KEGG   ORTHOLOGY: K10956
Entry
K10956                      KO                                     

Name
SEC61A
Definition
protein transport protein SEC61 subunit alpha
Pathway
ko03060  Protein export
ko04141  Protein processing in endoplasmic reticulum
ko04145  Phagosome
ko05110  Vibrio cholerae infection
Disease
H00541  Autosomal dominant tubulointerstitial kidney disease
H02011  Familial juvenile hyperuricemic nephropathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   03060 Protein export
    K10956  SEC61A; protein transport protein SEC61 subunit alpha
   04141 Protein processing in endoplasmic reticulum
    K10956  SEC61A; protein transport protein SEC61 subunit alpha
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K10956  SEC61A; protein transport protein SEC61 subunit alpha
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05110 Vibrio cholerae infection
    K10956  SEC61A; protein transport protein SEC61 subunit alpha
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   02044 Secretion system
    K10956  SEC61A; protein transport protein SEC61 subunit alpha
Secretion system [BR:ko02044]
 Sec (secretion) system
  Eukaryotic Sec-SRP protein
   K10956  SEC61A; protein transport protein SEC61 subunit alpha
Other DBs
TC: 3.A.5.4 3.A.5.8 3.A.5.9
Genes
HSA: 29927(SEC61A1) 55176(SEC61A2)
PTR: 450305(SEC61A2) 460669(SEC61A1)
PPS: 100979100(SEC61A2) 100979567(SEC61A1)
GGO: 101145654(SEC61A1) 101147036(SEC61A2)
PON: 100173741(SEC61A1) 100174115(SEC61A2)
NLE: 100599187(SEC61A2) 100603743(SEC61A1)
MCC: 100427731(SEC61A2) 709787(SEC61A1)
MCF: 102116756(SEC61A1) 102119298(SEC61A2)
CSAB: 103228100(SEC61A1) 103237891
RRO: 104656940(SEC61A1) 104664883(SEC61A2)
RBB: 108519219 108537478(SEC61A1) 108538528(SEC61A2)
CJC: 100413259(SEC61A1) 100415365(SEC61A2)
SBQ: 101038739(SEC61A1) 101041434(SEC61A2)
MMU: 53421(Sec61a1) 57743(Sec61a2)
MCAL: 110295994(Sec61a1) 110311759(Sec61a2)
MPAH: 110315724(Sec61a1) 110333596(Sec61a2)
RNO: 361273(Sec61a2) 80843(Sec61a1)
CGE: 100767375(Sec61a1) 100771837(Sec61a2)
NGI: 103730347(Sec61a1) 103738699(Sec61a2)
HGL: 101711449(Sec61a1) 101724032(Sec61a2)
CCAN: 109682444(Sec61a2) 109684702(Sec61a1)
OCU: 100338258(SEC61A2) 100338900(SEC61A1)
TUP: 102480124(SEC61A2) 102490355(SEC61A1)
CFA: 404006(SEC61A1) 478007(SEC61A2)
VVP: 112914480(SEC61A1) 112933357(SEC61A2)
AML: 100478647(SEC61A1) 100484123(SEC61A2)
UMR: 103669615(SEC61A1) 103676291(SEC61A2)
UAH: 113241066(SEC61A2) 113257265(SEC61A1)
ORO: 101363735(SEC61A2) 101365069(SEC61A1)
