KEGG   ORTHOLOGY: K13289Help
Entry
K13289                      KO                                     

Name
CTSA, CPY
Definition
cathepsin A (carboxypeptidase C) [EC:3.4.16.5]
Pathway
ko04142  Lysosome
ko04614  Renin-angiotensin system
Disease
H00276  Galactosialidosis
H00422  Glycoproteinoses
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09141 Transport and catabolism
   04142 Lysosome
    K13289  CTSA, CPY; cathepsin A (carboxypeptidase C)
 09150 Organismal Systems
  09152 Endocrine system
   04614 Renin-angiotensin system
    K13289  CTSA, CPY; cathepsin A (carboxypeptidase C)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases
    K13289  CTSA, CPY; cathepsin A (carboxypeptidase C)
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts
    K13289  CTSA, CPY; cathepsin A (carboxypeptidase C)
   04131 Membrane trafficking
    K13289  CTSA, CPY; cathepsin A (carboxypeptidase C)
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K13289  CTSA, CPY; cathepsin A (carboxypeptidase C)
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.16  Serine-type carboxypeptidases
    3.4.16.5  carboxypeptidase C
     K13289  CTSA, CPY; cathepsin A (carboxypeptidase C)
Peptidases [BR:ko01002]
 Serine Peptidases
  Family S10
   K13289  CTSA, CPY; cathepsin A (carboxypeptidase C)
Chaperones and folding catalysts [BR:ko03110]
 Intramolecular chaperones
  Other peptidases
   K13289  CTSA, CPY; cathepsin A (carboxypeptidase C)
Membrane trafficking [BR:ko04131]
 Autophagy
  Chaperone mediated autophagy (CMA)
   Other CMA associated proteins
    K13289  CTSA, CPY; cathepsin A (carboxypeptidase C)
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of other body fluids (saliva and urine)
   K13289  CTSA, CPY; cathepsin A (carboxypeptidase C)
BRITE hierarchy
Other DBs
COG: COG2939
GO: 0004185
Genes
HSA: 5476(CTSA)
PTR: 458290(CTSA)
PPS: 100969338(CTSA)
GGO: 101150972(CTSA)
PON: 100173381(CTSA)
NLE: 100584301(CTSA)
MCC: 708592(CTSA)
MCF: 101866185(CTSA)
CSAB: 103245139(CTSA)
RRO: 104678820(CTSA)
RBB: 108533329(CTSA)
CJC: 100413773(CTSA)
SBQ: 101033824(CTSA)
MMU: 19025(Ctsa)
RNO: 296370(Ctsa)
CGE: 100772055(Ctsa)
NGI: 103737935(Ctsa)
HGL: 101720484(Ctsa)
CCAN: 109689272(Ctsa)
OCU: 100339600(CTSA)
TUP: 102485953(CTSA) 102488508
CFA: 611146(CTSA)
AML: 100474665(CTSA)
UMR: 103669857(CTSA)
ORO: 101379146(CTSA)
FCA: 101085538
PTG: 102958713(CTSA)
AJU: 106969007(CTSA)
BTA: 518169(CTSA)
BOM: 102280027(CTSA)
BIU: 109567503(CTSA)
PHD: 102322563(CTSA)
CHX: 102182324(CTSA)
OAS: 101113615(CTSA)
SSC: 100156798(CTSA)
CFR: 102508708(CTSA)
CDK: 105087842(CTSA)
BACU: 103017862(CTSA)
LVE: 103087262(CTSA)
OOR: 101276848(CTSA)
ECB: 100071127(CTSA)
EPZ: 103551923(CTSA)
EAI: 106843038(CTSA)
MYB: 102259776(CTSA)
