KEGG ORTHOLOGY: K12388

ORTHOLOGY: K12388

Entry

K12388                      KO

Symbol

SORT1

Name

sortilin

Pathway

map04142

Lysosome

map04722

Neurotrophin signaling pathway

map04979

Cholesterol metabolism

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    K12388  SORT1; sortilin
09150 Organismal Systems
  09154 Digestive system
   04979 Cholesterol metabolism
    K12388  SORT1; sortilin
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K12388  SORT1; sortilin

Other DBs

GO:	0010465 0030379

TC:	9.A.63.1.3

Genes

HSA:	6272(SORT1)

PTR:	112204967(SORT1)

PPS:	100974043(SORT1)

GGO:	101150274(SORT1) 129532935

PON:	100457993(SORT1)

PPYG:

129020148(SORT1)

NLE:	100579848(SORT1)

HMH:	116469660(SORT1)

SSYN:

134733787(SORT1)

MCC:	698310(SORT1)

MCF:	102123074(SORT1)

MTHB:

126929405

MNI:	105479283(SORT1)

CSAB:

103224291(SORT1)

CATY:

105594332(SORT1)

PANU:

101006123(SORT1)

TGE:	112624210(SORT1)

MLEU:

105530956(SORT1)

RRO:	104655888(SORT1)

RBB:	108519634(SORT1)

TFN:	117075729(SORT1)

PTEH:

111556001(SORT1)

CANG:

105516072(SORT1)

CJC:	100403209(SORT1)

SBQ:	101029164(SORT1)

CIMI:

108283105(SORT1)

ANAN:

105727857(SORT1)

CSYR:

103272281(SORT1)

MMUR:

105863980(SORT1)

LCAT:

123634993(SORT1)

PCOQ:

105813755(SORT1)

OGA:	100947840(SORT1)

MMU:	20661(Sort1)

MCAL:

110290878(Sort1)

MPAH:

110320859(Sort1)

RNO:	83576(Sort1)

MCOC:

116093623(Sort1)

ANU:	117706862(Sort1)

MUN:	110545520(Sort1)

CGE:	100750717(Sort1)

MAUA:

101825752(Sort1)

PROB:

127216855(Sort1)

PLEU:

114699978(Sort1)

MORG:

121462664(Sort1)

MFOT:

126487893

AAMP:

119800895(Sort1)

NGI:	103747872(Sort1)

HGL:	101698000(Sort1)

CPOC:

100718269(Sort1)

CCAN:

109685946

DORD:

105997474(Sort1)

DSP:	122109511(Sort1)

PLOP:

125363800(Sort1)

NCAR:

124977135

MMMA:

107158615(Sort1)

OCU:

100340764

OPI:	101527373(SORT1)

TUP:	102472968(SORT1)

GVR:	103585495(SORT1)

CFA:	479915(SORT1)

CLUD:

112640719(SORT1)

VVP:	112918258(SORT1)

VLG:	121486684(SORT1)

NPO:	129519311(SORT1)

AML:	100465908(SORT1)

UMR:	103674994(SORT1)

UAH:	113244928(SORT1)

UAR:	123795113(SORT1)

ELK:

111143153

LLV:

125096833

MPUF:

101687956(SORT1)

MNP:	132001250(SORT1)

MLK:	131809920(SORT1)

NVS:	122900288(SORT1)

ORO:	101369752(SORT1)

EJU:	114207881(SORT1)

ZCA:	113909905(SORT1)

MLX:	118019036(SORT1)

NSU:	110580666(SORT1)

FCA:	101090199(SORT1)

PYU:	121027622(SORT1)

PCOO:

112871039(SORT1)

PBG:	122480886(SORT1)

PVIV:

125173994(SORT1)

LRUF:

124516554

PTG:	102954219(SORT1)

PPAD:

109271987(SORT1)

PUC:

125912300

AJU:

106977714

HHV:	120244503(SORT1)

BTA:	511591(SORT1)

