KEGG ORTHOLOGY: K10693

ORTHOLOGY: K10693

Entry

K10693                      KO

Symbol

MYCBP2, PAM

Name

RCR-type E3 ubiquitin transferase [EC:2.3.2.33]

Pathway

map04361

Axon regeneration

Brite

KEGG Orthology (KO) [BR:ko00001]
09150 Organismal Systems
  09158 Development and regeneration
   04361 Axon regeneration
    K10693  MYCBP2, PAM; RCR-type E3 ubiquitin transferase
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10693  MYCBP2, PAM; RCR-type E3 ubiquitin transferase
Enzymes [BR:ko01000]
2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.33  RCR-type E3 ubiquitin transferase
     K10693  MYCBP2, PAM; RCR-type E3 ubiquitin transferase
Ubiquitin system [BR:ko04121]
Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    K10693  MYCBP2, PAM; RCR-type E3 ubiquitin transferase

Genes

HSA:	23077(MYCBP2)

PTR:	452608(MYCBP2)

PPS:	100984032(MYCBP2)

GGO:	101142597(MYCBP2)

PON:	100451266(MYCBP2)

NLE:	100581654(MYCBP2)

HMH:	116467497(MYCBP2)

MCC:	696734(MYCBP2)

MCF:	101867408(MYCBP2)

MTHB:

126940497

MNI:	105481778(MYCBP2)

CSAB:

103214597(MYCBP2)

CATY:

105597929(MYCBP2)

PANU:

101009741(MYCBP2)

TGE:	112610727(MYCBP2)

MLEU:

105554273(MYCBP2)

RRO:	104671175(MYCBP2)

RBB:	108516636(MYCBP2)

TFN:	117063665(MYCBP2)

PTEH:

111522156(MYCBP2)

CANG:

105520253(MYCBP2)

CJC:	100413363(MYCBP2)

SBQ:	101053013(MYCBP2)

CIMI:

108282823(MYCBP2)

CSYR:

103254969(MYCBP2)

MMUR:

105855857(MYCBP2)

LCAT:

123649302(MYCBP2)

PCOQ:

105804984(MYCBP2)

OGA:	100965082(MYCBP2)

MMU:	105689(Mycbp2)

MCAL:

110309324(Mycbp2)

MPAH:

110325255(Mycbp2)

RNO:	290447(Mycbp2)

MCOC:

116085304(Mycbp2)

ANU:	117705748(Mycbp2)

MUN:	110560794(Mycbp2)

CGE:	100763589(Mycbp2)

MAUA:

101827749(Mycbp2)

PROB:

127230123(Mycbp2)

PLEU:

114690201(Mycbp2)

MORG:

121462632(Mycbp2)

MFOT:

126503151

AAMP:

119800431(Mycbp2)

NGI:	103724869(Mycbp2)

HGL:	101712951(Mycbp2)

CPOC:

100726232(Mycbp2)

CCAN:

109687459 109687461

DORD:

105980304(Mycbp2)

DSP:	122112742(Mycbp2)

PLOP:

125348188(Mycbp2)

NCAR:

124984839

MMMA:

107153259(Mycbp2)

OCU:

100350249

OPI:	101522353(MYCBP2)

TUP:	102472161(MYCBP2)

GVR:	103588560(MYCBP2)

CFA:	476952(MYCBP2)

CLUD:

112655748(MYCBP2)

VVP:	112907184 112934310

VLG:	121476887(MYCBP2)

NPO:	129516386(MYCBP2)

AML:	100469795(MYCBP2)

UMR:	103659207(MYCBP2)

UAH:	113251431(MYCBP2)

UAR:	123801013(MYCBP2)

ELK:

111146914

LLV:

125094715

MPUF:

101692610(MYCBP2)

MNP:	132002776(MYCBP2)

MLK:	131814063(MYCBP2)

NVS:	122907162(MYCBP2)

ORO:	101376178(MYCBP2)

EJU:	114211543(MYCBP2)

ZCA:	113921027(MYCBP2)

MLX:	118009319(MYCBP2)

NSU:	110587605(MYCBP2)

LWW:	102750624(MYCBP2)

FCA:	101089233(MYCBP2)

