KEGG   ORTHOLOGY: K10609Help
Entry
K10609                      KO                                     

Name
CUL4
Definition
cullin 4
Pathway
ko03420  Nucleotide excision repair
ko04120  Ubiquitin mediated proteolysis
Module
M00385  Cul4-DDB1-DDB2 complex
M00386  Cul4-DDB1-CSA complex
Disease
H00658  Syndromic X-linked mental retardation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K10609  CUL4; cullin 4
  09124 Replication and repair
   03420 Nucleotide excision repair
    K10609  CUL4; cullin 4
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10609  CUL4; cullin 4
   03400 DNA repair and recombination proteins
    K10609  CUL4; cullin 4
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K10609  CUL4; cullin 4
KEGG modules [BR:ko00002]
 Structural complex
  Genetic information processing
   Ubiquitin system
    M00385  Cul4-DDB1-DDB2 complex
     K10609  CUL4; cullin 4
    M00386  Cul4-DDB1-CSA complex
     K10609  CUL4; cullin 4
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   Cul4 complex
    Cullin
     K10609  CUL4; cullin 4
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic Type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    GGR (global genome repair) factors
     Cul4-DDB2 complex
      K10609  CUL4; cullin 4
    TCR (transcription coupled repair) factors
     Cul4-CSA complex
      K10609  CUL4; cullin 4
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K10609  CUL4; cullin 4
BRITE hierarchy
Genes
HSA: 8450(CUL4B) 8451(CUL4A)
PTR: 107968010(CUL4A) 465835(CUL4B)
PPS: 100971038(CUL4B) 100986425(CUL4A)
GGO: 101139272(CUL4A) 101153028(CUL4B)
PON: 100440815(CUL4B) 100453992(CUL4A)
NLE: 100579811(CUL4A) 100592746(CUL4B)
MCC: 696410(CUL4B) 714302(CUL4A)
MCF: 102120603(CUL4B) 102125306(CUL4A)
CSAB: 103214836(CUL4A) 103247359(CUL4B)
RRO: 104655318(CUL4B) 104659902(CUL4A)
RBB: 108521807(CUL4A) 108522824 108534998(CUL4B)
CJC: 100394843(CUL4B) 100411111(CUL4A)
SBQ: 101028075(CUL4B) 101049379(CUL4A)
MMU: 72584(Cul4b) 99375(Cul4a)
RNO: 302502(Cul4b) 361181(Cul4a)
CGE: 100760883(Cul4a) 100763989(Cul4b) 100767300
NGI: 103734860(Cul4b) 103746287(Cul4a)
HGL: 101703310(Cul4a) 101711205(Cul4b)
CCAN: 109686927(Cul4a) 109692327(Cul4b)
OCU: 100351102(CUL4B) 100354247(CUL4A)
TUP: 102483313(CUL4A) 102491948(CUL4B)
CFA: 492102(CUL4B) 607683(CUL4A)
AML: 100470988(CUL4A) 100475326(CUL4B)
UMR: 103657525(CUL4A) 103680235(CUL4B)
ORO: 101367397(CUL4A) 101378186(CUL4B) 101378994
FCA: 101091076(CUL4A) 677873(CUL4B)
AJU: 106986119(CUL4B) 106986708(CUL4A) 106989859
BTA: 539668(CUL4B) 617935(CUL4A)
BOM: 102272968(CUL4A) 102281513(CUL4B)
BIU: 109555249(CUL4B) 109567103(CUL4A)
PHD: 102320888(CUL4A) 102327165(CUL4B)
CHX: 102175217(CUL4A) 102190766(CUL4B)
OAS: 101113913(CUL4B) 101119145(CUL4A)