BOM:	102287024(SORT1)

BIU:	109555979(SORT1)

BBUB:

102412668(SORT1)

BBIS:

104981679(SORT1)

CHX:	102170013(SORT1)

OAS:	101104538(SORT1)

BTAX:

128045316(SORT1)

ODA:	120856739(SORT1)

CCAD:

122436589(SORT1)

MBEZ:

129541746(SORT1)

SSC:	106504120(SORT1)

CFR:	102523390(SORT1)

CBAI:

105063641(SORT1)

CDK:	105085639(SORT1)

VPC:	102544276(SORT1)

BACU:

103011580(SORT1)

BMUS:

118895714(SORT1)

LVE:	103083004(SORT1)

OOR:	101274878(SORT1)

DLE:	111180079(SORT1)

PCAD:

102994133(SORT1)

PSIU:

116752845(SORT1)

NASI:

112397803(SORT1)

ECB:	100061385(SORT1)

EPZ:	103553061(SORT1)

EAI:	106827375(SORT1)

MYB:	102246899(SORT1)

MYD:	102759868(SORT1)

MMYO:

118673773(SORT1)

MLF:	102433677(SORT1)

MDT:	132221361(SORT1)

PKL:	118727425(SORT1)

EFUS:

103291146(SORT1)

MNA:	107545312(SORT1)

DRO:	112314023(SORT1)

SHON:

118990040(SORT1)

AJM:	119054491(SORT1)

PDIC:

114489068(SORT1)

PHAS:

123804832(SORT1)

MMF:	118637219(SORT1)

PPAM:

129063821(SORT1)

HAI:	109375290(SORT1)

RFQ:	117015426(SORT1)

PALE:

102891077(SORT1)

PGIG:

120584983(SORT1)

PVP:	105297275(SORT1)

RAY:	107516137(SORT1)

MJV:	108400474(SORT1)

TOD:	119237278(SORT1)

SARA:

101556396(SORT1)

SETR:

125997406(SORT1)

LAV:	100664931(SORT1)

TMU:

101348304

ETF:	101660326(SORT1)

DNM:	101445972(SORT1)

MDO:	100033052(SORT1)

GAS:	123247133(SORT1)

SHR:	100921440(SORT1)

AFZ:

127559391

PCW:	110218137(SORT1)

TVP:	118856102(SORT1)

OAA:	100073401(SORT1)

GGA:	100858592(SORT1)

PCOC:

116238751(SORT1)

CJO:	107324746(SORT1)

TPAI:

128087975(SORT1)

LMUT:

125684228(SORT1)

NMEL:

110388362(SORT1)

APLA:

101790562(SORT1)

ACYG:

125181145(SORT1)

CATA:

118259531(SORT1)

AFUL:

116498829(SORT1)

ETL:	114073345(SORT1)

FPG:	101919257(SORT1)

FCH:	102057838(SORT1)

SHAB:

115602182(SORT1)

TALA:

116963051(SORT1)

ACHC:

115335144(SORT1)

HLE:	104842319(SORT1)

AGEN:

126052295

CSTI:

104554472(SORT1)

EGZ:	104123419(SORT1)

NNI:	104017538(SORT1)

CLV:	102095413(SORT1)

CUCA:

104062311(SORT1)

BREG:

104641290(SORT1)

AAM:	106495453(SORT1)

AROW:

112974926(SORT1)

NPD:	112944608(SORT1)

TGT:	104564475(SORT1)

DNE:	112995456(SORT1)

SCAM:

104145084(SORT1)

ASN:	102380936(SORT1)

AMJ:	102560367(SORT1)

CPOO:

109317552(SORT1)

PSS:	102454570(SORT1)

CMY:	102933588(SORT1)

CCAY:

125625059(SORT1)

DCC:	119846201(SORT1)

CPIC:

101938695(SORT1)

TST:	117876058(SORT1)

CABI:

116836182(SORT1)

MRV:	120404478(SORT1)

ACS:	100561957(sort1)

