ORTHOLOGY: K10631 Help
Entry
Symbol
TOPORS
Name
E3 ubiquitin-protein ligase Topors [EC:
2.3.2.27 ]
Disease
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09180 Brite Hierarchies
09182 Protein families: genetic information processing
04121 Ubiquitin system
K10631 TOPORS; E3 ubiquitin-protein ligase Topors
03036 Chromosome and associated proteins
K10631 TOPORS; E3 ubiquitin-protein ligase Topors
09183 Protein families: signaling and cellular processes
03037 Cilium and associated proteins
K10631 TOPORS; E3 ubiquitin-protein ligase Topors
Enzymes [BR:ko01000 ]
2. Transferases
2.3 Acyltransferases
2.3.2 Aminoacyltransferases
2.3.2.27 RING-type E3 ubiquitin transferase
K10631 TOPORS; E3 ubiquitin-protein ligase Topors
Ubiquitin system [BR:ko04121 ]
Ubiquitin ligases (E3)
Single Ring-finger type E3
Other single Ring-finger type E3
K10631 TOPORS; E3 ubiquitin-protein ligase Topors
UBL E3 ligases
K10631 TOPORS; E3 ubiquitin-protein ligase Topors
Chromosome and associated proteins [BR:ko03036 ]
Eukaryotic type
Centrosome formation proteins
Centriole proteins
K10631 TOPORS; E3 ubiquitin-protein ligase Topors
Cilium and associated proteins [BR:ko03037 ]
Primary cilia and associated proteins
Other primary cilia associated proteins
K10631 TOPORS; E3 ubiquitin-protein ligase Topors
BRITE hierarchy
Other DBs
Genes
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Taxonomy UniProt
Reference
Authors
Chu D, Kakazu N, Gorrin-Rivas MJ, Lu HP, Kawata M, Abe T, Ueda K, Adachi Y
Title
Cloning and characterization of LUN, a novel ring finger protein that is highly expressed in lung and specifically binds to a palindromic sequence.
Journal
Sequence
Reference
Authors
Marshall H, Bhaumik M, Aviv H, Moore D, Yao M, Dutta J, Rahim H, Gounder M, Ganesan S, Saleem A, Rubin E
Title
Deficiency of the dual ubiquitin/SUMO ligase Topors results in genetic instability and an increased rate of malignancy in mice.
Journal
Sequence
Reference
Authors
Chakarova CF, Khanna H, Shah AZ, Patil SB, Sedmak T, Murga-Zamalloa CA, Papaioannou MG, Nagel-Wolfrum K, Lopez I, Munro P, Cheetham M, Koenekoop RK, Rios RM, Matter K, Wolfrum U, Swaroop A, Bhattacharya SS
Title
TOPORS, implicated in retinal degeneration, is a cilia-centrosomal protein.
Journal
Sequence
Reference
Authors
Lin L, Ozaki T, Takada Y, Kageyama H, Nakamura Y, Hata A, Zhang JH, Simonds WF, Nakagawara A, Koseki H
Title
topors, a p53 and topoisomerase I-binding RING finger protein, is a coactivator of p53 in growth suppression induced by DNA damage.
Journal
Sequence