SSC: 100513454(CUL4B) 100517912(CUL4A)
CFR: 102519353(CUL4A) 102520399(CUL4B)
CDK: 105091340(CUL4A) 105098890(CUL4B)
BACU: 103003114(CUL4B) 103005631(CUL4A)
LVE: 103073348(CUL4A) 103087771(CUL4B)
OOR: 101277202(CUL4A) 101287963(CUL4B)
ECB: 100033930(CUL4A) 100033938(CUL4B)
EPZ: 103549668(CUL4A) 103561722 103564256(CUL4B)
EAI: 106824850(CUL4B) 106827203 106848185(CUL4A)
MYB: 102244215(CUL4B) 102247731(CUL4A)
MYD: 102759962(CUL4B) 102763819(CUL4A)
HAI: 109377059(CUL4B) 109383928(CUL4A)
PALE: 102883045(CUL4A) 102892859(CUL4B)
LAV: 100656882(CUL4A) 100660215(CUL4B)
MDO: 100016493(CUL4A) 100020368(CUL4B)
SHR: 100920722(CUL4A) 100933866(CUL4B)
OAA: 100078785(CUL4A) 100079138(CUL4B)
GGA: 418744(CUL4A) 422364(CUL4B)
MGP: 100542698(CUL4B) 100549149(CUL4A)
CJO: 107306306(CUL4A) 107312915(CUL4B)
APLA: 101795785(CUL4B) 101797069(CUL4A)
ACYG: 106038578(CUL4B) 106046445(CUL4A)
TGU: 100221731(CUL4B) 100225644(CUL4A)
GFR: 102039065(CUL4B) 102045394(CUL4A)
FAB: 101805658(CUL4B) 101820105(CUL4A)
PHI: 102112844(CUL4A) 102113382(CUL4B)
PMAJ: 107202655(CUL4A) 107203802(CUL4B)
CCW: 104686109(CUL4A) 104694437(CUL4B)
FPG: 101910426(CUL4B) 101923321(CUL4A)
FCH: 102052151(CUL4A) 102059042(CUL4B)
CLV: 102089059(CUL4B) 102094418(CUL4A)
EGZ: 104124096(CUL4B) 104132460(CUL4A)
AAM: 106487543(CUL4B) 106493949(CUL4A)
ASN: 102371527(CUL4A) 102373742(CUL4B)
AMJ: 102569442(CUL4A) 106736817(CUL4B)
PSS: 102451715(CUL4B) 102462888(CUL4A)
CMY: 102932602(CUL4A) 102938840(CUL4B)
CPIC: 101934462(CUL4B) 101937389(CUL4A)
ACS: 100559251(cul4a) 100564485(cul4b)
PVT: 110074107(CUL4A) 110089988(CUL4B)
PBI: 103054675(CUL4B)
GJA: 107110927(CUL4A) 107123738(CUL4B)
XLA: 100158294(cul4a.S) 108698360 108708452 735163(cul4b.S)
XTR: 100151714(cul4b) 548647(cul4a)
NPR: 108789938(CUL4B) 108791700(CUL4A)
DRE: 394002(cul4a) 560313(cul4b)
IPU: 108258603(cul4a) 108269011(cul4b)
AMEX: 103047305(cul4a) 103047409(cul4b) 111188264
TRU: 101061504(cul4a) 101078550(cul4b)
LCO: 104920003(cul4a)
NCC: 104941332(cul4b) 104958718(cul4a)
MZE: 101482497(cul4b) 101485787
OLA: 101154851 101161413(cul4b)
XMA: 102236511(cul4a) 102237253(cul4b)
PRET: 103461975(cul4a) 103471554(cul4b)
NFU: 107377978(cul4b) 107381630(cul4a)
LCF: 108888006(cul4a) 108895402
HCQ: 109518745(cul4b) 109524525(cul4a)
BPEC: 110158854(cul4b) 110173102(cul4a)
ELS: 105020052(cul4a) 105025584(cul4b)
SFM: 108923190(cul4b) 108930986 108938617(cul4a)
LCM: 102353120(CUL4A) 102362429(CUL4B)
CMK: 103178581(cul4b) 103185525(cul4a)
CIN: 100175879(cul4a)
SPU: 592454
APLC: 110986006
SKO: 100373891
DME: Dmel_CG8711(Cul4)
DSI: Dsimw501_GD27026(Dsim_GD27026)
MDE: 101891962
AAG: 5578219
AME: 409279
BIM: 100740815
BTER: 100642213
SOC: 105201760
AEC: 105151481
ACEP: 105620001
PBAR: 105425267
