KEGG   ORTHOLOGY: K11217
Entry
K11217                      KO                                     
Symbol
JAK1
Name
Janus kinase 1 [EC:2.7.10.2]
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map04151  PI3K-Akt signaling pathway
map04217  Necroptosis
map04380  Osteoclast differentiation
map04550  Signaling pathways regulating pluripotency of stem cells
map04620  Toll-like receptor signaling pathway
map04621  NOD-like receptor signaling pathway
map04630  JAK-STAT signaling pathway
map04658  Th1 and Th2 cell differentiation
map04659  Th17 cell differentiation
map05140  Leishmaniasis
map05145  Toxoplasmosis
map05152  Tuberculosis
map05160  Hepatitis C
map05161  Hepatitis B
map05162  Measles
map05163  Human cytomegalovirus infection
map05164  Influenza A
map05165  Human papillomavirus infection
map05166  Human T-cell leukemia virus 1 infection
map05167  Kaposi sarcoma-associated herpesvirus infection
map05168  Herpes simplex virus 1 infection
map05169  Epstein-Barr virus infection
map05171  Coronavirus disease - COVID-19
map05200  Pathways in cancer
map05203  Viral carcinogenesis
map05212  Pancreatic cancer
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H02537  Autoinflammation, immune dysregulation, and eosinophilia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04630 JAK-STAT signaling pathway
    K11217  JAK1; Janus kinase 1
   04151 PI3K-Akt signaling pathway
    K11217  JAK1; Janus kinase 1
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K11217  JAK1; Janus kinase 1
  09144 Cellular community - eukaryotes
   04550 Signaling pathways regulating pluripotency of stem cells
    K11217  JAK1; Janus kinase 1
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K11217  JAK1; Janus kinase 1
   04621 NOD-like receptor signaling pathway
    K11217  JAK1; Janus kinase 1
   04658 Th1 and Th2 cell differentiation
    K11217  JAK1; Janus kinase 1
   04659 Th17 cell differentiation
    K11217  JAK1; Janus kinase 1
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K11217  JAK1; Janus kinase 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K11217  JAK1; Janus kinase 1
   05203 Viral carcinogenesis
    K11217  JAK1; Janus kinase 1
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K11217  JAK1; Janus kinase 1
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K11217  JAK1; Janus kinase 1
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K11217  JAK1; Janus kinase 1
   05161 Hepatitis B
    K11217  JAK1; Janus kinase 1
   05160 Hepatitis C
    K11217  JAK1; Janus kinase 1
   05171 Coronavirus disease - COVID-19
    K11217  JAK1; Janus kinase 1
   05164 Influenza A
    K11217  JAK1; Janus kinase 1
   05162 Measles
    K11217  JAK1; Janus kinase 1
   05168 Herpes simplex virus 1 infection
    K11217  JAK1; Janus kinase 1
   05163 Human cytomegalovirus infection
    K11217  JAK1; Janus kinase 1
   05167 Kaposi sarcoma-associated herpesvirus infection
    K11217  JAK1; Janus kinase 1
   05169 Epstein-Barr virus infection
    K11217  JAK1; Janus kinase 1
   05165 Human papillomavirus infection
    K11217  JAK1; Janus kinase 1
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K11217  JAK1; Janus kinase 1
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K11217  JAK1; Janus kinase 1
   05140 Leishmaniasis
    K11217  JAK1; Janus kinase 1
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K11217  JAK1; Janus kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K11217  JAK1; Janus kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K11217  JAK1; Janus kinase 1
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  JAK family [OT]
   K11217  JAK1; Janus kinase 1
Other DBs
GO: 0004715
Genes
HSA: 3716(JAK1)
PTR: 743373(JAK1)
PPS: 100972202(JAK1)
GGO: 101133331(JAK1)
PON: 100433477(JAK1)
PPYG: 129034648(JAK1)
NLE: 100588162(JAK1)
HMH: 116457829(JAK1)
SSYN: 129458731(JAK1)
MCC: 677689(JAK1)
MCF: 102123983(JAK1)
MTHB: 126935739
MNI: 105498461(JAK1)
CSAB: 103224682(JAK1)
CATY: 105595926(JAK1)
PANU: 101002872(JAK1)
TGE: 112620491(JAK1)
MLEU: 105543512(JAK1)
RRO: 104668074(JAK1)
RBB: 108532886(JAK1)
TFN: 117092033(JAK1)
PTEH: 111541367(JAK1)
CANG: 105510845(JAK1)
CJC: 100385835(JAK1)
SBQ: 101031615(JAK1)
CIMI: 108313230(JAK1)
ANAN: 105710272(JAK1)
CSYR: 103262860(JAK1)
MMUR: 105872820(JAK1)
LCAT: 123635562(JAK1)
PCOQ: 105806352(JAK1)
OGA: 100955095(JAK1)
MMU: 16451(Jak1)
MCAL: 110292243(Jak1)
MPAH: 110322912(Jak1)
RNO: 84598(Jak1)
MCOC: 116096295(Jak1)
ANU: 117709127(Jak1)
MUN: 110555551(Jak1)
CGE: 100754824(Jak1)
MAUA: 101843653(Jak1)
PROB: 127224978(Jak1)
PLEU: 114693732(Jak1)
MORG: 121448662(Jak1)
MFOT: 126497894
AAMP: 119816123(Jak1)
NGI: 103732475(Jak1)
HGL: 101710283(Jak1)
CPOC: 100726895(Jak1)
CCAN: 109699504(Jak1)
DORD: 105988847(Jak1)
DSP: 122110980(Jak1)
PLOP: 125355256(Jak1)
NCAR: 124977081
MMMA: 107141689(Jak1)
OCU: 100352594
OPI: 101535293(JAK1)
TUP: 102471806(JAK1)
GVR: 103591505(JAK1)
CFA: 442952(JAK1)
CLUD: 112647170(JAK1)
VVP: 112907887(JAK1)
VLG: 121499401(JAK1)
NPO: 129497055(JAK1)
AML: 100473460(JAK1)
UMR: 103663059(JAK1)
UAH: 113254577(JAK1)
UAR: 123795350(JAK1)
ELK: 111142881
LLV: 125097987
MPUF: 101683109(JAK1)
MNP: 132000969(JAK1)
MLK: 131809752(JAK1)
NVS: 122900048(JAK1)
ORO: 101365648(JAK1)
EJU: 114208347(JAK1)
ZCA: 113908976(JAK1)
MLX: 118019316(JAK1)
NSU: 110571840(JAK1)
LWW: 102736730(JAK1)
FCA: 101084377(JAK1)
PYU: 121027253(JAK1)
PCOO: 112871857(JAK1)
PBG: 122480600(JAK1)
PVIV: 125173198(JAK1)
LRUF: 124515396
PTG: 102960189(JAK1)
PPAD: 109266731(JAK1)
PUC: 125913423
AJU: 106983739
HHV: 120232606(JAK1)
BTA: 537201(JAK1)
BOM: 102286137(JAK1)
BIU: 109556202(JAK1)
BBUB: 102405285(JAK1)
BBIS: 104988726(JAK1)
CHX: 102182846(JAK1)
OAS: 101110716(JAK1)
BTAX: 128044816(JAK1)
ODA: 120857038(JAK1)
CCAD: 122436869(JAK1)
MBEZ: 129541821(JAK1)
SSC: 397202(JAK1)
CFR: 102519873(JAK1)
CBAI: 105064618(JAK1)
CDK: 105107124(JAK1)
VPC: 102544505(JAK1)
BACU: 103004050(JAK1)
BMUS: 118895748(JAK1)
LVE: 103072682(JAK1)
OOR: 101275383(JAK1)
DLE: 111178461(JAK1)
PCAD: 102988182(JAK1)
PSIU: 116756336(JAK1)
NASI: 112412959(JAK1)
ECB: 100054008(JAK1)
EPZ: 103560394(JAK1)
EAI: 106838751(JAK1)
MYB: 102260801(JAK1)
MYD: 102756517(JAK1)
MMYO: 118675339(JAK1)
MLF: 102442353(JAK1)
PKL: 118724308(JAK1)
EFUS: 103284092(JAK1)
MNA: 107533604(JAK1)
DRO: 112309187(JAK1)
SHON: 118985040(JAK1)
AJM: 119042494(JAK1)
PDIC: 114498103(JAK1)
PHAS: 123816436(JAK1)
MMF: 118626049(JAK1)
PPAM: 129071023(JAK1)
HAI: 109384938(JAK1)
RFQ: 117026596(JAK1)
PALE: 102880365(JAK1)
PGIG: 120583126(JAK1)
PVP: 105298360(JAK1)
RAY: 107517940(JAK1)
MJV: 108405993(JAK1)
TOD: 119235485(JAK1)
SARA: 101556525(JAK1)
SETR: 126010825(JAK1)
LAV: 100655548(JAK1)
TMU: 101346613
ETF: 101664197(JAK1)
DNM: 101432776(JAK1)
MDO: 100031307(JAK1)
GAS: 123245763(JAK1)
SHR: 100916991(JAK1)
AFZ: 127563200
PCW: 110212891(JAK1)
TVP: 118847807(JAK1)
OAA: 100082981(JAK1)
GGA: 395681(JAK1)
PCOC: 116235600(JAK1)
MGP: 100551269
CJO: 107317736(JAK1)
TPAI: 128072732(JAK1)
LMUT: 125692986(JAK1)
NMEL: 110402219(JAK1)
APLA: 101794879(JAK1)
ACYG: 106043591(JAK1)
CATA: 118256994(JAK1)
AFUL: 116491721(JAK1)
TGU: 115496244(JAK1)
LSR: 110473260(JAK1)
PMOA: 120503356(JAK1)
OTC: 121345104(JAK1)
PRUF: 121362034(JAK1)
GFR: 102041288(JAK1)
FAB: 101805872(JAK1)
OMA: 130256302(JAK1)
PHI: 102100416(JAK1)
PMAJ: 107208260(JAK1)
CCAE: 111922174 111932966(JAK1)
CCW: 104695136(JAK1)
CBRC: 103621569(JAK1)
ETL: 114061064(JAK1)
ZAB: 102069725(JAK1)
ZLE: 135450862(JAK1)
ACHL: 103804631(JAK1)
SVG: 106849721(JAK1)
MMEA: 130576053(JAK1)
HRT: 120756774(JAK1)
FPG: 101921412(JAK1)
FCH: 102048655(JAK1)
CLV: 102098386(JAK1)
EGZ: 104123929(JAK1)
NNI: 104009246(JAK1)
PCRI: 104023978(JAK1)
PLET: 104620090(JAK1)
EHS: 104512937(JAK1)
PCAO: 104052406
ACUN: 113482681(JAK1)
TALA: 104358413(JAK1)
PADL: 103913972(JAK1)
AFOR: 103898448(JAK1)
ACHC: 115349347(JAK1)
HALD: 104325645
HLE: 104828083(JAK1)
AGEN: 126042376
GCL: 127019362
CCRI: 104159339(JAK1)
CSTI: 104559294(JAK1)
CMAC: 104481714
MUI: 104536595(JAK1)
BREG: 104642521(JAK1)
FGA: 104077951
GSTE: 104258839(JAK1)
LDI: 104347663(JAK1)
MNB: 103778867
OHA: 104327217(JAK1)
NNT: 104411815(JAK1)
SHAB: 115611271(JAK1)
DPUB: 104298902(JAK1)
PGUU: 104469294
CPEA: 104397948(JAK1)
AVIT: 104275089(JAK1)
CVF: 104285506(JAK1)
RTD: 128914166(JAK1)
CUCA: 104066560(JAK1)
TEO: 104374521(JAK1)
BRHI: 104494851(JAK1)
AAM: 106487285(JAK1)
AROW: 112970278(JAK1)
NPD: 112945520(JAK1)
TGT: 104564512(JAK1)
DNE: 112990090(JAK1)
SCAM: 104153079(JAK1)
ASN: 102382170(JAK1)
AMJ: 106736893(JAK1)
CPOO: 109307560(JAK1)
GGN: 109305437(JAK1)
PSS: 102454892(JAK1)
CMY: 102944623(JAK1)
CCAY: 125640792(JAK1)
DCC: 119860825(JAK1)
CPIC: 101947775(JAK1)
TST: 117881998(JAK1)
CABI: 116824382(JAK1)
MRV: 120369825(JAK1)
ACS: 100559328(jak1)
ASAO: 132774014(JAK1)
PVT: 110085695(JAK1)
SUND: 121928485(JAK1)
PBI: 103059257(JAK1)
PMUR: 107294340(JAK1)
CTIG: 120301540(JAK1)
TSR: 106550876(JAK1)
PGUT: 117674995(JAK1)
APRI: 131195208(JAK1)
NSS: 113411084(JAK1)
VKO: 123023384(JAK1)
PMUA: 114598891(JAK1)
PRAF: 128415636(JAK1)
ZVI: 118088746(JAK1)
HCG: 128322523(JAK1)
GJA: 107124605(JAK1)
STOW: 125434014(JAK1)
EMC: 129330016(JAK1)
XLA: 108714222(jak1.L) 446697(jak1.S)
XTR: 100038172(jak1)
NPR: 108792339(JAK1)
RTEM: 120946247(JAK1)
BBUF: 120979022(JAK1)
BGAR: 122943855(JAK1)
MUO: 115472966(JAK1)
GSH: 117346115(JAK1)
DRE: 30280(jak1)
PTET: 122346374(jak1) 122358118
LROH: 127166357(jak1) 127180583
OMC: 131542390(jak1) 131554000
PPRM: 120471384 120493136(jak1)
RKG: 130091126(jak1) 130096828
MAMB: 125250111 125273972(jak1)
TROS: 130554381 130557104(jak1)
TDW: 130418263 130424792(jak1)
MANU: 129442698 129450110(jak1)
IFU: 128609813 128614429(jak1)
PHYP: 113531996(jak1) 113539949
SMEO: 124388090 124390997(jak1)
TFD: 113642692(jak1) 113647124
TVC: 132844311(jak1) 132848178
TRN: 134312101 134317246(jak1)
AMEX: 103033818(jak1) 103044144
CMAO: 118807976(jak1) 118825625
CHAR: 105891377 105913201(jak1)
TRU: 101072065(jak1)
TFS: 130529289(jak1)
LCO: 109139938(jak1)
NCC: 104950514(jak1)
TBEN: 117495715(jak1)
CGOB: 115006554(jak1)
PGEO: 117445389(jak1)
GACU: 117542661(jak1)
EMAC: 134869978(jak1)
ELY: 117254119(jak1)
EFO: 125896456(jak1)
PLEP: 121964491(jak1)
SLUC: 116039076(jak1)
ECRA: 117950246(jak1)
ESP: 116696159(jak1)
PFLV: 114561113(jak1)
GAT: 120824018(jak1)
PPUG: 119216944(jak1)
AFB: 129094115(jak1)
CLUM: 117729236(jak1)
PSWI: 130193581(jak1)
MSAM: 119900406(jak1)
SCHU: 122878395(jak1)
CUD: 121511897(jak1)
ALAT: 119028104(jak1)
MZE: 101464192(jak1)
ONL: 100690671(jak1)
OAU: 116336403(jak1)
OLA: 101175389(jak1)
OML: 112150103(jak1)
CSAI: 133458618(jak1)
XMA: 102225542(jak1)
XCO: 114150872(jak1)
XHE: 116725573(jak1)
PRET: 103463041(jak1)
PFOR: 103137225(jak1)
PLAI: 106951066(jak1)
PMEI: 106921188(jak1)
GAF: 122837966(jak1)
PPRL: 129376865(jak1)
CVG: 107087221(jak1)
CTUL: 119778925(jak1)
GMU: 124873826(jak1)
NFU: 107392913(jak1)
KMR: 108238415(jak1)
ALIM: 106521643(jak1)
NWH: 119430571(jak1)
AOCE: 111582047(jak1)
MCEP: 125008987(jak1)
CSEM: 103395542(jak1)
POV: 109636630(jak1)
SSEN: 122780670(jak1)
HHIP: 117760732(jak1)
HSP: 118120768(jak1)
PPLT: 128448642(jak1)
SMAU: 118318639(jak1)
LCF: 108897047
SDU: 111220102(jak1)
SLAL: 111645354(jak1)
XGL: 120791353(jak1)
HCQ: 109518981(jak1)
SSCV: 125973872
SBIA: 133503183(jak1)
PEE: 133406130(jak1)
PTAO: 133480559(jak1)
BPEC: 110167954(jak1)
MALB: 109961706(jak1)
BSPL: 114853126(jak1)
SJO: 128362384(jak1)
SALP: 111957137 111975385(jak1)
ELS: 105011918(jak1) 105024705
SFM: 108935121 108935468(jak1)
PKI: 111834843(jak1) 111841014
AANG: 118225684(jak1) 118229660
LOC: 102694623(jak1)
PSPA: 121294162 121326424(jak1)
PSEX: 120515193(jak1)
LCM: 102364080(JAK1)
CMK: 103189591(jak1)
RTP: 109918768(jak1)
CPLA: 122554426(jak1)
HOC: 132819061(jak1)
LERI: 129701095(jak1)
SCLV: 120335186
DFR: 124498031
MESC: 110614209
 » show all
Reference
PMID:1848670
  Authors
Wilks AF, Harpur AG, Kurban RR, Ralph SJ, Zurcher G, Ziemiecki A
  Title
Two novel protein-tyrosine kinases, each with a second phosphotransferase-related catalytic domain, define a new class of protein kinase.
