KEGG   ORTHOLOGY: K12314
Entry
K12314                      KO                                     
Symbol
ACTC1
Name
actin, alpha cardiac muscle
Pathway
map04260  Cardiac muscle contraction
map04261  Adrenergic signaling in cardiomyocytes
map05410  Hypertrophic cardiomyopathy
map05414  Dilated cardiomyopathy
Disease
H00292  Hypertrophic cardiomyopathy
H00294  Dilated cardiomyopathy
H00546  Atrial septal defect
H01216  Left ventricular noncompaction
H01219  Restrictive cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09153 Circulatory system
   04260 Cardiac muscle contraction
    K12314  ACTC1; actin, alpha cardiac muscle
   04261 Adrenergic signaling in cardiomyocytes
    K12314  ACTC1; actin, alpha cardiac muscle
 09160 Human Diseases
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K12314  ACTC1; actin, alpha cardiac muscle
   05414 Dilated cardiomyopathy
    K12314  ACTC1; actin, alpha cardiac muscle
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04812 Cytoskeleton proteins
    K12314  ACTC1; actin, alpha cardiac muscle
   04147 Exosome
    K12314  ACTC1; actin, alpha cardiac muscle
Cytoskeleton proteins [BR:ko04812]
 Eukaryotic cytoskeleton proteins
  Actin filaments / Microfilaments
   Actins
    Actins
     K12314  ACTC1; actin, alpha cardiac muscle
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of colorectal cancer cells
   K12314  ACTC1; actin, alpha cardiac muscle
  Exosomal proteins of bladder cancer cells
   K12314  ACTC1; actin, alpha cardiac muscle
Genes
HSA: 70(ACTC1)
PTR: 453307(ACTC1)
PPS: 100987752
GGO: 101150071(ACTC1)
PON: 100442237
NLE: 100603570(ACTC1)
MCC: 697367(ACTC1)
MCF: 102135975(ACTC1)
CSAB: 103245896(ACTC1)
CATY: 105574124(ACTC1)
PANU: 101020447(ACTC1)
TGE: 112627532(ACTC1)
RRO: 104665644(ACTC1)
RBB: 108543689(ACTC1)
TFN: 117070916(ACTC1)
PTEH: 111554612(ACTC1)
CJC: 100398865(ACTC1)
SBQ: 101037742(ACTC1)
CSYR: 103268331(ACTC1)
MMUR: 105872390(ACTC1)
OGA: 100943877(ACTC1)
MMU: 11464(Actc1)
MCAL: 110308886(Actc1)
MPAH: 110317581(Actc1)
RNO: 29275(Actc1)
MCOC: 116090660(Actc1)
MUN: 110555967(Actc1)
CGE: 100766388(Actc1)
PLEU: 114697505(Actc1)
NGI: 103740516(Actc1)
HGL: 101723544(Actc1)
CPOC: 100731953(Actc1)
CCAN: 109677781(Actc1)
DSP: 122114665(Actc1)
NCAR: 124971702
OCU: 100340339(ACTC1)
OPI: 101524138(ACTC1)
TUP: 102486241(ACTC1)
CFA: 478250(ACTC1)
VVP: 112919920(ACTC1)
VLG: 121484876(ACTC1) 121488685
AML: 100464234(ACTC1)
UMR: 103673559(ACTC1) 103679895
UAH: 113242071(ACTC1)
UAR: 123776450(ACTC1)
ELK: 111158552
LLV: 125105260
MPUF: 101684977(ACTC1)
ORO: 101383699(ACTC1)
EJU: 114221336(ACTC1)
ZCA: 113910477(ACTC1)
MLX: 118003185(ACTC1)
FCA: 101095586(ACTC1)
PYU: 121041457(ACTC1)
