KEGG ORTHOLOGY: K11147

ORTHOLOGY: K11147

Entry

K11147                      KO

Symbol

DHRS4

Name

dehydrogenase/reductase SDR family member 4 [EC:1.1.-.-]

Pathway

map00830

Retinol metabolism

map01100

Metabolic pathways

map04146

Peroxisome

Reaction

R08379

retinol: NADP+ oxidoreductase

R08383

Brite

KEGG Orthology (KO) [BR:ko00001]
09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00830 Retinol metabolism
    K11147  DHRS4; dehydrogenase/reductase SDR family member 4
09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K11147  DHRS4; dehydrogenase/reductase SDR family member 4

Genes

HSA:	10901(DHRS4)

PTR:	452804 744508(DHRS4L1)

PPS:	100974941(DHRS4) 117975776

GGO:	101144919 115930536

PON:	100172190(DHRS4)

PPYG:

129012836

NLE:	100601577 100604631(DHRS4)

SSYN:

129489329

MCC:	106999361 714145(DHRS4L2) 714613(DHRS4) 714661(DHRS4L1)

MCF:	102131691 102133978 123574698

MTHB:

126958818 126958825

MNI:	105477843 105477844 105477845

CSAB:

103228700(DHRS4L2) 103231490

CATY:

105598751 105598753 105600250 105600251

PANU:

101009538 101012719

TGE:	112628937 112629107

MLEU:

105547203(DHRS4)

RRO:	104662710 104662713

RBB:	108515803 108522865 108532369

TFN:	117069941 117069942

PTEH:

CANG:

CJC:

SBQ:

CIMI:

ANAN:

CSYR:

MMUR:

LCAT:

PCOQ:

OGA:

MMU:	28200(Dhrs4)

MCAL:

110309271

MPAH:

110325487

RNO:	266686(Dhrs4)

MCOC:

ANU:

ASYL:

MUN:

CGE:

MAUA:

PROB:

PLEU:

MORG:

MFOT:

AAMP:

119800043(Dhrs4)

NGI:

103739441

HGL:	101708169(Dhrs4)

CPOC:

CCAN:

DORD:

DSP:

PLOP:

NCAR:

MMMA:

ITI:

OCU:	100009020(DHRS4)

OPI:

101522868

TUP:	102486679(DHRS4)

GVR:

103590174

CFA:	480254(DHRS4)

CLUD:

VVP:

VLG:

NPO:

AML:	100468167(DHRS4)

UMR:

UAH:

UAR:

ELK:

LLV:

MPUF:

MNP:

MLK:

NVS:	122894208(DHRS4)

ORO:

EJU:

ZCA:

MLX:

NSU:

LWW:

FCA:

PYU:

PCOO:

PBG:

PVIV:

LRUF:

LGF:

AJU:

PTG:	102951758(DHRS4)

PPAD:

PUC:

PLEZ:

HHV:

BTA:	281360(DHRS4)

BOM:

BIU:

BBUB:

BBIS:

CHX:

OAS:

BTAX:

CSUM:

ODA:

CCAD:

MREE:

OVR:

MBEZ:

SSC:	397082(DHRS4)

CFR:

CBAI:

CDK:

VPC:

BACU:

103017836(DHRS4)

BMUS:

LVE:

OOR:

LALB:

DLE:

PCAD:

PSIU:

PPHC:

NASI:

ECB:	100054994(DHRS4)

EAI:

MYB:

MYD:

MMYO:

MLF:

MDT:

MYUM:

PKL:

EFUS:

MNA:

DRO:

SHON:

AJM:

PDIC:

PHAS:

MMF:

PPAM:

HAI:

RFQ:

PALE:

PGIG:

PVP:

RAY:

MJV:

TOD:

SARA:

SFUM:

SETR:

LAV:

TMU:

ETF:

DNM:

MDO:	100030652(DHRS4)

GAS:

SHR:

AFZ:

PCW:

TVP:	118828140 118828141 118828143 118828144 118828895 118828897

PBRV:

138168911

OAA:

100092951

TACU:

