Entry
Symbol
SETD1, SET1
Name
[histone H3]-lysine4 N-trimethyltransferase SETD1 [EC:
2.1.1.354 ]
Pathway
Disease
H02463 Syndromic intellectual developmental disorder
H02535 Neurodevelopmental disorder with dysmorphic facies
Brite
KEGG Orthology (KO) [BR:ko00001 ]
09100 Metabolism
09105 Amino acid metabolism
00310 Lysine degradation
K11422 SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1
09180 Brite Hierarchies
09182 Protein families: genetic information processing
03036 Chromosome and associated proteins
K11422 SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1
Enzymes [BR:ko01000 ]
2. Transferases
2.1 Transferring one-carbon groups
2.1.1 Methyltransferases
2.1.1.354 [histone H3]-lysine4 N-trimethyltransferase
K11422 SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1
Chromosome and associated proteins [BR:ko03036 ]
Eukaryotic type
Histone modification proteins
HMTs (histone methyltransferases)
HKMTs (histone lysine methyltransferases)
K11422 SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1
HMT complexes
COMPASS/SET1 complex
K11422 SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1
COMPASS/SET1 complex (yeast)
K11422 SETD1, SET1; [histone H3]-lysine4 N-trimethyltransferase SETD1
BRITE hierarchy
Other DBs
Genes
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Taxonomy UniProt
Reference
Authors
Wysocka J, Myers MP, Laherty CD, Eisenman RN, Herr W
Title
Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1.
Journal
Sequence
Reference
Authors
Boa S, Coert C, Patterton HG
Title
Saccharomyces cerevisiae Set1p is a methyltransferase specific for lysine 4 of histone H3 and is required for efficient gene expression.
Journal
Sequence