ASAO:

132773768(SORT1)

PVT:	110085278(SORT1)

SUND:

121928274(SORT1)

PBI:	103048926(SORT1)

PMUR:

107302526(SORT1)

CTIG:

120298927(SORT1)

TSR:	106542530(SORT1)

PGUT:

117664042(SORT1)

APRI:

131194156(SORT1)

PTEX:

113446976 113447771

NSS:	113418795 113418956

VKO:	123029987(SORT1)

PMUA:

114599179(SORT1)

PRAF:

128415956(SORT1)

ZVI:	118088308(SORT1)

HCG:	128325365(SORT1)

GJA:	107111197(SORT1)

STOW:

125433018(SORT1)

EMC:	129329992(SORT1)

XLA:	100158281(sort1.S)

XTR:	100490074(sort1)

NPR:	108800608(SORT1)

RTEM:

120927169(SORT1)

BBUF:

120995081(SORT1)

BGAR:

122933363(SORT1)

MUO:	115482002(SORT1)

GSH:	117347346(SORT1)

DRE:	406511(sort1a) 560593(si:dkey-159a18.1) 799153(sort1b)

SRX:	107711994 107715784 107718224 107731125 107738834

SANH:

107659546 107668073 107679020 107685983 107694153 107699055

SGH:	107550487 107582375 107591329 107591814

CCAR:

109060597 109066474 109067872 109094627 109104183

CAUA:

113048105 113055362 113062463 113093986 113107569 113107611 113110903

CGIB:

127956919(si:dkey-159a18.1) 127963251 127968550 127974091 128018647 128022139

PTET:

122343512(si:dkey-159a18.1) 122350155(sort1b) 122354493(sort1a)

LROH:

127163720(si:dkey-159a18.1) 127169599(sort1b) 127173026(sort1a)

OMC:	131539651(si:dkey-159a18.1) 131545492(sort1b) 131549797(sort1a)

PPRM:

120469106(sort1b) 120476957(si:dkey-159a18.1) 120480757(sort1a)

RKG:	130072234(si:dkey-159a18.1) 130083512(sort1a) 130094608(sort1b)

MAMB:

125245658(si:dkey-159a18.1) 125256481(sort1a) 125279820(sort1b)

CIDE:

127510837(si:dkey-159a18.1) 127516932 127522042

CERY:

137021447(sort1a) 137024498(si:dkey-159a18.1) 137027128(sort1b)

MASI:

127414951 127424000 127426418 127428184 127435049(si:dkey-159a18.1) 127436759

TROS:

130548168(si:dkey-159a18.1) 130568027(sort1b) 130571308(sort1a)

TDW:	130410377(sort1a) 130420292(si:dkey-159a18.1) 130440250(sort1b)

MANU:

129414688(sort1b) 129427572(sort1a) 129431729(si:dkey-159a18.1)

IPU:	108254943(sort1a) 108265432(sort1b) 108279534(si:dkey-159a18.1)

IFU:	128607908(sort1b) 128623690(si:dkey-159a18.1) 128624746(sort1a)

PHYP:

113527773 113539626 113544568

SMEO:

124400190(sort1b) 124401018(si:dkey-159a18.1) 124402431(sort1a)

TFD:	113645454 113648587(sort1a) 113655909(sort1b)

TVC:	132837726(sort1a) 132853674(sort1b) 132858849(si:dkey-159a18.1)

TRN:	134301784(sort1a) 134318175(sort1b) 134323568(si:dkey-159a18.1)

AMEX:

103040108(si:dkey-159a18.1) 103040260(sort1a) 103047724(sort1b)

CMAO:

118799628(sort1a) 118812070(si:dkey-159a18.1) 118813782(sort1b)

EEE:	113575543 113578937(sort1) 113579988

CHAR:

105897350(sort1b) 122130318(si:dkey-159a18.1)

TRU:	101073281 101077962 101078112

TFS:	130518946(si:dkey-159a18.1) 130524253 130529411(sort1b)

