KEGG ORTHOLOGY: K12491

ORTHOLOGY: K12491

Entry

K12491                      KO

Symbol

AGAP

Name

Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1/3/4/5/6/9/11

Pathway

map04144

Endocytosis

Brite

KEGG Orthology (KO) [BR:ko00001]
09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K12491  AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1/3/4/5/6/9/11
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K12491  AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1/3/4/5/6/9/11
Membrane trafficking [BR:ko04131]
Endosome - Golgi transport
  Arf GTPases and associated proteins
   Arf GTPase associated proteins
    K12491  AGAP; Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 1/3/4/5/6/9/11

Genes

HSA:	116987(AGAP1) 116988(AGAP3) 119016(AGAP4) 414189(AGAP6) 642517(AGAP9) 729092(AGAP5)

PTR:	100610757 107972947 112204566 112204587 472624(AGAP3) 736391(AGAP11) 738814 744080(AGAP1)

PPS:	100976089(AGAP5) 100979237(AGAP3) 100982385(AGAP1) 117974570 117974584 117974668(AGAP11)

GGO:	101141934 101143406 101144261(AGAP5) 101151336(AGAP3) 101153314(AGAP1) 109024846(AGAP11)

PON:	100443282(AGAP3) 100450509 100454640(AGAP1) 100459535 112135135 112135152

NLE:	100586848 100595310(AGAP3) 100595465(AGAP1) 115830349 115831272 115833813

HMH:	116464301 116809852(AGAP1) 116814543(AGAP3)

MCC:	106992395 693652(AGAP1) 698796 714140(AGAP3) 718978

MCF:	101925511(AGAP3) 102119037 102140657(AGAP1) 102142032

MTHB:

126932606 126951574 126962601

MNI:	105473862(AGAP1) 105474909(AGAP3) 112429224

CSAB:

103215806 103215858 103218136(AGAP1) 103227243(AGAP3) 103247696

CATY:

105578345(AGAP1) 105584743(AGAP3) 105591413 105591463 105593664 105593706(AGAP11)

PANU:

101000696(AGAP3) 101006217 101016116(AGAP1) 103881574

TGE:	112620836(AGAP3) 112631319 112636057(AGAP1)

MLEU:

105534359 105539828(AGAP1) 105542699(AGAP3) 105547387 105547390

RRO:	104653681 104663265(AGAP1) 104675410(AGAP3) 104680729

RBB:	108523020 108524861 108532534(AGAP3) 108540973(AGAP1) 108541896

TFN:	117072833(AGAP3) 117082369 117088191 117094346(AGAP1)

PTEH:

111551486(AGAP3) 111551970 111553752(AGAP1)

CANG:

105502924(AGAP1) 105511331(AGAP3) 105517741

CJC:	100404056(AGAP1) 100409036(AGAP3)

SBQ:	101039065(AGAP3) 101050142(AGAP1)

CIMI:

108297602(AGAP3) 108310654(AGAP1)

CSYR:

103251238 103256961(AGAP1) 103275290(AGAP3)

MMUR:

105865694(AGAP1) 105883180(AGAP3)

LCAT:

123644160(AGAP1) 123647510(AGAP3)

PCOQ:

105813995(AGAP1) 105824600(AGAP3)

OGA:	100948134(AGAP1) 100953680(AGAP3)

MMU:	213990(Agap3) 347722(Agap1)

MCAL:

110292849(Agap1) 110293877(Agap3)

MPAH:

110315931(Agap3) 110321305(Agap1)

RNO:	316611(Agap1) 362300(Agap3)

MCOC:

116088745(Agap1) 116097552(Agap3)

ANU:	117721026(Agap3) 117722531(Agap1)

MUN:	110556558(Agap1) 110562555(Agap3)

CGE:	100769383(Agap3) 100770318(Agap1)

MAUA:

101835127(Agap3) 101839678(Agap1)

PROB:

127226676(Agap1) 127235791(Agap3)

PLEU:

114700079(Agap3) 114700698(Agap1)

MORG:

121439955(Agap3) 121447185(Agap1)

