KEGG ORTHOLOGY: K12388

ORTHOLOGY: K12388

Entry

K12388                      KO

Symbol

SORT1

Name

sortilin

Pathway

map04142

Lysosome biogenesis

map04722

Neurotrophin signaling pathway

map04979

Cholesterol metabolism

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome biogenesis
    K12388  SORT1; sortilin
09150 Organismal Systems
  09154 Digestive system
   04979 Cholesterol metabolism
    K12388  SORT1; sortilin
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K12388  SORT1; sortilin

Other DBs

GO:	0010465 0030379

TC:	9.A.63.1.3

Genes

HSA:	6272(SORT1)

PTR:	112204967(SORT1)

PPS:	100974043(SORT1)

GGO:	101150274(SORT1) 129532935

PON:	100457993(SORT1)

PPYG:

129020148(SORT1)

NLE:	100579848(SORT1)

HMH:	116469660(SORT1)

SSYN:

134733787(SORT1)

MCC:	698310(SORT1)

MCF:	102123074(SORT1)

MTHB:

126929405

MNI:	105479283(SORT1)

CSAB:

103224291(SORT1)

CATY:

105594332(SORT1)

PANU:

101006123(SORT1)

TGE:	112624210(SORT1)

MLEU:

105530956(SORT1)

RRO:	104655888(SORT1)

RBB:	108519634(SORT1)

TFN:	117075729(SORT1)

PTEH:

111556001(SORT1)

CANG:

105516072(SORT1)

CJC:	100403209(SORT1)

SBQ:	101029164(SORT1)

CIMI:

108283105(SORT1)

ANAN:

105727857(SORT1)

CSYR:

103272281(SORT1)

MMUR:

105863980(SORT1)

LCAT:

123634993(SORT1)

ERUF:

138390905(SORT1)

PCOQ:

105813755(SORT1)

OGA:	100947840(SORT1)

MMU:	20661(Sort1)

MCAL:

110290878(Sort1)

MPAH:

110320859(Sort1)

RNO:	83576(Sort1)

MCOC:

116093623(Sort1)

ANU:	117706862(Sort1)

ASYL:

127682802(Sort1)

MUN:	110545520(Sort1)

CGE:	100750717(Sort1)

MAUA:

101825752(Sort1)

PROB:

127216855(Sort1)

PLEU:

114699978(Sort1)

PMAV:

102913924(Sort1)

MORG:

121462664(Sort1)

MFOT:

126487893

AAMP:

119800895(Sort1)

CNL:	130889400(Sort1)

NGI:	103747872(Sort1)

HGL:	101698000(Sort1)

CPOC:

100718269(Sort1)

CCAN:

109685946

DORD:

105997474(Sort1)

DSP:	122109511(Sort1)

DMER:

138816453(Sort1)

PLOP:

125363800(Sort1)

NCAR:

124977135

MMMA:

107158615(Sort1)

ITI:	101955236(Sort1)

OCU:

100340764

OPI:	101527373(SORT1)

OCZ:	121168792(SORT1)

TUP:	102472968(SORT1)

GVR:	103585495(SORT1)

CFA:	479915(SORT1)

CLUD:

112640719(SORT1)

VVP:	112918258(SORT1)

VLG:	121486684(SORT1)

NPO:	129519311(SORT1)

AML:	100465908(SORT1)

UMR:	103674994(SORT1)

UAH:	113244928(SORT1)

UAR:	123795113(SORT1)

ELK:

111143153

LLV:

125096833

MPUF:

101687956(SORT1)

MNP:	132001250(SORT1)

MLK:	131809920(SORT1)

NVS:	122900288(SORT1)

ORO:	101369752(SORT1)

EJU:	114207881(SORT1)

ZCA:	113909905(SORT1)

MLX:	118019036(SORT1)

MANO:

123859297(SORT1)

NSU:	110580666(SORT1)

FCA:	101090199(SORT1)

PYU:	121027622(SORT1)

PCOO:

112871039(SORT1)

PBG:	122480886(SORT1)

PVIV:

125173994(SORT1)

LRUF:

124516554

LGF:	123598382(SORT1)

