125838(NOD2)
CFR: 102504506(NOD2)
CDK: 105097522(NOD2)
BACU: 103020823(NOD2)
LVE: 103077202(NOD2)
OOR: 101271819(NOD2)
DLE: 111164994(NOD2)
PCAD: 102992305(NOD2)
ECB: 100059123(NOD2)
EPZ: 103556599(NOD2)
EAI: 106822712(NOD2)
MYB: 102252363(NOD2)
MYD: 102765180(NOD2)
MNA: 107531027(NOD2)
HAI: 109383342(NOD2)
DRO: 112296773(NOD2)
PALE: 102881890(NOD2)
RAY: 107512244(NOD2)
MJV: 108408571(NOD2)
LAV: 100677763(NOD2)
TMU: 101340794
MDO: 100018299(NOD2)
PCW: 110207478(NOD2)
OAA: 100090933(NOD2)
XLA: 108713994
NPR: 108792772(NOD2)
DRE: 777696(nod2)
IPU: 100379166(nod2)
PHYP: 113541009(nod2)
AMEX: 103045336(nod2)
EEE: 113585364(nod2)
TRU: 724045(nod2)
LCO: 104940686(nod2)
NCC: 104958220(nod2)
MZE: 101479180(nod2)
ONL: 100702947(nod2)
OLA: 101164467(nod2)
XMA: 102229465(nod2)
XCO: 114143165(nod2)
PRET: 103462648(nod2)
CVG: 107088493(nod2)
NFU: 107379163
KMR: 108243321(nod2)
ALIM: 106517234(nod2)
AOCE: 111572260(nod2)
CSEM: 103398555(nod2)
POV: 109624923(nod2)
LCF: 108876863(nod2)
SDU: 111219530(nod2)
SLAL: 111651623 111672267(nod2)
HCQ: 109513982(nod2)
BPEC: 110175243(nod2)
MALB: 109955896(nod2)
SASA: 106562391 106587579(nod2)
OTW: 112239235(nod2)
SALP: 111965017(nod2)
ELS: 105025697(nod2)
SFM: 108932944(nod2)
PKI: 111832753(nod2)
LCM: 102355950(NOD2)
RTP: 109916031(nod2)
SPIS: 111339699
 » show all
Reference
  Authors
Fiil BK, Damgaard RB, Wagner SA, Keusekotten K, Fritsch M, Bekker-Jensen S, Mailand N, Choudhary C, Komander D, Gyrd-Hansen M
  Title
OTULIN restricts Met1-linked ubiquitination to control innate immune signaling.
  Journal
Mol Cell 50:818-30 (2013)
DOI:10.1016/j.molcel.2013.06.004
Reference
  Authors
Ogura Y, Inohara N, Benito A, Chen FF, Yamaoka S, Nunez G
  Title
Nod2, a Nod1/Apaf-1 family member that is restricted to monocytes and activates NF-kappaB.
  Journal
J Biol Chem 276:4812-8 (2001)
DOI:10.1074/jbc.M008072200
  Sequence
[hsa:64127]

DBGET integrated database retrieval system