KEGG   ORTHOLOGY: K12646Help
Entry
K12646                      KO                                     

Name
DDX58, RIG-I
Definition
ATP-dependent RNA helicase DDX58 [EC:3.6.3.14]
Pathway
ko04064  NF-kappa B signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04623  Cytosolic DNA-sensing pathway
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05164  Influenza A
ko05168  Herpes simplex infection
ko05169  Epstein-Barr virus infection
Disease
H01571  Singleton-Merten syndrome (SMS)
Brite
KEGG Orthology (KO) [BR:ko00001]
 Environmental Information Processing
  Signal transduction
   04064 NF-kappa B signaling pathway
    K12646  DDX58, RIG-I; ATP-dependent RNA helicase DDX58
 Organismal Systems
  Immune system
   04622 RIG-I-like receptor signaling pathway
    K12646  DDX58, RIG-I; ATP-dependent RNA helicase DDX58
   04623 Cytosolic DNA-sensing pathway
    K12646  DDX58, RIG-I; ATP-dependent RNA helicase DDX58
 Human Diseases
  Infectious diseases
   05162 Measles
    K12646  DDX58, RIG-I; ATP-dependent RNA helicase DDX58
   05164 Influenza A
    K12646  DDX58, RIG-I; ATP-dependent RNA helicase DDX58
   05161 Hepatitis B
    K12646  DDX58, RIG-I; ATP-dependent RNA helicase DDX58
   05160 Hepatitis C
    K12646  DDX58, RIG-I; ATP-dependent RNA helicase DDX58
   05168 Herpes simplex infection
    K12646  DDX58, RIG-I; ATP-dependent RNA helicase DDX58
   05169 Epstein-Barr virus infection
    K12646  DDX58, RIG-I; ATP-dependent RNA helicase DDX58
Enzymes [BR:ko01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.3  Acting on acid anhydrides to catalyse transmembrane movement of substances
    3.6.3.14  H+-transporting two-sector ATPase
     K12646  DDX58, RIG-I; ATP-dependent RNA helicase DDX58
Pattern recognition receptors [BR:ko04054]
 Cytoplasmic pattern recognition receptors
  RIG-I-like receptors
   K12646  DDX58, RIG-I; ATP-dependent RNA helicase DDX58
BRITE hierarchy
Genes
HSA: 23586(DDX58)
PTR: 465035(DDX58)
PPS: 100967985(DDX58)
GGO: 101135326(DDX58)
PON: 100443290(DDX58)
NLE: 100606548(DDX58)
MCC: 704638(DDX58)
MCF: 102141351(DDX58)
CSAB: 103219311(DDX58)
RRO: 104655060(DDX58)
RBB: 108529797(DDX58)
CJC: 100408692(DDX58)
SBQ: 101044233(DDX58)
MMU: 230073(Ddx58)
RNO: 297989(Ddx58)
CGE: 100766319(Ddx58)
NGI: 103748447(Ddx58)
HGL: 101717131(Ddx58)
CCAN: 109683803(Ddx58)
OCU: 100347707(DDX58)
CFA: 100855560(DDX58)
AML: 100469453(DDX58)
UMR: 103667020(DDX58)
ORO: 101383901(DDX58)
FCA: 101095926(DDX58)
PTG: 102953066(DDX58)
AJU: 106976066(DDX58)
BTA: 504760(DDX58)
BOM: 102280551(DDX58)
BIU: 109562815(DDX58)
PHD: 102335349(DDX58)
CHX: 102183788(DDX58)
OAS: 101107257(DDX58)
SSC: 396723(DDX58)
CFR: 102524392(DDX58)
CDK: 105085563(DDX58)
BACU: 103020032(DDX58)
LVE: 103089123(DDX58)
OOR: 101277446(DDX58)
ECB: 100067920(DDX58)
EPZ: 103550256(DDX58)
EAI: 106841474(DDX58)
MYB: 102242345 102244773(DDX58)
MYD: 102751776(DDX58)
HAI: 109371521(DDX58)
RSS: 109448578(DDX58)
PALE: 102881037(DDX58)
LAV: 100661613(DDX58)
TMU: 101340796
OAA: 100078060(DDX58)
APLA: 101789567(DDX58)
ACYG: 106040220(DDX58)
TGU: 100222705(DDX58)
GFR: 102040159(DDX58)
FAB: 101809434(DDX58)
PHI: 102107316(DDX58)
PMAJ: 107216072(DDX58)
CCW: 104689783(DDX58)
FPG: 101917977(DDX58)
FCH: 102047325(DDX58)
CLV: 102098789(DDX58)
EGZ: 104135075(DDX58)
AAM: 106486905(DDX58)
ASN: 102388849(DDX58)
AMJ: 102565282(DDX58)
PSS: 102452744(DDX58)
CMY: 102936061(DDX58)
CPIC: 101952584(DDX58)
ACS: 100565793(ddx58)
PVT: 110084585(DDX58)
PBI: 103062221(DDX58)
GJA: 107113238(DDX58)
XLA: 108713708
XTR: 100495207(ddx58)
NPR: 108785404(DDX58)
DRE: 100333797(ddx58)
SRX: 107737973(ddx58)
SANH: 107673161 107702171(ddx58)
SGH: 107570187(ddx58)
IPU: 101154681(ddx58)
AMEX: 103047126(ddx58)
SASA: 100302577(ddx58)
ELS: 105006239
SFM: 108926073(ddx58)
LCM: 102361129(DDX58)
CMK: 103187211(ddx58)
SKO: 102805200
CEL: CELE_D2005.5(drh-3)
CBR: CBG08270(Cbr-drh-3)
BMY: Bm1_50735
OBI: 106868709
EPA: 110244496
ADF: 107341930
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Yoneyama M, Kikuchi M, Natsukawa T, Shinobu N, Imaizumi T, Miyagishi M, Taira K, Akira S, Fujita T
  Title
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses.
  Journal
Nat Immunol 5:730-7 (2004)
DOI:10.1038/ni1087

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