  Journal
Mol Cell Biol 11:2057-65 (1991)
DOI:10.1128/MCB.11.4.2057
  Sequence
[hsa:3716]

KEGG   ORTHOLOGY: K05856
Entry
K05856                      KO                                     
Symbol
LCK
Name
lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]
Pathway
map04064  NF-kappa B signaling pathway
map04380  Osteoclast differentiation
map04650  Natural killer cell mediated cytotoxicity
map04658  Th1 and Th2 cell differentiation
map04659  Th17 cell differentiation
map04660  T cell receptor signaling pathway
map05135  Yersinia infection
map05166  Human T-cell leukemia virus 1 infection
map05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
map05340  Primary immunodeficiency
Disease
H00093  Combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
   04660 T cell receptor signaling pathway
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
   04658 Th1 and Th2 cell differentiation
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
   04659 Th17 cell differentiation
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09163 Immune disease
   05340 Primary immunodeficiency
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  SRC family
   K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation proteins
   Kinases and associated factors
    K05856  LCK; lymphocyte cell-specific protein tyrosine kinase
Other DBs
GO: 0004715
Genes
HSA: 3932(LCK)
PTR: 456715(LCK)
PPS: 100979670(LCK)
GGO: 101151112(LCK)
PON: 100436326(LCK)
PPYG: 129020410(LCK)
NLE: 100585201(LCK)
HMH: 116472414(LCK)
SSYN: 129469198(LCK)
MCC: 717704(LCK)
MCF: 102140916(LCK)
MTHB: 126957341
MNI: 105494636(LCK)
CSAB: 103225952(LCK)
CATY: 105594825(LCK)
PANU: 101006803(LCK)
TGE: 112629154(LCK)
MLEU: 105535062(LCK)
RRO: 104654761(LCK)
RBB: 108518588(LCK)
TFN: 117092949(LCK)
PTEH: 111547561(LCK)
CANG: 105521275(LCK)
CJC: 100410584(LCK)
SBQ: 101041579(LCK)
CIMI: 108303945(LCK)
ANAN: 105709116(LCK)
CSYR: 103249770(LCK)
MMUR: 105871813(LCK)
LCAT: 123635834(LCK)
PCOQ: 105808545(LCK)
OGA: 100964949(LCK)
MMU: 16818(Lck)
MCAL: 110292164(Lck)
MPAH: 110322849(Lck)
RNO: 313050(Lck)
MCOC: 116096709(Lck)
ANU: 117708651(Lck)
MUN: 110548547(Lck)
CGE: 100759316(Lck)
MAUA: 101837225(Lck)
PROB: 127225402(Lck)
PLEU: 114705667(Lck)
MORG: 121448144(Lck)
MFOT: 126507357
AAMP: 119816479(Lck)
NGI: 103745927(Lck)
HGL: 101714396(Lck)
CPOC: 100728811(Lck)
CCAN: 109692973(Lck)
DORD: 105988873(Lck)
DSP: 122110955(Lck)
PLOP: 125354858(Lck)
NCAR: 124986736
MMMA: 107142003(Lck)
OCU: 100349102
OPI: 101518566(LCK)
TUP: 102468526(LCK)
GVR: 103594929(LCK)
CFA: 478151(LCK)
CLUD: 112660139(LCK)
VVP: 112931744(LCK)
VLG: 121497458(LCK)
NPO: 129513760(LCK)
AML: 100477981(LCK)
UMR: 103666444(LCK)
UAH: 113268359(LCK)
UAR: 123782388(LCK)
ELK: 111142990
LLV: 125098819
MPUF: 101682422(LCK)
MNP: 132001992(LCK)
MLK: 131809629(LCK)
NVS: 122898640(LCK)
ORO: 101383028(LCK)
EJU: 114217100(LCK)
ZCA: 113932258(LCK)
MLX: 118019751(LCK)
NSU: 110574851(LCK)
LWW: 102728925(LCK)
FCA: 101098805(LCK)
PYU: 121025386(LCK)
PCOO: 112871853(LCK)
PBG: 122480237(LCK)
PVIV: 125172178(LCK)
LRUF: 124515043
PTG: 102967826(LCK)
PPAD: 109255318(LCK)
PUC: 125912825
AJU: 106982436
HHV: 120232408(LCK)
BTA: 508890(LCK)
BOM: 102264903(LCK)
BIU: 109572368(LCK)
BBUB: 102406784(LCK)
BBIS: 104986377(LCK)
CHX: 102171746(LCK)
OAS: 100216439(LCK)
BTAX: 128062412(LCK)
ODA: 120854212(LCK)
CCAD: 122426634(LCK)
MBEZ: 129537772(LCK)
SSC: 100233188(LCK)
CFR: 102507741(LCK)
CBAI: 105066766(LCK)
CDK: 105085793(LCK)
VPC: 102530493(LCK)
BACU: 102998192(LCK)
BMUS: 118899108(LCK)
LVE: 103069516(LCK)
OOR: 101271418(LCK)
DLE: 111175513(LCK)
PCAD: 102992010(LCK)
PSIU: 116759447(LCK)
NASI: 112414291(LCK)
ECB: 100146139(LCK)
EPZ: 103552084(LCK)
EAI: 106829050(LCK)
MYB: 102242493(LCK)
MYD: 102764895(LCK)
MMYO: 118677022(LCK)
MLF: 102428805(LCK)
PKL: 118723752(LCK)
EFUS: 103300142(LCK)
MNA: 107542423(LCK)
DRO: 112299317(LCK)
SHON: 118997726(LCK)
AJM: 119052321(LCK)
PDIC: 114497642(LCK) 114503225
PHAS: 123832115(LCK)
MMF: 118626449(LCK)
PPAM: 129069029(LCK)
HAI: 109390746(LCK) 109390751
RFQ: 117027840(LCK)
PALE: 102891182(LCK)
PGIG: 120581990(LCK)
PVP: 105290574(LCK)
RAY: 107513587(LCK)
MJV: 108407415(LCK)
TOD: 119235229(LCK)
SARA: 101555087(LCK)
SETR: 126011131(LCK)
LAV: 100666557(LCK)
TMU: 101358037
ETF: 101638066(LCK)
DNM: 101445129(LCK)
MDO: 100025680(LCK)
GAS: 123243232(LCK)
SHR: 100922118(LCK)
AFZ: 127555504
PCW: 110206265(LCK)
TVP: 118837714(LCK)
OAA: 100078190(LCK)
GGA: 396460(LCK)
PCOC: 116229968(LCK)
MGP: 100547084(LCK)
CJO: 107323874(LCK)
TPAI: 128088397(LCK)
LMUT: 125703997(LCK)
NMEL: 110387471(LCK)
APLA: 119713655(LCK)
ACYG: 106037891(LCK)
CATA: 118255709(LCK)
AFUL: 116498165(LCK)
TGU: 115498263(LCK)
LSR: 110475352(LCK)
SCAN: 103823477(LCK)
PMOA: 120511706(LCK)
OTC: 121342819(LCK)
PRUF: 121359973(LCK)
GFR: 102044922(LCK)
FAB: 101820768(LCK)
OMA: 130262360(LCK)
PHI: 102102392(LCK)
PMAJ: 107214075(LCK)
CCAE: 111945885
CBRC: 103616944(LCK)
ETL: 114073234
ZLE: 135457274(LCK)
ACHL: 103805070(LCK)
SVG: 106858817(LCK)
MMEA: 130587692
HRT: 120763062(LCK)
FPG: 101919897(LCK)
FCH: 102055232(LCK)
CLV: 102085229(LCK)
EGZ: 104134930(LCK)
NNI: 104017767(LCK)
PLET: 104625915
ACUN: 113488171(LCK)
TALA: 116964264(LCK)
PADL: 103923795(LCK)
AFOR: 103903550(LCK)
ACHC: 115351470(LCK)
HLE: 104837123(LCK)
AGEN: 126047332
GCL: 127025009
CCRI: 104163956
MUI: 104547826(LCK)
BREG: 104633600(LCK)
NNT: 104401864(LCK)
SHAB: 115615863(LCK)
DPUB: 104307367(LCK)
CPEA: 104391337(LCK)
AVIT: 104271650
CVF: 104285996(LCK)
RTD: 128918778(LCK)
CUCA: 104060092(LCK)
AAM: 106493274(LCK)
AROW: 112975690(LCK)
NPD: 112950754(LCK)
DNE: 112982044(LCK)
ASN: 102374716(LCK)
AMJ: 102562977(LCK)
CPOO: 109318500(LCK)
GGN: 109294070(LCK)
PSS: 102450693(LCK)
CMY: 102938279(LCK)
CCAY: 125624797(LCK)
DCC: 119845478(LCK)
CPIC: 101942842(LCK)
TST: 117868367(LCK)
CABI: 116829146(LCK)
MRV: 120389216(LCK)
ACS: 100556474(lck)
ASAO: 132780430(LCK)
PVT: 110082790(LCK)
SUND: 121916163(LCK)
PBI: 103065569(LCK)
PMUR: 107285506(LCK)
CTIG: 120301789(LCK)
PGUT: 117663289(LCK)
APRI: 131204288(LCK)
PTEX: 113437615(LCK)
NSS: 113416045(LCK)
VKO: 123020879(LCK)
PMUA: 114601668(LCK)
PRAF: 128418873(LCK)
ZVI: 118087446(LCK)
HCG: 128333316(LCK)
GJA: 107107743(LCK)
STOW: 125434750(LCK)
EMC: 129343398(LCK)
XLA: 100036955(lck.L) 108708930(lck.S)
XTR: 100497656(lck)
NPR: 108795316(LCK)
RTEM: 120926815(LCK)
BBUF: 120995397(LCK)
BGAR: 122932213(LCK)
MUO: 115480753(LCK)
GSH: 117365843(LCK)
DRE: 414333(lck)
SGH: 107582994(lck) 107583665
PTET: 122361691(lck)
LROH: 127179410(lck)
OMC: 131523686(lck)
PPRM: 120459746(lck)
RKG: 130097505(lck)
MAMB: 125268803(lck)
CIDE: 127499019
TROS: 130560339(lck)
TDW: 130436550(lck)
MANU: 129417657(lck)
IPU: 108270195(lck)
IFU: 128612541(lck)
PHYP: 113545028
SMEO: 124389969(lck)
TFD: 113641446(lck)
TVC: 132852035(lck)
TRN: 134324882(lck)
AMEX: 103032401(lck)
CMAO: 118823871(lck)
EEE: 113576333
CHAR: 105895630(lck)
TRU: 101075948(lck)
TFS: 130513115(lck)
LCO: 104919312(lck)
NCC: 104946729(lck)
TBEN: 117476162(lck) 117492714(blk)
CGOB: 115027294(lck)
PGEO: 117440069(blk) 117467859(lck)
GACU: 117540308(blk) 117550070(lck)
EMAC: 134876980(blk) 134881483(lck)
ELY: 117266641(lck)
EFO: 125901165(lck)
PLEP: 121953214(lck)
SLUC: 116042509(lck)
ECRA: 117935545(lck)
ESP: 116669616(lck)
PFLV: 114546842(lck)
GAT: 120833302(lck)
PPUG: 119228056(lck)
AFB: 129103958(lck)
CLUM: 117725134(lck)
PSWI: 130201741(lck)
MSAM: 119910103(lck)
SCHU: 122862437(lck)
CUD: 121526410(lck)
ALAT: 119034491(lck)
MZE: 101474633(lck)
ONL: 100712193(lck)
OAU: 116311076(lck)
OLA: 100170631(lck) 101163706(blk)
OML: 112144897(lck) 112158066(blk)
CSAI: 133462946(lck)
XMA: 102224821(lck) 102225667(blk)
XCO: 114134400(lck) 114158151(blk)
XHE: 116709277(lck) 116733655(blk)
PRET: 103457625(blk) 103458632(lck)
PFOR: 103138649(blk) 103153408(lck) 103153566
PLAI: 106951738(lck) 106959608(blk)
PMEI: 106907763(lck) 106912704 106923252(blk)
GAF: 122825490(blk) 122846479(lck)
PPRL: 129351244(blk) 129365517(lck)
CVG: 107082827 107096412(lck)
CTUL: 119774176(lck) 119788352(blk)
GMU: 124856067(lck) 124881588(blk)
NFU: 107377504(blk) 107392534(lck)
KMR: 108232471(lck) 108242452(blk)
ALIM: 106518262(lck) 106525299
NWH: 119417890(blk) 119427173(lck)
AOCE: 111578479(lck)
MCEP: 125024188(lck)
CSEM: 103382672(lck)
POV: 109627923(lck)
SSEN: 122761263(lck)
HHIP: 117756594(lck)
HSP: 118116947(lck)
PPLT: 128450435(lck)
SMAU: 118286005(lck)
LCF: 108898014
SDU: 111225420(lck)
SLAL: 111650089(lck)
XGL: 120795167(lck)
HCQ: 109520801(lck)
SSCV: 125980929
SBIA: 133512926(lck)
PEE: 133413234(lck)
PTAO: 133468361(blk) 133487496(lck)
BPEC: 110155252(lck) 110155529
MALB: 109964987(lck)
BSPL: 114848985(lck)
SJO: 128375174(lck)
SASA: 100194878(lck) 106578585(lck)
OGO: 124001171(lck) 124046369
SALP: 111963179 111968811(lck)
CCLU: 121538780(lck) 121544388
ELS: 105015810(lck)
SFM: 108931279(lck)
PKI: 111833034(lck)
AANG: 118214135(lck)
LOC: 102690129(lck)
PSPA: 121308352
PSEX: 120517568(lck)
LCM: 102361989(LCK)
CMK: 103184977 103185670(lck)
RTP: 109923406
CPLA: 122563454
HOC: 132830112
LERI: 129697207 129709956(lck)
BGT: 106080295
HRF: 124114485
HRJ: 124291946
 » show all
Reference
PMID:3493153
  Authors
Koga Y, Caccia N, Toyonaga B, Spolski R, Yanagi Y, Yoshikai Y, Mak TW
  Title
A human T cell-specific cDNA clone (YT16) encodes a protein with extensive homology to a family of protein-tyrosine kinases.
  Journal
Eur J Immunol 16:1643-6 (1986)
DOI:10.1002/eji.1830161229
  Sequence
[hsa:3932]
Reference
PMID:8293463
  Authors
Weiss A, Littman DR
  Title
Signal transduction by lymphocyte antigen receptors.
  Journal
Cell 76:263-74 (1994)
DOI:10.1016/0092-8674(94)90334-4
Reference
  Authors
Tsun A, Qureshi I, Stinchcombe JC, Jenkins MR, de la Roche M, Kleczkowska J, Zamoyska R, Griffiths GM
  Title
Centrosome docking at the immunological synapse is controlled by Lck signaling.
