KEGG   ORTHOLOGY: K11121
Entry
K11121                      KO                                     

Name
SIR2
Definition
NAD+-dependent protein deacetylase SIR2 [EC:2.3.1.286]
Pathway
ko00760  Nicotinate and nicotinamide metabolism
ko01100  Metabolic pathways
ko04213  Longevity regulating pathway - multiple species
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    K11121  SIR2; NAD+-dependent protein deacetylase SIR2
 09150 Organismal Systems
  09149 Aging
   04213 Longevity regulating pathway - multiple species
    K11121  SIR2; NAD+-dependent protein deacetylase SIR2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins
    K11121  SIR2; NAD+-dependent protein deacetylase SIR2
   03036 Chromosome and associated proteins
    K11121  SIR2; NAD+-dependent protein deacetylase SIR2
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.286  protein acetyllysine N-acetyltransferase
     K11121  SIR2; NAD+-dependent protein deacetylase SIR2
DNA replication proteins [BR:ko03032]
 Eukaryotic type
  DNA Replication Termination Factors
   Telomere proteins
    SIR proteins
     K11121  SIR2; NAD+-dependent protein deacetylase SIR2
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Histone modification proteins
   Sir proteins
    K11121  SIR2; NAD+-dependent protein deacetylase SIR2
Other DBs
RN: R10633 R10634
COG: COG0846
Genes
SCE: YDL042C(SIR2) YDR191W(HST4) YOL068C(HST1) YOR025W(HST3) YPL015C(HST2)
AGO: AGOS_AEL013C AGOS_AEL229W AGOS_AGL018C AGOS_AGL118W
ERC: Ecym_4171 Ecym_5284 Ecym_5587 Ecym_7309
KLA: KLLA0_A07172g KLLA0_D18535g KLLA0_F11033g KLLA0_F14663g
LTH: KLTH0A02596g KLTH0C08690g KLTH0F08514g KLTH0G05720g
VPO: Kpol_1011p1 Kpol_1030p1 Kpol_1032p18 Kpol_479p29 Kpol_495p15
ZRO: ZYRO0A05566g ZYRO0B05148g ZYRO0C04246g ZYRO0F03960g
CGR: CAGL0C05357g CAGL0F05621g CAGL0H08239g CAGL0K01463g CAGL0L08668g
NCS: NCAS_0B03050(NCAS0B03050) NCAS_0C03490(NCAS0C03490) NCAS_0G00840(NCAS0G00840) NCAS_0I02150(NCAS0I02150) NCAS_0J00610(NCAS0J00610)
NDI: NDAI_0A06750(NDAI0A06750) NDAI_0B05490(NDAI0B05490) NDAI_0C06280(NDAI0C06280) NDAI_0F00930(NDAI0F00930) NDAI_0G02830(NDAI0G02830)
TPF: TPHA_0A00880(TPHA0A00880) TPHA_0C00480(TPHA0C00480) TPHA_0L00930(TPHA0L00930) TPHA_0M00390(TPHA0M00390) TPHA_0P00380(TPHA0P00380)
TBL: TBLA_0D02680(TBLA0D02680) TBLA_0E03350(TBLA0E03350) TBLA_0F00920(TBLA0F00920) TBLA_0G03160(TBLA0G03160) TBLA_0H03210(TBLA0H03210) TBLA_0J00780(TBLA0J00780)
TDL: TDEL_0A04790(TDEL0A04790) TDEL_0C01020(TDEL0C01020) TDEL_0D04710(TDEL0D04710) TDEL_0F05200(TDEL0F05200)
KAF: KAFR_0B01640(KAFR0B01640) KAFR_0B06160(KAFR0B06160) KAFR_0C01100(KAFR0C01100) KAFR_0C05870(KAFR0C05870) KAFR_0F02130(KAFR0F02130)
PIC: PICST_2658(SIR2) PICST_32025(HST2) PICST_40594(SIR3) PICST_49645(HST3)
NCR: NCU00523(nst-2) NCU03059(nst-3) NCU04737(nst-1)
NTE: NEUTE1DRAFT72738(NEUTE1DRAFT_72738) NEUTE1DRAFT88650(NEUTE1DRAFT_88650) NEUTE1DRAFT92837(NEUTE1DRAFT_92837)
ANG: ANI_1_1776074(An08g02500) ANI_1_3338024(An02g14390) ANI_1_988014(An01g07390)
SPO: SPAC1783.04c(hst4) SPBC16D10.07c(sir2) SPCC132.02(hst2)
ABP: AGABI1DRAFT110720(AGABI1DRAFT_110720) AGABI1DRAFT74670(AGABI1DRAFT_74670)
ABV: AGABI2DRAFT189378(AGABI2DRAFT_189378) AGABI2DRAFT224508(AGABI2DRAFT_224508)
LMA: LMJF_26_0210(SIR2RP1)
LIF: LINJ_26_0200(SIR2RP1)
LBZ: LBRM_26_0210a(SIR2)
LPAN: LPMP_260210(SIR2)
 » show all
Reference
  Authors
Shankaranarayana GD, Motamedi MR, Moazed D, Grewal SI
  Title
Sir2 regulates histone H3 lysine 9 methylation and heterochromatin assembly in fission yeast.
  Journal
Curr Biol 13:1240-6 (2003)
DOI:10.1016/S0960-9822(03)00489-5
  Sequence
Reference
  Authors
Celic I, Masumoto H, Griffith WP, Meluh P, Cotter RJ, Boeke JD, Verreault A
  Title
The sirtuins hst3 and Hst4p preserve genome integrity by controlling histone h3 lysine 56 deacetylation.
  Journal
Curr Biol 16:1280-9 (2006)
DOI:10.1016/j.cub.2006.06.023
  Sequence
Reference
  Authors
Borra MT, Langer MR, Slama JT, Denu JM
  Title
Substrate specificity and kinetic mechanism of the Sir2 family of NAD+-dependent histone/protein deacetylases.
  Journal
Biochemistry 43:9877-87 (2004)
DOI:10.1021/bi049592e
  Sequence

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