KEGG   ORTHOLOGY: K11540Help
Entry
K11540                      KO                                     

Name
CAD
Definition
carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase [EC:6.3.5.5 2.1.3.2 3.5.2.3]
Pathway
ko00240  Pyrimidine metabolism
ko00250  Alanine, aspartate and glutamate metabolism
ko01100  Metabolic pathways
Module
M00051  Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP
Disease
H00118  Congenital disorders of glycosylation type I
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09104 Nucleotide metabolism
   00240 Pyrimidine metabolism
    K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
  09105 Amino acid metabolism
   00250 Alanine, aspartate and glutamate metabolism
    K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases
    K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
KEGG modules [BR:ko00002]
 Pathway module
  Nucleotide metabolism
   Pyrimidine metabolism
    M00051  Uridine monophosphate biosynthesis, glutamine (+ PRPP) => UMP
     K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
Enzymes [BR:ko01000]
 2. Transferases
  2.1  Transferring one-carbon groups
   2.1.3  Carboxy- and carbamoyltransferases
    2.1.3.2  aspartate carbamoyltransferase
     K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
 3. Hydrolases
  3.5  Acting on carbon-nitrogen bonds, other than peptide bonds
   3.5.2  In cyclic amides
    3.5.2.3  dihydroorotase
     K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
 6. Ligases
  6.3  Forming carbon-nitrogen bonds
   6.3.5  Carbon-nitrogen ligases with glutamine as amido-N-donor
    6.3.5.5  carbamoyl-phosphate synthase (glutamine-hydrolysing)
     K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
Peptidases [BR:ko01002]
 Cysteine Peptidases
  Family C26: gamma-glutamyl hydrolase family
   K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
 Metallo Peptidases
  Family M38: beta-aspartyl dipeptidase family
   K11540  CAD; carbamoyl-phosphate synthase / aspartate carbamoyltransferase / dihydroorotase
BRITE hierarchy
Other DBs
RN: R00256 R00575 R01395 R01397 R01993 R10948 R10949
GO: 0004088 0004070 0004151
Genes
HSA: 790(CAD)
PTR: 470338(CAD)
PPS: 100989545(CAD)
GGO: 101138023(CAD)
PON: 100444071(CAD)
NLE: 100604681(CAD)
MCC: 699460(CAD)
MCF: 102128048(CAD)
CSAB: 103220607(CAD)
RRO: 104668500(CAD)
RBB: 108532706(CAD)
CJC: 100405052(CAD)
SBQ: 101034080(CAD)
MMU: 69719(Cad)
RNO: 24240(Cad)
CGE: 100689232(Cad)
NGI: 103735684(Cad)
HGL: 101710382(Cad)
CCAN: 109679699(Cad)
OCU: 100352236(CAD)
TUP: 102478104(CAD)
CFA: 483009(CAD)
AML: 100465885(CAD)
UMR: 103671649(CAD)
ORO: 101382379(CAD)
FCA: 101091102(CAD)
PTG: 102971909(CAD)
AJU: 106967912(CAD)
BTA: 504261(CAD)
BOM: 102271526(CAD)
BIU: 109566291(CAD)
PHD: 102327944(CAD)
CHX: 102179779(CAD)
OAS: 101115776(CAD)
SSC: 100624530(CAD)
CFR: 102513447(CAD)
CDK: 105098535(CAD)
BACU: 103012656(CAD)
LVE: 103070440(CAD)
OOR: 101271999(CAD)
ECB: 100055366(CAD)
EPZ: 103546468(CAD)
EAI: 106837038(CAD)
MYB: 102255715(CAD)
MYD: 102767883(CAD)
HAI: 109380279(CAD)