AJU:

106977714

PTG:	102954219(SORT1)

PPAD:

109271987(SORT1)

PUC:

125912300

PLEZ:

122228278(SORT1)

HHV:	120244503(SORT1)

CCRU:

144232737(SORT1)

BTA:	511591(SORT1)

BOM:	102287024(SORT1)

BIU:	109555979(SORT1)

BJV:	133244162(SORT1)

BBUB:

102412668(SORT1)

BKE:	129655012(SORT1)

BBIS:

104981679(SORT1)

CHX:	102170013(SORT1)

OAS:	101104538(SORT1)

OCAN:

138431933(SORT1)

BTAX:

128045316(SORT1)

CSUM:

138073020(SORT1)

ODA:	120856739(SORT1)

CCAD:

122436589(SORT1)

MREE:

136148049(SORT1)

MBEZ:

129541746(SORT1)

SSC:	106504120(SORT1)

CFR:	102523390(SORT1)

CBAI:

105063641(SORT1)

CDK:	105085639(SORT1)

VPC:	102544276(SORT1)

BACU:

103011580(SORT1)

BMUS:

118895714(SORT1)

LVE:	103083004(SORT1)

OOR:	101274878(SORT1)

LALB:

132514558(SORT1)

GMF:	115859684(SORT1)

DDP:	132434919(SORT1)

DLE:	111180079(SORT1)

PCAD:

102994133(SORT1)

PSIU:

116752845(SORT1)

PPHC:

136122541(SORT1)

NASI:

112397803(SORT1)

ECB:	100061385(SORT1)

EPZ:	103553061(SORT1)

EAI:	106827375(SORT1)

MYB:	102246899(SORT1)

MYD:	102759868(SORT1)

MMYO:

118673773(SORT1)

MLF:	102433677(SORT1)

MDT:	132221361(SORT1)

MYUM:

138995984(SORT1)

PKL:	118727425(SORT1)

EFUS:

103291146(SORT1)

MNA:	107545312(SORT1)

DRO:	112314023(SORT1)

SHON:

118990040(SORT1)

AJM:	119054491(SORT1)

PDIC:

114489068(SORT1)

PHAS:

123804832(SORT1)

MMF:	118637219(SORT1)

PPAM:

129063821(SORT1)

HAI:	109375290(SORT1)

RFQ:	117015426(SORT1)

PALE:

102891077(SORT1)

PGIG:

120584983(SORT1)

PVP:	105297275(SORT1)

RAY:	107516137(SORT1)

MJV:	108400474(SORT1)

TOD:	119237278(SORT1)

SARA:

101556396(SORT1)

SFUM:

130046188(SORT1)

SETR:

125997406(SORT1)

LAV:	100664931(SORT1)

TMU:

101348304

ETF:	101660326(SORT1)

DNM:	101445972(SORT1)

MDO:	100033052(SORT1)

GAS:	123247133(SORT1)

SHR:	100921440(SORT1)

AFZ:

127559391

PCW:	110218137(SORT1)

TVP:	118856102(SORT1)

PBRV:

138162909(SORT1)

MLAO:

141488345(SORT1)

OAA:	100073401(SORT1)

TACU:

119930524(SORT1)

GGA:	100858592(SORT1)

PCOC:

116238751(SORT1)

CJO:	107324746(SORT1)

TPAI:

128087975(SORT1)

LMUT:

125684228(SORT1)

NMEL:

110388362(SORT1)

APLA:

101790562(SORT1)

AACU:

137843996(SORT1)

OJA:	118158350(SORT1)

ACYG:

125181145(SORT1)

CATA:

118259531(SORT1)

AFUL:

116498829(SORT1)

ETL:	114073345(SORT1)

FPG:	101919257(SORT1)

FCH:	102057838(SORT1)

FRS:	119158534(SORT1)

SHAB:

115602182(SORT1)

ANOC:

141969625(SORT1)

SURA:

141954433(SORT1)

TALA:

116963051(SORT1)

ACHC:

115335144(SORT1)

HLE:	104842319(SORT1)

AGEN:

126052295

HHAR:

128154619(SORT1)

BBUT:

142043633(SORT1)

CSTI:

104554472(SORT1)

PPUS:

135191359(SORT1)

EGZ:	104123419(SORT1)

NNI:	104017538(SORT1)

PARX:

142067338(SORT1)

CBOR:

142093368(SORT1)

CBOY:

140643234(SORT1)

MAME:

142418969(SORT1)

CLV:	102095413(SORT1)

CNIC:

135996913(SORT1)

CUCA:

104062311(SORT1)

PCUR:

138730491(SORT1)

BREG:

104641290(SORT1)

GAME:

129196458(SORT1)

CRID:

134525672(SORT1)

LMIC:

141733512(SORT1)

NARQ:

141477714(SORT1)

AAM:	106495453(SORT1)

AROW:

112974926(SORT1)

NPD:	112944608(SORT1)

TGT:	104564475(SORT1)

DNE:	112995456(SORT1)

SCAM:

104145084(SORT1)

ASN:	102380936(SORT1)

AMJ:	102560367(SORT1)

CPOO:

109317552(SORT1)

PSS:	102454570(SORT1)

CIZ:	142001941(SORT1)

CMY:	102933588(SORT1)

CCAY:

125625059(SORT1)

LKP:	140901203(SORT1)

NDS:	141975470(SORT1)

DCC:	119846201(SORT1)

CPIC:

101938695(SORT1)

TST:	117876058(SORT1)

CABI:

116836182(SORT1)

MRV:	120404478(SORT1)

EMQ:	137142258(SORT1)

ACS:	100561957(sort1)

ASAO:

132773768(SORT1)

PVT:	110085278(SORT1)

SUND:

121928274(SORT1)

PBI:	103048926(SORT1)

PMUR:

107302526(SORT1)

CTIG:

120298927(SORT1)

TSR:	106542530(SORT1)

PGUT:

117664042(SORT1)

PCAE:

139314135(SORT1)

APRI:

131194156(SORT1)

PTEX:

113446976 113447771

NSS:	113418795 113418956

VKO:	123029987(SORT1)

PMUA:

114599179(SORT1)

PRAF:

128415956(SORT1)

ZVI:	118088308(SORT1)

HCG:	128325365(SORT1)

GJA:	107111197(SORT1)

STOW:

125433018(SORT1)

EMC:	129329992(SORT1)

XLA:	100158281(sort1.S)

XTR:	100490074(sort1)

NPR:	108800608(SORT1)

RTEM:

120927169(SORT1)

ACAT:

141128552(SORT1)

PADS:

140330407(SORT1)

BBUF:

120995081(SORT1)

BGAR:

122933363(SORT1)

DTC:	141047401(SORT1)

PWL:	138299806(SORT1)

MUO:	115482002(SORT1)

GSH:	117347346(SORT1)

DRE:	406511(sort1a) 560593 799153(sort1b)

DAES:

130222971(si:dkey-159a18.1) 130233527(sort1b) 130237091(sort1a)

SRX:	107711994 107715784 107718224 107731125 107738834

SANH:

107659546 107668073 107679020 107685983 107694153 107699055

SGH:	107550487 107582375 107591329 107591814

CCAR:

109060597 109066474(sort1a) 109067872 109078614 109094627 109104183

CAUA:

113048105 113055362 113062463 113093986 113107569 113107611 113110903

CGIB:

127956919(si:dkey-159a18.1) 127963251 127968550 127974091 128018647 128022139

PTET:

122343512(si:dkey-159a18.1) 122350155(sort1b) 122354493(sort1a)

LROH:

127163720(si:dkey-159a18.1) 127169599(sort1b) 127173026(sort1a)

GRF:	141286529(sort1b) 141293895(sort1a) 141333481

OMC:	131539651(si:dkey-159a18.1) 131545492(sort1b) 131549797(sort1a)

PPRM:

120469106(sort1b) 120476957(si:dkey-159a18.1) 120480757(sort1a)

RKG:	130072234(si:dkey-159a18.1) 130083512(sort1a) 130094608(sort1b)

MAMB:

125245658(si:dkey-159a18.1) 125256481(sort1a) 125279820(sort1b)

CIDE:

127510837(si:dkey-159a18.1) 127516932 127522042

CERY:

137021447(sort1a) 137024498(si:dkey-159a18.1) 137027128(sort1b)

MASI:

127414951 127424000 127426418 127428184 127435049(si:dkey-159a18.1) 127436759

TROS:

130548168(si:dkey-159a18.1) 130568027(sort1b) 130571308(sort1a)

TDW:	130410377(sort1a) 130420292(si:dkey-159a18.1) 130440250(sort1b)

MANU:

129414688(sort1b) 129427572(sort1a) 129431729

PDAB:

135718739(sort1a) 135729388(sort1b) 135749792

IPU:	108254943(sort1a) 108265432(sort1b) 108279534(si:dkey-159a18.1)

IFU:	128607908(sort1b) 128623690(si:dkey-159a18.1) 128624746(sort1a)

PHYP:

113527773 113539626 113544568

SMEO:

124400190(sort1b) 124401018(si:dkey-159a18.1) 124402431(sort1a)

TFD:	113645454 113648587(sort1a) 113655909(sort1b)

TVC:	132837726(sort1a) 132853674(sort1b) 132858849(si:dkey-159a18.1)

CGAR:

128511593(sort1a) 128530744(sort1b) 128534492(si:dkey-159a18.1)

NGRA:

132870243(si:dkey-159a18.1) 132874565(sort1a) 132893173(sort1b)

TRN:	134301784(sort1a) 134318175(sort1b) 134323568(si:dkey-159a18.1)

AMEX:

103040108(si:dkey-159a18.1) 103040260(sort1a) 103047724(sort1b)

CMAO:

118799628(sort1a) 118812070(si:dkey-159a18.1) 118813782(sort1b)

EEE:	113575543 113578937(sort1) 113579988

CHAR:

105897350(sort1b) 122130318(si:dkey-159a18.1)

SPIL:

134062486(si:dkey-159a18.1) 134087156(sort1b)

ASAD:

121697778(si:dkey-159a18.1) 121712821(sort1b)

TRU:	101073281 101077962 101078112

TFS:	130518946(si:dkey-159a18.1) 130524253 130529411(sort1b)

TNG:	GSTEN00013983G001 GSTEN00020810G001 GSTEN00028183G001

LCO:	104918792 104925228 104926808(sort1)

NCC:	104942233(sort1) 104943012 104968091

TBEN:

117485095(si:dkey-159a18.1) 117486582 117494164(sort1b)

CGOB:

115008380 115010888 115028317

PGEO:

117444858 117449130(sort1b)

GACU:

117541864(sort1b) 117547530 117559175(si:dkey-159a18.1)

EMAC:

134861952(sort1b) 134879507(si:dkey-159a18.1) 134883100

ELY:	117249476 117256413 117258234(sort1b)

EFO:	125883058(si:dkey-159a18.1) 125891201(sort1b)

PLEP:

121946769(sort1b) 121959136 121963885

SLUC:

116040733(sort1b) 116060117(si:dkey-159a18.1) 116067155

ECRA:

117938443(si:dkey-159a18.1) 117943318 117948380(sort1b)

ESP:	116672763 116688068 116692859(sort1)

PFLV:

114550494 114554875 114558115(sort1)

GAT:	120817890(si:dkey-159a18.1) 120829508(sort1b) 120835216

PPUG:

119211264(si:dkey-159a18.1) 119223339(sort1b) 119229870

AFB:	129099354(sort1b) 129105635 129112450(si:dkey-159a18.1)

CLUM:

117726026(si:dkey-159a18.1) 117734140(sort1b)

PSWI:

130199150(sort1b) 130200766(si:dkey-159a18.1)

CANA:

137791457(si:dkey-159a18.1) 137796817 137799989(sort1b)

CVE:	137876998(si:dkey-159a18.1) 137879558 137889765(sort1b)

MSAM:

119883763 119886509 119905585(sort1b) 119918549(si:dkey-159a18.1)

SCHU:

122867968 122871110(si:dkey-159a18.1) 122882350(sort1b)