PBG: 122468819(ACTC1)
PTG: 102958158(ACTC1)
PPAD: 109263206(ACTC1)
AJU: 106969798(ACTC1)
HHV: 120241888(ACTC1)
BTA: 533219(ACTC1)
BOM: 102266730(ACTC1)
BIU: 109564901(ACTC1)
BBUB: 102402622(ACTC1)
CHX: 102170606(ACTC1)
OAS: 101111554(ACTC1)
ODA: 120853247(ACTC1) 120867442
CCAD: 122443347(ACTC1)
SSC: 100152267(ACTC1)
CFR: 102524504(ACTC1)
CBAI: 105076871(ACTC1)
CDK: 105089985(ACTC1)
VPC: 102536147(ACTC1) 102544879(ACTA1)
BACU: 103001576(ACTC1)
LVE: 103074529(ACTC1)
OOR: 101287649(ACTC1)
DLE: 111181781(ACTC1)
PCAD: 102996486(ACTC1)
PSIU: 116749865(ACTC1)
ECB: 100057678(ACTC1)
EPZ: 103549173(ACTC1)
EAI: 106835151(ACTC1)
MYB: 102247353(ACTC1)
MYD: 102763375(ACTC1)
MMYO: 118649467(ACTC1)
MLF: 102435405(ACTC1)
MNA: 107543021(ACTC1)
PKL: 118723947(ACTC1)
HAI: 109386250(ACTC1)
DRO: 112311247(ACTC1)
SHON: 118993629(ACTC1)
AJM: 119040247(ACTC1)
PDIC: 114491619(ACTC1)
PHAS: 123808170(ACTC1)
MMF: 118620606(ACTC1)
RFQ: 117024179(ACTC1)
PALE: 102880535(ACTC1)
PGIG: 120587219(ACTC1)
PVP: 105288607(ACTC1)
RAY: 107508080(ACTC1)
MJV: 108396706
TOD: 119237896(ACTC1)
SARA: 101546466(ACTC1)
LAV: 100658146(ACTC1)
TMU: 101341415
DNM: 101443467(ACTC1)
MDO: 100026925(ACTC1)
GAS: 123235979(ACTC1) 123254541
SHR: 100918763(ACTC1)
PCW: 110214160(ACTC1)
OAA: 100086207(ACTC1) 100088994
GGA: 423298(ACTC1) 426652(ACTBL2L)
PCOC: 116229100 116229330(ACTC1)
CJO: 107311421(ACTA1) 107314384 107314994(ACTC1)
NMEL: 110400816(ACTC1) 110401710
APLA: 101792025(ACTC1) 101803316
ACYG: 106031717(ACTC1) 106044622
AFUL: 116490045 116490308(ACTC1)
TGU: 100229664(ACTC1)
LSR: 110475286(ACTC1)
SCAN: 103826575(ACTC1)
PMOA: 120500352(ACTC1)
OTC: 121331502(ACTC1)
PRUF: 121362526
GFR: 102038037(ACTC1)
FAB: 101808145(ACTC1)
PHI: 102099989(ACTC1)
PMAJ: 107206305(ACTC1)
CCAE: 111942704
CCW: 104684380(ACTC1)
ETL: 114055305(ACTC1)
ZAB: 102067828(ACTC1)
FPG: 101914921(ACTC1) 101915966
FCH: 102050360(ACTC1) 102051901
CLV: 102084489 102093431(ACTC1)
EGZ: 104126475(ACTC1)
NNI: 104009401 104015900(ACTC1)
ACUN: 113480547(ACTC1) 113481280
TALA: 104363846(ACTC1) 104364034
PADL: 103921934(ACTC1) 103925776
ACHC: 115335583(ACTC1) 115352224
AAM: 106482816(ACTC1) 106498226
AROW: 112970906(ACTC1) 112977262
NPD: 112943475 112958082(ACTC1)
DNE: 112979618(ACTC1) 112983091
AMJ: 102570695 106736711(ACTC1)
CPOO: 109308415(ACTRT3) 109321048 109321560(ACTC1)
GGN: 109287959(ACTRT3) 109298700(ACTC1) 109298981
CMY: 102931639 102939680(ACTC1)
CPIC: 101941415 101944575(ACTC1)
TST: 117876655(ACTC1) 117877029
CABI: 116821643(ACTC1) 116825210
MRV: 120402762 120405035(ACTC1)
TSR: 106552958
PGUT: 117665444 117665724(ACTC1)
VKO: 123026375 123026633(ACTC1)
XLA: 108699710(actc1.S) 108716753(acta1.L) 379351(MGC75582.L) 379752(actc1.L) 432314(acta1.S) 779096(acta4.L) 779129(MGC75582.S)