MFOT:

126489415 126514300

AAMP:

119808246(Agap3) 119820692(Agap1)

NGI:	103726204(Agap1) 103745368(Agap3)

HGL:	101706435(Agap3) 101714494(Agap1)

CPOC:

100713648(Agap3) 100730105(Agap1)

CCAN:

109684653 109694439(Agap3)

DORD:

105990785(Agap1) 105993872(Agap3)

DSP:	122105916(Agap3) 122107218(Agap1)

PLOP:

125347319(Agap3) 125350157(Agap1)

NCAR:

124978999 124990342

OCU:	100344961 100351262 127493716

OPI:	101518169(AGAP3) 101534587(AGAP1)

TUP:	102499505(AGAP1) 102500019(AGAP3)

GVR:	103585098(AGAP3) 103592031(AGAP1)

CFA:	100688009(AGAP3) 606892(AGAP1)

CLUD:

112663628(AGAP3) 112669948(AGAP1)

VVP:	112916209(AGAP3) 112925477(AGAP1)

VLG:	121489307(AGAP3) 121497199(AGAP1)

NPO:	129515826(AGAP3) 129523373(AGAP1)

AML:	100466971(AGAP3) 100484869(AGAP1)

UMR:	103660951(AGAP3) 103662834(AGAP1)

UAH:	113241482(AGAP3) 113250312(AGAP1)

UAR:	123788770(AGAP3) 123790037(AGAP1)

ELK:	111154323 111157513

LLV:	125081329 125095253

MPUF:

101678666(AGAP1) 101680320(AGAP3)

NVS:	122902442(AGAP1) 122905205(AGAP3)

ORO:	101368422(AGAP1) 101385421(AGAP3)

EJU:	114198009(AGAP3) 114198010 114210884(AGAP1)

ZCA:	113911610(AGAP3) 113919511(AGAP1)

MLX:	118011914(AGAP1) 118026804(AGAP3)

NSU:	110570947(AGAP1) 110582981(AGAP3)

LWW:	102740558(AGAP3) 115937432

FCA:	101080564(AGAP1) 101082390(AGAP3)

PYU:	121014386(AGAP1) 121022886(AGAP3)

PCOO:

112866507(AGAP3) 112867554(AGAP1)

PBG:	122481946(AGAP1) 122488535(AGAP3)

LRUF:

124516378 124524283

PTG:	102948546(AGAP1) 102968392(AGAP3)

PPAD:

109252380(AGAP3) 109264859(AGAP1)

PUC:	125911029 125930499

AJU:	106968421 106969573

HHV:	120229524(AGAP1) 120230911(AGAP3)

BTA:	522241(AGAP1) 616302(AGAP3)

BOM:	102265478 102268106(AGAP3) 102277707(AGAP1)

BIU:	109556931(AGAP1) 109558038(AGAP3)

BBUB:

102392889(AGAP1) 102415445(AGAP3)

BBIS:

105001102(AGAP3) 105004447(AGAP1)

CHX:	102174535(AGAP1) 102187027(AGAP3)

OAS:	101111683(AGAP1) 101113584(AGAP3)

BTAX:

128045821(AGAP1) 128046424(AGAP3)

ODA:	120856484(AGAP1) 120877886(AGAP3)

CCAD:

122437285(AGAP1) 122438872(AGAP3)

SSC:	100620812(AGAP1) 100625238(AGAP3)

CFR:	102509453(AGAP3) 102521211(AGAP1)

CBAI:

105063620(AGAP1) 105067036(AGAP3)

CDK:	105085546(AGAP1) 105098675(AGAP3)

VPC:	102528449(AGAP3) 102538167(AGAP1)

BACU:

102997337(AGAP3) 103014392(AGAP1)

LVE:	103081532(AGAP1) 103083187(AGAP3)

OOR:	101274062(AGAP3) 101275474(AGAP1)

DLE:	111171962(AGAP1) 111176752(AGAP3)

PCAD:

102988499(AGAP3) 102992226

PSIU:

116756577(AGAP1) 116759462(AGAP3)

NASI:

112404706(AGAP1) 112405906(AGAP3)

ECB:	100064153(AGAP3) 100065931(AGAP1)

EPZ:	103540836(AGAP1) 103564175(AGAP3) 103564939

EAI:	106823326(AGAP3) 106844867(AGAP1)

MYB:	102252647(AGAP3) 102258341(AGAP1)

MYD:	102756492(AGAP3) 102774854(AGAP1)

MMYO:

118661100(AGAP1) 118679395(AGAP3)

MLF:	102417230(AGAP1) 102430776(AGAP3)

MNA:	107524903(AGAP3) 107541569

PKL:	118704766(AGAP3) 118709012(AGAP1)

HAI:	109374043(AGAP1) 109389644(AGAP3)

DRO:	112308081(AGAP1) 112308271(AGAP3)

SHON:

118975542(AGAP3) 119003108(AGAP1)

AJM:	119039228(AGAP3) 119042366 119061042(AGAP1)

PDIC:

114494610(AGAP1) 114507588(AGAP3)

PHAS:

123817943(AGAP3) 123823209(AGAP1)

MMF:	118620109(AGAP3) 118625477(AGAP1)

RFQ:	117018037(AGAP3) 117025670(AGAP1)

PALE:

102880579(AGAP1) 102891079(AGAP3)

PGIG:

120600635 120601499(AGAP3)

PVP:	105303757(AGAP3)

RAY:	107517811(AGAP1) 107520292 107520308(AGAP3)

MJV:	108391847(AGAP3) 108395395

TOD:	119248896(AGAP3) 119255228(AGAP1)

SARA:

101558385(AGAP3) 101558605(AGAP1)

LAV:	100656618(AGAP1) 100670042(AGAP3)

TMU:	101343131 101347146

ETF:	101646037(AGAP3) 101661492(AGAP1)

DNM:

111764096

MDO:	100018281(AGAP3)

GAS:	123250516(AGAP3)

SHR:	100916663(AGAP3) 100919606(AGAP1)

AFZ:	127539035 127562971

PCW:	110199895(AGAP1) 110201941(AGAP3)

OAA:	100077669(AGAP1) 100089203(AGAP2) 103165920(AGAP3)

GGA:	424024(AGAP1) 768507(AGAP3)

PCOC:

116236035(AGAP1) 116242829(AGAP3)

MGP:	100544373 100548342(AGAP1)

CJO:	107308709(AGAP3) 107316379(AGAP1)

TPAI:

128077147(AGAP1) 128087179(AGAP3)

NMEL:

110390698(AGAP3) 110400393(AGAP1)

APLA:

101790473(AGAP3) 101799120

ACYG:

106034477(AGAP1) 106045950(AGAP3)

AFUL:

116486146(AGAP3) 116490752(AGAP1)

TGU:	100217852(AGAP3) 100223100(AGAP1)

LSR:	110473512(AGAP1) 110475105(AGAP3)

SCAN:

103814765(AGAP1) 103824489(AGAP3)

PMOA:

120499642(AGAP1) 120510556(AGAP3)

OTC:	121333305(AGAP1) 121334874(AGAP3)

PRUF:

121351781(AGAP1) 121355534(AGAP3)

GFR:	102033236(AGAP1) 102034761(AGAP3)

FAB:	101808539(AGAP1) 101811508(AGAP3)

PHI:	102108476(AGAP1) 102111482(AGAP3)

PMAJ:

107199985(AGAP3) 107207259(AGAP1)

CCAE:

111925500 111931849(AGAP1)

CCW:	104684257(AGAP3) 104694562(AGAP1)

CBRC:

103617021(AGAP3) 103621876(AGAP1)

ETL:	114068001(AGAP3) 114069982

ZAB:

102063444

ACHL:

103801031

SVG:	106861802(AGAP3) 106861982(AGAP1)

FPG:	101912836(AGAP3) 101923201(AGAP1)

FCH:	102048420(AGAP1) 102058562(AGAP3)

CLV:	102086060 102091913(AGAP1)

EGZ:	104123241(AGAP1) 104127869(AGAP3)

