KEGG   ORTHOLOGY: K12350
Entry
K12350                      KO                                     

Name
SMPD1, ASM
Definition
sphingomyelin phosphodiesterase [EC:3.1.4.12]
Pathway
ko00600  Sphingolipid metabolism
ko01100  Metabolic pathways
ko04071  Sphingolipid signaling pathway
ko04142  Lysosome
ko04217  Necroptosis
Disease
H00137  Niemann-Pick disease type A/B
H00423  Sphingolipidosis
H00424  Defects in the degradation of sphingomyelin
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00600 Sphingolipid metabolism
    K12350  SMPD1, ASM; sphingomyelin phosphodiesterase
 09130 Environmental Information Processing
  09132 Signal transduction
   04071 Sphingolipid signaling pathway
    K12350  SMPD1, ASM; sphingomyelin phosphodiesterase
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    K12350  SMPD1, ASM; sphingomyelin phosphodiesterase
  09143 Cell growth and death
   04217 Necroptosis
    K12350  SMPD1, ASM; sphingomyelin phosphodiesterase
Enzymes [BR:ko01000]
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.4  Phosphoric-diester hydrolases
    3.1.4.12  sphingomyelin phosphodiesterase
     K12350  SMPD1, ASM; sphingomyelin phosphodiesterase
Other DBs
RN: R02541
GO: 0004767
Genes
HSA: 6609(SMPD1)
PTR: 450990(SMPD1)
PPS: 100994517(SMPD1)
GGO: 101145253(SMPD1)
PON: 100172518(SMPD1)
NLE: 100596565(SMPD1)
MCC: 711248(SMPD1)
MCF: 102136513(SMPD1)
CSAB: 103241532(SMPD1)
RRO: 104678292(SMPD1)
RBB: 108543246(SMPD1)
CJC: 100400920(SMPD1)
SBQ: 101027471(SMPD1)
MMU: 20597(Smpd1)
MCAL: 110297745(Smpd1)
MPAH: 110313478(Smpd1)
RNO: 308909(Smpd1)
MUN: 110559577(Smpd1)
CGE: 100760557(Smpd1)
NGI: 103737560(Smpd1)
HGL: 101699079(Smpd1)
CCAN: 109695569(Smpd1)
OCU: 100353898(SMPD1)
TUP: 102468976(SMPD1)
CFA: 485334(SMPD1)
VVP: 112910870(SMPD1)
AML: 100475585(SMPD1)
UMR: 103681411(SMPD1)
UAH: 113245851(SMPD1)
ORO: 101383347(SMPD1)
ELK: 111159436
FCA: 101099497(SMPD1)
PTG: 102964338(SMPD1)
PPAD: 109271061(SMPD1)
AJU: 106981163(SMPD1)
BTA: 505097(SMPD1)
BOM: 102284273(SMPD1)
BIU: 109569729(SMPD1)
BBUB: 102398828(SMPD1)
CHX: 102179963(SMPD1)
OAS: 100307047(SMPD1)
SSC: 100518980(SMPD1)
CFR: 102509587(SMPD1)
CDK: 105097918(SMPD1)
BACU: 102998207(SMPD1)
LVE: 103079318(SMPD1)
OOR: 101271703(SMPD1)
DLE: 111169136(SMPD1)
PCAD: 102974263(SMPD1)
ECB: 100069949(SMPD1)
EPZ: 103553547(SMPD1)
EAI: 106838188(SMPD1)
MYB: 102255688(SMPD1)
MYD: 102768084(SMPD1)
MNA: 107540477(SMPD1)
HAI: 109376525(SMPD1)
DRO: 112312799(SMPD1)
PALE: 102889583(SMPD1)
RAY: 107504370(SMPD1)
MJV: 108408097(SMPD1)
LAV: 100668454(SMPD1)
TMU: 101350928
MDO: 100030863(SMPD1)
SHR: 100916633(SMPD1)
PCW: 110200480(SMPD1)
OAA: 103166989(SMPD1)
GGA: 419077(SMPD1)
MGP: 104916845(SMPD1)
CJO: 107308580(SMPD1)
NMEL: 110404680(SMPD1)
APLA: 110354702(SMPD1)
TGU: 100221728(SMPD1)
LSR: 110474971(SMPD1)
SCAN: 103824415(SMPD1)