XTR: 394673(acta4) 394698(actc1) 394982(MGC75582) 448346(acta1)
BBUF: 120981786(ACTC1) 120988887 120997871(ACTRT3) 120998599
BGAR: 122921503(ACTC1) 122924331 122933741(ACTRT3) 122934088
DRE: 337770(si:ch73-187m15.4) 408256(actc1a) 415164(acte1) 550445(acta1a) 570210(actc2) 58114(actc1b)
PPRM: 120460348(acte1) 120477686(actc1b) 120480042(acta1b) 120488726(acta1a) 120493795(actc1a) 120494120(actc2)
IPU: 108257679(actc2) 108258095(actc1a) 108258624(acta1a) 108264857 108269395(acte1) 108269850 124626966
SMEO: 124377101(actc2) 124377193(actc1a) 124378397(acta1a) 124385997(acte1) 124389968 124390080 124395545 124400632(acta1b)
TFD: 113636109(acte1) 113638829 113648008(actc2) 113655680(actc1a) 113660301(actc1b) 113661105(acta1b) 113663672(acta1a)
ELY: 117252602(acta1b) 117256023(acta1a) 117266627 117267022 117270614(actc1a)
PLEP: 121942312(acta1a) 121951369(acta1b) 121953212 121953743 121955164(actc1a)
SLUC: 116035720 116049845(acta1a) 116057592 116060522(acta1b) 116066187(actc1a)
ECRA: 117935922 117953779(acta1b) 117961217(actc1a) 117962125(acta1a)
PPUG: 119195173(actc1a) 119196063(acta1b) 119227458 119227655
MSAM: 119890821(acta1b) 119896821 119898218(acta1a) 119909244(actc1a) 119909895
CUD: 121508155(acta1a) 121510138(acta1b) 121521277(actc1a) 121526002 121526107
OAU: 116311282(actc1a) 116313239(acta1b) 116321490(acta1a) 116322369 116326097
OML: 112138110(acta1a) 112144614 112157710(actc1a) 112161115(acta1b)
PRET: 103457336 103458530 103458759(actc1) 103462807(acta1)
PFOR: 103136121 103136490(acta1) 103154821(actc1) 103156675
PLAI: 106949430 106959002(acta1) 106959035 106961437(actc1)
PMEI: 106906445(actc1) 106907938 106915026 106924149(acta1)
GAF: 122824882(actc1a) 122842308(acta1b) 122846001 122846687
GMU: 124867557(acta1b) 124881790(actc1a) 124884866
KMR: 108233466(actc1a) 108234028 108235814 108237352(acta1b)
NWH: 119418606(actc1a) 119422625(acta1a) 119423215(acta1b) 119427281 119427288
SSEN: 122772298(acta1b) 122782779 122782840 122784046(actc1a)
HHIP: 117753815(acta1b) 117756580 117756773 117758333(actc1a) 117764434(acta1a)
XGL: 120788983(actc1a) 120795307 120795337 120800720(acta1a) 120804960(acta1b)
LCM: 102352337(ACTC1) 102364634
CMK: 103175184(actc1) 103180967
AGS: 114120988
RMD: 113557908
PTRU: 123502967
MMER: 123565617
 » show all
Reference
  Authors
Jiang HK, Qiu GR, Li-Ling J, Xin N, Sun KL
  Title
Reduced ACTC1 expression might play a role in the onset of congenital heart disease by inducing cardiomyocyte apoptosis.
  Journal
Circ J 74:2410-8 (2010)
DOI:10.1253/circj.CJ-10-0234
  Sequence
[hsa:70] [rno:29275]

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