NNI:	104010008(AGAP1) 104011536(AGAP3)

PCAO:

104041620

ACUN:

113477520(AGAP3) 113481995(AGAP1)

TALA:

104358639(AGAP1) 104368149(AGAP3)

PADL:

103914171(AGAP1) 103922138(AGAP3)

AFOR:

103897138(AGAP3) 103903829(AGAP1)

ACHC:

115339044(AGAP3) 115342496(AGAP1)

HALD:

104318221(AGAP1)

HLE:	104829425(AGAP3) 104838258(AGAP1)

AGEN:

126037690 126038419

GCL:	127012533 127018643

OHA:	104327537(AGAP1) 104332981(AGAP3)

NNT:	104402576(AGAP3)

SHAB:

115608058(AGAP1) 115610205(AGAP3)

DPUB:

104298510(AGAP3) 104300531(AGAP1)

PGUU:

104462849

CPEA:

104389090 104397792(AGAP1)

AVIT:

104278268

CVF:	104288712(AGAP1) 104290113(AGAP3)

CUCA:

104061725(AGAP3) 104067375(AGAP1)

AAM:

106484430

AROW:

112976170 112976245(AGAP1)

NPD:	112953399 112954279(AGAP1)

DNE:	112985790(AGAP1)

SCAM:

104141274(AGAP3) 104151165(AGAP1)

ASN:	102382091(AGAP1) 102382693(AGAP3)

AMJ:	102570866(AGAP3) 102576502(AGAP1)

CPOO:

109305642 109322688(AGAP1)

GGN:	109301951(AGAP1)

PSS:	102460119(AGAP1)

CMY:	102929673(AGAP1) 102940633(AGAP3)

CPIC:

101953785(AGAP3) 101953895(AGAP1)

TST:	117871963(AGAP3) 117884791(AGAP1)

CABI:

116834492(AGAP3) 116836451(AGAP1)

MRV:	120374425(AGAP1) 120397573(AGAP3)

ACS:	100552442(agap1)

PVT:	110082564(AGAP3) 110083702 110086103

SUND:

121930650(AGAP1) 121933022(AGAP3)

PBI:	103056152 103063382(AGAP3)

PMUR:

107297807(AGAP3)

CTIG:

120318306(AGAP3)

TSR:	106550753(AGAP3)

PGUT:

117669210(AGAP3) 117671094(AGAP1)

PTEX:

113441055(AGAP1)

NSS:	113419556(AGAP1)

VKO:	123019563(AGAP3) 123024272(AGAP1)

PMUA:

114582028(AGAP1) 114607270(AGAP3)

ZVI:	118092269(AGAP3) 118096856(AGAP1)

HCG:	128329349(AGAP3) 128339374(AGAP1)

GJA:	107108223(AGAP3) 107123193

STOW:

125434760(AGAP1) 125440704

XLA:	108703035 108704618 108719636 431967(agap1.L)

XTR:	100485248(agap1) 101735127(agap3)

NPR:	108788511(AGAP1) 108803603

RTEM:

120941766 120943892(AGAP1)

BBUF:

121000964(AGAP3) 121008955(AGAP1)

BGAR:

122922323 122944695(AGAP1)

DRE:	100148154(agap1) 324332(agap3)

SRX:	107709574 107717265 107732092(agap3) 107748916

SANH:

107663355 107677248(agap3) 107677621 107688827 107690985

SGH:	107555304 107562224 107586321 107596328 107599726

CCAR:

109050039 109096555 109105236

CAUA:

113050743 113092649 113096730

CGIB:

127946369 127959696 128013181 128015437

PTET:

122329607(agap3) 122346737(agap1) 122346782

LROH:

127155421(agap3) 127166515(agap1)

PPRM:

120466997(agap1) 120486083 120488161(agap3)

MAMB:

125257975(agap3) 125274263(agap1)

CIDE:

127505922 127513893

MASI:

127432158 127434114 127445734 127449219

IPU:	108264036 108272907(agap1)

PHYP:

113533844(agap3) 113538377(agap1)

