KEGG ORTHOLOGY: K10596

ORTHOLOGY: K10596

Entry

K10596                      KO

Symbol

UBE4A

Name

ubiquitin conjugation factor E4 A [EC:2.3.2.27]

Pathway

map04120

Ubiquitin mediated proteolysis

Disease

H02715

Neurodevelopmental disorder with defects of ubiquitin-proteasome system

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K10596  UBE4A; ubiquitin conjugation factor E4 A
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10596  UBE4A; ubiquitin conjugation factor E4 A
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K10596  UBE4A; ubiquitin conjugation factor E4 A
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  U-box type E3
   K10596  UBE4A; ubiquitin conjugation factor E4 A

Genes

HSA:	9354(UBE4A)

PTR:	451586(UBE4A)

PPS:	100976919(UBE4A)

GGO:	101151381(UBE4A)

PON:	100189732(UBE4A)

PPYG:

129007969(UBE4A)

NLE:	100582860(UBE4A)

HMH:	116477009(UBE4A)

SSYN:

129479723(UBE4A)

MCC:	699836(UBE4A)

MCF:	102135339(UBE4A)

MTHB:

126936041

MNI:	105476411(UBE4A)

CSAB:

103248589(UBE4A)

CATY:

105582473(UBE4A)

PANU:

101018155(UBE4A)

TGE:	112605824(UBE4A)

MLEU:

105528219(UBE4A)

RRO:	104665575(UBE4A)

RBB:	108536380(UBE4A)

TFN:	117081218(UBE4A)

PTEH:

111540207(UBE4A)

CANG:

105501210(UBE4A)

CJC:	100405033(UBE4A)

SBQ:	101030487(UBE4A)

CIMI:

108300598(UBE4A)

ANAN:

105729550(UBE4A)

CSYR:

103252227(UBE4A)

MMUR:

105876050(UBE4A)

LCAT:

123641517(UBE4A)

PCOQ:

105819198(UBE4A)

OGA:	100965963(UBE4A)

MMU:	140630(Ube4a)

MCAL:

110301356(Ube4a)

MPAH:

110327792(Ube4a)

RNO:	315608(Ube4a)

MCOC:

116073933(Ube4a)

ANU:	117699259(Ube4a)

ASYL:

127689152(Ube4a)

MUN:	110549095(Ube4a)

CGE:	100757349(Ube4a)

MAUA:

101836099(Ube4a)

PROB:

127231624(Ube4a)

PLEU:

114691191(Ube4a)

MORG:

121438255(Ube4a)

MFOT:

126510030

AAMP:

119810782(Ube4a)

NGI:	103748300(Ube4a)

HGL:	101711837(Ube4a)

CPOC:

100726213(Ube4a)

CCAN:

109689974(Ube4a)

DORD:

105980788(Ube4a)

DSP:	122110343(Ube4a)

DMER:

138810767 138838984

PLOP:

125349621(Ube4a)

NCAR:

124958634

MMMA:

107145808(Ube4a)

ITI:	101959529 101970846

OCU:

100353223

OPI:	101530108(UBE4A)

TUP:	102497795(UBE4A)

GVR:	103592272(UBE4A)

CFA:	479418(UBE4A)

CLUD:

112671245(UBE4A)

VVP:	112920350(UBE4A)

VLG:	121500041(UBE4A)

NPO:	129496994(UBE4A)

AML:	100482208(UBE4A)

UMR:	103662334(UBE4A)

UAH:	113259998(UBE4A)

UAR:	123792620(UBE4A)

ELK:

111153725

LLV:

125078231

MPUF:

101676881(UBE4A)

MNP:	132027451(UBE4A)

MLK:	131836626(UBE4A)

NVS:	122912330(UBE4A)

ORO:	101386558(UBE4A)

EJU:	114211287(UBE4A)

ZCA:	113914093(UBE4A)

MLX:	118013280(UBE4A)

NSU:	110586136(UBE4A)

LWW:	102730475(UBE4A)

FCA:	101089796(UBE4A)

PYU:	121035467(UBE4A)

PCOO:

112865264(UBE4A)

PBG:	122483029(UBE4A)

PVIV:

125176517(UBE4A)

LRUF:

124504767

LGF:	123600740(UBE4A)

AJU:

106966113

PTG:	102967583(UBE4A)

PPAD:

109278558(UBE4A)

PUC:

125909369

PLEZ:

122199143(UBE4A)

HHV:	120229980(UBE4A)

