KEGG ORTHOLOGY: K11988

ORTHOLOGY: K11988

Entry

K11988                      KO

Symbol

SHH

Name

sonic hedgehog

Pathway

map04340

Hedgehog signaling pathway

map04360

Axon guidance

map05200

Pathways in cancer

map05205

Proteoglycans in cancer

map05217

Basal cell carcinoma

map05226

Gastric cancer

Disease

H00267

Holoprosencephaly

H00652

Solitary median maxillary central incisor syndrome

H01027

Microphthalmia

H01160

Schizencephaly

Brite

KEGG Orthology (KO) [BR:ko00001]
09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    K11988  SHH; sonic hedgehog
09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    K11988  SHH; sonic hedgehog
09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K11988  SHH; sonic hedgehog
   05205 Proteoglycans in cancer
    K11988  SHH; sonic hedgehog
  09162 Cancer: specific types
   05226 Gastric cancer
    K11988  SHH; sonic hedgehog
   05217 Basal cell carcinoma
    K11988  SHH; sonic hedgehog
09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K11988  SHH; sonic hedgehog
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins
    K11988  SHH; sonic hedgehog
Peptidases and inhibitors [BR:ko01002]
Cysteine peptidases
  Family C46: hedgehog family
   K11988  SHH; sonic hedgehog
Glycosaminoglycan binding proteins [BR:ko00536]
Heparan sulfate / Heparin
  Morphogens
   K11988  SHH; sonic hedgehog

Other DBs

GO:

0005113

Genes

HSA:

6469(SHH)

PTR:	743371(SHH)

PPS:	100995872(SHH)

GGO:	101146888(SHH)

PON:	100461003(SHH)

PPYG:

129040701(SHH)

NLE:	100582247(SHH)

HMH:	116809362(SHH)

SSYN:

129476903(SHH)

MCC:	716553(SHH)

MCF:	102120970(SHH)

MTHB:

126951534

MNI:	105474965(SHH)

CSAB:

103227290(SHH)

CATY:

105573097(SHH)

PANU:

101020074(SHH)

TGE:	112620976(SHH)

MLEU:

105534384(SHH)

RRO:	104666156(SHH)

RBB:	108520988(SHH)

TFN:	117073036(SHH)

PTEH:

111551526(SHH)

CANG:

105511473(SHH)

CJC:	100395600(SHH)

SBQ:	101034605(SHH)

CIMI:

108296988(SHH)

ANAN:

105712294(SHH)

MMUR:

105883225(SHH)

LCAT:

123647279(SHH)

PCOQ:

105818206(SHH)

OGA:	100946098(SHH)

MMU:	20423(Shh)

MCAL:

110294612(Shh)

MPAH:

110316392(Shh)

RNO:	29499(Shh)

MCOC:

116097591(Shh)

ANU:	117720757(Shh)

MUN:	110560215(Shh)

CGE:	100773402(Shh)

MAUA:

101831524(Shh)

PROB:

127235756(Shh)

PLEU:

114689766(Shh)

MORG:

121440052(Shh)

MFOT:

126487216

AAMP:

119808182(Shh)

NGI:	103745341(Shh)

HGL:	101719896(Shh)

CPOC:

100732014(Shh)

CCAN:

109702047(Shh)

DSP:	122105862(Shh)

PLOP:

125345721(Shh)

NCAR:

124991984

MMMA:

107156278(Shh)

OCU:

100352774

OPI:	101534025(SHH)

TUP:	102483981(SHH)

GVR:

103582293

CFA:	608860(SHH)

CLUD:

112663058(SHH)

VLG:	121488899(SHH)

NPO:	129516222(SHH)

AML:	100481788(SHH)

UMR:	103660977(SHH)

UAH:	113241522(SHH)

UAR:	123788743(SHH)

ELK:

111154521

LLV:

125081422

MPUF:

101681010(SHH)

MNP:	132015525(SHH)

MLK:	131829988(SHH)

NVS:	122904187(SHH)

ORO:	101374415(SHH)

EJU:	114201788(SHH)

ZCA:	113910924(SHH)

MLX:	118026795(SHH)

NSU:	110579735(SHH)

LWW:	102747361(SHH)

FCA:	111557492(SHH)

PYU:

121024563

PBG:	122488366(SHH)

PVIV:

125154159(SHH)

LRUF:

124523508

PPAD:

109252339(SHH)

PUC:

125930503

AJU:

113596760

HHV:	120230892(SHH)

BTA:	286821(SHH)

BOM:	102271735(SHH)

BBUB:

102412043(SHH)

BBIS:

104980588(SHH)

CHX:	102170201(SHH)

OAS:	101117666(SHH)

BTAX:

128046961(SHH)

ODA:	120877607(SHH)

CCAD:

122438805(SHH)

MBEZ:

129552183(SHH)

SSC:	100512749(SHH)

CFR:	102522058(SHH)

CBAI:

105069468(SHH)

CDK:	105098271(SHH)

VPC:	102532948(SHH)

BACU:

102998170(SHH)

BMUS:

118900452(SHH)

LVE:	103077728(SHH)

OOR:	101270161(SHH)

DLE:	111176269(SHH)

PCAD:

102977789(SHH)

PSIU:

116759433(SHH)

NASI:

112395781(SHH)

ECB:	100147450(SHH)

EPZ:	103559504(SHH)

EAI:	106823318(SHH)

MYB:	102254867(SHH)

MMYO:

118679449(SHH)

MDT:	132242584(SHH)

PKL:	118712271(SHH)

EFUS:

103299591(SHH)

MNA:	107524916(SHH)

DRO:	112308317(SHH)

SHON:

118989379(SHH)

AJM:	119039271(SHH)

PDIC:

114507829(SHH)

PHAS:

123817982(SHH)

MMF:	118620273(SHH)

PPAM:

129071477(SHH)

HAI:	109391492(SHH)

RFQ:	117018290(SHH)

PALE:

102882514(SHH)

PGIG:

120582128(SHH)

PVP:	105298927(SHH)

RAY:	107518868(SHH)

MJV:	108406980(SHH)

TOD:	119256260(SHH)

SARA:

101553644(SHH)

SETR:

126025482(SHH)

LAV:	100669796(SHH)

TMU:

101351744

ETF:	101639628(SHH)

DNM:	101438572(SHH)

MDO:	100016531(SHH)

GAS:	123249854(SHH)

SHR:	100925029(SHH)

AFZ:

127564650

PCW:	110223909(SHH)

TVP:	118852186(SHH)

OAA:	100081692(SHH)

GGA:	395615(SHH)

PCOC:

116244423(SHH)

MGP:	100546709(SHH)

CJO:	107308849(SHH)

TPAI:

128086348(SHH)

LMUT:

125696335(SHH)

NMEL:

110395049(SHH)

APLA:

101805147(SHH)

ACYG:

106038889(SHH)

CATA:

118260147(SHH)

AFUL:

116486437(SHH)

TGU:	100222391(SHH)

LSR:	110468547(SHH)

SCAN:

103812722(SHH)

PMOA:

120504293(SHH)

OTC:	121338100(SHH)

PRUF:

121365209(SHH)

GFR:	102040849(SHH)

FAB:	101807935(SHH)

OMA:	130249998(SHH)

PHI:	102103261(SHH)

PMAJ:

107201071(SHH)

CCW:	104686517(SHH)

CBRC:

103612088(SHH)

ETL:	114055534(SHH)

ZAB:	102062749(SHH)

ZLE:	135443582(SHH)

SVG:	106850705(SHH)

MMEA:

130576410(SHH)

HRT:	120756586(SHH)

SATI:

136358572(SHH)

FPG:	101912554(SHH)

FCH:	102047067(SHH)

SHAB:

115618194(SHH)

ACUN:

113477267(SHH)

TALA:

116965616(SHH)

ACHC:

115339789(SHH)

HLE:	104843121(SHH)

AGEN:

126037878

GCL:

127013566

DPUB:

104298543(SHH)

EGZ:

104125281

NNI:	104022293(SHH)

PADL:

103915631(SHH)

AFOR:

103901040(SHH)

CLV:	102093186(SHH)

MUI:

104543173

CUCA:

104057035(SHH)

OHA:	104339058(SHH)

CPEA:

104397125(SHH)

RTD:	128905513(SHH)

AROW:

112967770(SHH)

NPD:	112959039(SHH)

TGT:	104564705(SHH)

DNE:	112985021(SHH)

ASN:	102383680(SHH)

AMJ:	102570851(SHH)

CPOO:

109306891(SHH)

GGN:	109291235(SHH)

PSS:	102444691(SHH)

CMY:	102932065(SHH)

CCAY:

125631241(SHH)

DCC:	119852286(SHH)

CPIC:

101935657(SHH)