TNG:	GSTEN00013983G001 GSTEN00020810G001 GSTEN00028183G001

LCO:	104918792 104925228 104926808(sort1)

NCC:	104942233(sort1) 104943012 104968091

TBEN:

117485095(si:dkey-159a18.1) 117486582 117494164(sort1b)

CGOB:

115008380 115010888 115028317

PGEO:

117444858(si:dkey-159a18.1) 117449130(sort1b)

GACU:

117541864(sort1b) 117547530 117559175(si:dkey-159a18.1)

EMAC:

134861952(sort1b) 134879507(si:dkey-159a18.1) 134883100

ELY:	117249476(si:dkey-159a18.1) 117256413 117258234(sort1b)

EFO:	125883058(si:dkey-159a18.1) 125891201(sort1b)

PLEP:

121946769(sort1b) 121959136 121963885

SLUC:

116040733(sort1b) 116060117(si:dkey-159a18.1) 116067155

ECRA:

117938443(si:dkey-159a18.1) 117943318 117948380(sort1b)

ESP:	116672763 116688068 116692859(sort1)

PFLV:

114550494 114554875 114558115(sort1)

GAT:	120817890(si:dkey-159a18.1) 120829508(sort1b) 120835216

PPUG:

119211264(si:dkey-159a18.1) 119223339(sort1b) 119229870

AFB:	129099354(sort1b) 129105635 129112450(si:dkey-159a18.1)

CLUM:

117726026(si:dkey-159a18.1) 117734140(sort1b)

PSWI:

130199150(sort1b) 130200766(si:dkey-159a18.1)

MSAM:

119883763 119886509 119905585(sort1b) 119918549(si:dkey-159a18.1)

SCHU:

122867968 122871110(si:dkey-159a18.1) 122882350(sort1b)

CUD:	121505461(si:dkey-159a18.1) 121507563 121518004(sort1b)

ALAT:

119021683 119022227(sort1b) 119032841(si:dkey-159a18.1)

MZE:	101465533 101478643 101483207

ONL:	100696864 100710311(sort1) 109194165

OAU:	116309728(sort1b) 116326398 116335051(si:dkey-159a18.1)

OLA:	101157659 101158853 101169531

OML:	112140788 112153541(si:dkey-159a18.1) 112159473(sort1b)

CSAI:

133424570(si:dkey-159a18.1) 133448799 133457255(sort1b)

XMA:	102219283 102222980 102237523

XCO:	114135539 114141662 114160999

XHE:	116710478 116726314 116736891

PRET:

103459212 103464892 103467174(sort1)

PFOR:

103144340(sort1) 103146243 103151056

PLAI:

106946547 106950083(sort1) 106960118

PMEI:

106917378(sort1) 106918507 106918885

GAF:	122826162(si:dkey-159a18.1) 122829672 122834181 122837069

PPRL:

129358233 129372272(sort1b) 129375645(si:dkey-159a18.1)

CVG:	107083332 107087491(sort1) 107101171

CTUL:

119782151(sort1b) 119789331(si:dkey-159a18.1) 119791816

GMU:	124856989 124868543(sort1b) 124883229(si:dkey-159a18.1)

NFU:	107385578 107385764 107390796(sort1)

KMR:	108233213(si:dkey-159a18.1) 108236843(sort1b) 108246871

ALIM:

106513217(sort1) 106514773 106525759

NWH:	119412617 119417287(sort1b) 119428494(si:dkey-159a18.1)

AOCE:

111578146 111581518(sort1) 111587439

MCEP:

124999850 125004135(sort1b) 125007191

CSEM:

103382662 103384806(sort1) 103386091

POV:	109628899 109630800 109632668

SSEN:

122766103(si:dkey-159a18.1) 122768697 122776997(sort1b)

HHIP:

117757456(si:dkey-159a18.1) 117761491 117764321(sort1b)

HSP:	118101550(si:dkey-159a18.1) 118104446 118111326(sort1b)