EARM:

139283042 139288726(sort1b) 139304950

CUD:	121505461(si:dkey-159a18.1) 121507563 121518004(sort1b)

SPUL:

138589601(sort1b) 138599818

LMIX:

132956275(si:dkey-159a18.1) 132977445 132989912(sort1b)

HTC:	141795968 141798851(sort1b) 141810679

ALAT:

119021683 119022227(sort1b) 119032841(si:dkey-159a18.1)

ASTR:

137589335(si:dkey-159a18.1) 137595167 137613558(sort1b)

PKLU:

139209472(sort1b) 139212843 139221780

MZE:	101465533(si:dkey-159a18.1) 101478643 101483207(sort1b)

ONL:	100696864 100710311(sort1) 109194165

OAU:	116309728(sort1b) 116326398 116335051(si:dkey-159a18.1)

OLA:	101157659 101158853 101169531

OML:	112140788 112153541(si:dkey-159a18.1) 112159473(sort1b)

CSAI:

133424570(si:dkey-159a18.1) 133448799 133457255(sort1b)

XMA:	102219283 102222980 102237523

XCO:	114135539 114141662 114160999

XHE:	116710478 116726314 116736891

PRET:

103459212 103464892 103467174(sort1)

PFOR:

103144340(sort1) 103146243 103151056

PLAI:

106946547 106950083(sort1) 106960118

PMEI:

106917378(sort1) 106918507 106918885

GAF:	122826162(si:dkey-159a18.1) 122829672 122834181 122837069

PPRL:

129358233 129372272(sort1b) 129375645(si:dkey-159a18.1)

CVG:	107083332 107087491(sort1) 107101171

CTUL:

119782151(sort1b) 119789331(si:dkey-159a18.1) 119791816

GMU:	124856989 124868543(sort1b) 124883229(si:dkey-159a18.1)

NFU:	107385578 107385764 107390796(sort1)

KMR:	108233213(si:dkey-159a18.1) 108236843(sort1b) 108246871

ALIM:

106513217(sort1) 106514773 106525759

NWH:	119412617 119417287(sort1b) 119428494(si:dkey-159a18.1)

LTU:	140271371(sort1b) 140282667 140303639

AOCE:

111578146(si:dkey-159a18.1) 111581518(sort1b) 111587439

EJA:	138192890(sort1b) 138202800 138207604

BFRE:

138615370(sort1b) 138627796 138631085

MCEP:

124999850 125004135(sort1b) 125007191

CSEM:

103382662 103384806(sort1) 103386091

POV:	109628899 109630800 109632668

SSEN:

122766103(si:dkey-159a18.1) 122768697 122776997(sort1b)

SSOE:

131456855(si:dkey-159a18.1) 131461357 131468241(sort1b)

HHIP:

117757456(si:dkey-159a18.1) 117761491 117764321(sort1b)

HSP:	118101550(si:dkey-159a18.1) 118104446 118111326(sort1b)

PPLT:

128428654(si:dkey-159a18.1) 128441807(sort1b) 128457502

SMAU:

118309180 118316295(sort1b) 118318769(si:dkey-159a18.1)

LCF:	108876422(sort1b) 108889267(si:dkey-159a18.1) 108889404

SDU:	111218999 111221539 111224697

SLAL:

111656469 111667885 111670663

XGL:	120783042 120797117(si:dkey-159a18.1) 120803842(sort1b)

HCQ:	109510400 109520163 109522482

SSCV:

125977347 125988042(sort1b) 125992033(si:dkey-159a18.1)

SBIA:

133493774(si:dkey-159a18.1) 133507505 133510427(sort1b)

PEE:	133397261(si:dkey-159a18.1) 133406821(sort1b) 133408817

PTAO:

133471857(si:dkey-159a18.1) 133483871 133484878(sort1b)

BPEC:

110161759 110164982(sort1) 110168402

ENY:	140363498 140368168 140375599

MALB:

109956056 109959854 109971296

BSPL:

114855942 114859424(sort1b) 114862661(si:dkey-159a18.1)