TST:	117872034(SHH)

CABI:

116826862(SHH)

MRV:	120396688(SHH)

ACS:	100557233(shh)

ASAO:

132778980(SHH)

PVT:	110071907(SHH)

SUND:

121932871(SHH)

PBI:	103063349(SHH)

PMUR:

107303327(SHH)

CTIG:

120308942(SHH)

TSR:	106549769(SHH)

PGUT:

117654749(SHH)

APRI:

131197515(SHH)

PTEX:

113447874(SHH)

NSS:	113420819(SHH)

VKO:	123020817(SHH)

PMUA:

114607175(SHH)

PRAF:

128398269(SHH)

ZVI:	118091980(SHH)

HCG:	128331968(SHH)

GJA:	107116932(SHH)

STOW:

125441218(SHH)

EMC:	129337960(SHH)

XLA:	108719826(shh.S) 398047(shh.L)

XTR:	100487601(shh)

NPR:	108785020(SHH)

RTEM:

120941069(SHH)

BBUF:

121002705(SHH)

BGAR:

122938586(SHH)

MUO:

115466969

GSH:	117354316 117354317

DRE:	30269(shha) 30444(shhb)

SRX:	107724414 107732558 107742131 107751367

SANH:

107653282(shh) 107664041 107684761 107686079

SGH:	107550703 107556063 107586383 107591009

CCAR:

109092851 109107238 109111740

CAUA:

113045579 113051666 113106149(shh) 113117713

CGIB:

127950753 127961242 128016766 128029598

PTET:

122348068(shha) 122357165(shhb)

LROH:

127168210(shha) 127175136(shhb)

OMC:	131543280(shha) 131552354(shhb)

PPRM:

120481930(shhb) 120490998(shha)

RKG:	130101664(shhb)

MAMB:

125251556(shhb) 125264959(shha)

CIDE:

127505594 127516702

CERY:

137003063(shhb) 137030364(shha)

MASI:

127441027 127442386 127444417 127451846

TROS:

130552753(shha) 130554642(shhb)

TDW:	130417932(shhb) 130423223(shha)

MANU:

129442149(shhb) 129446134(shha)

IPU:	108267066(shha) 108280234(shhb)

IFU:	128609756(shha) 128624402(shhb)

PHYP:

113539995 113543033

SMEO:

124386987(shha) 124403134(shhb)

TFD:	113640367(shhb) 113649169(shha)

TVC:	132838510(shhb) 132848225(shha)

TRN:	134302574(shhb) 134311275(shha)

AMEX:

103032897(shhb) 103046459(shha)

CMAO:

118797073(shhb) 118826614(shha)

EEE:	113572012 113585054

CHAR:

105900478(shhb) 122131833(shha)

TRU:	446055(shh)

TFS:	130514035(shha)

TNG:	GSTEN00023991G001

LCO:	104926923(shh) 104930803

NCC:	104951474(shh)

TBEN:

117494806(shha)

CGOB:

115025820(shh)

PGEO:

117465828(shha)

GACU:

117541236(shha)

EMAC:

134883775(shha)

ELY:	117264422(shha) 117272329

EFO:	125881715(shha) 125902812(shhb)

PLEP:

121951804 121960752(shha)

SLUC:

116043916 116045345(shha)

ECRA:

117937514(shha) 117954621(shhb)

ESP:	116672387(shh) 116699652

PFLV:

114549430(shh) 114565492

GAT:	120811983(shha)

PPUG:

119198282(shha)

AFB:	129110923(shha)

CLUM:

117749630(shha)

PSWI:

130206583(shha)

MSAM:

119910765(shha)

SCHU:

122866972(shha) 122886606(shhb)

CUD:	121527387(shha)

ALAT:

119008225(shha) 119011316

ASTR:

137587554(shha)

MZE:	101468555(shh)

ONL:	100706984(shh)

OAU:	116314512(shha)

OLA:	100049186(shh)

OML:	112151023(shha)

CSAI:

133423502(shha)

XMA:	102222680(shh)

XCO:	114136393(shh)

XHE:	116712358(shh)

PRET:

103456900(shh)

PFOR:

103140457

PLAI:

106957868(shh)

PMEI:

106929395(shh)

GAF:	122824116(shha)

PPRL:

129364981(shha)

CVG:	107086501(shh)

CTUL:

119791724(shha)

GMU:	124858403(shha)

NFU:	107382481(shh)

KMR:	108230333(shha)