SMEO:

124383291(agap1) 124384054(agap3)

TFD:	113634417(agap1) 113659040(agap3)

AMEX:

103021555(agap3) 103044997(agap1)

CMAO:

118807736(agap1) 118822696(agap3)

EEE:	113574006(agap1) 113583773

TRU:	101068094 101077181

TNG:	GSTEN00009195G001 GSTEN00016165G001

LCO:	104917672(agap3) 104935717

NCC:	104944179(agap3)

CGOB:

115017239(agap1) 115023093(agap3)

ELY:	117250234 117271557(agap3)

EFO:	125884807(agap1) 125902507(agap3)

PLEP:

121951995(agap3)

SLUC:

116044455(agap1) 116045988(agap3)

ECRA:

117954571(agap3)

ESP:	116698553(agap3)

PFLV:

114550879(agap1) 114564937

GAT:	120815586 120815587

PPUG:

119205201(agap3) 119219648(agap1)

MSAM:

119896928(agap1) 119902002(agap3)

SCHU:

122871891(agap1) 122887514(agap3)

CUD:	121506339(agap1) 121519555(agap3)

ALAT:

119010933(agap3) 119015209(agap1)

MZE:	101466495(agap3) 101478076

ONL:	100699975(agap3) 100708930

OAU:	116318729(agap3) 116320476(agap1)

OLA:	101165954 101174700(agap3)

OML:	112147159(agap3) 112156744(agap1)

XMA:	102234049 102235584

XCO:	114140524 114147241

XHE:	116715645 116722055(agap3)

PRET:

103456779 103479692(agap3)

PFOR:

103135768(agap3) 103150926(agap1)

PLAI:

106950367 106963472

PMEI:

106924461(agap1) 106930559(agap3)

GAF:	122826964(agap1) 122840752(agap3)

CVG:	107096020 107101700

CTUL:

119795358(agap1) 119796999(agap3)

GMU:	124861409(agap1) 124869424(agap3)

NFU:	107383869 107384564

KMR:	108229328 108241672(agap3) 108251224

ALIM:

106517616 106533574(agap3)

NWH:	119415163(agap3) 119428996

AOCE:

111568621(agap3) 111584937

MCEP:

125000643(agap1) 125010316(agap3)

CSEM:

103389825 103396318(agap3)

POV:

109647667

SSEN:

122758287(agap1) 122786885(agap3)

HHIP:

117777501 117778018(agap3)

HSP:	118103502(agap1) 118117408(agap3)

LCF:	108873194 108883369

SDU:	111230953(agap3) 111235540(agap1)

SLAL:

111646881(agap1) 111653298

XGL:	120798019(agap1) 120798688(agap3)

HCQ:	109521264 109528479

SSCV:

125985330 125989490

BPEC:

110159619 110170680

MALB:

109955612 109957777(agap3)

BSPL:

114844790(agap3) 114845618(agap1)

SASA:

106569352 106575763 106599824

STRU:

115157183 115169596 115179814 115196446

OTW:	112226803 112260627

OMY:	110508590 110527298 110528752 110530474

OGO:	124009166 124024201 124026107 124041748

ONE:	115102958 115114558

SALP:

111956608 111978956

SNH:	120020277 120051388(agap1) 120055970

CCLU:

121535350 121537935 121575656(agap1) 121581035

ELS:	105019589(agap3) 105023125

SFM:	108918896(agap1) 108937662(agap3)

PKI:	111845842 111850201

AANG:

118214390(agap1) 118233814(agap3)

LOC:	102682579 102698967(agap1)

PSPA:

121312828 121314324 121322443 121322894

ARUT:

117400573 117409584 117427180 117435284(agap3)

PSEX:

120529443(agap3) 120530702(agap1)

LCM:	102347078(AGAP3) 102349459(AGAP1) 102358531

CMK:	103186690(agap1) 103189572 103190004

RTP:	109926116 109931729 109934102

CPLA:

122543279 122548781(agap3) 122551409(agap1)

BFO:

BBEL:

CIN:

SCLV:

SPU:

APLC:

AJC:

SKO:

DME:	Dmel_CG31811(CenG1A)

DER:

6540778

DSE:

6611217

DSI:	Dsimw501_GD23935(Dsim_GD23935)

DYA:	Dyak_GE18693

DAN:

DSR:

DPO:

DPE:

DMN:

DWI:

DGR:

DMO:	Dmoj_GI12625

DAZ:

DNV:

DHE:

DVI:

CCAT:

BOD:

RZE:	108356312 108357919

MDE:

SCAC:

LCQ:

LSQ:

HIS:

AGA:	AgaP_AGAP009160

ACOZ:

AARA:

AMER:

ASTE:

AALI:

AAG:

AALB:

109410812 109421249 115253743

CQU:	CpipJ_CPIJ015091

CPII:

CNS:

BCOO:

AME:

ALAB:

BIM:

BBIF:

BVK:

BVAN:

BTER:

BPYO:

CCAL:

OBB:

MGEN:

NMEA:

CGIG:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

FEX:

LHU:

PGC:

OBO:

PCF:

PFUC:

VPS:

LHT:

LBD:

MDL:

CGLO:

FAS:

DAM:

AGIF:

CINS:

CCIN:

TCA:

DPA:

SOY:

AGRG:

CSET:

AGB:

LDC:

NVL:

APLN:

PPYR:

OTU:

BMOR:

BMAN:

MSEX:

DPL:	KGM_205567

BANY:

NIQ:

PMAC:

PPOT:

PXU:

PRAP:

PBX:

PNAP:

ZCE:

CCRC:

HAW:

HZE:

TNL:

SLIU:

OFU:

PXY:

CFEL:

API:

DNX:

AGS:

RMD:

BTAB:

DCI:

CLEC:

HHAL:

NLU:

PHU:	Phum_PHUM522550

FOC:

TPAL:

ZNE:

CSEC:

SGRE:

FCD:

DPX:	DAPPUDRAFT_44591

DMK:

PVM:

PJA:

PCHN:

PMOO:

HAME:

PCLA:

PTRU:

ESN:

HAZT:

EAF:	111703330 111714448 111715451

LSM:

121118807

PPOI:

119111829

ISC:	IscW_ISCW014072

DSV:

RSAN:

RMP:

VDE:

VJA:

TUT:

DPTE:

DFR:

CSCU:

PTEP:

SDM:

LPOL:

106457348 106462048 106465525 106474252

PMEO:

129583484

CEL:	CELE_Y39A1A.15(cnt-2)

CBR:	CBG_18339(Cbr-cnt-2)

LOA:	LOAG_10171

TSP:	Tsp_07531 Tsp_12499

HRO:	HELRODRAFT_109375 HELRODRAFT_110061 HELRODRAFT_180559

LGI:	LOTGIDRAFT_128465

PCAN:

BGT:

GAE:

HRF:

HRJ:

CRG:

MYI:

PMAX:

MMER:

OBI:

OSN:

LAK:

SMM:	Smp_052420 Smp_198010

OVI:	T265_09322 T265_12983

EGL:

NVE:

EPA:

ATEN:

ADF:

AMIL:

PDAM:

SPIS:

DGT:

XEN:

HMG:

TAD:	TRIADDRAFT_21576

AQU:

100634243

ACAN:

ACA1_090060

» show all

Reference

PMID:12640130

Authors

Xia C, Ma W, Stafford LJ, Liu C, Gong L, Martin JF, Liu M

Title

GGAPs, a new family of bifunctional GTP-binding and GTPase-activating proteins.

Journal

Mol Cell Biol 23:2476-88 (2003)
DOI:10.1128/MCB.23.7.2476-2488.2003

Sequence

[hsa:116987]

All links

Ontology (2)   
   KEGG BRITE (2)   
Pathway (2)   
   KEGG PATHWAY (2)   
Gene (3637)   
   KEGG GENES (928)   
   KEGG MGENES (373)   
   RefGene (2322)   
   OC (14)   
Literature (1)   
   PubMed (1)   
All databases (3642)   

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