PYU:	121037827(MYCBP2)

PCOO:

112860301(MYCBP2)

PBG:	122483640(MYCBP2)

PVIV:

125162475(MYCBP2)

LRUF:

124513066

PTG:	102972230(MYCBP2)

PPAD:

109264206(MYCBP2)

PUC:

125933879

AJU:

106965757

HHV:	120245403(MYCBP2)

BTA:	534496(MYCBP2)

BOM:	102265576(MYCBP2)

BIU:	109566887(MYCBP2)

BBUB:

102416199(MYCBP2)

BBIS:

104999578(MYCBP2)

CHX:	102190428(MYCBP2)

OAS:	101102993(MYCBP2)

BTAX:

128057836(MYCBP2)

ODA:	120883026(MYCBP2)

CCAD:

122447358(MYCBP2)

MBEZ:

129556432(MYCBP2)

SSC:	100156216(MYCBP2)

CFR:	102510373(MYCBP2)

CBAI:

105083657(MYCBP2)

CDK:	105103149(MYCBP2)

VPC:	102527240(MYCBP2)

BACU:

103016264(MYCBP2)

BMUS:

118884105(MYCBP2)

LVE:	103069781(MYCBP2)

OOR:	101289007(MYCBP2)

DLE:	111176477(MYCBP2)

PCAD:

102995571(MYCBP2)

PSIU:

116743054(MYCBP2)

NASI:

112405500(MYCBP2)

ECB:	100053014(MYCBP2)

EPZ:

103556062

EAI:	106843084(MYCBP2)

MYB:	102253398(MYCBP2)

MYD:	102761670(MYCBP2)

MMYO:

118649623(MYCBP2)

MLF:	102421448(MYCBP2)

PKL:	118728828(MYCBP2)

EFUS:

103288387(MYCBP2)

MNA:	107539858(MYCBP2)

DRO:	112312466(MYCBP2)

SHON:

118996124(MYCBP2)

AJM:	119047869(MYCBP2)

PDIC:

114508478(MYCBP2)

PHAS:

123818846(MYCBP2)

MMF:	118622279(MYCBP2)

PPAM:

129080923(MYCBP2)

HAI:	109389062(MYCBP2)

RFQ:	117021816(MYCBP2)

PALE:

102879756(MYCBP2)

PGIG:

120621519(MYCBP2)

PVP:	105304179(MYCBP2)

RAY:	107513073(MYCBP2)

MJV:	108404968(MYCBP2)

TOD:	119259908(MYCBP2)

SARA:

101546532(MYCBP2)

LAV:	100661251(MYCBP2)

TMU:

101355836

ETF:	101654526(MYCBP2)

DNM:	101434779(MYCBP2)

MDO:	100013024(MYCBP2)

GAS:	123242659(MYCBP2)

SHR:	100931136(MYCBP2)

AFZ:

127553327

PCW:	110198796(MYCBP2)

OAA:	100081768(MYCBP2)

GGA:	418808(MYCBP2)

PCOC:

116239268(MYCBP2)

MGP:	100545152(MYCBP2)

CJO:	107308046(MYCBP2)

TPAI:

128092196(MYCBP2)

LMUT:

125703269(MYCBP2)

NMEL:

110408390(MYCBP2)

APLA:

101790448(MYCBP2)

ACYG:

106043922(MYCBP2)

CATA:

118255219(MYCBP2)

AFUL:

116487061(MYCBP2)

TGU:	100224418(MYCBP2)

LSR:	110480244(MYCBP2)

SCAN:

103812272(MYCBP2)

PMOA:

120504803(MYCBP2)

OTC:	121344202(MYCBP2)

PRUF:

121355637(MYCBP2)

GFR:	102032331(MYCBP2)

FAB:	101817180(MYCBP2)

OMA:	130253038(MYCBP2)

PHI:	102102663(MYCBP2)

PMAJ:

107202200(MYCBP2)

CCAE:

111927766(MYCBP2)

CCW:	104695873(MYCBP2)

CBRC:

103624432(MYCBP2)

ETL:	114062623(MYCBP2)

ZAB:	102068990(MYCBP2)

ACHL:

103803051(MYCBP2)

SVG:	106849995(MYCBP2)