  Journal
J Cell Biol 192:663-74 (2011)
DOI:10.1083/jcb.201008140

KEGG   ORTHOLOGY: K08890
Entry
K08890                      KO                                     
Symbol
BLK
Name
B lymphoid tyrosine kinase [EC:2.7.10.2]
Pathway
map04662  B cell receptor signaling pathway
Disease
H00410  Maturity onset diabetes of the young (MODY)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04662 B cell receptor signaling pathway
    K08890  BLK; B lymphoid tyrosine kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08890  BLK; B lymphoid tyrosine kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K08890  BLK; B lymphoid tyrosine kinase
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  SRC family
   K08890  BLK; B lymphoid tyrosine kinase
Other DBs
GO: 0004715
Genes
HSA: 640(BLK)
PTR: 463991(BLK)
PPS: 100989728(BLK)
GGO: 101149169(BLK)
PON: 100442545(BLK)
PPYG: 129042922(BLK)
NLE: 100601418(BLK)
HMH: 116473819(BLK)
SSYN: 129487486(BLK)
MCC: 696892(BLK)
MCF: 102134629(BLK)
MTHB: 126961061
MNI: 105491181(BLK)
CSAB: 103215326(BLK)
CATY: 105579384(BLK)
PANU: 101012728(BLK)
TGE: 112630034(BLK)
MLEU: 105532599(BLK)
RRO: 104679109(BLK)
RBB: 108536705(BLK)
TFN: 117063391(BLK)
PTEH: 111551355(BLK)
CANG: 105512402(BLK)
CJC: 100412187(BLK)
SBQ: 101046927(BLK)
CIMI: 108312515(BLK)
ANAN: 105720708(BLK)
CSYR: 103272696(BLK)
MMUR: 105864819(BLK)
PCOQ: 105807222(BLK)
OGA: 100953369(BLK)
MMU: 12143(Blk)
MCAL: 110309102(Blk)
MPAH: 110325256(Blk)
RNO: 364403(Blk)
MCOC: 116084545(Blk)
ANU: 117705441(Blk)
MUN: 110561868(Blk)
CGE: 100755534(Blk)
MAUA: 101842881(Blk)
PROB: 127230264(Blk)
PLEU: 114703376(Blk)
MORG: 121459646(Blk)
MFOT: 126507694
AAMP: 119800117(Blk)
NGI: 103730016(Blk)
HGL: 101707209(Blk)
CPOC: 100714723(Blk)
CCAN: 109678919(Blk)
DORD: 105991594(Blk)
DSP: 122125289(Blk)
PLOP: 125339293(Blk)
NCAR: 124982545
MMMA: 107153861(Blk)
OCU: 100345996
OPI: 101530673(BLK)
TUP: 102480506(BLK)
GVR: 103596274(BLK)
CFA: 486080(BLK)
CLUD: 112669650(BLK)
VVP: 112926712(BLK)
VLG: 121496652(BLK)
NPO: 129493706(BLK)
AML: 100479355(BLK)
UMR: 103675935(BLK)
UAH: 113269925(BLK)
UAR: 123793540(BLK)
LLV: 125092931
MPUF: 101691826(BLK)
MNP: 131999448(BLK)
MLK: 131833704(BLK)
NVS: 122919192(BLK)
ORO: 101377076(BLK)
EJU: 114217382(BLK)
ZCA: 113925691(BLK)
MLX: 118022390(BLK)
NSU: 110588505(BLK)
LWW: 102730375(BLK)
FCA: 101084104(BLK)
PYU: 121026978(BLK)
PCOO: 112858898(BLK)
PBG: 122474342(BLK)
PVIV: 125164566(BLK)
LRUF: 124520848
PTG: 102967571(BLK)
PPAD: 109262389(BLK)
AJU: 106975803
HHV: 120222045(BLK)
BTA: 532587(BLK)
BOM: 102283803(BLK)
BIU: 109562780(BLK)
BBUB: 102412376(BLK)
BBIS: 104988815(BLK)
CHX: 102174117(BLK)
OAS: 101111167(BLK)
BTAX: 128052176(BLK)
ODA: 120857741(BLK)
CCAD: 122453187(BLK)
MBEZ: 129557243(BLK)
SSC: 100623761(BLK)
CFR: 102520055(BLK)
CBAI: 105083374(BLK)
CDK: 105101938(BLK)
VPC: 102529562(BLK)
BACU: 103000707(BLK)
BMUS: 118897022(BLK)
LVE: 103091634(BLK)
OOR: 101284189(BLK)
DLE: 111185368(BLK)
PCAD: 102982502(BLK)
PSIU: 116755991(BLK)
NASI: 112410700(BLK)
ECB: 100065099(BLK)
EPZ: 103565478(BLK)
EAI: 106822585(BLK)
MYB: 102243589(BLK)
MYD: 102769847(BLK)
MMYO: 118659301(BLK)
MLF: 102423825(BLK)
PKL: 118711446(BLK)
EFUS: 103294358(BLK)
MNA: 107535018(BLK)
DRO: 112312450(BLK)
SHON: 118984320(BLK)
AJM: 119049443(BLK)
PDIC: 114502911(BLK)
PHAS: 123813778(BLK)
MMF: 118615701(BLK)
PPAM: 129072449(BLK)
HAI: 109379519(BLK)
RFQ: 117037947(BLK)
PALE: 102898235(BLK)
PGIG: 120613350(BLK)
PVP: 105291570(BLK)
RAY: 107518857(BLK)
MJV: 108402366(BLK)
TOD: 119257026(BLK)
SARA: 101558444(BLK)
SETR: 126005815(BLK)
LAV: 100677743(BLK)
TMU: 101361885
ETF: 101642053(BLK)
DNM: 101433029(BLK)
MDO: 100032697(BLK)
GAS: 123234903(BLK)
SHR: 100923306(BLK)
AFZ: 127548518
PCW: 110207648(BLK)
TVP: 118843011(BLK)
OAA: 100076440(BLK)
GGA: 422035(BLK)
PCOC: 116235589(BLK)
MGP: 100544594(BLK)
CJO: 107312432(BLK)
TPAI: 128085314(BLK)
LMUT: 125689785(BLK)
NMEL: 110396499(BLK)
APLA: 101794713(BLK)
ACYG: 106038127(BLK)
CATA: 118256520(BLK)
AFUL: 116487790(BLK)
TGU: 100223292(BLK)
LSR: 110475987(BLK)
SCAN: 103821296(BLK)
PMOA: 120496818(BLK)
OTC: 121347463(BLK)
PRUF: 121360791(BLK)
GFR: 102031459(BLK)
FAB: 101816827(BLK)
OMA: 130250787(BLK)
PHI: 102102766(BLK)
PMAJ: 107202585(BLK)
CCAE: 111927368(BLK)
CCW: 104696874(BLK)
CBRC: 103613272(BLK)
ETL: 114069194(BLK)
ZAB: 102069020(BLK)
ZLE: 135445106(BLK)
ACHL: 103798659(BLK)
SVG: 106863205(BLK)
MMEA: 130585629
HRT: 120750848(BLK)
FPG: 101916421(BLK)
FCH: 102060264(BLK)
CLV: 102092955(BLK)
EGZ: 104127260(BLK)
NNI: 104014690(BLK)
PCRI: 104035595
PLET: 104623268
EHS: 104512854
PCAO: 104041288
ACUN: 113478164(BLK)
TALA: 104355483(BLK)
PADL: 103913230(BLK)
AFOR: 103906888(BLK)
ACHC: 115351320(BLK)
HALD: 104321201
HLE: 104841451(BLK)
AGEN: 126046586
GCL: 127014185
CCRI: 104165240
CMAC: 104479960(BLK)
MUI: 104538559
BREG: 104632799(BLK)
FGA: 104071003
GSTE: 104262589
LDI: 104343996(BLK)
MNB: 103780836
OHA: 104336470(BLK)
NNT: 104404686(BLK)
SHAB: 115609478(BLK)
DPUB: 104306742(BLK)
PGUU: 104465049(BLK)
CPEA: 104392757(BLK)
AVIT: 104276923(BLK)
CVF: 104289049(BLK)
RTD: 128907750(BLK)
CUCA: 104060733(BLK)
TEO: 104378499
BRHI: 104492081
AAM: 106482525
AROW: 112963763(BLK)
NPD: 112948644(BLK)
TGT: 104571872
DNE: 112991172(BLK)
SCAM: 104138993(BLK)
ASN: 102373406(BLK)
AMJ: 102570125(BLK)
CPOO: 109311515(BLK)
GGN: 109300248(BLK)
PSS: 102452970(BLK)
CMY: 102931113(BLK)
CCAY: 125634706(BLK)
DCC: 119853351(BLK)
CPIC: 101941279(BLK)
TST: 117875408(BLK)
CABI: 116815287(BLK)
MRV: 120401329(BLK)
ACS: 100559493(blk)
ASAO: 132761615(BLK)
PVT: 110091211
SUND: 121919940(BLK)
PBI: 103053213(BLK)
PMUR: 107289318(BLK)
CTIG: 120318778
TSR: 106541703
PGUT: 117667722(BLK)
APRI: 131189039(BLK)
PTEX: 113446321(BLK)
NSS: 113424349(BLK)
VKO: 123033601(BLK)
PMUA: 114593387(BLK)
PRAF: 128411410(BLK)
ZVI: 118082711(BLK)
HCG: 128324206(BLK)
GJA: 107123785(BLK)
STOW: 125437251(BLK)
EMC: 129325123(BLK)
XLA: 108717237(blk.L)
XTR: 100496460(blk)
NPR: 108800193
RTEM: 120936179
BBUF: 120997195(BLK)
BGAR: 122934092(BLK)
MUO: 115465160(BLK)
GSH: 117357343(BLK)
DRE: 567764(blk)
PTET: 122325552(blk)
LROH: 127183409(blk)
OMC: 131527399(blk)
PPRM: 120494220(blk)
RKG: 130097578(blk)
MAMB: 125278945(blk)
CIDE: 127502228
TROS: 130566141(blk)
TDW: 130434572(blk)
MANU: 129429707(blk)
IPU: 108258139(blk)
IFU: 128601292(blk)
PHYP: 113545292(blk)
SMEO: 124377071(blk)
TFD: 113644829(blk)
TVC: 132843339(blk)
TRN: 134320043(blk)
AMEX: 103025639(blk)
CMAO: 118815509(blk)
EEE: 113569917
CHAR: 105897722(blk)
TRU: 101064341(blk)
TFS: 130516519(blk)
LCO: 104922438(blk)
NCC: 104962275(blk)
CGOB: 115003648(blk)
ELY: 117270745(blk)
EFO: 125896546(blk)
PLEP: 121955291(blk)
SLUC: 116066308(blk)
ECRA: 117961399(blk)
ESP: 116706739(blk)
PFLV: 114572758(blk)
GAT: 120808376(blk)
PPUG: 119195409(blk)
AFB: 129107630(blk)
CLUM: 117727474(blk)
PSWI: 130202133(blk)
MSAM: 119909242(blk)
SCHU: 122862835(blk)
CUD: 121521442(blk)
ALAT: 119013026(blk)
MZE: 101474727(blk)
ONL: 100692749(blk)
OAU: 116314080(blk)
CSAI: 133464427(blk)
AOCE: 111588222
MCEP: 124999102(blk)
CSEM: 103398683
POV: 109632326
SSEN: 122784452(blk)
HHIP: 117758461(blk)
HSP: 118099891(blk)
PPLT: 128459902(blk)
SMAU: 118289790(blk)
LCF: 108895563
SDU: 111238823(blk)
SLAL: 111653479
XGL: 120788797(blk)
HCQ: 109524848(blk)
SSCV: 125989786
SBIA: 133496809(blk)
PEE: 133416761(blk)
MALB: 109970011(blk)
BSPL: 114849933(blk)
SASA: 106608341
STRU: 115149525(blk)
OTW: 112247817(blk)
OMY: 110522661(blk)
OGO: 123995469(blk)
OKI: 109879154(blk)
OKE: 118381208(blk)
SNH: 120019419(blk)
CCLU: 121548491(blk)
ELS: 109614593(blk)
AANG: 118222871(si:ch73-340m8.2) 118229054(blk)
LOC: 102683224
PSPA: 121316437(lck) 121317321
ARUT: 117410400
PSEX: 120526327(blk)
LCM: 102350125
RTP: 109918180(si:ch73-340m8.2)
CPLA: 122543725(si:ch73-340m8.2)
HOC: 132806709
RPHI: 132732416
 » show all
Reference
PMID:7822795
  Authors
Islam KB, Rabbani H, Larsson C, Sanders R, Smith CI
  Title
Molecular cloning, characterization, and chromosomal localization of a human lymphoid tyrosine kinase related to murine Blk.
  Journal
J Immunol 154:1265-72 (1995)
  Sequence
[hsa:640]

KEGG   ORTHOLOGY: K08891
Entry
K08891                      KO                                     
Symbol
FGR, SRC2
Name
tyrosine-protein kinase Fgr [EC:2.7.10.2]
Pathway
map04062  Chemokine signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    K08891  FGR, SRC2; tyrosine-protein kinase Fgr
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08891  FGR, SRC2; tyrosine-protein kinase Fgr
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K08891  FGR, SRC2; tyrosine-protein kinase Fgr
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K08891  FGR, SRC2; tyrosine-protein kinase Fgr
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  SRC family
   K08891  FGR, SRC2; tyrosine-protein kinase Fgr
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K08891  FGR, SRC2; tyrosine-protein kinase Fgr
Other DBs
GO: 0004715
Genes
HSA: 2268(FGR)
PTR: 739516(FGR)
PPS: 100980496(FGR)
GGO: 101140064(FGR)
PON: 100442468(FGR)
PPYG: 129042496(FGR)
NLE: 100586175(FGR)
HMH: 116813148(FGR)
SSYN: 129472013(FGR)
MCC: 716296(FGR)
MCF: 102117662(FGR)
MTHB: 126957410
MNI: 105494540(FGR)
CSAB: 103225283(FGR)
CATY: 105594897(FGR)
PANU: 101001002(FGR)
TGE: 112625564(FGR)
MLEU: 105540926(FGR)
RRO: 104675721(FGR)
RBB: 108518213(FGR)
TFN: 117093029(FGR)
PTEH: 111547623(FGR)
CANG: 105521341(FGR)
CJC: 100392203(FGR)
SBQ: 101046244(FGR)
CIMI: 108308747(FGR)
ANAN: 105708334(FGR)
CSYR: 103262719(FGR)
MMUR: 105863555(FGR)
LCAT: 123634330(FGR)
PCOQ: 105811723(FGR)
OGA: 100952235(FGR)
MMU: 14191(Fgr)
MCAL: 110292330(Fgr)
MPAH: 110323859(Fgr)
RNO: 79113(Fgr)
MCOC: 116096778(Fgr)
ANU: 117708804(Fgr)
MUN: 110552538(Fgr)
CGE: 100758687(Fgr)
MAUA: 101824636(Fgr)
PROB: 127225481(Fgr)
PLEU: 114705972(Fgr)
MORG: 121448177(Fgr)
MFOT: 126506643
AAMP: 119816480(Fgr)
NGI: 103737072(Fgr)
HGL: 101704214(Fgr)
CPOC: 100735748(Fgr)
CCAN: 109696043(Fgr)
DORD: 105999534(Fgr)
DSP: 122115233(Fgr)
PLOP: 125354790(Fgr)
NCAR: 124959355
MMMA: 107142068(Fgr)
OCU: 100342557
OPI: 101533433(FGR)
TUP: 102499209(FGR)
GVR: 103592728(FGR)
CFA: 487341(FGR)
CLUD: 112660162(FGR)
VVP: 112931768(FGR)
VLG: 121498137(FGR)
NPO: 129513258(FGR)
AML: 100467541(FGR)
UMR: 103666500(FGR)
UAH: 113268434(FGR)
UAR: 123782348(FGR)
ELK: 111142853
LLV: 125098407
MPUF: 101690028(FGR)
MNP: 132001884(FGR)
MLK: 131809392(FGR)
NVS: 122899636(FGR)
ORO: 101366929(FGR)
EJU: 114216975(FGR)
ZCA: 113911304(FGR)
MLX: 118019815(FGR)
NSU: 110574804(FGR)
LWW: 102747597(FGR)
FCA: 101083781(FGR)
PYU: 121024148(FGR)
PCOO: 112871756(FGR)
PBG: 122480160(FGR)
PVIV: 125172669(FGR)
LRUF: 124516381
PTG: 102956263(FGR)
PPAD: 109256809(FGR)
PUC: 125912877
AJU: 106977542
HHV: 120232480(FGR)
BTA: 516133(FGR)
BOM: 102277882(FGR)
BIU: 109573058(FGR)
BBUB: 102415198(FGR)
BBIS: 104981176(FGR)
CHX: 102177575(FGR)
OAS: 101107075(FGR)
BTAX: 128063768(FGR)
ODA: 120855129(FGR)
CCAD: 122426870(FGR)
MBEZ: 129538140(FGR)
SSC: 100513738(FGR)
CFR: 102519666(FGR)
CBAI: 105063438(FGR)
CDK: 105100713(FGR)
VPC: 102534441(FGR)
BACU: 103016939(FGR)
BMUS: 118886020(FGR)
LVE: 103079693(FGR)
OOR: 101269287(FGR)
DLE: 111163272(FGR)
PCAD: 102975495(FGR)
PSIU: 116754306(FGR)
NASI: 112414258(FGR)
ECB: 100056804(FGR)
EPZ: 103562782(FGR)
EAI: 106839104(FGR)
MYB: 102256827(FGR)
MYD: 102751689(FGR)
MMYO: 118676724(FGR)
MLF: 102417849(FGR)
PKL: 118724718(FGR)
EFUS: 103292055(FGR)
MNA: 107542316(FGR)
DRO: 112299496(FGR)
SHON: 118977776(FGR)
AJM: 119052294(FGR)
PDIC: 114497816(FGR)
PHAS: 123832038(FGR)
MMF: 118626506(FGR)
PPAM: 129069222(FGR)
HAI: 109386779(FGR)
RFQ: 117027522(FGR)
PALE: 102885470(FGR)
PGIG: 120596074(FGR)
PVP: 105290517(FGR)
RAY: 107503580(FGR)
MJV: 108386551(FGR)
TOD: 119236195(FGR)
SARA: 101539494(FGR)
SETR: 126011407(FGR)
LAV: 100654897(FGR)
TMU: 101361519
ETF: 101648666(FGR)
DNM: 101435989(FGR)
GAS: 123241033(FGR)
SHR: 100918989(FGR)
AFZ: 127555622
PCW: 110206155(FGR)
TVP: 118839910(FGR)
OAA: 100092688(FGR)
CSTI: 104561458
LDI: 104354660
ACAR: 104524113
SCAM: 104152388
XLA: 108708097 108709526(fgr.S)
XTR: 100493811(fgr)
NPR: 108786632(FGR)
RTEM: 120927361(FGR)
BBUF: 120995220(FGR)
BGAR: 122933184(FGR)
BFO: 118411035
AJC: 117116541
OED: 125660410
MMER: 123525718
MAEA: 128220025
 » show all
Reference
  Authors
Sergeant S, Waite KA, Heravi J, McPhail LC
  Title
Phosphatidic acid regulates tyrosine phosphorylating activity in human neutrophils: enhancement of Fgr activity.
