KEGG   ORTHOLOGY: K11412
Entry
K11412                      KO                                     

Name
SIRT2, SIR2L2
Definition
NAD+-dependent protein deacetylase sirtuin 2 [EC:2.3.1.286]
Pathway
ko00760  Nicotinate and nicotinamide metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    K11412  SIRT2, SIR2L2; NAD+-dependent protein deacetylase sirtuin 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11412  SIRT2, SIR2L2; NAD+-dependent protein deacetylase sirtuin 2
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.286  protein acetyllysine N-acetyltransferase
     K11412  SIRT2, SIR2L2; NAD+-dependent protein deacetylase sirtuin 2
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Histone modification proteins
   HDACs (histone deacetylases)
    SIRTs (sirtuins, class III HDACs)
     K11412  SIRT2, SIR2L2; NAD+-dependent protein deacetylase sirtuin 2
Other DBs
RN: R10633 R10634
Genes
HSA: 22933(SIRT2)
PTR: 456013(SIRT2)
PPS: 100979564(SIRT2)
GGO: 101148685(SIRT2)
PON: 100172430(SIRT2)
NLE: 100599033(SIRT2)
MCC: 100425019(SIRT2)
MCF: 101865690(SIRT2)
CSAB: 103234644(SIRT2)
RRO: 104676170(SIRT2)
RBB: 108539022(SIRT2)
CJC: 100393634(SIRT2)
SBQ: 101028915(SIRT2)
MMU: 64383(Sirt2)
MCAL: 110297295(Sirt2)
MPAH: 110319971(Sirt2)
RNO: 361532(Sirt2)
MUN: 110552523(Sirt2)
CGE: 100768923(Sirt2)
NGI: 103750724(Sirt2)
HGL: 101715152(Sirt2)
CCAN: 109695820(Sirt2)
OCU: 100337887(SIRT2)
TUP: 102497077(SIRT2)
CFA: 612558(SIRT2)
VVP: 112928407(SIRT2)
AML: 100467019(SIRT2)
UMR: 103661014(SIRT2)
UAH: 113243599(SIRT2)
ORO: 101386846(SIRT2)
ELK: 111161432
FCA: 101099513(SIRT2)
PTG: 102948519(SIRT2)
PPAD: 109256621(SIRT2)
AJU: 106988309(SIRT2)
BTA: 504463(SIRT2)
BOM: 102284477(SIRT2)
BIU: 109572599(SIRT2)
BBUB: 102408248(SIRT2)
CHX: 102181151(SIRT2)
OAS: 101113169(SIRT2)
SSC: 100125964(SIRT2)
CFR: 102522802(SIRT2)
CDK: 105093303(SIRT2)
BACU: 103016517(SIRT2)
LVE: 103075387(SIRT2)
OOR: 101280224(SIRT2)
DLE: 111180885(SIRT2)
PCAD: 102995091(SIRT2)
ECB: 100146611(SIRT2)
EPZ: 103564559(SIRT2)
EAI: 106836076(SIRT2)
MYB: 102261472(SIRT2)
MYD: 102769161(SIRT2)
MNA: 107532201(SIRT2)
HAI: 109395378(SIRT2)
DRO: 112320128(SIRT2)
PALE: 102882055(SIRT2)
RAY: 107520972(SIRT2)
MJV: 108395443(SIRT2)
LAV: 100660519(SIRT2)
TMU: 101357511
MDO: 100013652(SIRT2)
PCW: 110202303(SIRT2)
OAA: 103166548(SIRT2)
GGA: 548628(SIRT2)
MGP: 100543343
NMEL: 110389127(SIRT2)
LSR: 110478778(SIRT2)
GFR: 102031922
PHI: 102100758(SIRT2)
PMAJ: 107199375(SIRT2)
ETL: 114071415(SIRT2)
AAM: 106491452
ASN: 102385173(SIRT2)
AMJ: 102560050(SIRT2)
PSS: 102444070(SIRT2)
CMY: 102933136(SIRT2)
CPIC: 101948487(SIRT2)
ACS: 100559366(sirt2)
PVT: 110075685(SIRT2)
PBI: 103058243(SIRT2)
PMUR: 107297307(SIRT2)
PMUA: 114603233(SIRT2)
GJA: 107121997(SIRT2)
XLA: 108708898 495688(sirt2.S)
