KEGG   ORTHOLOGY: K10630Help
Entry
K10630                      KO                                     

Name
RBCK1, HOIL1
Definition
RanBP-type and C3HC4-type zinc finger-containing protein 1 [EC:2.3.2.31]
Pathway
ko04217  Necroptosis
ko04621  NOD-like receptor signaling pathway
Disease
H01744  Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.31  RBR-type E3 ubiquitin transferase
     K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   RBR proteins
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
  Multi subunit Ring-finger type E3
   LUBAC complex
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
BRITE hierarchy
Genes
HSA: 10616(RBCK1)
PTR: 458025(RBCK1)
PPS: 100981890(RBCK1)
GGO: 101147960(RBCK1) 109025247
PON: 100438712(RBCK1)
NLE: 100603577(RBCK1)
MCC: 714692(RBCK1)
MCF: 102126740(RBCK1)
CSAB: 103247827(RBCK1)
RRO: 104660808(RBCK1)
RBB: 108544535(RBCK1)
CJC: 100411512(RBCK1)
SBQ: 101038299(RBCK1)
MMU: 24105(Rbck1)
RNO: 60383(Rbck1)
CGE: 100761016(Rbck1)
NGI: 103751631(Rbck1)
HGL: 101721667(Rbck1)
CCAN: 109687017(Rbck1)
OCU: 100347560(RBCK1)
TUP: 102473168(RBCK1)
CFA: 485818(RBCK1)
AML: 100471387(RBCK1)
UMR: 103674489(RBCK1)
ORO: 101374350(RBCK1)
FCA: 101083505(RBCK1)
PTG: 102970756(RBCK1)
AJU: 106985976(RBCK1)
BTA: 504400(RBCK1)
BOM: 102280624(RBCK1)
BIU: 109567335(RBCK1)
PHD: 102333071(RBCK1)
CHX: 102181220(RBCK1)
OAS: 101122207(RBCK1)
SSC: 100519985(RBCK1)
CFR: 102513471(RBCK1)
CDK: 105100807(RBCK1)
BACU: 103000245(RBCK1)
LVE: 103084814(RBCK1)
OOR: 101285270(RBCK1)
ECB: 100067987(RBCK1)
EPZ: 103556916(RBCK1)
EAI: 106833755(RBCK1)
MYB: 102252422(RBCK1)
MYD: 102759068(RBCK1)
HAI: 109384455(RBCK1)
RSS: 109460116(RBCK1)
PALE: 102884021(RBCK1)
LAV: 100654220(RBCK1)
TMU: 101349597
MDO: 100011102(RBCK1)
SHR: 100919033(RBCK1)
MGP: 104915434(RBCK1)
CJO: 107307646
APLA: 101791176
ACYG: 106049457
FAB: 101820455
PHI: 102106906(SHARPIN)
FPG: 101917453(SHARPIN)
FCH: 102047647(SHARPIN)
CLV: 106146052
ASN: 102374341(SHARPIN) 102381829(RBCK1)
AMJ: 102558277 102565394(RBCK1)
CMY: 102933957(RBCK1)
CPIC: 101952313(SHARPIN) 101954121(RBCK1)
ACS: 100562899(rbck1) 100564158(sharpin)
PVT: 110084806 110090830(RBCK1)
GJA: 107117859(SHARPIN) 107119331(RBCK1)
XTR: 100491300(rbck1)
NPR: 108802101(RBCK1)
DRE: 431715(rbck1) 569903(shrprbck1r)
IPU: 108255080(rbck1) 108268220
AMEX: 103029459 103044240(rbck1)
TRU: 101064989 101070545(rbck1)
NCC: 104941376 104946202(rbck1)
MZE: 101476206 101485343(rbck1)
XMA: 102226939 102234963(rbck1)
PRET: 103482437 108166280(rbck1)
HCQ: 109511977 109521524(rbck1)
SASA: 100194956(ub7i3) 106590417
ELS: 105017073(rbck1) 105019569
LCM: 102349730(SHARPIN) 102349954(RBCK1)
CMK: 103179690(sharpin) 103188626(rbck1)
CIN: 100169995(zf(ring/rbz)-1)
SPU: 592806
APLC: 110974755
AAG: 5568606
AME: 410462(GB17157)
BIM: 100744318
BTER: 100645959
SOC: 105194710
AEC: 105151339
ACEP: 105618461
PBAR: 105422878
HST: 105182285
CFO: 105255569
LHU: 105676353
PGC: 109853085
NVI: 100116938
TCA: 663202
DPA: 109542344
NVL: 108561039
BMOR: 101741592
PMAC: 106713327
PRAP: 110998073
API: 100168362
DNX: 107163184
ZNE: 110833674
TUT: 107367038
CRG: 105321103
OBI: 106879872
EPA: 110245865
ADF: 107358878
HMG: 100206370
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Zhang M, Tian Y, Wang RP, Gao D, Zhang Y, Diao FC, Chen DY, Zhai ZH, Shu HB
  Title
Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3.
  Journal
Cell Res 18:1096-104 (2008)
DOI:10.1038/cr.2008.277
Reference
  Authors
Yamanaka K, Ishikawa H, Megumi Y, Tokunaga F, Kanie M, Rouault TA, Morishima I, Minato N, Ishimori K, Iwai K
  Title
Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2.
  Journal
Nat Cell Biol 5:336-40 (2003)
DOI:10.1038/ncb952
  Sequence
[hsa:10616]

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