FCA: 101086402(SEC61A2) 101089426(SEC61A1)
PTG: 102955516(SEC61A2) 102966531(SEC61A1)
PPAD: 109256060(SEC61A1) 109273727(SEC61A2)
AJU: 106971003(SEC61A2) 106986127(SEC61A1)
BTA: 505064(SEC61A1) 614128(SEC61A2)
BOM: 102264991(SEC61A1) 102283876(SEC61A2)
BIU: 109567871(SEC61A2) 109576222(SEC61A1)
BBUB: 102389095(SEC61A1) 102412467(SEC61A2)
CHX: 102173946(SEC61A2) 102175814(SEC61A1)
OAS: 101108676(SEC61A2) 101114060(SEC61A1)
SSC: 100155306(SEC61A1) 100511831(SEC61A2)
CFR: 102505665(SEC61A2) 102523145(SEC61A1)
CDK: 105090114(SEC61A1) 105100311(SEC61A2)
BACU: 103012399(SEC61A1) 103015508(SEC61A2)
LVE: 103079854 103086204(SEC61A1) 103088812(SEC61A2)
OOR: 101271372(SEC61A2) 101275317 101281798 101284382(SEC61A1)
DLE: 111168794(SEC61A1) 111178002(SEC61A2)
PCAD: 102978958(SEC61A1) 102987023(SEC61A2) 102996121 112063169
ECB: 100054080(SEC61A1) 100069336(SEC61A2)
EPZ: 103558629(SEC61A1) 103563360(SEC61A2)
EAI: 106834472(SEC61A1) 106836525(SEC61A2)
MYB: 102243493(SEC61A2) 102253190(SEC61A1)
MYD: 102755050(SEC61A2) 102770957(SEC61A1)
MNA: 107525213(SEC61A1) 107530245(SEC61A2)
HAI: 109390484(SEC61A2) 109391269(SEC61A1)
DRO: 112322639(SEC61A2) 112322883(SEC61A1)
PALE: 102895305(SEC61A2) 102896092(SEC61A1)
RAY: 107503655(SEC61A1) 107504854(SEC61A2)
MJV: 108394206(SEC61A1) 108395810(SEC61A2)
LAV: 100653932(SEC61A2) 100672139(SEC61A1)
MDO: 100013623(SEC61A2) 100027900(SEC61A1)
SHR: 100926239(SEC61A2) 100927239(SEC61A1)
PCW: 110204938(SEC61A1) 110217362(SEC61A2)
OAA: 100075168(SEC61A1) 100085428(SEC61A2)
GGA: 416023(SEC61A1) 426369(SEC61A2)
MGP: 100538490(SEC61A1) 100540625(SEC61A2)
CJO: 107317364(SEC61A2) 107319981(SEC61A1)
NMEL: 110392261(SEC61A2) 110404854(SEC61A1)
APLA: 101793156(SEC61A2) 101805438(SEC61A1)
ACYG: 106038064(SEC61A1) 106046212(SEC61A2)
TGU: 100230635(SEC61A2) 100232642(SEC61A1)
LSR: 110470927(SEC61A2) 110471485(SEC61A1)
SCAN: 103813571(SEC61A2) 103817022(SEC61A1)
GFR: 102043686(SEC61A1) 102045195(SEC61A2)
FAB: 101810680(SEC61A1) 101819921(SEC61A2)
PHI: 102101105(SEC61A2) 102110505(SEC61A1)
PMAJ: 107204634(SEC61A2) 107210406(SEC61A1)
CCAE: 111923120(SEC61A2) 111935079(SEC61A1)
CCW: 104683473(SEC61A1) 104694503(SEC61A2)
ETL: 114057950(SEC61A1) 114066634(SEC61A2)
FPG: 101912538(SEC61A1) 101914707(SEC61A2)
FCH: 102046030(SEC61A2) 102057607(SEC61A1)
CLV: 102086241(SEC61A2) 102093863(SEC61A1)
EGZ: 104126631(SEC61A1) 104135762(SEC61A2)
NNI: 104014623(SEC61A2) 104022671(SEC61A1)
ACUN: 113484941(SEC61A1) 113491257(SEC61A2)
PADL: 103914411(SEC61A1) 103915025(SEC61A2)