SJO:	128356216 128357535(sort1b) 128385101(si:dkey-159a18.1)

SSCO:

133987621(sort1b) 134003940 134004402(si:dkey-159a18.1)

TTY:	137175744(si:dkey-159a18.1) 137181774 137184392(sort1b)

GMH:	115531952 115552381(sort1) 115557379

SASA:

106566365 106572865 106583135 106609576

STRU:

115150672 115165329 115168686 115180367 115199093

OTW:	112233911 112233932 112235433 112254515(sort1a) 112257656

OMY:	110490779 110492692 110499876(si:dkey-159a18.1) 110528030(sort1a) 110531272

OGO:	123994379 124014166 124031356(sort1a) 124032372 124045475

ONE:	115120980 115121390 115124373 115132532

OKI:	109864509 109875708 109878576 109884909 109891068

OKE:	118373560 118377253 118379459 118379993 118400236

OMM:	135503892 135515085(si:dkey-159a18.1) 135515705 135527729 135542016(sort1a)

OCLA:

139368989 139379289 139413468 139416939

SALP:

111970017 112069068 112070422

SNH:	120031844(si:dkey-159a18.1) 120049152 120059027 120061452 120065144

SFON:

129815608(sort1a) 129829507 129838585(si:dkey-159a18.1) 129861316

CCLU:

121537717 121542451 121546140 121555455 121577694

ELS:	105020387 105029199(sort1)

OEP:	134019263(sort1b) 134025456 134037437(si:dkey-159a18.1)

SFM:	108923278 108931371 108933583

PKI:	111834313 111853402 111858921(sort1)

AANG:

118208294 118210913(sort1a) 118231676(si:dkey-159a18.1)

AROT:

135234898 135237558(sort1a) 135258948(si:dkey-159a18.1)

CCOG:

133110429(sort1a) 133135346(si:dkey-159a18.1) 133138852

LOC:	102687967 102693542(sort1)

PSPA:

121299992 121300196 121319022

ARUT:

117414801 117419984(si:dkey-159a18.1) 117427537 117964481

PSEX:

120525888(sort1b) 120534003

LCM:	102345670 102365987(SORT1)

CMK:	103179426 103182556

RTP:	109916673 109926785(sort1a)

CPLA:

122559514 122563138

CPUN:

140458253 140467369(sort1a)

HOC:	132824991 132828370

SCAU:

119954961 119977998

LERI:

129706207 129708949

HAKA:

140717355 140734706

PMRN:

116949436 116952725 116957817(SORT1)

LRJ:	133342559 133356640 133356680

BFO:

BBEL:

CIN:

SCLV:

CLEP:

SPU:

LPIC:

LVG:

AJJ:

APLC:

ARUN:

AAMU:

AFIL:

SKO:

PFLL:

HRO:	HELRODRAFT_116302

LGI:	LOTGIDRAFT_231095

PVUL:

PCAN:

LSAX:

BARL:

BGT:

GAE:

HRF:

HRJ:

HASI:

HCRA:

CRG:

CANU:

MYI:

PMAX:

AIRR:

YBA:

MMER:

RPHI:

DPOL:

MAEA:

OBI:

OSN:	115210579 115210665

LJP:

135470188

LAK:

106167010

SMM:	Smp_179360

OVI:	T265_15239

EGL:

LLON:

NVE:

EPA:

ATEN:

ADF:

AMIL:

MCAZ:

MFOO:

PDAM:

SPIS:

HMG:

HSY:

RES:

AQU:

CCLM:

Reference

PMID:15987945

Authors

Chen ZY, Ieraci A, Teng H, Dall H, Meng CX, Herrera DG, Nykjaer A, Hempstead BL, Lee FS

Title

Sortilin controls intracellular sorting of brain-derived neurotrophic factor to the regulated secretory pathway.

Journal

J Neurosci 25:6156-66 (2005)
DOI:10.1523/JNEUROSCI.1017-05.2005

Sequence

[hsa:6272]

All links

Ontology (3)   
   GO (2)   
   TC (1)   
Gene (837)   
   MGENES (371)   
   RefGene (458)   
   OC (8)   
All databases (840)   

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