119921062

GGA:	426247(DHRS4)

PCOC:

MGP:

CJO:

TPAI:

LMUT:

NMEL:

ACYG:

AFUL:

LSR:

OTC:

ATRC:

FAB:

PHI:

ZLE:

CCIC:

134055924(DHRS1)

AGEN:

MNB:

CBOY:

CLV:

CNIC:

RTD:

ASN:

AMJ:	102562999(DHRS4)

PSS:

CMY:

CCAY:

DCC:

CPIC:

MRV:

ACS:

ASAO:

132777618 132779191 132779192

PVT:

SUND:

PBI:

PMUR:

CTIG:

TSR:

PGUT:

PCAE:

APRI:

PTEX:

NSS:

VKO:

PMUA:

PRAF:

ZVI:	118091080 118095236

HCG:

GJA:

STOW:

EMC:

XLA:	444771(dhrs4.L)

XTR:	548501(dhrs4)

NPR:

108786752

RTEM:

120918641 120937582 120941112 120943359 120943586

ACAT:

141143749 141143765 141143781 141145707

BBUF:

120989039

BGAR:

122923498

DTC:	141089114 141096202 141096204

PWL:	138265063 138265362 138265363 138265366 138265367 138265368 138265369 138265370 138266552 138292044 138292045 138299703 138299704 138299705 138301554

MUO:

115458016

GSH:

117350934

DRE:	393539(dhrs4)

SRX:	107742330 107753983

SANH:

107669257

SGH:	107563424 107588148 107588149

CCAR:

109055805 109092934(dhrs4) 122137891

CAUA:

113052129 113105714

CGIB:

127961798 128017141

PTET:

122349467(dhrs4)

LROH:

127168497(dhrs4)

GRF:	141331287(dhrs4)

OMC:	131544313(dhrs4)

PPRM:

120462617(dhrs4)

RKG:	130102637(dhrs4)

MAMB:

125264513(dhrs4)

CIDE:

127515418

CERY:

137030260(dhrs4)

MASI:

127441013 127450365

TROS:

130559219(dhrs4)

TDW:	130416169(dhrs4)

MANU:

129440243 129440268(dhrs4)

PDAB:

135730657 135730658 135730769

IPU:	100528099(dhrs4)

IFU:	128610272(dhrs4)

PHYP:

113540352

SMEO:

124387286(dhrs4)

TFD:	113663206(dhrs4)

TVC:	132848858(dhrs4)

CGAR:

128527880(dhrs4)

NGRA:

132895343(dhrs4)

TRN:	134312408(dhrs4)

AMEX:

103023174(dhrs4)

CMAO:

118826639(dhrs4)

EEE:

113578295

CHAR:

105894196(dhrs4)

SPIL:

134059512(dhrs4)

TRU:	101067892 101070166

TFS:	130522494 130522496 130522497 130523338

TNG:	GSTEN00025883G001 GSTEN00025891G001

LCO:

104932907

NCC:

104943221

TBEN:

117488135(dhrs4)

CGOB:

115023517

PGEO:

117463393(dhrs4)

GACU:

117539241(dhrs4)

EMAC:

134872413(dhrs4)

ELY:	117246276(dhrs4)

EFO:	125883657 125883663(dhrs4)

PLEP:

121962004(dhrs4)

SLUC:

116043252(dhrs4)

ECRA:

117934702(dhrs4)

ESP:

116707021

PFLV:

114545515

GAT:	101340253(dhrs4)

PPUG:

119221917(dhrs4)

AFB:	129093139(dhrs4)

CLUM:

117747472(dhrs4)

PSWI:

130211592(dhrs4)

CANA:

137792015(dhrs4)

CVE:	137885860(dhrs4)

MSAM:

119911465(dhrs4)

SCHU:

122869957(dhrs4)

CUD:	121504583(dhrs4)

SPUL:

138600809(dhrs4)

LMIX:

132958092(dhrs4)

ALAT:

119027154(dhrs4)

ASTR:

137590188 137590190 137590193 137590194(dhrs4) 137590195

MZE:

101487754

ONL:

100690619

OAU:	116312343(dhrs4)

OLA:	101171443(dhrs4)

OML:	112155911(dhrs4)

CSAI:

133419965(dhrs4)

XMA:

XCO:

XHE:

PRET:

PFOR:

PLAI:

PMEI:

GAF:	122820062(dhrs4)

PPRL:

129379398(dhrs4)

CVG:

107102491

CTUL:

119773353(dhrs4)

GMU:	124881219(dhrs4)

NFU:

107377281

KMR:	108245900(dhrs4)

ALIM:

106526440

NWH:	119408919(dhrs4)

AOCE:

111567481(dhrs4)

EJA:	138210538(dhrs4)

BFRE:

138633023(dhrs4)

MCEP:

125008115(dhrs4)

CSEM:

103388416

POV:

109634849

SSEN:

122766143(dhrs4)

SSOE:

131456113(dhrs4)

HHIP:

117779302(dhrs4)

HSP:	118102538(dhrs4)

PPLT:

128430224(dhrs4)

SMAU:

118287832(dhrs4)

LCF:	108903040(dhrs4)

SDU:

111235588

SLAL:

111647163

XGL:	120797608(dhrs4)

HCQ:

109508428

SSCV:

125976153(dhrs4)

SBIA:

133494519(dhrs4)

PEE:	133397715(dhrs4)

PTAO:

133472892(dhrs4)

BPEC:

110171969

ENY:	140371709(dhrs4)

MALB:

109974421

BSPL:

114867567(dhrs4)

SJO:	128384022(dhrs4)

SSCO:

134005431(dhrs4)

GMH:

115529683

SASA:

100195937(dhrs4) 106608855

STRU:

115194402 115198403

OTW:	112214630 112235592

OMY:	110500488(dhrs4) 110531631

OGO:	124008248(dhrs4) 124014074

ONE:	115133438 115137972

OKI:	109896965 109906430

OKE:	118373540 118392091

OMM:	135510490 135516228

OCLA:

139378916 139416016

SALP:

112069114

SNH:	120030305 120049722(dhrs4)

CCLU:

121572191 123482966

ELS:

105020560

OEP:	134009770(dhrs4)

SFM:

108931992

PKI:

111859313

AANG:

118231356(dhrs4)

AROT:

135258731(dhrs4)

CCOG:

133114653(dhrs4)

LOC:

102692526

PSPA:

121306880(dhrs4)

PSEX:

120525607 120525617 120525793

LCM:	102359768 102361264

CMK:

103186045

RTP:

109911798

CPLA:

122544221 122545310 122546597

HOC:	132833858(dhrs4)

LERI:

129693396(dhrs4)

HAKA:

140731983(dhrs4)

PMRN:

116945828 116954118

LRJ:	133340232 133355744

BFO:

118417901

BBEL:

109483263

CIN:

100182243

SCLV:

120329237 120329238 120329239 120329240 120329241 120329789 120333271 120338305 120341287 120345446

SPU:

764565

LPIC:

129276969 129276985

AJJ:	139958730 139958743 139959623 139960140 139960689 139960690 139962889 139962951 139965445 139966248 139967128 139972896 139972928

APLC:

ARUN:

AAMU:

AFIL:

AJC:

SKO:	102801913 102802030 102802162 102809480

PFLL:

139119121 139127629 139127641 139127645 139127646 139127647 139127658 139127660 139127668 139127670 139127673 139139698 139139935 139139967 139139968 139147111

DME:	Dmel_CG10672(Dhrs4)

DER:

6544046

DSE:

6610857

DSI:	Dsimw501_GD28594(Dsim_GD28594)

DYA:	Dyak_GE20571

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI11985

DAZ:

108613237

DNV:

108651200

DHE:

111601657

DVI:	6624356(Dhrs4)

CCAT:

101456452

BOD:

106614096

BDR:

105232906

RZE:	108354102 108356739 108360082

AOQ:

129240633

ALUD:

128859691

TDA:	119668303 119669356

MDE:

SCAC:

LCQ:

LSQ:

CVJ:	135953836(Dhrs4)

GFS:

119645262

ECOE:

129945851

CLON:

129608635 129617823

HIS:	119648803 119649855 119650048

AGA:

ACOZ:

AARA:

AMER:

ASTE:

AMAP:

AFUN:

AMOU:

AMRS:

AALI:

118462850 118464321 118467768

ACOS:

AAG:

AALB:

ASUA:

CQU:	CpipJ_CPIJ011391

CPII:

120426340

CBRI:

134832874 134832875

CNS:

116336694

BCOO:

119073143 119080967 119085592

LLL:	129794133 129794145 129794146 129794287 129794288 129794289

PPAP:

129801031 129801032 129801033 129803733 129804358 129804359 129804812

AME:	100577607 412304(DHRS4)

ACER:

108001177 108003751

ALAB:

122710394 122717771

ADR:	102675070 102679201

AFLR:

BIM:

BBIF:

BVK:

BVAN:

BHUN:

BTER:

BAFF:

BPYO:

BPAS:

FVI:

CCAL:

OBB:

OLG:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

COBS:

139110479(Dhrs4)

TLN:	139811301(Dhrs4)

HST:	105186173 112589585

DQU:	106749117 106751697

CFO:	105249294 105249295 112637050

FEX:	115234959 115239667

PMEC:

138933685(Dhrs4) 138936570

LHU:	105674036(Dhrs4)

PGC:

OBO:

PCF:

PFUC:

VPS:

VCRB:

VVE:

NVI:

CSOL:

TPRE:

LHT:

LBD:

CCIN:

DSM:

NPT:	124215488(DHRS4)

NFB:

NLO:

NVG:

AROA:

TCA:	658998 659077(DHRS4)

TMOL:

138134612 138134627

DPA:

109534503

ESIM:

136414232(Dhrs4)

EFOR:

136346236(Dhrs4)

SOY:

AGRG:

ATD:

CSET:

HAXR:

AGB:	108904714 108907839 108909766 108910077

LDC:	111513839 111518118 111518121

DVV:	114349468 126889491

NVL:

108566925

APLN:

108739739

PPYR:

116159670 116160913 116167219 116174107 116181757 116181758

OTU:	111423231 111423383 111423544

BMOR:

101739283 101745761

BMAN:

114243608 114252238

MSEX:

115451859

DPL:	KGM_211640

BANY:

MJU:

NIQ:

VCD:

MCIX:

PMAC:

PXU:

BPHI:

137919202(Dhrs4)

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

LSIN:

AAGE:

HAW:

HZE:

TNL:

SLIU:

OFU:

ONU:

ATRA:

GMW:

PXY:

PGW:

LGLY:

CSTB:

CFUM:

141430409(Dhrs4)

CFEL:

113382154 113385376 113387022

CCRN:

123298110 123298112 123299058

API:

DNX:

AGS:

RMD:

ACOO:

DVT:

BTAB:

DCI:	103509679 103521809

CLEC:

106663222

HHAL:

106686247(Dhrs4)

NLU:

111049473

HVI:

124359442

MQU:

128983288

PHU:	Phum_PHUM009820

FOC:

TPAL:

ZNE:

CSEC:

PAME:

138713696(Dhrs4)

SGRE:

126356318

BROR:

134531156

IEL:

124163573

HAMR:

139696196(Dhrs4)

FCD:

110858305

DPX:	DAPPUDRAFT_241363 DAPPUDRAFT_302551 DAPPUDRAFT_310758(CBR1) DAPPUDRAFT_316810 DAPPUDRAFT_329598

DMK:	116916745 116927162 116927163

DPZ:	124314787 124321278 124321280 124326412 124326417 124326420 124340434

AFRA:

136034474

PVM:	113824316(Dhrs4)

PJA:

PCHN:

PMOO:

HAME:

PCLA:

CQD:	128702677(Dhrs4)

PTRU:

123510361

ESN:

126995923

MNZ:	135215329 135215657

MRJ:	136843130(Dhrs4)

PORN:

139764400

HAZT:

108668227 108668230 108670147 108673949 108676551

EAF:

111702513

LSM:

121129867

PPOI:

119109754 119109759 119109781

ISC:

8036463

DSV:	119440837 119454003

RSAN:

RMP:

VDE:

VJA:

GOE:

TUT:

DPTE:

DFR:

CSCU:

CVS:

PTEP:

ABRU:

UDV:

SDM:

PMEO:

CEL:	CELE_F36H9.3(dhs-13) CELE_F54F3.4(dhrs-4)

CBR:	CBG_09503 CBG_24129(Cbr-dhs-13)

CRQ:	GCK72_017639 GCK72_017640 GCK72_019265

NAI:	NECAME_06678 NECAME_11972

HRO:	HELRODRAFT_185211 HELRODRAFT_70909

LGI:	LOTGIDRAFT_211528

PVUL:

PCAN:

LSAX:

BGT:

GAE:	121388161 121388162 121390887 121390889 121391892

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

CVN:	111128239 111128430

OED:

125650114

MYI:	110453415 110453425

PMAX:

117337776 117337778

AIRR:

138315940 138315941

MCAF:

127701854

MMER:

123548564 123548984 123550552 128557811 128557816

RPHI:

132714634 132733025 132733026 132733027

DPOL:

127845835 127846509 127846786

MAEA:

OBI:

OSN:

LJP:

LAK:

LLON:

NVE:

EPA:

ATEN:

ADF:	107331201 107345735

AMIL:

114965080

MCAZ:

138018654 138019285 138021318 138021519 138022496 138022497

MFOO:

137970671 137993259 137993340 137998140 137998141 138009135

PDAM:

SPIS:

DGT:

XEN:

HMG:

HSY:

RES:

TAD:	TRIADDRAFT_25681 TRIADDRAFT_37528 TRIADDRAFT_60225

AQU:

100637653

ATH:	AT4G05530(IBR1)

ALY:

9308741

CRB:

17884114

CSAT:

104707566 104717281 104737282

EUS:	EUTSA_v10028901mg

BRP:	103834242 103839858

BNA:	106360981 106366122 106381589 106383089

BOE:	106315618 106331951

RSZ:	108822229 108823865 130506851

THJ:

104813498

CPAP:

110812618 110812660 110812661

CIT:	102609143 102609432

CIC:	CICLE_v10016358mg

PVY:

116137566

MINC:

123192298 123218848

TCC:	18597252 18597253

GRA:	105768703 105775016 105778033

GHI:	107905675 107905900 107924910 107925101 107930299 107930440

GAB:	108452933 108458188 108459736

HSYR:

120131488 120137042 120156216 120183476 120194574 120206107 120206108

DZI:	111274045 111274046 111280801

EGR:

104445655

RARG:

115757061

GMX:	100170726 100527263 100809582

GSJ:	114367279 114387307 114394111

PVU:	137806744 137832181

VRA:	106767212 106775931

VAR:	108335009 108343249

VUN:

114176407

VUM:	124832973 124833618

CCAJ:

109804417 109808996

APRC:

113847794 113852896 113870011

MTR:

TPRA:

CAM:

PSAT:

VVO:

LJA:	130711832 130722186

ADU:	107466349 107482955

AIP:	107616208 107636575 107638671

AHF:	112706105 112722848 112764327 112779140 112795968

LANG:

109362935

PCIN:

129298681 129306353

QSA:	O6P43_008885 O6P43_011977 O6P43_031302

FVE:

AANS:

RCN:

PPER:

PMUM:

PAVI:

PDUL:

MDM:	103408758 103427787 103446766

MSYL:

126587492 126623967

PXB:	103946314 103948232

PCOX:

137726451 137726455 137726900 137728984

ZJU:

107414722

MNT:

21396782

CSAV:

115707384 115707385 115707387 115707388

CSV:

CMO:

BHJ:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:

MEAN:

JCU:

HBR:	110646345 110654491 110654492 110666230

MESC:

110603038 110622300

POP:	7484272 7484330

PEU:	105108154 105108155

PALZ:

118049382 118049384

PNZ:	133702554 133702861

JRE:

CILL:

CAVE:

AGLU:

QSU:	112007474 112007476

QLO:	115965483 115965515 115979164 115979255 115980236 115989230 115989231 115992349

TWL:

119989692

VVI:

100257814

VRI:	117923601 117923660

SLY:

101264111

SPEN:

107015731

SOT:	102584499 102604081

SSTN:

125844155 125861826

SDUL:

129869999 129870749

CANN:

107851184 107870095

LBB:	132614659 132615572 132615723

NTA:	107775270 107788737 107798923 107823087

NSY:	104220534 104232378

NTO:	104117575 104118055

NAU:	109237891 109242865

INI:	109165019 109165185

ITR:

116032421

SIND:

105168013

OEU:	111402414 111407169

EGT:

SSPL:

SMIL:

SHIS:

APAN:

HPUM:

PHUA:

PEBU:

HAN:	110865100 110884084 110910819

ECAD:

122581700 122582943

LSV:	111891004 111900568

CCAV:

112502472 112519724

DCR:	108202343 108207108 108209492

CSIN:

114305075 114308144

RVL:	131315893 131315894

AEW:	130760091 130795586

DLT:

127807913

BVG:	104883006 104883007

SOE:

110788723

CQI:	110687429 110731270 110731271

ATRI:

MOF:

NNU:

MING:

TSS:

PSOM:

113283954 113336237 113348529

OSA:

DOSA:

OBR:

OGL:

BDI:

ATS:

TDC:	119301116 119308640

TAES:

123103327 123111518 123120767

TUA:	125508935 125508937

LPER:

127300340

LRD:	124653610 124654289

SBI:	8069012 8084637

ZMA:	100273876 100282854

MFLO:

136513669 136545691 136545758

SITA:

101760373

SVS:	117846284 117849697

PVIR:

PHAI:

PAUA:

TANG:

PDA:

EGU:

MUS:

ZOF:	122026910 122029344

DCT:

PEQ:

AOF:

MSIN:

ACAK:

NCOL:

ATR:

CJF:

SMO:	SELMODRAFT_165154 SELMODRAFT_270475

PPP:

112294971

CRE:	CHLRE_03g191850v5

VCN:	VOLCADRAFT_107595

MNG:

MNEG_8546

CSL:	COCSUDRAFT_54002

CVR:	CHLNCDRAFT_58302

APRO:

F751_3220

CCP:	CHC_T00009571001

FPOA:

FPOAC1_005451

FVN:	FVRRES_06011

FMU:	J7337_013412

MBR:	MONBRDRAFT_28844

TET:	TTHERM_00011540

PTM:	GSPATT00018029001

GTT:	GUITHDRAFT_149798

MAD:

HP15_3924

MBS:	MRBBS_3184

MPQ:	ABA45_15110

MSQ:	BKP64_14335

CMR:	Cycma_4642

CAMU:

CA2015_4453

EVI:	Echvi_3364

EST:	DN752_01525

ECHI:

FKX85_16765

AQB:	D1818_00370

AQA:	D1815_06940

AQD:	D1816_06350

» show all

Reference

PMID:17230527

Authors

Song XH, Liang B, Liu GF, Li R, Xie JP, Du K, Huang DY

Title

Expression of a novel alternatively spliced variant of NADP(H)-dependent retinol dehydrogenase/reductase with deletion of exon 3 in cervical squamous carcinoma.

Journal

Int J Cancer 120:1618-26 (2007)
DOI:10.1002/ijc.22306

Sequence

[hsa:10901]

Reference

PMID:12604222

Authors

Usami N, Ishikura S, Abe H, Nagano M, Uebuchi M, Kuniyasu A, Otagiri M, Nakayama H, Imamura Y, Hara A

Title

Cloning, expression and tissue distribution of a tetrameric form of pig carbonyl reductase.

Journal

Chem Biol Interact 143-144:353-61 (2003)
DOI:10.1016/S0009-2797(02)00210-7

Sequence

[ssc:397082]

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