KEGG   ORTHOLOGY: K11204Help
Entry
K11204                      KO                                     

Name
GCLC
Definition
glutamate--cysteine ligase catalytic subunit [EC:6.3.2.2]
Pathway
ko00270  Cysteine and methionine metabolism
ko00480  Glutathione metabolism
ko01100  Metabolic pathways
ko04212  Longevity regulating pathway - worm
ko04216  Ferroptosis
Module
M00118  Glutathione biosynthesis, glutamate => glutathione
Disease
H00668  Anemia due to disorders of glutathione metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09105 Amino acid metabolism
   00270 Cysteine and methionine metabolism
    K11204  GCLC; glutamate--cysteine ligase catalytic subunit
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K11204  GCLC; glutamate--cysteine ligase catalytic subunit
 09140 Cellular Processes
  09143 Cell growth and death
   04216 Ferroptosis
    K11204  GCLC; glutamate--cysteine ligase catalytic subunit
 09150 Organismal Systems
  09149 Aging
   04212 Longevity regulating pathway - worm
    K11204  GCLC; glutamate--cysteine ligase catalytic subunit
KEGG modules [BR:ko00002]
 Pathway module
  Amino acid metabolism
   Other amino acid metabolism
    M00118  Glutathione biosynthesis, glutamate => glutathione
     K11204  GCLC; glutamate--cysteine ligase catalytic subunit
Enzymes [BR:ko01000]
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.2  Acid-D-amino-acid ligases (peptide synthases)
    6.3.2.2  glutamate---cysteine ligase
     K11204  GCLC; glutamate--cysteine ligase catalytic subunit
BRITE hierarchy
Other DBs
RN: R00894 R10993
GO: 0004357
Genes
HSA: 2729(GCLC)
PTR: 742732(GCLC)
PPS: 100995141(GCLC)
GGO: 101128718(GCLC)
PON: 100454425(GCLC)
NLE: 100607388(GCLC)
MCC: 710508(GCLC)
MCF: 102138491(GCLC)
CSAB: 103221339(GCLC)
RRO: 104662843(GCLC)
RBB: 108530203(GCLC)
CJC: 100404379(GCLC)
SBQ: 101047032(GCLC)
MMU: 14629(Gclc)
RNO: 25283(Gclc)
CGE: 100752019(Gclc)
NGI: 103736919(Gclc)
HGL: 101718793(Gclc)
CCAN: 109699974(Gclc)
OCU: 100342383(GCLC)
TUP: 102475503(GCLC)
CFA: 609822(GCLC)
AML: 100466011(GCLC)
UMR: 103664124(GCLC)
ORO: 101372808(GCLC)
FCA: 101096568(GCLC)
PTG: 102949666(GCLC)
AJU: 106973075(GCLC)
BTA: 512468(GCLC)
BOM: 102268521(GCLC)
BIU: 109577226(GCLC)
PHD: 102327526(GCLC)
CHX: 102180090(GCLC)
OAS: 101114822(GCLC)
SSC: 100522018(GCLC)
CFR: 102516188(GCLC)
CDK: 105099540(GCLC)
BACU: 103012546(GCLC)
LVE: 103082965(GCLC)
OOR: 101269295(GCLC)
ECB: 100056731(GCLC)
EPZ: 103553259(GCLC)
EAI: 106845572(GCLC)
MYB: 102259643(GCLC)
MYD: 102763103(GCLC)
HAI: 109396353(GCLC)
RSS: 109448918(GCLC)
PALE: 102895728(GCLC)
LAV: 100668966(GCLC)
TMU: 101349482
MDO: 100014379(GCLC)
SHR: 100930103(GCLC)
OAA: 100078137(GCLC)
GGA: 421894(GCLC)
MGP: 100543712(GCLC)
CJO: 107312116(GCLC)
APLA: 101799767(GCLC)
ACYG: 106030429(GCLC)
TGU: 100218278(GCLC)
SCAN: 103820009(GCLC)
GFR: 102035643(GCLC)
FAB: 101809593(GCLC)
PHI: 102104562(GCLC)
PMAJ: 107202092(GCLC)
CCAE: 111925880(GCLC)
CCW: 104693503(GCLC)
FPG: 101924789(GCLC)
FCH: 102048845(GCLC)
CLV: 102090846(GCLC)
EGZ: 104126227(GCLC)
NNI: 104014393(GCLC)
ACUN: 113478403(GCLC)
AAM: 106493252(GCLC)
ASN: 102370232(GCLC)
AMJ: 102575202(GCLC)
PSS: 102462808(GCLC)
CMY: 102934093(GCLC)
CPIC: 101935836(GCLC)
ACS: 100554798(gclc)
PVT: 110090238(GCLC)
PBI: 103059842(GCLC)
PMUR: 107292158(GCLC) 107301634
GJA: 107121117(GCLC)