XTR: 100489469(sirt2)
NPR: 108787683(SIRT2)
DRE: 322309(sirt2)
SGH: 107567264(sirt2) 107598806
IPU: 108280670(sirt2)
PHYP: 113543155(sirt2)
AMEX: 103038996(sirt2)
EEE: 113584652(sirt2)
TRU: 101073832(sirt2)
LCO: 104939914(sirt2)
MZE: 101487109(sirt2)
ONL: 100690476(sirt2)
OLA: 101155450(sirt2)
XMA: 102238400(sirt2)
XCO: 114161611(sirt2)
PRET: 103474864(sirt2)
CVG: 107100054(sirt2)
NFU: 107373563(sirt2)
KMR: 108250375(sirt2)
ALIM: 106522134(sirt2)
AOCE: 111566026(sirt2)
CSEM: 103378255(sirt2)
POV: 109634618(sirt2)
LCF: 108883126(sirt2)
SDU: 111232857(sirt2)
SLAL: 111654251(sirt2)
HCQ: 109510864(sirt2)
BPEC: 110153590(sirt2)
MALB: 109952557(sirt2)
SASA: 100380582(sirt2)
OTW: 112265282
SALP: 111949522(sirt2)
ELS: 105026873(sirt2)
SFM: 108928676(sirt2)
PKI: 111844087(sirt2)
LCM: 102353165(SIRT2)
CMK: 103171827(sirt2)
RTP: 109936753
BFO: 118429801
CIN: 100185251
SPU: 585308
DME: Dmel_CG5085(Sirt2)
DER: 6553774
DSI: Dsimw501_GD19348(Dsim_GD19348)
DSR: 110188388
DPE: 6587768
DMN: 108155385
DWI: 6649511
DVI: 6630384
MDE: 101899889
LCQ: 111674804
AAG: 5567072
AALB: 109432118
AME: 409532
BIM: 100744089
BTER: 100643290
CCAL: 108632093
OBB: 114880365
SOC: 105198533
MPHA: 105832557
AEC: 105153256
ACEP: 105621466
PBAR: 105425957
VEM: 105564293
HST: 105187266
DQU: 106741707
CFO: 105257885
LHU: 105671326
PGC: 109860827
OBO: 105282728
PCF: 106787897
NVI: 100123744
CSOL: 105363047
MDL: 103571823
TCA: 657506
DPA: 109534891
NVL: 108560532
BMOR: 692483(Sirt2)
BMAN: 114246434
PMAC: 106721435
PRAP: 110994246
HAW: 110377464
TNL: 113498481
BTAB: 109040978
CLEC: 106665282
ZNE: 110840477
FCD: 110847861
PVM: 113807387
DPTE: 113791844
CSCU: 111627411
BMY: Bm1_30475
PCAN: 112570094
OBI: 106876924
SHX: MS3_06244
EGL: EGR_05039
EPA: 110252827
ADF: 107357040
AMIL: 114956360
PDAM: 113671931
SPIS: 111343495
DGT: 114522073
OLU: OSTLU_16771(SRT3501)
MGL: MGL_0206
MRT: MRET_1109
DDI: DDB_G0283917(sir2A)
DFA: DFA_07194(sir2C)
EHI: EHI_151300(2.t00031)
SMIN: v1.2.013706.t1(symbB.v1.2.013706.t1) v1.2.035092.t1(symbB.v1.2.035092.t1)
 » show all
Reference
  Authors
Beirowski B, Gustin J, Armour SM, Yamamoto H, Viader A, North BJ, Michan S, Baloh RH, Golden JP, Schmidt RE, Sinclair DA, Auwerx J, Milbrandt J
  Title
Sir-two-homolog 2 (Sirt2) modulates peripheral myelination through polarity protein Par-3/atypical protein kinase C (aPKC) signaling.
  Journal
Proc Natl Acad Sci U S A 108:E952-61 (2011)
DOI:10.1073/pnas.1104969108
  Sequence
[hsa:22933] [mmu:64383] [rno:361532]
Reference
  Authors
North BJ, Marshall BL, Borra MT, Denu JM, Verdin E
  Title
The human Sir2 ortholog, SIRT2, is an NAD+-dependent tubulin deacetylase.
  Journal
Mol Cell 11:437-44 (2003)
DOI:10.1016/S1097-2765(03)00038-8
  Sequence
[hsa:22933]

DBGET integrated database retrieval system