BTA:	517544(UBE4A)

BOM:	102272004(UBE4A)

BIU:	109569531(UBE4A)

BBUB:

102416155(UBE4A)

BBIS:

104981368(UBE4A)

CHX:	102191718(UBE4A)

OAS:	101123231(UBE4A)

BTAX:

128060287(UBE4A)

CSUM:

138093277(UBE4A)

ODA:	120876321(UBE4A)

CCAD:

122449590(UBE4A)

MREE:

136176074(UBE4A)

OVR:	110133008(UBE4A)

MBEZ:

129554382(UBE4A)

SSC:	100513674(UBE4A)

CFR:	102518317(UBE4A)

CBAI:

105067816(UBE4A)

CDK:	105090169(UBE4A)

VPC:	102542076(UBE4A)

BACU:

103004305(UBE4A)

BMUS:

118899212(UBE4A)

LVE:	103069089(UBE4A)

OOR:	101279060(UBE4A)

LALB:

132526348(UBE4A)

GMF:	115842852(UBE4A)

DDP:	132429493(UBE4A)

DLE:	111166883(UBE4A)

PCAD:

102980334(UBE4A)

PSIU:

116757824(UBE4A)

PPHC:

136126361(UBE4A)

NASI:

112403947(UBE4A)

ECB:	100062986(UBE4A)

EPZ:	103546673(UBE4A)

EAI:	106840279(UBE4A)

MYB:	102239630(UBE4A)

MYD:	102754148(UBE4A)

MMYO:

118664235(UBE4A)

MLF:	102436214(UBE4A)

MDT:	132240480(UBE4A)

MYUM:

139017563(UBE4A)

PKL:	118710558(UBE4A)

EFUS:

103293738(UBE4A)

MNA:	107530800(UBE4A)

DRO:	112314185(UBE4A)

SHON:

118994759(UBE4A)

AJM:	119050764(UBE4A)

PDIC:

114500577(UBE4A)

PHAS:

123818065(UBE4A)

MMF:	118627532(UBE4A)

PPAM:

129085930(UBE4A)

HAI:	109385287(UBE4A)

RFQ:	117029902(UBE4A)

PALE:

102893988(UBE4A)

PGIG:

120622051(UBE4A)

PVP:	105310194(UBE4A)

RAY:	107502261(UBE4A)

MJV:	108385111(UBE4A)

TOD:	119240724(UBE4A)

SARA:

101546185(UBE4A)

SFUM:

130016914(UBE4A)

SETR:

126015588(UBE4A)

LAV:	100655010(UBE4A)

TMU:

101352481

ETF:	101656218(UBE4A)

DNM:	101412024(UBE4A)

MDO:	100025132(UBE4A)

GAS:	123242098(UBE4A)

SHR:	100918276(UBE4A)

PCW:	110207188(UBE4A)

TVP:	118840064(UBE4A)

PBRV:

138145063(UBE4A)

MLAO:

141507488(UBE4A)

OAA:	100090840(UBE4A)

TACU:

119934315(UBE4A)

GGA:	419758(UBE4A)

PCOC:

116233139(UBE4A)

MGP:	100540968(UBE4A)

CJO:	107324136(UBE4A)

TPAI:

128087483(UBE4A)

LMUT:

125703651(UBE4A)

NMEL:

110387547(UBE4A)

APLA:

101801554(UBE4A)

ACYG:

125182758(UBE4A)

CATA:

118252555(UBE4A)

AFUL:

116497847(UBE4A)

TGU:	100219555(UBE4A)

LSR:	110470424(UBE4A)

SCAN:

103822785(UBE4A)

PMOA:

120508376(UBE4A)

OTC:	121340747(UBE4A)

PRUF:

121348498(UBE4A)

ATRC:

139600990(UBE4A)

GFR:	102043864(UBE4A)

FAB:	101811483(UBE4A)

OMA:	130262433(UBE4A)

PHI:	102110358(UBE4A)

PMAJ:

107214458(UBE4A)

CCAE:

111939214(UBE4A)

CCW:	104692050(UBE4A)

CBRC:

103618626(UBE4A)

ACOE:

138098244(UBE4A)

ETL:	114056308(UBE4A)

ZAB:	102060586(UBE4A)

ZLE:	135457422(UBE4A)

ACHL:

103805494(UBE4A)

SVG:	106858189(UBE4A)

MMEA:

130581101(UBE4A)

HRT:	120762547(UBE4A)

SATI:

136371019(UBE4A)

CCIC:

134053587(UBE4A)

FPG:	101912930(UBE4A)

FCH:	102055709(UBE4A)

CCRI:

104157227(UBE4A)

NNT:	104405306(UBE4A)

SHAB:

115616431(UBE4A)

ACUN:

113488588(UBE4A)

TALA:

104365182(UBE4A)

ACHC:

115344883(UBE4A)

HALD:

104322353(UBE4A)

HLE:	104836375(UBE4A)

AGEN:

126038115

HHAR:

128140279(UBE4A)

GCL:

127025844

CSTI:

104552771(UBE4A)

MNB:	103782366(UBE4A)

DPUB:

104307282(UBE4A)

PPUS:

135191071(UBE4A)

AVIT:

104267084(UBE4A)

BRHI:

104501362(UBE4A)

EGZ:	104135367(UBE4A)

NNI:	104018512(UBE4A)

PCRI:

104029488(UBE4A)

PCAO:

104047262(UBE4A)

PADL:

103916552(UBE4A)

AFOR:

103894339(UBE4A)

FGA:	104080829(UBE4A)

GSTE:

104262605(UBE4A)

CBOY:

140661789(UBE4A)

CLV:	102090825(UBE4A)

CNIC:

135998807(UBE4A)

MUI:	104533263(UBE4A)

PGUU:

104465867(UBE4A)

PLET:

104628441(UBE4A)

CUCA:

104068681(UBE4A)

TEO:	104383766(UBE4A)

BREG:

104639044(UBE4A)

OHA:	104338119(UBE4A)

ACAR:

104528383(UBE4A)

CVF:	104296108(UBE4A)

RTD:	128918753(UBE4A)

CRID:

134524936(UBE4A)

AAM:	106485171(UBE4A)

AROW:

112962041(UBE4A)

NPD:	112948081(UBE4A)

TGT:	104580924(UBE4A)

DNE:	112991645(UBE4A)

SCAM:

104141012(UBE4A)

ASN:	102381774(UBE4A)

AMJ:	102568388(UBE4A)

CPOO:

109315398(UBE4A)

GGN:	109293931(UBE4A)

PSS:	102463884(UBE4A)

CMY:	102936220(UBE4A)

CCAY:

125625338(UBE4A)

DCC:	119846729(UBE4A)

CPIC:

101940751(UBE4A)

TST:	117868541(UBE4A)

CABI:

116822943(UBE4A)

MRV:	120375576(UBE4A)

ACS:	100560942(ube4a)

ASAO:

132782332(UBE4A)

PVT:	110079187(UBE4A)

SUND:

121935433(UBE4A)

PBI:	103064429(UBE4A)

PMUR:

107284804(UBE4A)

CTIG:

120307248(UBE4A)

TSR:	106540656(UBE4A)

PGUT:

117670186(UBE4A)

PCAE:

139323268(UBE4A)

APRI:

131203835(UBE4A)

PTEX:

113441852(UBE4A)

NSS:	113420880(UBE4A)

VKO:	123020244(UBE4A)

PMUA:

114585240(UBE4A)

PRAF:

128402516(UBE4A)

ZVI:	118097066(UBE4A)

HCG:	128333634(UBE4A)

GJA:	107112549(UBE4A)

STOW:

125442026(UBE4A)

EMC:	129342612(UBE4A)

XLA:	108696459(ube4a.L) 414451(ube4a.S)

XTR:	100101757(ube4a)

NPR:	108795004(UBE4A)

RTEM:

120915164(UBE4A)

ACAT:

141110824(UBE4A)

BBUF:

120995996(UBE4A)

BGAR:

122928718(UBE4A)

DTC:	141097812(UBE4A)

PWL:	138285151(UBE4A)

MUO:	115481639(UBE4A)

GSH:	117347499(UBE4A)

DRE:	557121(ube4a)

SRX:	107718272 107743704

SANH:

107683820 107690452

SGH:	107585600 107601729(ube4a)

CCAR:

109103207 109103208(ube4a)

CAUA:

113058441 113115072

CGIB:

127972681 128029224

PTET:

122359300(ube4a)

LROH:

127177150(ube4a)

GRF:	141285447(ube4a)

OMC:	131520460(ube4a)

PPRM:

120478576(ube4a)

RKG:	130096739(ube4a)

MAMB:

125249732(ube4a)

CIDE:

127496119

CERY:

137004404(ube4a)

MASI:

127422139 127430084

TROS:

130564370(ube4a)

TDW:	130428965(ube4a)

MANU:

129437999(ube4a)

PDAB:

135771105(ube4a)

IPU:

108277663

IFU:	128620983(ube4a)

PHYP:

113533006(ube4a)

SMEO:

124394450(ube4a)

TFD:	113660502(ube4a)

TVC:	132857639(ube4a)

CGAR:

128533179(ube4a)

NGRA:

132901459(ube4a)

TRN:	134334134(ube4a)

AMEX:

103036005(ube4a)

CMAO:

118800807(ube4a)

EEE:	113579451(ube4a)

CHAR:

105893752(ube4a)

SPIL:

134065794(ube4a)

TRU:	101074716(ube4a)

TFS:	130535397(ube4a)

TNG:	GSTEN00035708G001

LCO:	104936480(ube4a)

NCC:	104965387(ube4a)

TBEN:

117470346(ube4a)

CGOB:

115018040(ube4a)

PGEO:

117457286(ube4a)

GACU:

117552269(ube4a)

EMAC:

134880321(ube4a)

ELY:	117259955(ube4a)

EFO:	125888608(ube4a)

PLEP:

121943110(ube4a)

SLUC:

116047988(ube4a)

ECRA:

117942002(ube4a)

ESP:	116683111(ube4a)

PFLV:

114552784(ube4a)

GAT:	120823621(ube4a)

PPUG:

119215039(ube4a)

AFB:	129092570(ube4a)

CLUM:

117741363(ube4a)

PSWI:

130210994(ube4a)

CANA:

137790701(ube4a)

CVE:	137872373(ube4a)

MSAM:

119882940(ube4a)

SCHU:

122879114(ube4a)

CUD:	121521423(ube4a)

SPUL:

138597306(ube4a)

LMIX:

132980397(ube4a)

ALAT:

119008670(ube4a)

ASTR:

137597055(ube4a)

MZE:	101468844(ube4a)

ONL:	100711218(ube4a)

OAU:	116328175(ube4a)

OLA:	101166405(ube4a)

OML:	112149670(ube4a)

CSAI:

133441737(ube4a)

XMA:	102227336(ube4a)

XCO:	114133382(ube4a)

XHE:	116708138(ube4a)

PRET:

103474565(ube4a)

PFOR:

103155204(ube4a)

PLAI:

106957250(ube4a)

PMEI:

106908739(ube4a)

GAF:	122833183(ube4a)

PPRL:

129359149(ube4a)

CVG:	107088307(ube4a)

CTUL:

119782828(ube4a)

GMU:	124884240(ube4a)

NFU:	107380360(ube4a)

KMR:	108246036(ube4a)

ALIM:

106533990(ube4a)

NWH:	119410607(ube4a)

AOCE:

111579797(ube4a)

EJA:	138197304(ube4a)

BFRE:

138616133(ube4a)

MCEP:

125013821(ube4a)

CSEM:

103378136(ube4a)

POV:	109630367(ube4a)

SSEN:

122760616(ube4a)

SSOE:

131462910(ube4a)

HHIP:

117772949(ube4a)

HSP:	118106209(ube4a)

PPLT:

128440116(ube4a)

SMAU:

118299903(ube4a)

LCF:

108886383

SDU:	111228033(ube4a)

SLAL:

111650933(ube4a)

XGL:	120792346(ube4a)

HCQ:	109529393(ube4a)

SSCV:

125972872(ube4a)

SBIA:

133505109(ube4a)

PEE:	133405088(ube4a)

PTAO:

133482155(ube4a)

BPEC:

110154063(ube4a)

ENY:	140377468(ube4a)

MALB:

109960200(ube4a)

BSPL:

114868426(ube4a)

SJO:	128360347(ube4a)

SSCO:

133980722(ube4a)

GMH:	115561526(ube4a)

SASA:

106612478(ube4a)

STRU:

115162945 115205899

OTW:	112244676 112266727

OMY:	110503545 110507388

OGO:	124006001(ube4a) 124021787

ONE:	115137114 115141499

OKI:	109905388 109908870

OKE:	118386244 118397095

OMM:	135546070 135552541

OCLA:

139382770 139386101

SALP:

111949702 111960555(ube4a)

SNH:	120018421 120028666

CCLU:

121560717 121567357

ELS:	105011720(ube4a)

OEP:	134028910(ube4a)

SFM:	108936266(ube4a)

PKI:	111846263(ube4a)