RSS: 109449286(CAD)
PALE: 102896266(CAD)
LAV: 100656120(CAD)
TMU: 101359976
MDO: 100026061(CAD)
SHR: 100930182(CAD)
OAA: 100085020(CAD)
GGA: 428659(CAD)
MGP: 100547622(CAD)
CJO: 107312305(CAD)
ACYG: 106049900(CAD)
TGU: 100221353(CAD)
SCAN: 103824593(CAD)
GFR: 102044833(CAD)
FAB: 101809093(CAD)
PHI: 102101862(CAD)
PMAJ: 107198724(CAD)
CCAE: 111927462(CAD)
CCW: 104684514(CAD)
FPG: 101915663(CAD)
FCH: 102055000(CAD)
CLV: 102091228(CAD)
EGZ: 104132269(CAD)
NNI: 104009152(CAD)
AAM: 106497700(CAD)
ASN: 102374540(CAD)
AMJ: 102564082(CAD)
CMY: 102941481(CAD)
CPIC: 101931696(CAD)
ACS: 103282097 103282587(cad)
PVT: 110086992(CAD)
PBI: 103060670(CAD)
PMUR: 107286448(CAD)
GJA: 107113765(CAD)
XLA: 108716059(cad.L) 108717524
XTR: 100125119(cad)
NPR: 108803083(CAD)
DRE: 266992(cad)
SRX: 107727603(cad)
SANH: 107676241(cad)
CCAR: 109054371
IPU: 108256234(cad)
PHYP: 113528723(cad)
AMEX: 103044710(cad)
EEE: 113571203(cad)
TRU: 101071903(cad)
LCO: 104928828(cad)
NCC: 104950547
OLA: 101175119(cad)
XMA: 102224683(cad)
PRET: 103457308(cad)
NFU: 107377848(cad)
KMR: 108247065(cad)
CSEM: 103381268(cad)
LCF: 108890455(cad)
SDU: 111235926(cad)
HCQ: 109509530 109523514(cad)
BPEC: 110167003(cad)
MALB: 109954122 109970556(cad)
SALP: 111954105 112068127(cad)
ELS: 105017763(cad)
SFM: 108925182(cad)
PKI: 111854017(cad)
LCM: 102353472(CAD)
CMK: 103185793(cad)
CIN: 100176972
SPU: 580997
APLC: 110988169
SKO: 100373224
DME: Dmel_CG18572(r)
DER: 6550003
DPE: 6598264
DSI: Dsimw501_GD24842(Dsim_r)
DWI: 6641338
MDE: 101901505
AAG: 5572005
AME: 410408
BIM: 100743881
BTER: 100643742
SOC: 105197003
MPHA: 105840778
AEC: 105153614
ACEP: 105618642
HST: 105191437
DQU: 106741586
CFO: 105257739
LHU: 105675396
PGC: 109855546
OBO: 105280338
NVI: 100678143(CAD)
MDL: 103569765
TCA: 660900
DPA: 109533123
NVL: 108556632
PMAC: 106710718
PRAP: 110992680
HAW: 110370025
TNL: 113504558
API: 100163703
DNX: 107170492
CLEC: 106663568
ZNE: 110834919
FCD: 110863058
DPTE: 113795876
CEL: CELE_D2085.1(pyr-1)
CBR: CBG00515(Cbr-pyr-1)
CRG: 105319299
MYI: 110450403
OBI: 106882594
EPA: 110234980
PDAM: 113680153
SPIS: 111336945
HMG: 100208851(cad)
DDI: DDB_G0276335(pyr1-3)
DFA: DFA_05982(pyr1-3)
SMIN: v1.2.008091.t1(symbB.v1.2.008091.t1)
NGD: NGA_2087810(PYRB) NGA_2087820(PYRB)
SPAR: SPRG_05258
PBF: CFX0092_B0178(pyrC)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8619816
  Authors
Iwahana H, Fujimura M, Ii S, Kondo M, Moritani M, Takahashi Y, Yamaoka T, Yoshimoto K, Itakura M
  Title
Molecular cloning of a human cDNA encoding a trifunctional enzyme of carbamoyl-phosphate synthetase-aspartate transcarbamoylase-dihydroorotase in de Novo pyrimidine synthesis.
  Journal
Biochem Biophys Res Commun 219:249-55 (1996)
DOI:10.1006/bbrc.1996.0213
  Sequence
[hsa:790]
Reference
  Authors
Grande-Garcia A, Lallous N, Diaz-Tejada C, Ramon-Maiques S
  Title
Structure, functional characterization, and evolution of the dihydroorotase domain of human CAD.
  Journal
Structure 22:185-98 (2014)
DOI:10.1016/j.str.2013.10.016
  Sequence
[hsa:790]

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