ALIM:

106520994(shh)

NWH:	119426549(shha)

AOCE:

111562874 111580008(shh)

MCEP:

124996054(shhA)

CSEM:

103377530(shh)

POV:	109629475(shh)

SSEN:

122757969(shha)

HHIP:

117753694(shha)

HSP:	118098283(shha)

PPLT:

128425750(shha)

SMAU:

118291484(shha)

LCF:	108896315(shha)

SDU:	111233282 111237885(shh)

SLAL:

111650879 111665139(shh)

XGL:	120789949(shha) 120798565(shhb)

HCQ:	109524085 109524139

SSCV:

125985830

SBIA:

133492544(shha)

PEE:	133396732(shha)

PTAO:

133470070(shha)

BPEC:

110170075(shh)

MALB:

109961432(shh)

BSPL:

114853419(shha)

SJO:	128369175(shhb) 128382469(shha)

SASA:

106569233 106573850 106578610 106590104(shh) 106599328

STRU:

115154264 115157782 115169248 115195834

OTW:	112215632 112226468 112228005(shha) 112261116(shhb)

OMY:	100136227(shh) 110489984(shha) 110508279 110530356(shhb)

OGO:	123991103 124010050(shhb) 124039817(shha) 124040939

ONE:	115101782 115105141 115113953 115130408

OKI:	109871542 109874701 109899051 109909585

OKE:	118361529 118374086(shha) 118395113 118402074(shhb)

SALP:

111953755 111957050 111973333 111973569 111979675

SNH:	120019836 120028069 120050426 120055265

CCLU:

121534628(shhb) 121549996 121569851 121580948

ELS:	105019360 105024267

SFM:	108937058 108937569

PKI:	111840215 111840846 111857636

AANG:

118225055(shha)

LOC:	102683393(shh)

PSPA:

121310291 121314061

ARUT:

117394189(shha) 117399865

PSEX:

120529642(shha)

LCM:	102356687(SHH)

CMK:	103188357(shha)

RTP:	109923465(shha)

CPLA:

122543311 122550113(shha)

HOC:	132805711 132815838(shha)

LERI:

129714624(shha) 129714768(dhh)

PMRN:

116937290 116943789 116945605 116948535

LRJ:	133344911 133346218 133349862 133357278

BFO:

118403211

BBEL:

109474248

CIN:	445636(hh1)

LPIC:

RZE:

FVI:

TPRE:

LHT:

LBD:

CGLO:

FAS:

DAM:

AGIF:

CINS:

VCAN:

CCIN:

DSM:

AROA:

AGRG:

CSET:

LDC:

OTU:

CFEL:

DCI:

HHAL:

106681471(hh)

HVI:

SGRE:

DMK:

DPZ:

PJA:

PCHN:

CQD:

PTRU:

MNZ:

MRJ:

PPOI:

119091636 119099056 119107574

DSV:

119455325

DFR:

124490684

CVS:	136986919(hh)

UDV:

129234613

LPOL:

106465662 106467624 106478649

PVUL:

126822451

HRJ:	124264472 124278634

CRG:

CANU:

CVN:

OED:

PMAX:

MCAF:

MMER:

RPHI:

DPOL:

OSN:

LLON:

ATEN:

116292525 116301663 116306689

XEN:

HSY:

RES:

Reference

PMID:7583126

Authors

Lopez-Martinez A, Chang DT, Chiang C, Porter JA, Ros MA, Simandl BK, Beachy PA, Fallon JF

Title

Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage.

Journal

Curr Biol 5:791-6 (1995)
DOI:10.1016/S0960-9822(95)00156-4

Reference

PMID:10753901

Authors

Pepinsky RB, Rayhorn P, Day ES, Dergay A, Williams KP, Galdes A, Taylor FR, Boriack-Sjodin PA, Garber EA

Title

Mapping sonic hedgehog-receptor interactions by steric interference.

Journal

J Biol Chem 275:10995-1001 (2000)
DOI:10.1074/jbc.275.15.10995

Sequence

[hsa:6469]

All links

Ontology (4)   
   KEGG BRITE (3)   
   GO (1)   
Pathway (12)   
   KEGG PATHWAY (12)   
Disease (4)   
   KEGG DISEASE (4)   
Gene (1181)   
   KEGG GENES (545)   
   KEGG MGENES (114)   
   RefGene (521)   
   OC (1)   
Literature (2)   
   PubMed (2)   
All databases (1203)   

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