KEGG   ORTHOLOGY: K11413
Entry
K11413                      KO                                     

Name
SIRT3, SIR2L3
Definition
NAD+-dependent protein deacetylase sirtuin 3 [EC:2.3.1.286]
Pathway
ko00760  Nicotinate and nicotinamide metabolism
ko01100  Metabolic pathways
ko05230  Central carbon metabolism in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00760 Nicotinate and nicotinamide metabolism
    K11413  SIRT3, SIR2L3; NAD+-dependent protein deacetylase sirtuin 3
 09160 Human Diseases
  09161 Cancer: overview
   05230 Central carbon metabolism in cancer
    K11413  SIRT3, SIR2L3; NAD+-dependent protein deacetylase sirtuin 3
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11413  SIRT3, SIR2L3; NAD+-dependent protein deacetylase sirtuin 3
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.286  protein acetyllysine N-acetyltransferase
     K11413  SIRT3, SIR2L3; NAD+-dependent protein deacetylase sirtuin 3
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Histone modification proteins
   HDACs (histone deacetylases)
    SIRTs (sirtuins, class III HDACs)
     K11413  SIRT3, SIR2L3; NAD+-dependent protein deacetylase sirtuin 3
Other DBs
RN: R10633 R10634
Genes
HSA: 23410(SIRT3)
PTR: 450911(SIRT3)
PPS: 100973326(SIRT3)
GGO: 101126809(SIRT3)
PON: 100453970(SIRT3)
NLE: 100604320(SIRT3)
MCC: 720737(SIRT3)
MCF: 102142238(SIRT3)
CSAB: 103234991(SIRT3)
RRO: 104672643(SIRT3)
RBB: 108538000(SIRT3)
CJC: 100386098(SIRT3)
SBQ: 101050089(SIRT3)
MMU: 64384(Sirt3)
MCAL: 110297529(Sirt3)
MPAH: 110334277(Sirt3)
RNO: 293615(Sirt3)
MUN: 110553899(Sirt3)
CGE: 100762304(Sirt3)
NGI: 103751056(Sirt3)
HGL: 101697494(Sirt3)
CCAN: 109691498(Sirt3)
OCU: 100354500(SIRT3)
TUP: 102502361(SIRT3)
CFA: 475933(SIRT3)
VVP: 112914416(SIRT3)
AML: 100468963(SIRT3)
UMR: 103671025(SIRT3)
UAH: 113248769(SIRT3)
ORO: 101370518(SIRT3)
ELK: 111149798
FCA: 101087609(SIRT3)
PTG: 102948876(SIRT3)
PPAD: 109259795(SIRT3)
AJU: 106987944(SIRT3)
BTA: 614027(SIRT3)
BOM: 102274743(SIRT3)
BBUB: 102403716(SIRT3)
CHX: 102181661(SIRT3)
OAS: 101105454(SIRT3)
SSC: 100125971(SIRT3)
CFR: 102512075(SIRT3)
CDK: 105105732(SIRT3)
BACU: 103011694(SIRT3)
LVE: 103073899(SIRT3)
OOR: 101288599(SIRT3)
DLE: 111170308(SIRT3)
PCAD: 102992890
ECB: 100054908(SIRT3)
EPZ: 103539966(SIRT3)
EAI: 106843865(SIRT3)
MYB: 102252773(SIRT3)
MNA: 107544448(SIRT3)
HAI: 109378085(SIRT3)
DRO: 112317110(SIRT3)
PALE: 102887102(SIRT3)
RAY: 107506500(SIRT3)
MJV: 108384848(SIRT3)
LAV: 100654664(SIRT3)
TMU: 101348992
MDO: 100030763(SIRT3)
SHR: 100924073(SIRT3)
PCW: 110203709(SIRT3)
OAA: 100089118(SIRT3)
GGA: 422988(SIRT3)
MGP: 100538676(SIRT3)
