KEGG   ORTHOLOGY: K12313Help
Entry
K12313                      KO                                     

Name
ACTA2
Definition
actin, aortic smooth muscle
Pathway
ko04270  Vascular smooth muscle contraction
ko04371  Apelin signaling pathway
ko04926  Relaxin signaling pathway
Disease
H00801  Familial thoracic aortic aneurysm and dissection
H01396  Moyamoya disease
H01630  Patent ductus arteriosus
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04371 Apelin signaling pathway
    K12313  ACTA2; actin, aortic smooth muscle
 09150 Organismal Systems
  09152 Endocrine system
   04926 Relaxin signaling pathway
    K12313  ACTA2; actin, aortic smooth muscle
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K12313  ACTA2; actin, aortic smooth muscle
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K12313  ACTA2; actin, aortic smooth muscle
   04147 Exosome
    K12313  ACTA2; actin, aortic smooth muscle
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actins
    Actins
     K12313  ACTA2; actin, aortic smooth muscle
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K12313  ACTA2; actin, aortic smooth muscle
BRITE hierarchy
Genes
HSA: 59(ACTA2)
PTR: 466148(ACTA2)
PPS: 100987623(ACTA2)
GGO: 101151850(ACTA2)
PON: 100173819(ACTA2)
NLE: 100579983(ACTA2)
MCC: 100427024(ACTA2)
MCF: 102139312(ACTA2)
CSAB: 103216222(ACTA2)
RRO: 104675148(ACTA2)
RBB: 108526651(ACTA2)
CJC: 100396597(ACTA2)
SBQ: 101035102(ACTA2)
MMU: 11475(Acta2)
RNO: 81633(Acta2)
CGE: 100758575(Acta2)
NGI: 103738035(Acta2)
HGL: 101718388(Acta2)
CCAN: 109691143(Acta2)
OCU: 100009271(ACTA2)
TUP: 102476173(ACTA2)
CFA: 477587(ACTA2)
AML: 100470496(ACTA2)
UMR: 103661931(ACTA2)
ORO: 101363837(ACTA2)
FCA: 101093547(ACTA2)
PTG: 102950751(ACTA2)
AJU: 106980969(ACTA2)
BTA: 515610(ACTA2)
BOM: 102274194(ACTA2)
BIU: 109579170(ACTA2)
PHD: 102339866(ACTA2)
CHX: 102191486(ACTA2)
OAS: 101121051(ACTA2)
SSC: 733615(ACTA2)
CFR: 102516380(ACTA2)
CDK: 105102830(ACTA2)
BACU: 103020047(ACTA2)
LVE: 103076696(ACTA2)
OOR: 101270403(ACTA2)
ECB: 100062175(ACTA2)
EPZ: 103558122(ACTA2)
EAI: 106822179(ACTA2)
MYB: 102259532(ACTA2)
MYD: 102755942(ACTA2)
HAI: 109377704(ACTA2)
RSS: 109451057(ACTA2)
PALE: 102880134(ACTA2)
LAV: 100658952(ACTA2)
TMU: 101357176
MDO: 100012397(ACTA2)
OAA: 100074413(ACTA2)
GGA: 423787(ACTA2)
MGP: 100549984(ACTA2)
CJO: 107315889(ACTA2)
APLA: 101793497(ACTA2)
ACYG: 106044345(ACTA2)
SCAN: 103813933(ACTA2)
GFR: 102033705(ACTA2)
FAB: 101805665(ACTA2)
PHI: 102102121(ACTA2)
PMAJ: 107206852(ACTA2)
CCAE: 111931165(ACTA2)
CCW: 104696526(ACTA2)
FPG: 101915277(ACTA2)
FCH: 102045674(ACTA2)
CLV: 102084341(ACTA2)
EGZ: 104129155(ACTA2)
NNI: 104013129(ACTA2)
ACUN: 113481537(ACTA2)
AAM: 106487836(ACTA2)
ASN: 102372571(ACTA2)
AMJ: 102577392(ACTA2)
PSS: 102456465(ACTA2)
CMY: 102939405(ACTA2)
CPIC: 101937631(ACTA2)
ACS: 100551887(acta2)
PVT: 110083111(ACTA2)
PBI: 103064165
PMUR: 107302731
GJA: 107121656(ACTA2)
XLA: 100653490 431847(acta2.L)
XTR: 496696(acta2)
NPR: 108788870(ACTA2)
DRE: 322509(acta2)
SRX: 107758443
SANH: 107683715
SGH: 107584142
CCAR: 109099485
IPU: 100304861(acta2)
PHYP: 113527698(acta2)
AMEX: 103040556(acta2)
TRU: 101071783
LCO: 104936549
MZE: 101471135(acta2)
OLA: 101163135(acta2)
XMA: 102235924(acta2)
NFU: 107387497(acta2)
KMR: 108250739
CSEM: 103382302
LCF: 108891483
SDU: 111219689
HCQ: 109526523(acta2)
MALB: 109969639
ELS: 105006355(acta2)
SFM: 108932828 108939636(acta2)
LCM: 102349699(ACTA2) 102352432 102362539(ACTRT2)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Munot P, Saunders DE, Milewicz DM, Regalado ES, Ostergaard JR, Braun KP, Kerr T, Lichtenbelt KD, Philip S, Rittey C, Jacques TS, Cox TC, Ganesan V
  Title
A novel distinctive cerebrovascular phenotype is associated with heterozygous Arg179 ACTA2 mutations.
  Journal
Brain 135:2506-14 (2012)
DOI:10.1093/brain/aws172
Reference
PMID:2701935
  Authors
Kamada S, Kakunaga T
  Title
The nucleotide sequence of a human smooth muscle alpha-actin (aortic type) cDNA.
  Journal
Nucleic Acids Res 17:1767 (1989)
DOI:10.1093/nar/17.4.1767
  Sequence
[hsa:59]

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