  Journal
J Biol Chem 276:4737-46 (2001)
DOI:10.1074/jbc.M006571200
  Sequence
[hsa:2268]

KEGG   ORTHOLOGY: K08892
Entry
K08892                      KO                                     
Symbol
FRK, PTK5
Name
fyn-related kinase [EC:2.7.10.2]
Pathway
map04013  MAPK signaling pathway - fly
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04013 MAPK signaling pathway - fly
    K08892  FRK, PTK5; fyn-related kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08892  FRK, PTK5; fyn-related kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K08892  FRK, PTK5; fyn-related kinase
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  SRC family
   K08892  FRK, PTK5; fyn-related kinase
Other DBs
GO: 0004715
Genes
HSA: 2444(FRK)
PTR: 462953(FRK)
PPS: 100993183(FRK)
GGO: 101124601(FRK)
PON: 100448548(FRK)
PPYG: 129038592(FRK)
NLE: 100593495(FRK)
HMH: 116471168(FRK)
SSYN: 129472365(FRK)
MCC: 716267(FRK)
MCF: 101867326(FRK)
MTHB: 126952199
MNI: 105465460(FRK)
CSAB: 103240521(FRK)
CATY: 105581408(FRK)
PANU: 101021012(FRK)
TGE: 112623685(FRK)
MLEU: 105529614(FRK)
RRO: 104658191(FRK)
RBB: 108528208(FRK)
TFN: 117096957(FRK)
PTEH: 111547307(FRK)
CANG: 105506763(FRK)
CJC: 100403046(FRK)
SBQ: 101036910(FRK)
CIMI: 108281832(FRK)
ANAN: 105722730(FRK)
CSYR: 103257573(FRK)
MMUR: 105864975(FRK)
LCAT: 123633183(FRK)
PCOQ: 105815000(FRK)
OGA: 100958634(FRK)
MMU: 14302(Frk)
MCAL: 110303396(Frk)
MPAH: 110326363(Frk)
RNO: 79209(Frk)
MCOC: 116074982(Frk)
ANU: 117724903(Frk)
MUN: 110562222(Frk)
CGE: 100751157(Frk)
MAUA: 101837153(Frk)
PROB: 127215139(Frk)
PLEU: 114696873(Frk)
MORG: 121450017(Frk)
MFOT: 126499011
AAMP: 119821611(Frk)
NGI: 103749327(Frk)
HGL: 101710078(Frk)
CPOC: 100726734(Frk)
CCAN: 109680260(Frk)
DORD: 105998154(Frk)
DSP: 122099159(Frk)
PLOP: 125357201(Frk)
NCAR: 124989675
MMMA: 107154702(Frk)
OCU: 100348239
OPI: 101535676(FRK)
TUP: 102486580(FRK)
GVR: 103596308
CFA: 481970(FRK)
CLUD: 112658529(FRK)
VVP: 112925205(FRK)
VLG: 121489575(FRK)
NPO: 129512436(FRK)
AML: 100471968(FRK)
UMR: 103663480(FRK)
UAH: 113247893(FRK)
UAR: 123792973(FRK)
ELK: 111158302
LLV: 125102801
MPUF: 101682099(FRK)
MNP: 132018378(FRK)
MLK: 131833478(FRK)
NVS: 122903390(FRK)
ORO: 101363784(FRK)
EJU: 114219528(FRK)
ZCA: 113928069(FRK)
MLX: 118000572(FRK)
NSU: 110583365(FRK)
LWW: 102750810(FRK)
FCA: 101088668(FRK)
PYU: 121029934(FRK)
PCOO: 112862281(FRK)
PBG: 122489892(FRK)
PVIV: 125165156(FRK)
LRUF: 124528718
PTG: 102951753(FRK)
PUC: 125938832
AJU: 106984635
HHV: 120224336(FRK)
BTA: 509227(FRK)
BOM: 102281301(FRK)
BIU: 109563803(FRK)
BBUB: 102390747(FRK)
BBIS: 105000628(FRK)
CHX: 102176125(FRK)
OAS: 101106946(FRK)
BTAX: 128053324(FRK)
ODA: 120862476(FRK)
CCAD: 122422897(FRK)
MBEZ: 129561037(FRK)
SSC: 100157810(FRK)
CFR: 102506968(FRK)
CBAI: 105077147(FRK)
CDK: 105088367(FRK)
VPC: 102541316(FRK)
BACU: 103016942(FRK)
BMUS: 118905187(FRK)
LVE: 103088011(FRK)
OOR: 101273430(FRK)
DLE: 111164842(FRK)
PCAD: 102990651(FRK)
PSIU: 116763455(FRK)
NASI: 112407390(FRK)
ECB: 100072625(FRK)
EPZ: 103549739(FRK)
EAI: 106847040(FRK)
MYB: 102239672(FRK)
MYD: 102772664(FRK)
MMYO: 118660468(FRK)
MLF: 102426666(FRK)
PKL: 118705844(FRK)
EFUS: 103303491(FRK)
MNA: 107526310(FRK)
DRO: 112297025(FRK)
SHON: 119000194(FRK)
AJM: 119058718(FRK)
PDIC: 114495077(FRK)
PHAS: 123821971(FRK)
MMF: 118620742(FRK)
PPAM: 129067181(FRK)
HAI: 109371452(FRK)
RFQ: 117015220(FRK)
PALE: 102879309(FRK)
PGIG: 120608774(FRK)
PVP: 105295215(FRK)
RAY: 107520189(FRK)
MJV: 108394524(FRK)
TOD: 119253424(FRK)
SARA: 101546953 101558208(FRK)
SETR: 126007127(FRK)
LAV: 100672963(FRK)
TMU: 101343237
ETF: 101641612(FRK)
DNM: 101434690(FRK)
MDO: 100022866(FRK)
GAS: 123247769(FRK)
SHR: 100927092(FRK)
AFZ: 127562120
PCW: 110197610(FRK)
TVP: 118858635(FRK)
OAA: 100080924(FRK)
GGA: 421747(FRK)
PCOC: 116240487(FRK)
MGP: 100540680
CJO: 107311815(FRK)
TPAI: 128079561(FRK)
LMUT: 125689374(FRK)
NMEL: 110396944(FRK)
APLA: 101802320(FRK)
ACYG: 106032547(FRK)
CATA: 118243942(FRK)
AFUL: 116487471(FRK)
TGU: 100228210(FRK)
LSR: 110484653(FRK)
SCAN: 103822139(FRK)
PMOA: 120512848(FRK)
OTC: 121346183(FRK)
PRUF: 121359250(FRK)
GFR: 102038823(FRK)
FAB: 101809900(FRK)
OMA: 130251060(FRK)
PHI: 102113481(FRK)
PMAJ: 107202553(FRK)
CCAE: 111927168(FRK)
CCW: 104691248(FRK)
CBRC: 103619398(FRK)
ETL: 114065058(FRK)
ZAB: 102075135(FRK)
ZLE: 135444830(FRK)
ACHL: 103798334(FRK)
SVG: 106855005(FRK)
MMEA: 130589064(FRK)
HRT: 120750228(FRK)
FPG: 101920500(FRK)
FCH: 102049727(FRK)
CLV: 102091568(FRK)
EGZ: 104131985(FRK)
NNI: 104008604(FRK)
PCRI: 104038885(FRK)
PLET: 104617430(FRK)
EHS: 104513594(FRK)
PCAO: 104050224
ACUN: 113477621(FRK)
TALA: 104364078(FRK)
PADL: 103918366(FRK)
AFOR: 103907048(FRK)
ACHC: 115351249(FRK)
HALD: 104310744(PTK6)
HLE: 104835441(FRK)
AGEN: 126046005
GCL: 127013985
CCRI: 104165440(FRK)
CSTI: 104556689
CMAC: 104484987(FRK)
BREG: 104638168(FRK)
FGA: 104070025
GSTE: 104258374(FRK)
LDI: 104354417(FRK)
MNB: 103773458(FRK)
OHA: 104338808(FRK)
NNT: 104400374(FRK)
SHAB: 115609880(FRK)
DPUB: 104297455(FRK)
PGUU: 104459015(FRK)
ACAR: 104517887(FRK)
CPEA: 104395088(FRK)
AVIT: 104267645(FRK)
CVF: 104294063(FRK)
RTD: 128906982(FRK)
CUCA: 104060437(FRK)
TEO: 104378403(FRK)
BRHI: 104492937(FRK)
AAM: 106497950(FRK)
AROW: 112961149(FRK)
NPD: 112952762(FRK)
TGT: 104564435(FRK)
DNE: 112997485(FRK)
SCAM: 104148492(FRK)
ASN: 102376954(FRK)
AMJ: 102571064(FRK)
CPOO: 109311954(FRK)
GGN: 109299578(FRK)
PSS: 102445317(FRK)
CMY: 102946768(FRK)
CCAY: 125634257(FRK)
DCC: 119853017(FRK)
CPIC: 101944236(FRK)
TST: 117875012(FRK)
CABI: 116818029(FRK)
MRV: 120401003(FRK)
ACS: 100565945(frk)
ASAO: 132760886(FRK)
PVT: 110088509(FRK)
SUND: 121919095(FRK)
PBI: 103066044(FRK)
PMUR: 107292478(FRK)
CTIG: 120313524(FRK)
TSR: 106538777(FRK)
PGUT: 117660879(FRK)
APRI: 131193459(FRK)
PTEX: 113455313(FRK)
NSS: 113411564(FRK)
VKO: 123032918(FRK)
PMUA: 114594063(FRK)
PRAF: 128410458(FRK)
ZVI: 118082137(FRK)
HCG: 128329823(FRK)
GJA: 107108605(FRK)
STOW: 125430509(FRK)
EMC: 129326531(FRK)
XLA: 108716819(frk.L) 108717280(srpk2l.L) 108717526 108717930(frk.S)
XTR: 100488362(frk) 101733045
NPR: 108792713(FRK) 108803069
RTEM: 120935978 120937228(FRK)
BBUF: 120999889 121000007(FRK)
BGAR: 122935105(FRK) 122935708
MUO: 115467348(FRK)
GSH: 117358027(FRK)
DRE: 100332982(si:ch73-340m8.2) 567549(fynrk)
CGIB: 127933511(si:ch73-340m8.2) 127938614 127976315 127984524
PTET: 122324494(frk) 122361507
LROH: 127179817(si:ch73-340m8.2) 127183175(frk)
OMC: 131522673(si:ch73-340m8.2) 131526842(frk)
PPRM: 120471158(si:ch73-340m8.2) 120471162 120491933(frk)
RKG: 130084270(frk) 130088946(si:ch73-340m8.2)
MAMB: 125268318(si:ch73-340m8.2) 125277718(frk)
CIDE: 127499003(si:ch73-340m8.2) 127502593
TROS: 130560425(si:ch73-340m8.2) 130565606(frk)
TDW: 130434247(frk) 130437067(si:ch73-340m8.2)
MANU: 129417679(si:ch73-340m8.2)
IPU: 108270208(si:ch73-340m8.2)
IFU: 128612318(si:ch73-340m8.2) 128617868(frk)
SMEO: 124389892(si:ch73-340m8.2) 124401637(frk)
TFD: 113659705(si:ch73-340m8.2) 113661163(frk)
TVC: 132852350(si:ch73-340m8.2) 132854378(frk)
TRN: 134320908(frk) 134325712(si:ch73-340m8.2)
AMEX: 103029663 103039108(si:ch73-340m8.2) 111191729
CMAO: 118816049(frk) 118824117(si:ch73-340m8.2)
EEE: 113572689(blk) 113590562(frk)
CHAR: 105894825(frk)
TRU: 101079027(frk)
TFS: 130515895(frk)
LCO: 104932425(frk)
TBEN: 117498443(frk)
CGOB: 115003600(frk)
PGEO: 117440118(frk)
GACU: 117536588(frk)
EMAC: 134876750(frk)
ELY: 117270946(frk)
EFO: 125897636(frk)
PLEP: 121955299(frk)
SLUC: 116040356(frk)
ECRA: 117961943(frk)
ESP: 116705950(frk)
PFLV: 114573202(frk)
GAT: 120808357(frk)
PPUG: 119194725(frk)
AFB: 129106860(frk)
CLUM: 117727593(frk)
PSWI: 130202631(frk)
MSAM: 119908677(frk)
SCHU: 122862924(frk)
CUD: 121521271(frk)
ALAT: 119012541(frk)
MZE: 101477138(frk)
ONL: 100697010(frk)
OAU: 116327667(frk)
OLA: 101162804(frk)
OML: 112158412(frk)
CSAI: 133418607(frk)
XMA: 102221324
XCO: 114158825
XHE: 116734253
PRET: 103458002
PFOR: 103150868(ros1)
PLAI: 106944839
PMEI: 106921497(frk)
GAF: 122824842(frk)
PPRL: 129369130(frk)
CVG: 107100259(frk) 107100260
GMU: 124882373(frk)
NFU: 107384798(frk)
KMR: 108248744(frk)
NWH: 119418437(frk)
AOCE: 111587128(frk)
MCEP: 124999213(frk)
CSEM: 103380628(frk)
POV: 109632521(frk)
SSEN: 122784420(frk)
HHIP: 117757988(frk)
HSP: 118099265(frk)
PPLT: 128460259(frk)
SMAU: 118289813(frk)
LCF: 108899285
SDU: 111235998(frk)
SLAL: 111672922(frk)
XGL: 120789420(frk)
HCQ: 109509298(frk)
SSCV: 125990590
SBIA: 133496631(frk)
PEE: 133416838(frk)
PTAO: 133468659(frk)
BPEC: 110175755(frk)
MALB: 109967397(frk)
BSPL: 114849807(frk)
SJO: 128376790(frk)
ELS: 105009089 105017882(frk)
SFM: 108929355(frk)
PKI: 111843006(frk) 111857921
AANG: 118229698(frk)
LOC: 102683020 102692530(frk)
PSPA: 121316188(si:ch73-340m8.2) 121317578
ARUT: 117402345(si:ch73-340m8.2) 117403305 117410498
PSEX: 120525560(frk)
LCM: 102346223(FRK)
RTP: 109912089 109919891(frk)
CPLA: 122545866(frk) 122549562
HOC: 132815425 132832611(frk)
LERI: 129696046 129697331(frk) 129697656(si:ch73-340m8.2)
SCLV: 120345282
SPU: 583550(FRK)
APLC: 110985502
ARUN: 117304372
AJC: 117121626
SKO: 100375556
DME: Dmel_CG44128(Src42A)
DER: 6541987
DSE: 6619143
DSI: Dsimw501_GD10390(Dsim_GD10390)
DAN: 6493905
DPO: 6898659
DPE: 6592911
DWI: 6640625
DGR: 6560453
DNV: 108654220
DHE: 111603185
DVI: 6635862
RZE: 108375705
MDE: 101891623
SCAC: 106081252
CLON: 129610950
AALI: 118466479
AME: 412588
ACER: 108001965
ALAB: 122712759
ADR: 102679102
AFLR: 100864495
BIM: 100748206
BBIF: 117204366
BVK: 117235214
BVAN: 117153359
BTER: 100645834
BAFF: 126920185
BPYO: 122569854
BPAS: 132916369
FVI: 122527609
CCAL: 108628498
OBB: 114880823
OLG: 117608881
MGEN: 117223862
NMEA: 116425130
CGIG: 122395434
SOC: 105204850
MPHA: 105834045
AEC: 105150569
ACEP: 105620184
PBAR: 105426503
VEM: 105561241
HST: 105192003
DQU: 106747454
CFO: 105257753
FEX: 115235891
LHU: 105678611
PGC: 109856250
OBO: 105274605
PCF: 106784809
PFUC: 122523553
VPS: 122629019
VCRB: 124423851
VVE: 124949774
NVI: 100122717
CSOL: 105366356
TPRE: 106653245
LHT: 122497902
LBD: 127288725
MDL: 103579625
CGLO: 123264815
FAS: 105273116
DAM: 107035493
AGIF: 122850123
CINS: 118066759
VCAN: 122405621
CCIN: 107269379
DSM: 124410321
NPT: 124220053
NFB: 124183184
NLO: 107222098
NVG: 124305377
AROA: 105685557
TCA: 657585
DPA: 109540486
SOY: 115888055
AGRG: 126739337
AGB: 108904671
LDC: 111504250
DVV: 114327783
NVL: 108561209
APLN: 112904421
PPYR: 116160418
OTU: 111418908
BMOR: 100862655(SRC)
BMAN: 114252919
MSEX: 115447769
BANY: 112053050
MJU: 123875693
NIQ: 126774822
VCD: 124537452
MCIX: 123661557
PMAC: 106716786
PPOT: 106102457
PXU: 106114284
PRAP: 110995747
PBX: 123716070
PNAP: 125056559
ZCE: 119831742
CCRC: 123698983
LSIN: 126979387
AAGE: 121737377
HAW: 110376385(Src42a)
HZE: 124638592
TNL: 113494943
SLIU: 111361859
OFU: 114362786
ATRA: 106132557
GMW: 113521955
PGW: 126374301
LGLY: 125234387
CFEL: 113368311
CCRN: 123297474
API: 100160433
DNX: 107173261
AGS: 114132108
RMD: 113551528
ACOO: 126835976
DVT: 126893586
BTAB: 109043996
DCI: 103517710
CLEC: 106670482
HHAL: 106681417
NLU: 111049448
MQU: 128996311
FOC: 113201938
TPAL: 117642874
ZNE: 110836413
CSEC: 111868025
SGRE: 126271937
BROR: 134540400
IEL: 124158018
FCD: 110843706
PMOO: 119587866
ISC: 8054040
DSV: 119431106
RSAN: 119372145
VDE: 111243710
VJA: 111267935
TUT: 107364430
DPTE: 113795576
DFR: 124499983
PMEO: 129595346
CEL: CELE_F49B2.5(src-2)
CBR: CBG_08738(Cbr-src-2)
TSP: Tsp_11837
PVUL: 126817354
PCAN: 112573232
HRF: 124113739
CRG: 105328878
CANU: 128165696
CVN: 111119239
OED: 125669285
MYI: 110463305
PMAX: 117325962
MCAF: 127706211
MMER: 123525168
RPHI: 132723748
DPOL: 127874135
MAEA: 128213629
OBI: 106872948
OSN: 115222283
LJP: 135471650
LAK: 106171157
SHX: MS3_00004068(SRC42A_2)
EGL: EGR_06235
LLON: 135485896
NVE: 116617557
EPA: 110254398
HMG: 100215085
HSY: 130655753
 » show all
Reference
PMID:7696183
  Authors
Cance WG, Craven RJ, Bergman M, Xu L, Alitalo K, Liu ET
  Title
Rak, a novel nuclear tyrosine kinase expressed in epithelial cells.