XLA: 100049719(gclc.L) 100137615(gclc.S)
XTR: 780264(gclc)
NPR: 108788961(GCLC)
DRE: 326857(gclc)
SGH: 107570553(gclc) 107597697
IPU: 108263259(gclc)
PHYP: 113542179(gclc)
AMEX: 103047245(gclc)
TRU: 101071196(gclc)
LCO: 104939728(gclc)
NCC: 104948421(gclc)
MZE: 101472352(gclc)
OLA: 101169230(gclc)
XMA: 102219526(gclc)
PRET: 103476996(gclc)
NFU: 107396606(gclc)
KMR: 108234128(gclc)
CSEM: 103387418(gclc)
LCF: 108891100(gclc)
SDU: 111235190(gclc)
HCQ: 109516203(gclc)
BPEC: 110157175(gclc)
MALB: 109961911(gclc)
SASA: 100196780(gsh1) 106612605
ELS: 105021355(gclc)
SFM: 108932902(gclc)
LCM: 102364784(GCLC)
CMK: 103179004(gclc)
SPU: 589474(gclc)
APLC: 110975346
SKO: 102808159
DME: Dmel_CG2259(Gclc)
DER: 6550333
DPE: 6598248
DSI: Dsimw501_GD16129(Dsim_GD16129)
DWI: 6648338
AAG: 5570136
AME: 100578132
BIM: 100744532
BTER: 100649739
SOC: 105202145
MPHA: 105838958
AEC: 105154235
ACEP: 105622246
PBAR: 105422207
HST: 105187272
DQU: 106752239
CFO: 105254755
LHU: 105671457
PGC: 109863586
OBO: 105286103
PCF: 106786391
NVI: 100121797
TCA: 656567
DPA: 109546724
NVL: 108556393
BMOR: 101745128(GLC)
HAW: 110373042
TNL: 113492726
PXY: 105384723
API: 100160633
DNX: 107162321
CLEC: 106664888
ZNE: 110834233
FCD: 110847160
TUT: 107369131
DPTE: 113798830
CEL: CELE_F37B12.2(gcs-1)
CBR: CBG03249(Cbr-gcs-1)
BMY: Bm1_09550
TSP: Tsp_07922
CRG: 105337379
MYI: 110454508
OBI: 106880152
SHX: MS3_05369
EGL: EGR_00133
EPA: 110240413
ADF: 107341718
PDAM: 113673063
SCE: YJL101C(GSH1)
ERC: Ecym_6350
KMX: KLMA_30154(GSH1)
NCS: NCAS_0B07730(NCAS0B07730)
NDI: NDAI_0B05080(NDAI0B05080)
TPF: TPHA_0I00880(TPHA0I00880)
TBL: TBLA_0H02900(TBLA0H02900)
TDL: TDEL_0D01340(TDEL0D01340)
KAF: KAFR_0A03480(KAFR0A03480)
PIC: PICST_62151(GSH1)
CAL: CAALFM_C107880CA(GCS1)
CAUR: QG37_03484
SLB: AWJ20_2097(GSH1)
NCR: NCU01157
NTE: NEUTE1DRAFT120034(NEUTE1DRAFT_120034)
MGR: MGG_07317
SSCK: SPSK_04991
MAW: MAC_01134
MAJ: MAA_05600
CMT: CCM_00539
BFU: BCIN_14g03920(Bcgsh1)
MBE: MBM_02206
ANI: AN3150.2
ANG: ANI_1_1386024(An02g09720)
ABE: ARB_01253
TVE: TRV_01253
PTE: PTT_12856
SPO: SPAC22F3.10c(gcs1)
CNE: CNN00350
CNB: CNBN0330
HIR: HETIRDRAFT_61613(GS2)
LBC: LACBIDRAFT_247161(LbGCS)
ABP: AGABI1DRAFT71066(AGABI1DRAFT_71066)
ABV: AGABI2DRAFT203941(AGABI2DRAFT_203941)
MGL: MGL_2630
DDI: DDB_G0284651(gcsA)
DFA: DFA_03485(gcsA)
PYO: PY17X_0823100(PY01606)
PCB: PCHAS_082010(PC301294.00.0)
TAN: TA03765
TPV: TP03_0084
BBO: BBOV_I002580(19.m02298)
SMIN: v1.2.002819.t1(symbB.v1.2.002819.t1) v1.2.019114.t1(symbB.v1.2.019114.t1) v1.2.034264.t1(symbB.v1.2.034264.t1)
FCY: FRACYDRAFT_209641(GGCS)
SPAR: SPRG_03567
LMA: LMJF_18_1660(GSH1)
LIF: LINJ_18_1660(GSH1)
LBZ: LBRM_18_1700(GSH1)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Radyuk SN, Rebrin I, Luchak JM, Michalak K, Klichko VI, Sohal RS, Orr WC
  Title
The catalytic subunit of Drosophila glutamate-cysteine ligase is a nucleocytoplasmic shuttling protein.
  Journal
J Biol Chem 284:2266-74 (2009)
DOI:10.1074/jbc.M805913200
  Sequence
Reference
PMID:1350904
  Authors
Gipp JJ, Chang C, Mulcahy RT
  Title
Cloning and nucleotide sequence of a full-length cDNA for human liver gamma-glutamylcysteine synthetase.
  Journal
Biochem Biophys Res Commun 185:29-35 (1992)
DOI:10.1016/S0006-291X(05)80950-7
  Sequence
[hsa:2729]

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