MMEA:

130573787(MYCBP2)

HRT:	120748754(MYCBP2)

FPG:	101918329(MYCBP2)

FCH:	102047786(MYCBP2)

CLV:	102096062(MYCBP2)

EGZ:	104127059(MYCBP2)

NNI:	104018833(MYCBP2)

PLET:

104622936

ACUN:

113480407(MYCBP2)

TALA:

104356944(MYCBP2)

PADL:

103923690(MYCBP2)

AFOR:

103900939(MYCBP2)

ACHC:

115350547(MYCBP2)

HLE:	104838346(MYCBP2)

AGEN:

126045180

GCL:

127023281

CSTI:

104550189(MYCBP2)

MUI:	104548329(MYCBP2)

BREG:

104636606(MYCBP2)

FGA:

104072385

LDI:

104350390

MNB:	103776402(MYCBP2)

OHA:	104336658(MYCBP2)

SHAB:

115603828(MYCBP2)

DPUB:

104310323(MYCBP2)

CPEA:

104393986(MYCBP2)

CVF:	104294427(MYCBP2)

RTD:	128912547(MYCBP2)

CUCA:

104064920

BRHI:

104498957(MYCBP2)

AAM:	106491626(MYCBP2)

AROW:

112971751(MYCBP2)

NPD:	112951751(MYCBP2)

TGT:	104570872(MYCBP2)

DNE:	112995711(MYCBP2)

SCAM:

104147473(MYCBP2)

ASN:	102370186(MYCBP2)

AMJ:	102567283(MYCBP2)

CPOO:

109305504(MYCBP2)

GGN:	109302262(MYCBP2)

PSS:	102460319(MYCBP2)

CMY:	102943545(MYCBP2)

CCAY:

125637725(MYCBP2)

DCC:	119841927(MYCBP2)

CPIC:

101938064(MYCBP2)

TST:	117870877(MYCBP2)

CABI:

116828231(MYCBP2)

MRV:	120389425(MYCBP2)

ACS:	100560904(mycbp2)

ASAO:

132771438(MYCBP2)

PVT:	110073859(MYCBP2)

SUND:

121927234(MYCBP2)

PBI:	103060974(MYCBP2)

PMUR:

107303127(MYCBP2)

CTIG:

120318201(MYCBP2)

TSR:	106547866(MYCBP2)

PGUT:

117665293(MYCBP2)

APRI:

131200083(MYCBP2)

PTEX:

113439429(MYCBP2)

NSS:	113415878(MYCBP2)

VKO:	123027233(MYCBP2)

PMUA:

114596589(MYCBP2)

PRAF:

128411960(MYCBP2)

ZVI:	118085426(MYCBP2)

HCG:	128349363(MYCBP2)

GJA:	107108913(MYCBP2)

STOW:

125431096(MYCBP2)

EMC:	129326703(MYCBP2)

XLA:	108708496(mycbp2.L) 447587(mycbp2.S)

XTR:	100379925(mycbp2)

NPR:	108794355(MYCBP2)

BGAR:

122930948(MYCBP2)

MUO:	115468682(MYCBP2)

GSH:	117362656(MYCBP2)

DRE:	368439(mycbp2)

SRX:	107728238(mycbp2) 107749028

SANH:

107664005 107670894

SGH:	107549765 107549904

CCAR:

109079135 109095686

CAUA:

113053452 113109035(mycbp2)

CGIB:

127965571 128019527

PTET:

122351391(mycbp2)

LROH:

127171304(mycbp2)

OMC:	131547410(mycbp2)

PPRM:

120487163(mycbp2)

RKG:	130086075(mycbp2)

MAMB:

125269903(mycbp2)

CIDE:

127518813

MASI:

127446741 127447813

TROS:

130556189(mycbp2)

TDW:	130427320(mycbp2)

MANU:

129451899(mycbp2)

IPU:

108266340

IFU:	128608803(mycbp2)

PHYP:

113524237(mycbp2)

SMEO:

124383197(mycbp2)

TFD:	113654589(mycbp2)

TVC:	132850174(mycbp2)

AMEX:

103045757(mycbp2)

CMAO:

118803685(mycbp2)

EEE:

113577106

CHAR:

105893397(mycbp2)

TRU:	101073276(mycbp2)

TFS:	130536858(mycbp2)

TNG:	GSTEN00001239G001 GSTEN00027943G001

LCO:	104921457(mycbp2)

NCC:	104958638(mycbp2)

TBEN:

117481080(mycbp2)

CGOB:

115026614(mycbp2)

PGEO:

117466450(mycbp2)

GACU:

117544521(mycbp2)

EMAC:

134867035(mycbp2)

ELY:	117251270(mycbp2)

EFO:	125900161(mycbp2)

PLEP:

121948718(mycbp2)

SLUC:

116043573(mycbp2)

ECRA:

117953404(mycbp2)

ESP:	116698463(mycbp2)

PFLV:

114564481(mycbp2)

GAT:	120833792(mycbp2)

PPUG:

119228511(mycbp2)

AFB:	129104589(mycbp2)

CLUM:

117750210(mycbp2)

PSWI:

130203569(mycbp2)

MSAM:

119904339(mycbp2)

SCHU:

122885868(mycbp2)

CUD:	121522435(mycbp2)

ALAT:

119026456(mycbp2)

MZE:	101484105(mycbp2)

ONL:	100697810(mycbp2)

OAU:	116316041(mycbp2)

OLA:	101162404(mycbp2)

OML:	112155131(mycbp2)

CSAI:

133446223(mycbp2)

XMA:	102221295(mycbp2)

XCO:	114148233(mycbp2)

XHE:	116723172(mycbp2)

PRET:

103480554(mycbp2)

PFOR:

103134730(mycbp2)

PLAI:

106962344(mycbp2)

PMEI:

106927724(mycbp2)

GAF:	122840370(mycbp2)

PPRL:

129361105(mycbp2)

CVG:	107104580(mycbp2)

CTUL:

119794710(mycbp2)

GMU:	124870900(mycbp2)

NFU:	107389738(mycbp2)

KMR:	108232441(mycbp2)

ALIM:

106527137(mycbp2)

NWH:	119419371(mycbp2)

AOCE:

111568452(mycbp2)

MCEP:

125017437(mycbp2)

CSEM:

103391933(mycbp2)

POV:	109637960(mycbp2)

SSEN:

122763265(mycbp2)

HHIP:

117754800(mycbp2)

HSP:	118120431(mycbp2)

SMAU:

118320546(mycbp2)

LCF:

108901224

SDU:	111218291(mycbp2)

SLAL:

111673036(mycbp2)

XGL:	120801543(mycbp2)

HCQ:	109531235(mycbp2)

SSCV:

125974064

SBIA:

133512756(mycbp2)

PEE:	133410976(mycbp2)

PTAO:

133486395(mycbp2)

BPEC:

110170545(mycbp2)

MALB:

109965418(mycbp2)

BSPL:

114847386(mycbp2)

SJO:	128367943(mycbp2)

SASA:

100380858(mycb2) 106581613

STRU:

115156251(mycbp2) 115160590

OTW:	112225044(mycbp2) 112234653

OMY:	110501235(mycbp2) 110519948

OGO:	124041573 124043719

ONE:	115107163 115133812

OKI:	109870670(mycbp2) 109904047

OKE:	118367218 118385901(mycbp2)

SALP:

111959629(mycbp2) 111973092

SNH:	120058172 120064471

CCLU:

121536600(mycbp2) 121554853

ELS:	105029423(mycbp2)

SFM:	108920533(mycbp2) 108929997

PKI:	111836683(mycbp2)

AANG:

118213737(mycbp2)

LOC:	102688269(mycbp2)

PSPA:

121320927(mycbp2) 121327729

ARUT:

117405836 117407076(mycbp2)

PSEX:

120523768(mycbp2)

LCM:	102364952(MYCBP2)

CMK:	103176899(mycbp2)

CPLA:

122550534(mycbp2)

HOC:	132816397(mycbp2)

LERI:

129697970(mycbp2)

PMRN:

116943639(MYCBP2)

LRJ:	133349976(MYCBP2)

BFO:

BBEL:

CIN:

SPU:

LPIC:

APLC:

SKO:	100368165(MYCBP2)