AAM: 106485094(SEC61A2) 106500278(SEC61A1)
ASN: 102373630(SEC61A2) 102381045(SEC61A1)
AMJ: 102561868(SEC61A2) 106736938(SEC61A1)
PSS: 102458682(SEC61A1) 102460252(SEC61A2)
CMY: 102941548(SEC61A2) 102943934(SEC61A1)
CPIC: 101938621(SEC61A1) 101939960(SEC61A2)
ACS: 100567770(sec61a1)
PVT: 110081240(SEC61A2) 110088891(SEC61A1)
PBI: 103048227(SEC61A1) 103065081(SEC61A2)
PMUR: 107294279(SEC61A1) 107297193(SEC61A2)
TSR: 106547009(SEC61A1) 106550931(SEC61A2)
PMUA: 114591735(SEC61A1) 114605173(SEC61A2)
GJA: 107122943(SEC61A1)
XLA: 108714662(sec61a1.L) 379936(sec61a1.S)
XTR: 448033(sec61a1)
NPR: 108784976(SEC61A1)
DRE: 192298(sec61a1) 266796(sec61a1l)
CCAR: 109067675 109091081(sec61a1) 109091101
EEE: 113575977
TRU: 101061140(sec61a1) 101075256
ONL: 100696698 100703518(sec61a1)
OLA: 101169601 101175640(sec61a1)
CVG: 107094024(sec61a1) 107100419
KMR: 108235565 108241220(sec61a1)
CSEM: 103386165(sec61a1)
SDU: 111221564 111221582(sec61a1)
MALB: 109956207(sec61a1) 109964524
SASA: 100195187(s61a1) 100380825(sc61a) 106565561 106583199
LCM: 102358133(SEC61A1) 102359033(SEC61A2)
CMK: 103176668(sec61a1) 103187913(sec61a2)
RTP: 109921354 109929694(sec61a2)
BFO: 118415685
CIN: 100176997
APLC: 110987733
SKO: 100377121
DME: Dmel_CG9539(Sec61alpha)
DER: 6540948
DSE: 6613632
DSI: Dsimw501_GD22572(Dsim_GD22572)
DAN: 6498511
DSR: 110185078
DPE: 6593558
DMN: 108163319
DWI: 6646717
DAZ: 108611238
DNV: 115563309
DHE: 111596273
DVI: 6634213
MDE: 101890594
LCQ: 111674554
AME: 725571
BIM: 100747066
BTER: 100644740
CCAL: 108622582
OBB: 114876651
SOC: 105207861
MPHA: 105830263
AEC: 105154433
ACEP: 105621039
PBAR: 105428379
VEM: 105569478
HST: 105191762
DQU: 106752377
CFO: 105252208
LHU: 105669772
PGC: 109856141
OBO: 105276638
PCF: 106789016
MDL: 103571226
TCA: 658693
DPA: 109545449
ATD: 109597194
NVL: 108569651
BMOR: 733068(Sec61alpha)
BMAN: 114239861
PMAC: 106721338
PRAP: 110993494
HAW: 110383255
TNL: 113502385
API: 100144911(Sec61a1)
DNX: 107173078
AGS: 114123616
RMD: 113551304
BTAB: 109032299
CLEC: 106672125
ZNE: 110836545
FCD: 110846340
TUT: 107364556
CSCU: 111631285
PTEP: 107439636
CEL: CELE_Y57G11C.15(sec-61.A)
BMY: Bm1_38585
PCAN: 112571999
MYI: 110445924
OBI: 106872762
SHX: MS3_03569
NVE: 5507445
EPA: 110240522
ADF: 107337419
AMIL: 114963929
PDAM: 113667419
SPIS: 111338785
DGT: 114527080
HMG: 100200475
AQU: 100635757
LJA: Lj4g3v0880270.1(Lj4g3v0880270.1) Lj6g3v1049120.1(Lj6g3v1049120.1) Lj6g3v1049120.2(Lj6g3v1049120.2)