PPLT:

128428654(si:dkey-159a18.1) 128441807(sort1b) 128457502

SMAU:

118309180 118316295(sort1b) 118318769(si:dkey-159a18.1)

LCF:	108876422(sort1b) 108889267(si:dkey-159a18.1) 108889404

SDU:	111218999 111221539 111224697

SLAL:

111656469 111667885 111670663

XGL:	120783042 120797117(si:dkey-159a18.1) 120803842(sort1b)

HCQ:	109510400 109520163 109522482

SSCV:

125977347 125988042 125992033(si:dkey-159a18.1)

SBIA:

133493774(si:dkey-159a18.1) 133507505 133510427(sort1b)

PEE:	133397261(si:dkey-159a18.1) 133406821(sort1b) 133408817

PTAO:

133471857(si:dkey-159a18.1) 133483871 133484878(sort1b)

BPEC:

110161759 110164982(sort1) 110168402

MALB:

109956056 109959854 109971296

BSPL:

114855942 114859424(sort1b) 114862661(si:dkey-159a18.1)

SJO:	128356216 128357535(sort1b) 128385101(si:dkey-159a18.1)

SASA:

106566365 106572865 106583135 106609576

STRU:

115150672 115165329 115168686 115180367 115199093

OTW:	112233911 112233932 112235433 112254515(sort1a) 112257656

OMY:	110490779 110492692 110499876(si:dkey-159a18.1) 110528030(sort1a) 110531272

OGO:	123994379 124014166 124031356(sort1a) 124032372 124045475

ONE:	115120980 115121390 115124373 115132532

OKI:	109864509 109875708 109878576 109884909 109891068

OKE:	118373560 118377253 118379459 118379993 118400236

SALP:

111970017 112069068 112070422

SNH:	120031844(si:dkey-159a18.1) 120049152 120059027 120061452 120065144

CCLU:

121537717 121542451 121546140 121555455 121577694

ELS:	105020387 105029199(sort1)

SFM:	108923278 108931371 108933583

PKI:	111834313 111853402 111858921(sort1)

AANG:

118208294 118210913(sort1a) 118231676(si:dkey-159a18.1)

LOC:	102687967 102693542(sort1)

PSPA:

121299992 121300196 121319022

ARUT:

117414801 117419984(si:dkey-159a18.1) 117427537 117964481

PSEX:

120525888(sort1b) 120534003

LCM:	102345670 102365987(SORT1)

CMK:	103179426 103182556

RTP:	109916673 109926785(sort1a)

CPLA:

122559514 122563138

HOC:	132824991 132828370

LERI:

129706207 129708949

PMRN:

116949436 116952725 116957817(SORT1)

LRJ:	133342559 133356640 133356680

BFO:

BBEL:

CIN:

SCLV:

SPU:

LPIC:

APLC:

ARUN:

SKO:

HRO:	HELRODRAFT_116302

LGI:	LOTGIDRAFT_231095

PVUL:

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:	105321665 105349100

CANU:

MYI:

PMAX:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:	115210579 115210665

LJP:

135470188

LAK:

106167010

SMM:	Smp_179360

OVI:	T265_15239

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

HMG:

HSY:

RES:

AQU:

Reference

PMID:15987945

Authors

Chen ZY, Ieraci A, Teng H, Dall H, Meng CX, Herrera DG, Nykjaer A, Hempstead BL, Lee FS

Title

Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway.

Journal

J Neurosci 25:6156-66 (2005)
DOI:10.1523/JNEUROSCI.1017-05.2005

Sequence

[hsa:6272]

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Ontology (4)   
   KEGG BRITE (1)   
   GO (2)   
   TC (1)   
Pathway (6)   
   KEGG PATHWAY (6)   
Drug (3)   
   KEGG DRUG (3)   
Gene (1516)   
   KEGG GENES (679)   
   KEGG MGENES (371)   
   RefGene (458)   
   OC (8)   
Literature (1)   
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