DME:	Dmel_CG32592(hiw)

DER:

6550644

DSE:

6619582

DSI:	Dsimw501_GD15825(Dsim_GD15825)

DYA:	Dyak_GE16076

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI15368

DAZ:

108619000

DNV:	108656489 115565145

DHE:

CCAT:

BOD:

BDR:

AOQ:	129238267 129239679

TDA:

MDE:

SCAC:

LCQ:

LSQ:

GFS:

ECOE:

HIS:

ACOZ:

AARA:

AMER:

ASTE:

AFUN:

AAG:

AALB:

CQU:	CpipJ_CPIJ003142 CpipJ_CPIJ003145

CPII:

CNS:

BCOO:

AME:

ACER:

ALAB:

ADR:

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:	105149206 105149212

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

CINS:

VCAN:

CCIN:

DSM:

NPT:

NFB:

NLO:

NVG:

AROA:

TCA:	660160(Hiw)

DPA:

SOY:

AGRG:

ATD:

CSET:

LDC:

NVL:	108569690 108569691

APLN:

PPYR:

OTU:

BMOR:

BMAN:

DPL:	KGM_203404 KGM_203405

MJU:

PMAC:

PXU:

ZCE:

HAW:

TNL:

SLIU:

PXY:	105384136 105384139 105389683

PGW:

126380209

CCRN:

123294595

API:	100161379 115033055

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

HVI:

MQU:

PHU:	Phum_PHUM483630 Phum_PHUM483780

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

BROR:

FCD:

DPX:	DAPPUDRAFT_324455

DMK:

DPZ:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:

PTRU:

ESN:

HAZT:

EAF:

LSM:

TCF:

PPOI:

DSV:

RSAN:

RMP:

VDE:

VJA:

DPTE:

DFR:

CSCU:

PTEP:

ABRU:

UDV:

SDM:

CEL:	CELE_C01B7.6(rpm-1) CELE_F07B7.12(F07B7.12)

CBR:	CBG_00759(Cbr-rpm-1)

CRQ:	GCK72_018930

BMY:	BM_BM1864(Bm1864)

LOA:	LOAG_17782

TSP:

Tsp_05625

HRO:	HELRODRAFT_188971

LGI:	LOTGIDRAFT_153260 LOTGIDRAFT_205644

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:	105342162 117681841

CVN:

111125018

CANU:

128191831

OED:	125667423 125678670

MYI:

PMAX:

MMER:

RPHI:

DPOL:

OBI:

OSN:

LAK:

AQU:

MBR:	MONBRDRAFT_33522

SRE:	PTSG_02092 PTSG_11546

» show all

Reference

PMID:21098484

Authors

Holland S, Coste O, Zhang DD, Pierre SC, Geisslinger G, Scholich K

Title

The ubiquitin ligase MYCBP2 regulates transient receptor potential vanilloid receptor 1 (TRPV1) internalization through inhibition of p38 MAPK signaling.

Journal

J Biol Chem 286:3671-80 (2011)
DOI:10.1074/jbc.M110.154765

Sequence

[mmu:105689]

Reference

PMID:18308511

Authors

Han S, Witt RM, Santos TM, Polizzano C, Sabatini BL, Ramesh V

Title

Pam (Protein associated with Myc) functions as an E3 ubiquitin ligase and regulates TSC/mTOR signaling.

Journal

Cell Signal 20:1084-91 (2008)
DOI:10.1016/j.cellsig.2008.01.020

Sequence

[hsa:23077]

Reference

PMID:9689053

Authors

Guo Q, Xie J, Dang CV, Liu ET, Bishop JM

Title

Identification of a large Myc-binding protein that contains RCC1-like repeats.

Journal

Proc Natl Acad Sci U S A 95:9172-7 (1998)
DOI:10.1073/pnas.95.16.9172

Sequence

[hsa:23077]

All links

Ontology (3)   
   KEGG BRITE (3)   
Pathway (2)   
   KEGG PATHWAY (2)   
Chemical reaction (1)   
   KEGG ENZYME (1)   
Gene (9750)   
   KEGG GENES (622)   
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   RefGene (7593)   
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Literature (3)   
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All databases (9759)   

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