AANG:

118210381(ube4a)

AROT:

135236254(ube4a)

CCOG:

133107295(ube4a)

LOC:	102695041(ube4a)

PSPA:

121309408(ube4a)

ARUT:

117397220 117966539

PSEX:

120536066(ube4a)

LCM:	102349133(UBE4A)

CMK:	103180334(ube4a)

RTP:	109935608(ube4a)

CPLA:

122540589(ube4a)

HOC:	132829465(ube4a)

LERI:

129712256(ube4a)

HAKA:

140716898(ube4a)

PMRN:

116948125(UBE4A)

LRJ:	133342041(UBE4A)

CIN:

SCLV:

SPU:

LPIC:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:

PFLL:

DME:	Dmel_CG11070(Ube4A)

DER:

6542188

DSE:

6611418

DSI:	Dsimw501_GD23424(Dsim_GD23424)

DYA:	Dyak_GE14044

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI17728

DAZ:

108610811

DNV:

108649426

DHE:

111598785

DVI:	6627292(Ube4A)

CCAT:

BOD:

BDR:

RZE:

AOQ:

ALUD:

TDA:

MDE:

LCQ:

LSQ:

CVJ:	135951046(Ube4A)

GFS:

ECOE:

CLON:

HIS:

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ001165

CPII:

CBRI:

CNS:

BCOO:

LLL:

PPAP:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

ACOC:

MZT:	108722184(Ube4A)

CCOA:

108777930

PBAR:

105426543

VEM:

105556993

COBS:

139110644(Ube4a)

TLN:	139821509(Ube4a)

HST:

DQU:

CFO:

FEX:

PMEC:

138939324(Ube4a)

LHU:	105673568(Ube4A)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

MDL:

FAS:

DAM:

AGIF:

VCAN:

CCIN:

NPT:	124219883(Ube4A)

NFB:

NLO:

NVG:

AROA:

TCA:

TMOL:

138125182(Ube4A)

DPA:

109538857

ESIM:

136411398(Ube4A)

EFOR:

136349427(Ube4A)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:

LDC:

DVV:

NVL:

APLN:

PPYR:

BMOR:

BMAN:

MSEX:

DPL:	KGM_206462

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PPOT:

PXU:

BPHI:

137933327(Ube4A)

PRAP:

110992340

PBX:

123710469

PNAP:

125054179

ZCE:	119830811 119830812

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

141436849(Ube4A)

CFEL:

CCRN:

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

106686104(Ube4A)

NLU:

111046474

HVI:

124367360

MQU:

129004474

PHU:	Phum_PHUM438080

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138701327(Ube4A)

SGRE:

126350006

BROR:

134530287

IEL:

124158863

HAMR:

139685472(Ube4A)

DPX:	DAPPUDRAFT_56866

DMK:

116928361

DPZ:	124328493 124340490

AFRA:

136026079

PVM:	113812422(Ube4A)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

123775045(Ube4A)

CQD:	128694109(Ube4A)

PTRU:

123514748

ESN:

126982740

MNZ:

135198559

MRJ:	136833421(Ube4A)

PORN:

139758994(Ube4A)

HAZT:

108677290

EAF:

111697430

LSM:	121130551(Ube4A)

TCF:

PPOI:

ISC:

DSV:

RSAN:

RMP:

VDE:

VJA:

GOE:

DPTE:

DFR:

CSCU:

CVS:	136981013(Ube4A)

PTEP:

ABRU:

UDV:

SDM:

LPOL:

PMEO:

LGI:	LOTGIDRAFT_210561

PVUL:

PCAN:

LSAX:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:	111120881 111121932

OED:

MYI:

PMAX:

AIRR:

MCAF:

MMER:

123563504 123564122 123564123

RPHI:

DPOL:

MAEA:

OBI:

OSN:

LJP:

LAK:

SMM:	Smp_030780

SHX:	MS3_00008628(UBE4A)

OVI:	T265_03542

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_60429

AQU:

100641431

» show all

Reference

PMID:18069675

Authors

Sakiyama T, Fujita H, Tsubouchi H

Title

Autoantibodies against ubiquitination factor E4A (UBE4A) are associated with severity of Crohn's disease.

Journal

Inflamm Bowel Dis 14:310-7 (2008)
DOI:10.1002/ibd.20328

Sequence

[hsa:9354]

All links

Gene (2216)   
   MGENES (503)   
   RefGene (1710)   
   OC (3)   
All databases (2216)   

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