  Journal
Cell Growth Differ 5:1347-55 (1994)
  Sequence
[hsa:2444]

KEGG   ORTHOLOGY: K08893
Entry
K08893                      KO                                     
Symbol
HCK
Name
hemopoietic cell kinase [EC:2.7.10.2]
Pathway
map04062  Chemokine signaling pathway
map04666  Fc gamma R-mediated phagocytosis
map05167  Kaposi sarcoma-associated herpesvirus infection
Disease
H02660  Autoinflammation with pulmonary and cutaneous vasculitis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04666 Fc gamma R-mediated phagocytosis
    K08893  HCK; hemopoietic cell kinase
   04062 Chemokine signaling pathway
    K08893  HCK; hemopoietic cell kinase
 09160 Human Diseases
  09172 Infectious disease: viral
   05167 Kaposi sarcoma-associated herpesvirus infection
    K08893  HCK; hemopoietic cell kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08893  HCK; hemopoietic cell kinase
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K08893  HCK; hemopoietic cell kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K08893  HCK; hemopoietic cell kinase
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  SRC family
   K08893  HCK; hemopoietic cell kinase
Membrane trafficking [BR:ko04131]
 Exocytosis
  Calcium ion-dependent exocytosis
   Kinases and associated proteins
    K08893  HCK; hemopoietic cell kinase
Other DBs
GO: 0004715
Genes
HSA: 3055(HCK)
PTR: 458163(HCK)
PPS: 100975763(HCK)
GGO: 101149280(HCK)
PON: 100455620(HCK)
PPYG: 129021481(HCK)
NLE: 100587780(HCK)
HMH: 116461143(HCK)
SSYN: 129474502(HCK)
MCC: 715723(HCK)
MCF: 102115729(HCK)
MTHB: 126964221
MNI: 105496179(HCK)
CSAB: 103248155(HCK)
CATY: 105582249(HCK)
PANU: 101016095(HCK)
TGE: 112632946(HCK)
MLEU: 105539484(HCK)
RRO: 104653712(HCK)
RBB: 108524139(HCK)
TFN: 117068628(HCK)
PTEH: 111548133(HCK)
CANG: 105524623(HCK)
CJC: 100389637(HCK)
SBQ: 101032860(HCK)
CIMI: 108291185(HCK)
ANAN: 105719252(HCK)
CSYR: 103255160(HCK)
MMUR: 105865943(HCK)
LCAT: 123622835(HCK)
PCOQ: 105804972(HCK)
OGA: 100954296(HCK)
MMU: 15162(Hck)
MCAL: 110309091(Hck)
MPAH: 110317518(Hck)
RNO: 25734(Hck)
MCOC: 116091190(Hck)
ANU: 117704369(Hck)
MUN: 110550096(Hck)
CGE: 100773315(Hck)
MAUA: 101836672(Hck)
PROB: 127228521(Hck)
PLEU: 114705554(Hck)
MORG: 121460158(Hck)
MFOT: 126507069
AAMP: 119814087(Hck)
NGI: 103731073(Hck)
HGL: 101709222(Hck)
CPOC: 100714976(Hck)
CCAN: 109691761(Hck)
DORD: 105981479(Hck)
DSP: 122120233(Hck)
PLOP: 125353363(Hck)
NCAR: 124977986
MMMA: 107138980(Hck)
OCU: 100343961
OPI: 101519769(HCK)
TUP: 102491330(HCK)
GVR: 103594006(HCK)
CFA: 485828(HCK)
CLUD: 112673783(HCK)
VVP: 112909929(HCK)
VLG: 121477700(HCK)
NPO: 129495206(HCK)
AML: 100468494(HCK)
UMR: 103674340(HCK)
UAH: 113258471(HCK)
UAR: 123798585(HCK)
ELK: 111141509
LLV: 125109120
MPUF: 101670407(HCK)
MNP: 132021825(HCK)
MLK: 131807874(HCK)
NVS: 122916170(HCK)
ORO: 101383723(HCK)
EJU: 114220725(HCK)
ZCA: 113938080(HCK)
MLX: 118011341(HCK)
NSU: 110579337(HCK)
LWW: 102739741(HCK)
FCA: 101101207(HCK)
PYU: 121012328(HCK)
PCOO: 112869543(HCK)
PBG: 122496394(HCK)
PVIV: 125161726(HCK)
LRUF: 124503311
PTG: 102953452(HCK)
PPAD: 109272582(HCK)
PUC: 125936126
AJU: 106974647
HHV: 120235421(HCK)
BTA: 280814(HCK)
BOM: 102274987(HCK)
BIU: 109567352(HCK)
BBUB: 102410643(HCK)
BBIS: 104989906(HCK)
CHX: 102183977(HCK)
OAS: 101113167(HCK)
BTAX: 128058279(HCK)
ODA: 120868750(HCK)
CCAD: 122448276(HCK)
MBEZ: 129562253(HCK)
SSC: 100526085(HCK)
CFR: 102507677(HCK)
CBAI: 105073576(HCK)
CDK: 105100829(HCK)
VPC: 102528858(HCK)
BACU: 103015546(HCK)
BMUS: 118882005(HCK)
LVE: 103078130(HCK)
OOR: 101288667(HCK)
DLE: 111184309(HCK) 111184310
PCAD: 102977689(HCK)
PSIU: 116740009(HCK)
NASI: 112398513(HCK)
ECB: 100068557(HCK)
EPZ: 103554273(HCK)
EAI: 106833726(HCK)
MYB: 102256952(HCK)
MYD: 102756136(HCK)
MMYO: 118663803(HCK)
MLF: 102418447(HCK)
PKL: 118708178(HCK)
EFUS: 103285800(HCK)
MNA: 107527783(HCK)
DRO: 112303915(HCK)
SHON: 118985350(HCK)
AJM: 119047732(HCK)
PDIC: 114506945(HCK)
PHAS: 123814888(HCK)
MMF: 118618187(HCK)
PPAM: 129070785(HCK)
HAI: 109384426(HCK)
RFQ: 117015950(HCK)
PALE: 102890019(HCK)
PGIG: 120603531(HCK)
PVP: 105305509(HCK)
RAY: 107512878(HCK)
MJV: 108397287(HCK)
TOD: 119234305(HCK)
SARA: 101556901(HCK)
SETR: 126017360(HCK)
LAV: 100660288(HCK)
TMU: 101344005
ETF: 101646312(HCK)
DNM: 101436877(HCK)
MDO: 100010539(HCK)
GAS: 123235427(HCK)
SHR: 100913992(HCK)
AFZ: 127550442
PCW: 110211423(HCK)
TVP: 118843648(HCK)
OAA: 100085668(HCK)
GGA: 419280(HCK)
PCOC: 116225952(HCK)
MGP: 100543739(HCK)
CJO: 107323072(HCK)
TPAI: 128080951(HCK)
LMUT: 125701152(HCK)
NMEL: 110408000(HCK)
APLA: 101792612(HCK)
ACYG: 106047123(HCK)
CATA: 118258329(HCK)
AFUL: 116495852(HCK)
TGU: 100220059(HCK)
LSR: 110469018(HCK)
SCAN: 103818665(HCK)
PMOA: 120507022(HCK)
OTC: 121331606(HCK)
PRUF: 121348635(HCK)
GFR: 102036877(HCK)
FAB: 101812195(HCK)
OMA: 130261414(HCK)
PHI: 102101716(HCK)
PMAJ: 107213469(HCK)
CCAE: 111943147(HCK)
CCW: 104687710(HCK)
CBRC: 103616038(HCK)
ETL: 114063045(HCK)
ZAB: 102067552(HCK)
ZLE: 135456067(HCK)
ACHL: 103802604(HCK)
SVG: 106861614(HCK)
MMEA: 130573537(HCK)
HRT: 120760001(HCK)
FPG: 101910593(HCK)
FCH: 102055899(HCK)
CLV: 102096776(HCK)
EGZ: 104127632(HCK)
NNI: 104018316(HCK)
PCAO: 104047975
ACUN: 113487683(HCK)
TALA: 116964001(HCK)
PADL: 103912489(HCK)
AFOR: 103899157(HCK)
ACHC: 115339158(HCK)
HLE: 104832964(HCK)
AGEN: 126045472
GCL: 127023131
CSTI: 104558234
MUI: 104540920
BREG: 104635059
MNB: 103772812
OHA: 104326489(LCK)
NNT: 104402536
SHAB: 115615189(HCK)
DPUB: 104301445(HCK)
CPEA: 104385534(HCK)
CVF: 104293860(HCK)
RTD: 128916756(HCK)
CUCA: 104060798(HCK)
AAM: 106497371(HCK)
AROW: 112961963(HCK)
NPD: 112949614(HCK)
DNE: 112987294(HCK)
ASN: 102368801(HCK)
AMJ: 106737579(HCK)
CPOO: 109313085(HCK)
GGN: 109292514(HCK)
PSS: 106732490(HCK)
CMY: 102941333(HCK)
CCAY: 125621983(HCK)
DCC: 119841906(HCK)
CPIC: 101948814(HCK)
TST: 117885820(HCK)
CABI: 116816783(HCK)
MRV: 120380306(HCK)
ACS: 100557519(hck)
ASAO: 132772977(HCK)
PVT: 110086725(HCK)
SUND: 121928438(HCK)
PBI: 103054220(HCK)
PMUR: 107299503(HCK)
CTIG: 120296871(HCK)
APRI: 131194111(HCK)
PTEX: 113451379(HCK)
NSS: 113428839
VKO: 123036314(HCK)
PMUA: 114599837(HCK)
PRAF: 128416665(HCK)
ZVI: 118089194(HCK)
HCG: 128324743(HCK)
GJA: 107123021(HCK)
STOW: 125433774(HCK)
EMC: 129331352(HCK)
XLA: 373700(hck.L)
XTR: 548439(hck)
NPR: 108786954(HCK)
RTEM: 120919363(HCK)
BBUF: 121003346(HCK)
BGAR: 122940304(HCK)
DRE: 101885596(hck)
SGH: 107558239(hck) 107559464
LROH: 127154760(hck)
OMC: 131532434(hck)
PPRM: 120463238(hck)
RKG: 130077499(hck)
MAMB: 125259890(hck)
CIDE: 127504938
TROS: 130545341(hck)
TDW: 130409248(hck)
MANU: 129431031(hck)
IPU: 108275896
IFU: 128619664(hck)
PHYP: 113530620(hck)
SMEO: 124398777(hck)
TFD: 113641889(hck)
TVC: 132861872(hck)
TRN: 134333811(hck)
AMEX: 103036768(hck)
CMAO: 118822535(hck)
EEE: 113575473(hck)
CHAR: 105898956(hck)
TRU: 101067815(hck)
TFS: 130519911(hck)
LCO: 104933734(hck)
TBEN: 117492629(hck)
CGOB: 115010682(hck)
PGEO: 117442834(hck)
GACU: 117539034(hck)
EMAC: 134872372(hck)
ELY: 117257637(hck)
EFO: 125891249(hck)
PLEP: 121947517(hck)
SLUC: 116040767(hck)
ECRA: 117948366(hck)
ESP: 116693216(hck)
PFLV: 114558466(hck)
GAT: 120828828(hck)
PPUG: 119200291(hck) 119223429
AFB: 129100415(hck)
CLUM: 117733005(hck)
PSWI: 130199315(hck)
MSAM: 119905779(hck)
SCHU: 122882906(hck)
CUD: 121517388(hck)
ALAT: 119022948(hck)
MZE: 101483358(hck)
ONL: 100699435(hck)
OAU: 116315560(hck)
OLA: 101163900(hck)
OML: 112159674(hck)
CSAI: 133457530(hck)
XMA: 102216930(hck)
XCO: 114145598(hck)
XHE: 116724078(hck)
PRET: 103466927(hck)
PFOR: 103150214(hck)
PLAI: 106939342
PMEI: 106908045
GAF: 122830438(hck)
PPRL: 129371700(hck)
CVG: 107098932
CTUL: 119787601(hck)
GMU: 124875239(hck)
NFU: 107386929
KMR: 108246117(hck)
ALIM: 106523041(hck)
NWH: 119417202(hck)
AOCE: 111570488(hck)
MCEP: 125006698(hck)
CSEM: 103384757(hck)
POV: 109630933(hck)
SSEN: 122777515(hck)
HHIP: 117764119(hck)
HSP: 118111169(hck)
PPLT: 128441787(hck)
SMAU: 118316439(hck)
LCF: 108885037
SDU: 111237026(hck)
SLAL: 111651844
XGL: 120803647(hck)
HCQ: 109511820(hck)
SSCV: 125989058
SBIA: 133490674(hck)
PEE: 133400095(hck)
PTAO: 133475285(hck)
BPEC: 110169150(hck)
MALB: 109969986(hck)
BSPL: 114858678(hck)
SJO: 128357771(hck)
SASA: 100136375(hck) 106572127
OTW: 112215985(hck) 112221354
SALP: 111976955(hck) 112068453
SNH: 120058931 120061488(hck)
ELS: 105013770
SFM: 108925655(hck) 108926451
AANG: 118207244(hck) 118211520
LOC: 102689082(hck)
PSEX: 120514189(hck)
LCM: 102352014
CMK: 103172176
RTP: 109911600(hck) 125485490
LERI: 129707536(hck)
CQD: 128704027
PVUL: 126817723
RPHI: 132725543
LLON: 135486702
 » show all
Reference
PMID:9407116
  Authors
Warmuth M, Bergmann M, Priess A, Hauslmann K, Emmerich B, Hallek M
  Title
The Src family kinase Hck interacts with Bcr-Abl by a kinase-independent mechanism and phosphorylates the Grb2-binding site of Bcr.