FAB: 101809366(SMPD1)
PHI: 102113323(SMPD1)
PMAJ: 107198374(SMPD1)
CCW: 104698101(SMPD1)
FPG: 101921655(SMPD1)
FCH: 102052173(SMPD1)
ASN: 102379883(SMPD1)
AMJ: 106740329(SMPD1)
CMY: 119566932(SMPD1)
CPIC: 101951948(SMPD1)
ACS: 100560692(smpd1)
PVT: 110078105(SMPD1)
PBI: 103052650(SMPD1)
PMUR: 107288653(SMPD1)
TSR: 106556582(SMPD1)
PMUA: 114595163(SMPD1)
GJA: 107121986(SMPD1)
XLA: 108708792(smpd1.L)
XTR: 100487433(smpd1)
NPR: 108799754(SMPD1)
DRE: 556700(smpd1)
SANH: 107685009(smpd1) 107701086
SGH: 107556869
CCAR: 109073625(smpd1) 109097636
IPU: 108276936(smpd1)
PHYP: 113543515(smpd1)
AMEX: 103041167(smpd1)
EEE: 113581190(smpd1)
TRU: 101061586(smpd1)
LCO: 104923818(smpd1)
NCC: 104952263(smpd1)
MZE: 101476714(smpd1)
ONL: 100701733(smpd1)
OLA: 101174765(smpd1)
XMA: 102217535(smpd1)
XCO: 114152745(smpd1)
PRET: 103475516(smpd1)
CVG: 107087899(smpd1)
NFU: 107386969(smpd1)
KMR: 108236892(smpd1)
ALIM: 106514117(smpd1)
AOCE: 111566185(smpd1)
CSEM: 103395089(smpd1)
POV: 109628807(smpd1)
LCF: 108893766(smpd1)
SDU: 111234335(smpd1)
SLAL: 111666212(smpd1)
HCQ: 109517822(smpd1)
BPEC: 110158406(smpd1)
MALB: 109959320(smpd1)
SASA: 106563923(smpd1)
OTW: 112237414(smpd1)
SALP: 112071049(smpd1)
ELS: 105009397(smpd1)
SFM: 108921160(smpd1)
PKI: 111838002(smpd1)
LCM: 102347420 102358628(SMPD1)
RTP: 109938350(smpd1)
SPU: 584906
APLC: 110980481
DME: Dmel_CG3376(CG3376)
DER: 6548292
DSE: 6618785
DSI: Dsimw501_GD11848(Dsim_GD11848)
DAN: 6494251
DSR: 110187977
DVI: 6626002
MDL: 103569328
API: 100165015
DNX: 107163986
AGS: 114129030
RMD: 113557089
BTAB: 109041128
CLEC: 106674436
CSCU: 111619305
CEL: CELE_B0252.2(asm-1) CELE_W03G1.7(asm-3) CELE_ZK455.4(asm-2)
CBR: CBG01606(Cbr-asm-3) CBG11183(Cbr-asm-1) CBG17365(Cbr-asm-2)
TSP: Tsp_02761
CRG: 105348190
MYI: 110445858
OBI: 106880962
LAK: 106162855
NVE: 5502086
EPA: 110237104
ADF: 107334511
AMIL: 114976261
PDAM: 113680982
SPIS: 111324559
DGT: 114520293
HMG: 100199471
ERC: Ecym_4748
TDL: TDEL_0E03160(TDEL0E03160)
MGR: MGG_10275
ANG: ANI_1_1578094(An11g00670)
CNE: CNM02520
CNB: CNBM2360
ABP: AGABI1DRAFT115230(AGABI1DRAFT_115230)
ABV: AGABI2DRAFT194192(AGABI2DRAFT_194192)
DDI: DDB_G0270834(sgmA) DDB_G0293210(sgmB)
DFA: DFA_05558(sgmA) DFA_09070(sgmB)
EHI: EHI_040600(164.t00014)
 » show all
Reference
PMID:9603947
  Authors
Lin X, Hengartner MO, Kolesnick R
  Title
Caenorhabditis elegans contains two distinct acid sphingomyelinases.
  Journal
J Biol Chem 273:14374-9 (1998)
DOI:10.1074/jbc.273.23.14374
  Sequence
Reference
PMID:1840600
  Authors
Schuchman EH, Suchi M, Takahashi T, Sandhoff K, Desnick RJ
  Title
Human acid sphingomyelinase. Isolation, nucleotide sequence and expression of the full-length and alternatively spliced cDNAs.
  Journal
J Biol Chem 266:8531-9 (1991)
  Sequence
[hsa:6609]

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