DOSA: Os03t0213100-01(Os03g0213100) Os03t0692300-00(Os03g0692300) Os08t0254500-01(Os08g0254500) Os09t0347500-01(Os09g0347500) Os09t0347700-01(Os09g0347700) Os09t0512000-01(Os09g0512000)
ATS: 109731640(LOC109731640) 109741620(LOC109741620) 109764831(LOC109764831) 109770287(LOC109770287)
ZMA: 100217058 100276798 100280289(pco109407) 542482(csy1)
CRE: CHLREDRAFT_188207(SEC61A)
MIS: MICPUN_95488(SEC61a)
SCE: YBR283C(SSH1) YLR378C(SEC61)
KMX: KLMA_20424(SEC61) KLMA_50087(SSH1)
NCS: NCAS_0B07560(NCAS0B07560) NCAS_0J01340(NCAS0J01340)
NDI: NDAI_0B04900(NDAI0B04900) NDAI_0J02130(NDAI0J02130)
TPF: TPHA_0B02340(TPHA0B02340) TPHA_0I01160(TPHA0I01160)
TBL: TBLA_0C02600(TBLA0C02600) TBLA_0I02820(TBLA0I02820)
TDL: TDEL_0D01700(TDEL0D01700) TDEL_0E01420(TDEL0E01420)
KAF: KAFR_0A03640(KAFR0A03640) KAFR_0A06090(KAFR0A06090)
PIC: PICST_68832(SEC61) PICST_80530(SSH1)
SLB: AWJ20_1740(SEC61) AWJ20_2263(SEC61)
NCR: NCU08897
NTE: NEUTE1DRAFT116142(NEUTE1DRAFT_116142)
MGR: MGG_04856
SSCK: SPSK_06140
MAW: MAC_07314
MAJ: MAA_09744
CMT: CCM_09589
MBE: MBM_08204
ANI: AN7721.2
ANG: ANI_1_512034(An03g04340)
ABE: ARB_06748
TVE: TRV_03333
PTE: PTT_09674
CNE: CNI00040
CNB: CNBH0050
TASA: A1Q1_02607
MRR: Moror_6
ABP: AGABI1DRAFT114587(AGABI1DRAFT_114587)
ABV: AGABI2DRAFT194769(AGABI2DRAFT_194769)
MGL: MGL_1638
MRT: MRET_0735
DDI: DDB_G0278885(sec61a)
DFA: DFA_08267(sec61a)
EHI: EHI_164500(467.t00007)
PCB: PCHAS_136360(PC302415.00.0)
TAN: TA17425
TPV: TP03_0852
BBO: BBOV_I000080(16.m00785)
CPV: cgd7_950
SMIN: v1.2.009289.t1(symbB.v1.2.009289.t1) v1.2.009606.t1(symbB.v1.2.009606.t1)
PTI: PHATRDRAFT_56443(Sec61alpha)
TPS: THAPSDRAFT_28769(SEC61-2) THAPS_25355(SEC61-1)
NGA: Ngar_c02020(secY)
NVN: NVIE_013880(secY)
NEV: NTE_02794
BARC: AOA65_0151
BARB: AOA66_1261
LOKI: Lokiarch_00020(secY)
 » show all
Reference
  Authors
Rapoport TA
  Title
Protein translocation across the eukaryotic endoplasmic reticulum and bacterial plasma membranes.
  Journal
Nature 450:663-9 (2007)
DOI:10.1038/nature06384
Reference
  Authors
Jiang Y, Cheng Z, Mandon EC, Gilmore R
  Title
An interaction between the SRP receptor and the translocon is critical during cotranslational protein translocation.
  Journal
J Cell Biol 180:1149-61 (2008)
DOI:10.1083/jcb.200707196
  Sequence
Reference
  Authors
Lang S, Erdmann F, Jung M, Wagner R, Cavalie A, Zimmermann R
  Title
Sec61 complexes form ubiquitous ER Ca2+ leak channels.
  Journal
Channels (Austin) 5:228-35 (2011)
DOI:10.4161/chan.5.3.15314
  Sequence
[hsa:29927]

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