  Journal
J Biol Chem 272:33260-70 (1997)
DOI:10.1074/jbc.272.52.33260
Reference
PMID:3496523
  Authors
Quintrell N, Lebo R, Varmus H, Bishop JM, Pettenati MJ, Le Beau MM, Diaz MO, Rowley JD
  Title
Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.
  Journal
Mol Cell Biol 7:2267-75 (1987)
DOI:10.1128/MCB.7.6.2267
  Sequence
[hsa:3055]

KEGG   ORTHOLOGY: K08894
Entry
K08894                      KO                                     
Symbol
PTK6, BRK
Name
protein tyrosine kinase 6 [EC:2.7.10.2]
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08894  PTK6, BRK; protein tyrosine kinase 6
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K08894  PTK6, BRK; protein tyrosine kinase 6
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  SRC family
   K08894  PTK6, BRK; protein tyrosine kinase 6
Other DBs
GO: 0004715
Genes
HSA: 5753(PTK6)
PTR: 458409(PTK6)
PPS: 100972904(PTK6)
GGO: 129529064(PTK6)
PON: 100438236(PTK6)
PPYG: 129021745(PTK6)
NLE: 100589028(PTK6)
HMH: 116461390(PTK6)
SSYN: 129474613(PTK6)
MCC: 719598(PTK6)
MCF: 102130976(PTK6)
MTHB: 126929814
MNI: 105470724(PTK6)
CSAB: 103242654(PTK6)
CATY: 105592318(PTK6)
PANU: 101013484(PTK6)
TGE: 112633211(PTK6)
MLEU: 105548383(PTK6)
RRO: 104663849(PTK6)
RBB: 108535303(PTK6)
TFN: 117069112(PTK6)
PTEH: 111520502(PTK6)
CANG: 105506349(PTK6)
CJC: 100406453(PTK6)
SBQ: 101052155(PTK6)
CIMI: 108294003(PTK6)
ANAN: 105708838(PTK6)
CSYR: 103277256(PTK6)
OGA: 100957619(PTK6)
MMU: 20459(Ptk6)
MCAL: 110284564
MPAH: 110319512(Ptk6)
RNO: 366275(Ptk6)
MCOC: 116091558(Ptk6)
ANU: 117704519(Ptk6)
MUN: 110554762(Ptk6)
CGE: 100760877(Ptk6)
MAUA: 106021506(Ptk6)
PROB: 127222470(Ptk6)
PLEU: 114704179(Ptk6)
MORG: 121440904(Ptk6)
MFOT: 126506811
AAMP: 119814938(Ptk6)
NGI: 103742259(Ptk6)
HGL: 101722381(Ptk6)
CPOC: 100731622(Ptk6)
CCAN: 109701640(Ptk6)
DORD: 105996317
DSP: 122101815(Ptk6)
PLOP: 125353964(Ptk6)
NCAR: 124977189
MMMA: 107136183(Ptk6)
TUP: 102483648(PTK6)
GVR: 103596255(PTK6)
CFA: 102156300
CLUD: 112673338(PTK6)
VVP: 112932200
VLG: 121478275
NPO: 129522826(PTK6)
AML: 100484963(PTK6)
UMR: 103660564(PTK6)
UAH: 113258155(PTK6)
UAR: 123790806(PTK6)
ELK: 111141479
LLV: 125109485
MPUF: 101690868(PTK6)
MNP: 132022468(PTK6)
MLK: 131807709(PTK6)
NVS: 122915844(PTK6)
ORO: 101368279(PTK6)
EJU: 114199287(PTK6)
ZCA: 113938524(PTK6)
MLX: 118024050(PTK6)
NSU: 110569865(PTK6)
FCA: 101100294(PTK6)
PYU: 121020040(PTK6)
PCOO: 112868788(PTK6)
PBG: 122467160(PTK6)
PVIV: 125162813(PTK6)
LRUF: 124503263
PTG: 102955922(PTK6)
PPAD: 109253407(PTK6)
PUC: 125936406
AJU: 106973725
HHV: 120234949(PTK6)
BTA: 529814(PTK6)
BOM: 102282906(PTK6)
BIU: 109567252(PTK6)
BBUB: 102414357(PTK6)
BBIS: 104986194(PTK6)
CHX: 102182806(PTK6)
OAS: 101109378(PTK6)
BTAX: 128058787(PTK6)
ODA: 120868828(PTK6)
CCAD: 122448271(PTK6)
MBEZ: 129561083(PTK6)
SSC: 110257397(PTK6)
CFR: 102517907(PTK6)
CBAI: 105068465(PTK6)
CDK: 105103421(PTK6)
VPC: 102533198(PTK6)
BACU: 103017287(PTK6)
OOR: 101287509(PTK6)
DLE: 111186755(PTK6)
PCAD: 102996714(PTK6)
PSIU: 116739813(PTK6)
NASI: 112402943(PTK6)
ECB: 100060532(PTK6)
EPZ: 103562267(PTK6)
EAI: 106836316(PTK6)
MYD: 102759973(PTK6)
MMYO: 118663070(PTK6)
MLF: 102431327(PTK6)
PKL: 118712326(PTK6)
EFUS: 103300250(PTK6)
MNA: 107529036(PTK6)
DRO: 112304097(PTK6)
SHON: 118996590
AJM: 119055356
PDIC: 114506954
PHAS: 123815230(PTK6)
MMF: 118618445(PTK6)
PPAM: 129073868(PTK6)
HAI: 109380115(PTK6)
RFQ: 117016015(PTK6)
PALE: 102889938(PTK6)
PGIG: 120603938(PTK6)
PVP: 105301419(PTK6)
RAY: 107505783(PTK6)
MJV: 108394067(PTK6)
TOD: 119254767(PTK6)
SARA: 101554971(PTK6)
SETR: 126013929(PTK6)
LAV: 100672386(PTK6)
TMU: 101355663
ETF: 101640962(PTK6)
MDO: 100025045(PTK6)
GAS: 123235112(PTK6)
SHR: 100916163(PTK6)
AFZ: 127549026
PCW: 110205203(PTK6)
TVP: 118844795(PTK6)
OAA: 100075250(PTK6)
ASN: 102386170(PTK6)
AMJ: 102559175(PTK6)
CPOO: 109318734(PTK6)
GGN: 109292702(PTK6)
PSS: 102448027(PTK6)
CMY: 102945047(PTK6)
CCAY: 125622390(PTK6)
DCC: 119842137(PTK6)
CPIC: 101945793(PTK6)
TST: 117886237(PTK6)
CABI: 116816870(PTK6)
MRV: 120381326(PTK6)
ACS: 100555797(ptk6)
ASAO: 132773038(PTK6)
PVT: 110087585(PTK6)
SUND: 121928757(PTK6)
PBI: 103050114(PTK6)
PMUR: 107300901
CTIG: 120310805(PTK6)
PGUT: 117679401(PTK6)
APRI: 131195482(PTK6)
PTEX: 113434290(PTK6)
VKO: 123036346(PTK6)
PMUA: 114599755(PTK6)
PRAF: 128416580(PTK6)
ZVI: 118089347(PTK6)
HCG: 128325435(PTK6)
GJA: 107107010(PTK6)
EMC: 129329601(PTK6)
XTR: 100490792(ptk6)
NPR: 108789751(PTK6)
RTEM: 120918262(PTK6)
BBUF: 121004630(PTK6)
BGAR: 122922291(PTK6)
MUO: 115476048(PTK6)
GSH: 117345708(PTK6)
DRE: 555232(ptk6a) 767734(ptk6b)
SGH: 107549983(ptk6)
PTET: 122329019(ptk6b) 122350187(ptk6a)
LROH: 127154375(ptk6b) 127169962(ptk6a)
OMC: 131532456(ptk6b) 131545660(ptk6a)
PPRM: 120463757(ptk6b) 120469057(ptk6a)
RKG: 130072909(ptk6b) 130094660(ptk6a)
MAMB: 125260106(ptk6b) 125279956(ptk6a)
TROS: 130545346(ptk6b) 130568098(ptk6a)
TDW: 130408795(ptk6b) 130440280(ptk6a)
MANU: 129413474(ptk6a) 129430238
IPU: 108276246(ptk6b)
IFU: 128618948(ptk6b)
PHYP: 113530481
SMEO: 124399180(ptk6b)
TFD: 113641908(ptk6b)
TVC: 132861811(ptk6b)
TRN: 134333710(ptk6b)
AMEX: 103032752 103035560(ptk6a)
CMAO: 118812868(ptk6a) 118822461(ptk6b)
EEE: 113575491
CHAR: 105906368 105906748(ptk6b)
TRU: 101061819
TFS: 130530724(ptk6b)
LCO: 109140370
NCC: 104957326
TBEN: 117483461(ptk6b)
CGOB: 115004532
PGEO: 117449419(ptk6b)
GACU: 117558749(ptk6b)
EMAC: 134871374(ptk6b)
ELY: 117258223(ptk6b)
EFO: 125892262(ptk6b)
PLEP: 121946449(ptk6b)
SLUC: 116039088(ptk6b)
ECRA: 117947597(ptk6b)
PFLV: 114559258
GAT: 120829840(ptk6b)
PPUG: 119222375(ptk6b)
AFB: 129099349(ptk6b)
CLUM: 117733337(ptk6b)
PSWI: 130199733(ptk6b)
MSAM: 119905036(ptk6b)
SCHU: 122882619(ptk6b)
CUD: 121517793(ptk6b)
ALAT: 119022420(ptk6b)
MZE: 101476004
ONL: 100693436
OAU: 116328145(ptk6b)
OLA: 101169671
OML: 112158637(ptk6b)
XMA: 102236580(ptk6)
XCO: 114140266
XHE: 116718531
PRET: 103461925
PMEI: 106932193
GAF: 122830876(ptk6b)
PPRL: 129377173
CVG: 107096768(hck)
CTUL: 119799362(ptk6b)
GMU: 124871398(ptk6b)
AOCE: 111567104
MCEP: 124996689(ptk6b)
CSEM: 103385164
POV: 109641116
HHIP: 117764215(ptk6b)
HSP: 118111563(ptk6b)
PPLT: 128436438(ptk6b)
SMAU: 118317084(ptk6b)
LCF: 108887432
SDU: 111235000
SLAL: 111644151
XGL: 120803631(ptk6b)
HCQ: 109528635
SSCV: 125989218
SBIA: 133504493(ptk6b)
PEE: 133412630(ptk6b)
PTAO: 133482447(ptk6b)
BPEC: 110173722
MALB: 109965284
BSPL: 114858706(ptk6b)
SJO: 128357725
STRU: 115187519
OTW: 112239497
OMY: 110532831
OGO: 124032394
ONE: 115125689
OKI: 109886326
OKE: 118381636
SNH: 120058777(ptk6b)
CCLU: 121537360(ptk6b)
ELS: 105027944
PKI: 111835941 111837035(ptk6)
AANG: 118208225(ptk6b)
LOC: 102686032(ptk6)
PSPA: 121297767
PSEX: 120515188
LCM: 102352481(PTK6)
CMK: 103186299
RTP: 109928567
CPLA: 122560147
HOC: 132822953
LERI: 129707525
BBEL: 109476631
HRF: 124146294
OSN: 115229096
 » show all
Reference
  Authors
Mitchell PJ, Sara EA, Crompton MR
  Title
A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK.