CJO: 107314282(SIRT3)
NMEL: 110401506(SIRT3)
APLA: 101794570(SIRT3)
ACYG: 106047042(SIRT3)
TGU: 100225810(SIRT3)
LSR: 110467555(SIRT3)
SCAN: 103826814(SIRT3)
GFR: 102035189(SIRT3)
FAB: 101821658(SIRT3)
PHI: 102106576(SIRT3)
PMAJ: 107205276(SIRT3)
CCAE: 111930585(SIRT3)
CCW: 104684530(SIRT3)
ETL: 114063308(SIRT3)
FPG: 101914765(SIRT3)
FCH: 102049786(SIRT3)
CLV: 102089394(SIRT3)
EGZ: 104127879(SIRT3)
NNI: 104011402(SIRT3)
ACUN: 113481210(SIRT3)
PADL: 103925062(SIRT3)
AAM: 106489140(SIRT3)
ASN: 102384882(SIRT3)
AMJ: 102562277(SIRT3)
PSS: 102457485(SIRT3)
CMY: 102935907(SIRT3)
CPIC: 101933048(SIRT3)
ACS: 100555836(sirt3)
PVT: 110086196(SIRT3)
PBI: 103067152(SIRT3)
PMUR: 107294462(SIRT3) 107300980
TSR: 106547596(SIRT3)
PMUA: 114600420(SIRT3)
GJA: 107112732(SIRT3)
XLA: 108715195(sirt3.1.S) 734623(sirt3.2.L)
XTR: 100145681(sirt3.2) 100487410(sirt3.1)
DRE: 557125(si:dkey-103i16.6) 558775(sirt3)
CCAR: 109082995
IPU: 108264662 108270931(sirt3)
PHYP: 113534831 113536463(sirt3)
AMEX: 103043515 103044645(sirt3)
EEE: 113578364(sirt3) 113589963
TRU: 101066119 101067563(sirt3)
NCC: 104948251 104965729(sirt3)
MZE: 101471570 101474545(sirt3)
ONL: 100692411 100693812(sirt3)
OLA: 101161471(sirt3) 101165477
XMA: 102221405(sirt3) 102237357
XCO: 114143546(sirt3) 114156786
PRET: 103463032(sirt3) 103466083
CVG: 107082761(sirt3) 107104162
NFU: 107382055(sirt3) 107388944
KMR: 108239958 108249846(sirt3)
ALIM: 106513124(sirt3) 106515597
AOCE: 111582551(sirt3) 111586640
CSEM: 103378865(sirt3) 103380163
POV: 109624168 109646116(sirt3)
LCF: 108875294 108894168(sirt3)
SDU: 111223343(sirt3) 111228405
SLAL: 111656651(sirt3) 111661779
HCQ: 109514431(sirt3) 109531260
BPEC: 110163823 110164021(sirt3)
MALB: 109966902 109971564(sirt3)
OTW: 112218731 112240896(sirt3)
SALP: 111962500(sirt3)
ELS: 105007371(sirt3) 105022153
SFM: 108935931 108942368(sirt3)
PKI: 111838705 111859490(sirt3)
LCM: 102363985(SIRT3) 102364335
CMK: 103179899 103190967(sirt3)
RTP: 109928812(sirt3)
BFO: 118413992
CIN: 494364(sir2-a)
SPU: 579834
APLC: 110975043
SKO: 100376942
ZNE: 110830717
PVM: 113817827
TSP: Tsp_01124
PCAN: 112559032
MYI: 110447840
OBI: 106880884
LAK: 106176139
EGL: EGR_03429
NVE: 5519780
EPA: 110242639
ADF: 107348142
AMIL: 114956839
PDAM: 113665461
SPIS: 111320561
AQU: 100638465
 » show all
Reference
  Authors
Ahn BH, Kim HS, Song S, Lee IH, Liu J, Vassilopoulos A, Deng CX, Finkel T
  Title
A role for the mitochondrial deacetylase Sirt3 in regulating energy homeostasis.
  Journal
Proc Natl Acad Sci U S A 105:14447-52 (2008)
DOI:10.1073/pnas.0803790105
  Sequence
[hsa:23410] [mmu:64384]

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