HST: 105187248
CFO: 105252787
LHU: 105679571
PGC: 109857793
NVI: 100119803
TCA: 100141956
NVL: 108569081
BMOR: 101741946
PMAC: 106715992
PRAP: 110995734
API: 100163374
DNX: 107166551
ZNE: 110841214
FCD: 110844599
TUT: 107363745
CEL: CELE_F45E12.3(cul-4)
CBR: CBG13132(Cbr-cul-4)
BMY: Bm1_25235
MYI: 110441382
OBI: 106870643
LAK: 106180270
SHX: MS3_07720
EPA: 110236089
ADF: 107352081
HMG: 100199190
AQU: 105312296
CIT: 102612108
TCC: 18596492
EGR: 104444840
VRA: 106775868
VAR: 108343138
CCAJ: 109815299
CAM: 101512663
LJA: Lj6g3v1946230.1(Lj6g3v1946230.1)
FVE: 105350254
PPER: 18780724
PMUM: 103325198
PAVI: 110774021
PXB: 103951281
CSV: 101203512
CMO: 103487708
MCHA: 111010756
RCU: 8264103
JCU: 105633998
VVI: 100233055(CUL4)
SLY: 101248739 544135(cul4)
NSY: 104211991
NTO: 104094909
DCR: 108208987
BVG: 104883798
SOE: 110792205
OSA: 4334354
DOSA: Os03t0786800-01(Os03g0786800)
OBR: 102702831
BDI: 100834237
ATS: 109764931(LOC109764931)
SBI: 8084141
SITA: 101764039
DCT: 110112158
ATR: 18427318
SMO: SELMODRAFT_172620(CUL4-1) SELMODRAFT_180735(CUL4-2)
CRE: CHLREDRAFT_133199(CUL2)
MNG: MNEG_4938
APRO: F751_2615
PIC: PICST_80515(CUL4)
CAL: CAALFM_C106040WA(RTT101)
SLB: AWJ20_4881(CUL3)
NCR: NCU00272(cul-4)
NTE: NEUTE1DRAFT146458(NEUTE1DRAFT_146458)
MGR: MGG_14763
MAW: MAC_02547
MAJ: MAA_03473
CMT: CCM_07554
MBE: MBM_07035
CIM: CIMG_12322(CIMG09298)
ABE: ARB_03385
TVE: TRV_08069
PNO: SNOG_16062(SNOG_16061)
PTE: PTT_12369
SPO: SPAC3A11.08(pcu4)
ABP: AGABI1DRAFT69105(AGABI1DRAFT_69105)
ABV: AGABI2DRAFT217067(AGABI2DRAFT_217067)
MGL: MGL_0054
DDI: DDB_G0292794(culD)
DFA: DFA_00338(culD)
EHI: EHI_148160(1.t00141)
BBO: BBOV_III001760(17.m10479)
PTI: PHATRDRAFT_44571(CUL1_2)
SPAR: SPRG_01614
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Higa LA, Yang X, Zheng J, Banks D, Wu M, Ghosh P, Sun H, Zhang H
  Title
Involvement of CUL4 ubiquitin E3 ligases in regulating CDK inhibitors Dacapo/p27Kip1 and cyclin E degradation.
  Journal
Cell Cycle 5:71-7 (2006)
DOI:10.4161/cc.5.1.2266
  Sequence
[hsa:8450]
Reference
  Authors
Wang H, Zhai L, Xu J, Joo HY, Jackson S, Erdjument-Bromage H, Tempst P, Xiong Y, Zhang Y
  Title
Histone H3 and H4 ubiquitylation by the CUL4-DDB-ROC1 ubiquitin ligase facilitates cellular response to DNA damage.
  Journal
Mol Cell 22:383-94 (2006)
DOI:10.1016/j.molcel.2006.03.035
  Sequence
[hsa:8450 8451]
Reference
  Authors
Guerrero-Santoro J, Kapetanaki MG, Hsieh CL, Gorbachinsky I, Levine AS, Rapic-Otrin V
  Title
The cullin 4B-based UV-damaged DNA-binding protein ligase binds to UV-damaged chromatin and ubiquitinates histone H2A.
  Journal
Cancer Res 68:5014-22 (2008)
DOI:10.1158/0008-5472.CAN-07-6162
  Sequence
[hsa:8450]

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