  Journal
Oncogene 19:4273-82 (2000)
DOI:10.1038/sj.onc.1203775
  Sequence
[hsa:5753]

KEGG   ORTHOLOGY: K08895
Entry
K08895                      KO                                     
Symbol
SRMS
Name
tyrosine-protein kinase Srms [EC:2.7.10.2]
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08895  SRMS; tyrosine-protein kinase Srms
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K08895  SRMS; tyrosine-protein kinase Srms
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  SRC family
   K08895  SRMS; tyrosine-protein kinase Srms
Other DBs
GO: 0004715
Genes
HSA: 6725(SRMS)
PTR: 470000(SRMS)
PPS: 100973246(SRMS)
GGO: 129529067(SRMS)
PON: 100439938(SRMS)
PPYG: 129021710(SRMS)
NLE: 100579691(SRMS)
HMH: 116460802(SRMS)
SSYN: 129474612(SRMS)
MCC: 719587(SRMS)
MCF: 102131371(SRMS)
MTHB: 126929824
MNI: 105470485(SRMS)
CSAB: 103242659(SRMS)
CATY: 105592316(SRMS)
PANU: 101013114(SRMS)
TGE: 112632446(SRMS)
MLEU: 105548382(SRMS)
RRO: 104663899(SRMS)
RBB: 108535304(SRMS)
TFN: 117069114(SRMS)
PTEH: 111520487(SRMS)
CANG: 105506351(SRMS)
CJC: 100406817(SRMS)
SBQ: 101052803(SRMS)
CIMI: 108294011(SRMS)
ANAN: 105708839(SRMS)
CSYR: 103277347(SRMS)
MMUR: 105875743(SRMS)
LCAT: 123622777(SRMS)
PCOQ: 105818517
OGA: 100957935(SRMS)
MMU: 20811(Srms)
MPAH: 110318083(Srms) 110319457
RNO: 296472(Srms)
MCOC: 116092589(Srms)
ANU: 117704164(Srms)
MUN: 110554922(Srms)
CGE: 100766886(Srms)
MAUA: 101840659(Srms)
PROB: 127222462(Srms)
PLEU: 114704178(Srms)
MORG: 121440899(Srms)
MFOT: 126506903
AAMP: 119814675(Srms)
NGI: 103742260(Srms)
HGL: 101710519(Srms)
CPOC: 100731347(Srms)
CCAN: 109701641(Srms)
DSP: 122101822(Srms)
PLOP: 125353960(Srms)
NCAR: 124977434
MMMA: 107136161(Srms)
GVR: 103596254(SRMS)
CFA: 477286(SRMS)
CLUD: 112674265(SRMS)
VVP: 112932283(SRMS)
VLG: 121477718
AML: 100463761(SRMS)
UMR: 103660563(SRMS)
UAH: 113258811(SRMS)
UAR: 123790381(SRMS)
ELK: 111141911
LLV: 125109958
MPUF: 101691612(SRMS)
MNP: 132022113(SRMS)
MLK: 131840362(SRMS)
NVS: 122915516(SRMS)
ORO: 101367980(SRMS)
EJU: 114199286(SRMS)
ZCA: 113937707(SRMS)
MLX: 118024052(SRMS)
NSU: 110569816(SRMS)
LWW: 102743403(SRMS)
FCA: 101100042(SRMS)
PYU: 121020042(SRMS)
PCOO: 112869212(SRMS)
PBG: 122467159(SRMS)
PVIV: 125162217(SRMS)
LRUF: 124503261
PPAD: 109253406(SRMS)
PUC: 125936408
AJU: 106973703
HHV: 120234909(SRMS)
BTA: 521816(SRMS)
BOM: 102285711(SRMS)
BIU: 109567251(SRMS)
BBUB: 102414021(SRMS)
BBIS: 104986193(SRMS)
CHX: 102170159(SRMS)
OAS: 101118124(SRMS)
BTAX: 128058713(SRMS)
ODA: 120868830(SRMS)
CCAD: 122448777(SRMS)
MBEZ: 129561075(SRMS)
SSC: 110257399(SRMS)
CFR: 102522692(SRMS)
CBAI: 105068464(SRMS)
CDK: 105103430(SRMS)
VPC: 102545834(SRMS)
BACU: 103006129(SRMS)
BMUS: 118881275(SRMS)
PCAD: 102996431(SRMS)
ECB: 100060563(SRMS)
EPZ: 103562278(SRMS)
EAI: 106836314(SRMS)
MYB: 102244712
MYD: 102771935(SRMS)
MMYO: 118663072(SRMS)
MLF: 102442111(SRMS)
PKL: 118712307(SRMS)
EFUS: 103300292(SRMS)
MNA: 107529505(SRMS)
DRO: 112303899(SRMS)
MMF: 118619352(SRMS)
PPAM: 129073831(SRMS)
HAI: 109380039(SRMS)
RFQ: 117016055(SRMS)
PALE: 102895700(SRMS)
PGIG: 120603937(SRMS)
PVP: 105301463(SRMS)
RAY: 107511638(SRMS)
TOD: 119237713(SRMS)
SARA: 101555238(SRMS)
SETR: 126013928(SRMS)
LAV: 100672098(SRMS)
TMU: 101355407
ETF: 101658534(SRMS)
MDO: 100025024(SRMS)
GAS: 123235113(SRMS)
SHR: 100915904(SRMS)
AFZ: 127549027
PCW: 110205206(SRMS)
TVP: 118844600(SRMS)
OAA: 100075283(SRMS)
PCOC: 116227839(SRMS)
MGP: 100549540(SRMS)
CJO: 107323017(SRMS)
TPAI: 128080892
LMUT: 125701364
NMEL: 110408021(SRMS)
APLA: 101795926(SRMS)
ACYG: 106040781(SRMS)
CATA: 118248833
AFUL: 116495736
TGU: 100218088
LSR: 110469023
SCAN: 103818711
PMOA: 120507149(SRMS)
OTC: 121333094(SRMS)
PRUF: 121359484
GFR: 102045514(SRMS)
FAB: 101814966(SRMS)
OMA: 130261447(SRMS)
PHI: 102111085
PMAJ: 107213062
CCAE: 111938095
CCW: 104687665(SRMS)
CBRC: 103616398
ETL: 114056407
ZAB: 102074231(SRMS)
ZLE: 135456148(SRMS)
ACHL: 103801766
SVG: 106851761
MMEA: 130573587(SRMS)
HRT: 120760035(SRMS)
FPG: 101919607(SRMS)
FCH: 102046786
CLV: 102097504
EGZ: 104125119
NNI: 104020039
PCRI: 104036382(SRMS)
PLET: 104623773(SRMS)
EHS: 104502502
PCAO: 104053792(SRMS)
ACUN: 113487590
TALA: 104357468(SRMS)
PADL: 103919397
AFOR: 103894524
ACHC: 115339980(SRMS)
HALD: 104319609
HLE: 104833018
AGEN: 126045682
GCL: 127023276
CCRI: 104159041(SRMS)
CSTI: 104553890(SRMS)
CMAC: 104473959
MUI: 104542964
BREG: 104639674
FGA: 104079538
GSTE: 104261730(SRMS)
LDI: 104349053(SRMS)
MNB: 103777250(SRMS)
OHA: 104328815
NNT: 104408454
SHAB: 115615265
DPUB: 104306812(SRMS)
PGUU: 104463092
ACAR: 104522091
CPEA: 104389589
AVIT: 104275712
CVF: 104293893
RTD: 128916771(SRMS)
CUCA: 104060835
TEO: 104377552(SRMS)
BRHI: 104500568(SRMS)
AAM: 106482533
AROW: 112976125
NPD: 112949703
TGT: 104571972(SRMS)
SCAM: 104141948
ASN: 102376355(SRMS)
AMJ: 106736946(SRMS)
CPOO: 109318849(SRMS)
GGN: 109292587(SRMS)
PSS: 102447776(SRMS)
CMY: 102945267(SRMS)
CCAY: 125622389(SRMS)
DCC: 119842006(SRMS)
CPIC: 101946074(SRMS)
TST: 117886239(SRMS)
CABI: 116816867(SRMS)
MRV: 120381325(SRMS)
ACS: 100561566(srms)
ASAO: 132773037(SRMS)
PVT: 110087580(SRMS)
SUND: 121929350(SRMS)
PBI: 103051205(SRMS)
PMUR: 107298771
CTIG: 120310737(SRMS)
TSR: 106548056(SRMS)
PGUT: 117679400(SRMS)
APRI: 131195116(SRMS)
PTEX: 113434288(SRMS)
VKO: 123036241(SRMS)
PMUA: 114599756(SRMS)
PRAF: 128416581(SRMS)
ZVI: 118089217(SRMS)
HCG: 128322325(SRMS)
EMC: 129330651(SRMS)
NPR: 108789555(SRMS)
RTEM: 120918423(SRMS)
BBUF: 121004924(SRMS)
BGAR: 122922287(SRMS)
MUO: 115476547(SRMS)
GSH: 117345784(SRMS)
DRE: 100192213(srms)
PTET: 122329020(srms)
LROH: 127154376(srms)
OMC: 131532457(srms)
PPRM: 120463758(zgc:194282)
RKG: 130072910(srms)
MAMB: 125260107(srms)
CIDE: 127504444
TROS: 130571864(srms)
TDW: 130408798(srms)
IPU: 108276248(srms)
IFU: 128618949(srms)
PHYP: 113530480
SMEO: 124398872(srms)
TFD: 113641909(srms)
TVC: 132861812(srms)
TRN: 134333266(srms)
AMEX: 103032452(srms)
CMAO: 118822462(zgc:194282)
EEE: 113575492
CHAR: 105906798(srms)
TRU: 101079928
TFS: 130530722(srms)
LCO: 109142448
NCC: 104961184
TBEN: 117483457(zgc:194282)
CGOB: 115004531
PGEO: 117449418(zgc:194282)
GACU: 117558750(zgc:194282)
EMAC: 134871382(srms)
ELY: 117258224(zgc:194282)
EFO: 125892263(srms)
PLEP: 121946450(srms)
SLUC: 116039089(zgc:194282)
ECRA: 117947596(zgc:194282)
PFLV: 114558730
GAT: 120829760(zgc:194282)
PPUG: 119222374(zgc:194282)
AFB: 129099348(srms)
CLUM: 117733336(zgc:194282)
PSWI: 130199732(srms)
MSAM: 119905038(zgc:194282)
SCHU: 122882620(srms)
CUD: 121517794(zgc:194282)
ALAT: 119022421(zgc:194282)
MZE: 101475714
ONL: 100693162
OAU: 116328162(zgc:194282)
OLA: 101169425
OML: 112159099(zgc:194282)
CSAI: 133456982
XMA: 102236328
XCO: 114140265
XHE: 116718521
PRET: 103461911
PFOR: 103148179
PLAI: 106959237(hck)
PMEI: 106932194(hck)
GAF: 122830882(srms)
PPRL: 129377172
CVG: 107096775
CTUL: 119799427(zgc:194282)
GMU: 124871406(srms)
NFU: 107390561(hck)
KMR: 108241808
ALIM: 106528740
AOCE: 111588766
MCEP: 124996696(srmS)
CSEM: 103385165
POV: 109641115
SSEN: 122777101
HHIP: 117764226(zgc:194282)
HSP: 118111562(srms)
PPLT: 128436436(srms)
SMAU: 118317085(srms)
LCF: 108873293(srms) 108888742
SDU: 111234936
SLAL: 111644251
XGL: 120803632(zgc:194282)
HCQ: 109528636
SSCV: 125989219
PEE: 133412647(srms)
PTAO: 133482547(srms)
BPEC: 110173721
MALB: 109965192
BSPL: 114858707(srms)
ELS: 105013885
SFM: 108937001
PKI: 111837150
AANG: 118208226(zgc:194282)
LOC: 102684166(srms)
PSEX: 120514724
LCM: 102362739(SRMS)
CMK: 103186306
CPLA: 122560146
HOC: 132822952
LERI: 129707523
CFEL: 113388583
CQD: 128692567
EGL: EGR_10535
 » show all
Reference
  Authors
Goel RK, Miah S, Black K, Kalra N, Dai C, Lukong KE
  Title
The unique N-terminal region of SRMS regulates enzymatic activity and phosphorylation of its novel substrate docking protein 1.
  Journal
FEBS J 280:4539-59 (2013)
DOI:10.1111/febs.12420
  Sequence
[hsa:6725]

KEGG   ORTHOLOGY: K08896
Entry
K08896                      KO                                     
Symbol
BMX, ETK
Name
cytoplasmic tyrosine-protein kinase BMX [EC:2.7.10.2]
Brite
KEGG Orthology (KO) [BR:ko00001]
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08896  BMX, ETK; cytoplasmic tyrosine-protein kinase BMX
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K08896  BMX, ETK; cytoplasmic tyrosine-protein kinase BMX
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  TEC family
   K08896  BMX, ETK; cytoplasmic tyrosine-protein kinase BMX
Other DBs
GO: 0004715
Genes
HSA: 660(BMX)
PTR: 465510(BMX)
PPS: 100968853(BMX)
GGO: 101138973(BMX)
PON: 100432500(BMX)
PPYG: 129024769(BMX)
NLE: 100602159(BMX)
HMH: 116811531(BMX)
SSYN: 129476373(BMX)
MCC: 712722(BMX)
MCF: 102129195(BMX)
MTHB: 126946902
MNI: 105478156(BMX)
CSAB: 103231638(BMX)
CATY: 105574685(BMX)
PANU: 101003056(BMX)
TGE: 112615138(BMX)
MLEU: 105550586(BMX)
RRO: 104664537(BMX)
RBB: 108539694(BMX)
TFN: 117077263(BMX)
PTEH: 111531653(BMX)
CANG: 105523127(BMX)
CJC: 100408267(BMX)
SBQ: 101043579(BMX)
CIMI: 108291900(BMX)
ANAN: 105705084(BMX)
CSYR: 103267009(BMX)
MMUR: 105882412(BMX)
LCAT: 123628400(BMX)
PCOQ: 105805748(BMX)
OGA: 100951566(BMX)
MMU: 12169(Bmx)
MCAL: 110286756(Bmx)
MPAH: 110314542(Bmx)
RNO: 367786(Bmx)
MCOC: 116095338(Bmx)
ANU: 117694466(Bmx)
MUN: 110542479(Bmx)
CGE: 100751568(Bmx)
MAUA: 101823555(Bmx)
PROB: 127218186(Bmx)
PLEU: 114705724(Bmx)
MORG: 121439481(Bmx)
MFOT: 126512739
AAMP: 119804827(Bmx)
NGI: 103740290(Bmx)
HGL: 101726373(Bmx)
CPOC: 100733084(Bmx)
DORD: 105997642(Bmx)
DSP: 122108515(Bmx)
PLOP: 125344084(Bmx)
NCAR: 124971895
MMMA: 107144129(Bmx)
OCU: 100350848
OPI: 101527017(BMX)
TUP: 102485146(BMX)
GVR: 103606448(BMX)
CFA: 491750(BMX)
CLUD: 112653185(BMX)
VVP: 112910545(BMX)
VLG: 121482334(BMX)
NPO: 129518174(BMX)
AML: 100466050(BMX)
UMR: 103668125(BMX)
UAH: 113240704(BMX)
UAR: 123797271(BMX)
ELK: 111157143
LLV: 125091710
MPUF: 101672453(BMX)
MNP: 132007738(BMX)
MLK: 131821735(BMX)
NVS: 122896714(BMX)
ORO: 101372944(BMX)
EJU: 114218105(BMX)
ZCA: 113931460(BMX)
MLX: 118006981(BMX)
NSU: 110572471(BMX)
LWW: 102737884(BMX)
FCA: 101095795(BMX)
PYU: 121025626(BMX)
PCOO: 112871619(BMX)
PBG: 122476992(BMX)
PVIV: 125157588(BMX)
LRUF: 124509369
PTG: 102959317(BMX)
PPAD: 109248319(BMX)
PUC: 125931500
AJU: 106974234
HHV: 120232936(BMX)
BTA: 531514(BMX)
BOM: 102275158(BMX)
BBUB: 102409529(BMX)
CHX: 102185078(BMX)
OAS: 101103124(BMX)
BTAX: 128070035(BMX)
ODA: 120882558(BMX)
CCAD: 122434818(BMX)
MBEZ: 129564308(BMX)
SSC: 100516528(BMX)
CFR: 102523053(BMX)
CBAI: 105079296(BMX)
CDK: 105100401(BMX)
VPC: 102525818(BMX)
BACU: 103013973(BMX)
BMUS: 118888121(BMX)
LVE: 103086860(BMX)
OOR: 101283987(BMX)
DLE: 111168919(BMX)
PCAD: 102991459(BMX)
PSIU: 116747342(BMX)
NASI: 112399147(BMX)
ECB: 100051025(BMX)
EPZ: 103568002(BMX)
EAI: 106841576(BMX)
MYB: 102260023(BMX)
MYD: 102763746(BMX)
MMYO: 118654671(BMX)
MLF: 102420531(BMX)
PKL: 118719786(BMX)
EFUS: 103298183(BMX)
MNA: 107529498(BMX)
DRO: 112313359(BMX)
SHON: 118987250(BMX)
AJM: 119058336(BMX)
PDIC: 114504981(BMX)
PHAS: 123830042(BMX)
MMF: 118636480(BMX)
PPAM: 129076970(BMX)
HAI: 109395086(BMX)
RFQ: 117022980(BMX)
PALE: 102888651(BMX)
PGIG: 120611091(BMX)
PVP: 105293999(BMX)
RAY: 107497284(BMX)
MJV: 108390912(BMX)
TOD: 119246320(BMX)
SARA: 101538107(BMX)
SETR: 125998736(BMX)
LAV: 100665247(BMX)
TMU: 101343813
ETF: 101656711(BMX)
DNM: 101428355(BMX)
MDO: 100616925(BMX)
GAS: 123239672(BMX)
SHR: 100931666(BMX)
AFZ: 127553616
PCW: 110222444(BMX)
TVP: 118838314(BMX)
OAA: 100085207(BMX)
GGA: 428003(BMX)
PCOC: 116230728(BMX)
MGP: 100541340(BMX)
CJO: 107325574(BMX)
TPAI: 128076553(BMX)
LMUT: 125697915(BMX)
NMEL: 110392737(BMX)
APLA: 101792881(BMX)
ACYG: 106037797(BMX)
CATA: 118245702(BMX)
AFUL: 116495882(BMX)
FAB: 107604589(BMX)
PHI: 106628117(BMX)
CCAE: 111922778(BMX)
CCW: 109143919(BMX)
CBRC: 108445236(BMX)
ETL: 114066570(BMX)
FPG: 101916403(BMX)
FCH: 102051269(BMX)
CLV: 102095846(BMX)
EGZ: 104127313(BMX)
NNI: 104022576(BMX)
PCRI: 104029334(BMX)
PLET: 104624369(BMX)
EHS: 104504106
PCAO: 104049989(BMX)
ACUN: 113478739(BMX)
TALA: 104364305(BMX)
PADL: 103918226(BMX)
AFOR: 103896978(BMX)
ACHC: 115334710(BMX)
HALD: 104320753(BMX)
HLE: 104840581(BMX)
AGEN: 126052879
GCL: 127012562
CCRI: 104165696(BMX)
CSTI: 104562294(BMX)
CMAC: 104481127(BMX)
MUI: 104537502(BMX)
BREG: 104640960(BMX)
FGA: 104074160
GSTE: 104261685(BMX)
LDI: 104350308(BMX)
OHA: 104334988(BMX)
NNT: 104405452(BMX)
SHAB: 115603919(BMX)
ACAR: 104527264(BMX)
CPEA: 104385394(BMX)
AVIT: 104273418(BMX)
CVF: 104289994(BMX)
RTD: 128914885(BMX)
CUCA: 104063417(BMX)
TEO: 104370439(BMX)
BRHI: 104495533(BMX)
AAM: 106491091(BMX)
AROW: 112976184(BMX)
NPD: 112944000(BMX)
TGT: 104574049(BMX)
DNE: 112995641(BMX)
SCAM: 104140469(BMX)
ASN: 102370169(BMX)
AMJ: 102571236(BMX)
CPOO: 109306031(BMX)
GGN: 109303439(BMX)
PSS: 102456956(BMX)
CMY: 102945365(BMX)
CCAY: 125630737(BMX)
DCC: 119860179(BMX)
CPIC: 101951113(BMX)
TST: 117869512(BMX)
CABI: 116821845(BMX)
MRV: 120369766(BMX)
ACS: 100565102(bmx)
ASAO: 132771693(BMX)
PVT: 110075456(BMX)
SUND: 121925095
PBI: 103067928(BMX)
VKO: 123023849(BMX)
PMUA: 114596263(BMX)
PRAF: 128412398(BMX)
ZVI: 118085307(BMX)
HCG: 128350507(BMX)
GJA: 107115821(BMX)
STOW: 125431435(BMX)
EMC: 129325502(BMX)
MUO: 115469548(BMX)
GSH: 117362570(BMX)
IPU: 108259563
IFU: 128602890
PHYP: 113547429(bmx)
SMEO: 124380131
TFD: 113657152
TVC: 132838477
AMEX: 103025345
CMAO: 118802710
EEE: 113578246(bmx)
PKI: 111838143(bmx)
LOC: 102690635(bmx)
PSPA: 121320625
ARUT: 117406727
PSEX: 120523606
LCM: 102363317(BMX)
CMK: 103177479
 » show all
Reference
PMID:9520419
  Authors
Qiu Y, Robinson D, Pretlow TG, Kung HJ
  Title
Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells.
  Journal
Proc Natl Acad Sci U S A 95:3644-9 (1998)
DOI:10.1073/pnas.95.7.3644
  Sequence
[hsa:660]

KEGG   ORTHOLOGY: K07370
Entry
K07370                      KO                                     
Symbol
BTK
Name
Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]
Pathway
map04064  NF-kappa B signaling pathway
map04380  Osteoclast differentiation
map04611  Platelet activation
map04662  B cell receptor signaling pathway
map04664  Fc epsilon RI signaling pathway
map05169  Epstein-Barr virus infection
map05340  Primary immunodeficiency
Disease
H00085  Agammaglobulinemias
H00254  Growth hormone deficiency
H02035  Isolated growth hormone deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K07370  BTK; Bruton agammaglobulinemia tyrosine kinase
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K07370  BTK; Bruton agammaglobulinemia tyrosine kinase
   04662 B cell receptor signaling pathway
    K07370  BTK; Bruton agammaglobulinemia tyrosine kinase
   04664 Fc epsilon RI signaling pathway
    K07370  BTK; Bruton agammaglobulinemia tyrosine kinase
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K07370  BTK; Bruton agammaglobulinemia tyrosine kinase
 09160 Human Diseases
  09172 Infectious disease: viral
   05169 Epstein-Barr virus infection
    K07370  BTK; Bruton agammaglobulinemia tyrosine kinase
  09163 Immune disease
   05340 Primary immunodeficiency
    K07370  BTK; Bruton agammaglobulinemia tyrosine kinase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07370  BTK; Bruton agammaglobulinemia tyrosine kinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.10  Protein-tyrosine kinases
    2.7.10.2  non-specific protein-tyrosine kinase
     K07370  BTK; Bruton agammaglobulinemia tyrosine kinase
Protein kinases [BR:ko01001]
 Non-receptor tyrosine kinases
  TEC family
   K07370  BTK; Bruton agammaglobulinemia tyrosine kinase
Other DBs
GO: 0004715
Genes
HSA: 695(BTK)
PTR: 465759(BTK)
PPS: 100992723(BTK)
GGO: 101141049(BTK)
PON: 100443503(BTK)
PPYG: 129024908(BTK)
NLE: 100594539(BTK)
HMH: 116811871(BTK)
SSYN: 129476405(BTK)
MCC: 703000(BTK)
MCF: 102123534(BTK)
MTHB: 126945989
MNI: 105499313(BTK)
CSAB: 103232359(BTK)
CATY: 105592035(BTK)
PANU: 101008275(BTK)
TGE: 112615467(BTK)
MLEU: 105528165(BTK)
RRO: 104659579(BTK)
RBB: 108544993(BTK)
TFN: 117085522(BTK)
PTEH: 111536504(BTK)
CANG: 105520681(BTK)
CJC: 100406337(BTK)
SBQ: 101054345(BTK)
CIMI: 108287438(BTK)
ANAN: 105707832(BTK)
CSYR: 103254974(BTK)
MMUR: 105873066(BTK)
PCOQ: 105814900(BTK)
OGA: 100956054(BTK)
MMU: 12229(Btk)
MCAL: 110286488(Btk)
MPAH: 110313310(Btk)
RNO: 367901(Btk)
MCOC: 116088560(Btk)
ANU: 117694372(Btk)
MUN: 110541656(Btk)
CGE: 100772144(Btk)
MAUA: 101840648(Btk)
PROB: 127218588(Btk)
PLEU: 114697015(Btk)
MFOT: 126493562
AAMP: 119804704(Btk)
NGI: 103746197(Btk)
HGL: 101715242(Btk)
CPOC: 100714123(Btk)
CCAN: 109692203(Btk)
DORD: 105999931(Btk)
DSP: 122096887(Btk)
PLOP: 125343604(Btk)
NCAR: 124971859
MMMA: 107156260(Btk)
OCU: 100354225
OPI: 101516844(BTK)
TUP: 102472301(BTK)
GVR: 103600402(BTK)
CLUD: 112649417(BTK)
VVP: 112925763(BTK)
VLG: 121482285(BTK)
NPO: 129518807(BTK)
AML: 100472303(BTK)
UMR: 103672987(BTK)
UAH: 113244303(BTK)
UAR: 123793929(BTK)
ELK: 111159177
LLV: 125091607
MPUF: 101685094(BTK)
MNP: 132006911(BTK)
MLK: 131821271(BTK)
NVS: 122896979(BTK)
ORO: 101368233(BTK)
EJU: 114202535(BTK)
ZCA: 113930696(BTK)
MLX: 118022875(BTK)
NSU: 110585603(BTK)
LWW: 102733386(BTK)
FCA: 101088062(BTK)
PYU: 121024937(BTK)
PCOO: 112871134(BTK)
PBG: 122477972(BTK)
PVIV: 125156915(BTK)
LRUF: 124509577
PTG: 102948492(BTK)
PPAD: 109258849(BTK)
PUC: 125931830
AJU: 106984233
HHV: 120220893(BTK)
BTA: 533459(BTK)
BOM: 102284433(BTK)
BIU: 109555469(BTK)
BBUB: 102397606(BTK)
BBIS: 104998915(BTK)
CHX: 102176204(BTK)
OAS: 101105725(BTK)
BTAX: 128069852(BTK)
ODA: 120881312(BTK)
CCAD: 122434992(BTK)
MBEZ: 129534995(BTK)
SSC: 100627308(BTK)
CFR: 102521853(BTK)
CBAI: 105080742(BTK)
CDK: 105085487(BTK)
VPC: 102534116(BTK)
BACU: 103007481(BTK)
BMUS: 118888611(BTK)
LVE: 103086425(BTK)
OOR: 101282522(BTK)
DLE: 111178233(BTK)
PCAD: 102991038(BTK)
PSIU: 116747469(BTK)
NASI: 112400660(BTK)
ECB: 100057626(BTK)
EPZ: 103542797(BTK)
EAI: 106823084(BTK)
MYB: 102248642(BTK)
MYD: 102758552(BTK)
MMYO: 118654418(BTK)
MLF: 102422436(BTK)
PKL: 118720037(BTK)
EFUS: 103299705(BTK)
MNA: 107524029(BTK)
DRO: 112321325(BTK)
SHON: 118996677(BTK)
AJM: 119038485(BTK)
PDIC: 114505208(BTK)
PHAS: 123805219(BTK)
MMF: 118635763(BTK)
PPAM: 129069600(BTK)
HAI: 109374529(BTK) 109391632(TIMM29)
RFQ: 117024681(BTK)
PALE: 102878592(BTK)
PGIG: 120611559(BTK)
PVP: 105308057(BTK)
RAY: 107503613(BTK)
MJV: 108397835(BTK)
TOD: 119246027(BTK)
SARA: 101559413(BTK)
SETR: 125998575(BTK)
LAV: 100670387(BTK)
TMU: 101356880
ETF: 101649952(BTK)
DNM: 101426005(BTK)
MDO: 100022891(BTK)
GAS: 123253279(BTK)
SHR: 100929183(BTK)
AFZ: 127542490
PCW: 110192312(BTK)
TVP: 118832940(BTK)
OAA: 100080912(BTK)
GGA: 374075(BTK)
PCOC: 116229562(BTK)
MGP: 100540531(BTK)
CJO: 107312560(BTK)
TPAI: 128076116(BTK)
LMUT: 125699747(BTK)
NMEL: 110403020(BTK)
APLA: 101801225(BTK)
ACYG: 106037664(BTK)
CATA: 118245633(BTK)
AFUL: 116494396(BTK)
TGU: 100219452(BTK)
LSR: 110472678(BTK)
SCAN: 103824231(BTK)
PMOA: 120506161(BTK)
OTC: 121331749(BTK)
PRUF: 121363163(BTK)
GFR: 102034670(BTK)
FAB: 101820538(BTK)
OMA: 130253332(BTK)
PHI: 102110408(BTK)
PMAJ: 107203971(BTK)
CCAE: 111929395(BTK)
CCW: 104691647(BTK)
CBRC: 103617844(BTK)
ETL: 114066193(BTK)
ZAB: 102073407(BTK)
ZLE: 135447911(BTK)
ACHL: 103810257(BTK)
SVG: 106853738(BTK)
MMEA: 130577298(BTK)
HRT: 120762102(BTK)
FPG: 101911050(BTK)
FCH: 102050747(BTK)
CLV: 102089403(BTK)
EGZ: 104135432(BTK)
NNI: 104015352(BTK)
PCRI: 104039059(BTK)
PLET: 104623390(BTK)
EHS: 104506278(BTK)
PCAO: 104046387(BTK)
ACUN: 113479932(BTK)
TALA: 104364132(BTK)
PADL: 103923328(BTK)
AFOR: 103904783(BTK)
ACHC: 115333865(BTK)
HALD: 104314423(BTK)
HLE: 104832564(BTK)
AGEN: 126050343
GCL: 127019524
CCRI: 104166356(BTK)
CSTI: 104563929(BTK)
CMAC: 104482145(BTK)
MUI: 104536215(BTK)
BREG: 104634291(BTK)
FGA: 104073335(BTK)
GSTE: 104261635(BTK)
LDI: 104352532(BTK)
MNB: 103768553(BTK)
OHA: 104329560(BTK)
NNT: 104410008(BTK)
SHAB: 115612603(BTK)
DPUB: 104306357(BTK)
PGUU: 104463734(BTK)
ACAR: 104530109(BTK)
CPEA: 104388334(BTK)
AVIT: 104278685(BTK)
CVF: 104290171(BTK)
RTD: 128914722(BTK)
CUCA: 104069017(BTK)
TEO: 104378674(BTK)
BRHI: 104490616(BTK)
AAM: 106484985(BTK)
AROW: 112966366(BTK)
NPD: 112960427(BTK)
TGT: 104576116(BTK)
DNE: 112989771(BTK)
SCAM: 104152353(BTK)
ASN: 102379774(BTK)
AMJ: 102562876(BTK)
CPOO: 109310934(BTK)
GGN: 109300532(BTK)
PSS: 102452612(BTK)
CMY: 102945423(BTK)
CCAY: 125642112(BTK)
DCC: 119861584(BTK)
CPIC: 101931069(BTK)
TST: 117883246(BTK)
CABI: 116820013(BTK)
MRV: 120372414(BTK)
ACS: 100561192(btk)
ASAO: 132763025(BTK)
PVT: 110084914(BTK)
SUND: 121937322(BTK)
PBI: 103065824(BTK)
PMUR: 107291582(BTK)
CTIG: 120302396(BTK)
TSR: 106538787(BTK) 106544086
PGUT: 117669513(BTK)
APRI: 131183862(BTK)
PTEX: 113437804(BTK)
VKO: 123022084(BTK)
PMUA: 114589272(BTK)
PRAF: 128406373(BTK)
ZVI: 118088505(BTK)
HCG: 128335541(BTK)
GJA: 107123933(BTK)
EMC: 129341194(BTK)
XLA: 108698274(btk.L)
XTR: 100170477(btk)
NPR: 108799566(BTK)
RTEM: 120913056(BTK)
BBUF: 120977595(BTK)
BGAR: 122946795(BTK)
MUO: 115474308(BTK)
GSH: 117360250(BTK)
DRE: 568653(btk)
SANH: 107680332 107680953(btk)
PTET: 122357446(btk)
LROH: 127176171(btk)
OMC: 131553271(btk)
PPRM: 120466134(btk)
RKG: 130103927(btk)
MAMB: 125258799(btk)
CIDE: 127494513
TROS: 130563440(btk)
TDW: 130438275(btk)
MANU: 129422467(btk)
IPU: 108269130
IFU: 128611339(btk)
PHYP: 113542865(btk)
SMEO: 124386142(btk)
TFD: 113635851(btk)
TVC: 132855475(btk)
AMEX: 103034846(btk)
CMAO: 118807097(btk)
EEE: 113573405(btk)
CHAR: 105911755(btk)
TRU: 101073533(btk)
TFS: 130531550(btk)
LCO: 104925368(btk)
NCC: 104964530(btk)
TBEN: 117488719(btk)
CGOB: 115014295(btk)
PGEO: 117453540(btk)
GACU: 117541065(btk)
EMAC: 134859590(btk)
ELY: 117260742 117261478(btk)
EFO: 125894121(btk)
PLEP: 121948558(btk)
SLUC: 116052272(btk)
ECRA: 117952215(btk)
ESP: 116696721(btk)
PFLV: 114562534(btk)
GAT: 120818207(btk)
PPUG: 119211097(btk)
AFB: 129089645(btk)
CLUM: 117737142(btk)
PSWI: 130209377(btk)
MSAM: 119888677(btk)
SCHU: 122880464(btk)
CUD: 121516738(btk)
ALAT: 119007475(btk)
MZE: 101467854(btk)
ONL: 100711194(btk)
OAU: 116321038(btk)
OLA: 101168549(btk)
OML: 112153478(btk)
CSAI: 133447187(btk)
XMA: 102229275(btk)
XCO: 114139713(btk)
XHE: 116714919(btk)
PRET: 103471526(btk)
PFOR: 103151723(btk)
PLAI: 106949973(btk)
PMEI: 106920035(btk)
GAF: 122837087(btk)
CVG: 107093425(btk)
CTUL: 119781000(btk)
GMU: 124860234(btk)
NFU: 107377689(btk)
KMR: 108231212(btk)
ALIM: 106514519(btk)
NWH: 119408852(btk)
AOCE: 111577298(btk)
MCEP: 125007890(btk)
CSEM: 103390584(btk)
POV: 109627038(btk)
SSEN: 122778020(btk)
HHIP: 117768787(btk)
HSP: 118112325(btk)
PPLT: 128446017(btk)
SMAU: 118319376(btk)
LCF: 108895374
SDU: 111232725(btk)
SLAL: 111648188(btk)
XGL: 120785601(btk)
HCQ: 109515846(btk)
SSCV: 125985848
SBIA: 133508502(btk)
PEE: 133408063(btk)
PTAO: 133484818(btk)
BPEC: 110158863
MALB: 109956117(btk)
BSPL: 114864556(btk)
SJO: 128363187(btk)
SASA: 100194909(btk)
STRU: 115169806(btk)
OTW: 112221095(btk)
OMY: 110488987(btk)
OGO: 123993575(btk)
ONE: 115130866(btk)
OKI: 109864893(btk)
OKE: 118380475(btk)
SALP: 111965886(btk)
SNH: 120047991(btk)
ELS: 105025807(btk)
SFM: 108922820(btk) 108931000
PKI: 111833669(btk) 111835079
AANG: 118223100(btk) 118234831
LOC: 102682236(btk)
PSPA: 121295222 121318801(btk)
ARUT: 117430388(btk)
PSEX: 120537234(btk)
LCM: 102346267(BTK)
RTP: 109912332(btk)
CPLA: 122557051(btk)
HOC: 132820426(btk)
PMRN: 116943693
LRJ: 133350126
PCLA: 123744964
CRG: 105340386
CANU: 128192047
CVN: 111123968
XEN: 124445359
HSY: 130654071
RES: 135686898
 » show all
Reference
  Authors
Bradshaw JM
  Title
The Src, Syk, and Tec family kinases: distinct types of molecular switches.
  Journal
Cell Signal 22:1175-84 (2010)
DOI:10.1016/j.cellsig.2010.03.001
  Sequence
[hsa:695]
Reference
PMID:8380905
  Authors
Vetrie D, Vorechovsky I, Sideras P, Holland J, Davies A, Flinter F, Hammarstrom L, Kinnon C, Levinsky R, Bobrow M, et al.
  Title
The gene involved in X-linked agammaglobulinaemia is a member of the src family of protein-tyrosine kinases.
  Journal
Nature 361:226-33 (1993)
DOI:10.1038/361226a0
  Sequence
[hsa:695]

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