MYD: 102766118(CTSA)
HAI: 109379946(CTSA)
RSS: 109457055(CTSA)
PALE: 102888117(CTSA)
LAV: 100665041(CTSA) 100676352
TMU: 101347053
MDO: 100022069(CTSA) 100024941
SHR: 100915300 100933780(CTSA)
OAA: 100076065(CTSA)
GGA: 428163(CTSA)
MGP: 100547907(CTSA)
CJO: 107323140(CTSA)
APLA: 101801880(CTSA)
ACYG: 106047180(CTSA)
TGU: 100220062(CTSA)
GFR: 102038566(CTSA)
FAB: 101812393(CTSA)
PHI: 102113628(CTSA)
PMAJ: 107213227(CTSA)
CCW: 104687726(CTSA)
FPG: 101912460(CTSA)
FCH: 102045880(CTSA)
CLV: 102087924(CTSA)
EGZ: 104127960(CTSA)
AAM: 106497597(CTSA)
ASN: 102368270 102373938(CTSA)
AMJ: 102564952(CTSA) 102572879
PSS: 102460692(CTSA)
CMY: 102942772(CTSA)
CPIC: 101938768(CTSA)
ACS: 100559820 100561404(ctsa)
PVT: 110086236(CTSA)
PBI: 103049522(CTSA)
GJA: 107111356(CTSA)
XLA: 494810(ctsa.L)
XTR: 734066(ctsa)
NPR: 108793373(CTSA)
DRE: 321818(ctsa) 792966(si:ch211-122f10.4)
SRX: 107744356
SANH: 107666023
SGH: 107560512
CCAR: 109052126(ctsa)
IPU: 108271760(ctsa)
AMEX: 103035030(ctsa)
TRU: 101066746(ctsa) 101077421
LCO: 104927289 104933133(ctsa)
NCC: 104945215
MZE: 101480742 101482934(ctsa)
OLA: 101168356 101173697(ctsa)
XMA: 102229123 102234395(ctsa)
PRET: 103460358(ctsa)
NFU: 107384873(ctsa)
CSEM: 103386821(ctsa)
LCF: 108890718(ctsa)
HCQ: 109522647(ctsa)
BPEC: 110175414(ctsa)
ELS: 105016705(ctsa)
SFM: 108936511(ctsa)
LCM: 102354641(CTSA) 102367606
CMK: 103191463(ctsa)
APLC: 110988405
SKO: 100370840
TUT: 107366517
CEL: CELE_F13D12.6(F13D12.6) CELE_F41C3.5(F41C3.5) CELE_Y16B4A.2(Y16B4A.2) CELE_Y40D12A.2(ctsa-2)
BMY: Bm1_43130
MYI: 110453620
OBI: 106874211
LAK: 106171672
SCE: YBR139W YMR297W(PRC1)
NCS: NCAS_0F02120(NCAS0F02120) NCAS_0I02290(NCAS0I02290)
NDI: NDAI_0A06870(NDAI0A06870) NDAI_0C03670(NDAI0C03670)
TPF: TPHA_0A05520(TPHA0A05520)
TBL: TBLA_0C06920(TBLA0C06920)
TDL: TDEL_0G00500(TDEL0G00500)
KAF: KAFR_0I02520(KAFR0I02520)
SLB: AWJ20_4686(PRC1)
NCR: NCU00477
NTE: NEUTE1DRAFT82484(NEUTE1DRAFT_82484)
MGR: MGG_05663
MAW: MAC_06140
MAJ: MAA_05766
CMT: CCM_05858
BFU: BCIN_10g04320(Bccp4)
MBE: MBM_01234
ANI: AN5442.2
ANG: ANI_1_1208074(An08g08750) ANI_1_238044(An05g01870)
SPO: SPAC19G12.10c(cpy1)
LBC: LACBIDRAFT_189535(LbPR_S3) LACBIDRAFT_295014(LbPR_S2)
MGL: MGL_0285
LLO: LLO_1568
 » show all
TaxonomyKoalaUniProt
Reference
PMID:3028649
  Authors
Valls LA, Hunter CP, Rothman JH, Stevens TH
  Title
Protein sorting in yeast: the localization determinant of yeast vacuolar carboxypeptidase Y resides in the propeptide.
  Journal
Cell 48:887-97 (1987)
DOI:10.1016/0092-8674(87)90085-7
  Sequence
[sce:YMR297W]
Reference
  Authors
Hiraiwa M
  Title
Cathepsin A/protective protein: an unusual lysosomal multifunctional protein.
  Journal
Cell Mol Life Sci 56:894-907 (1999)
DOI:10.1007/s000180050482
Reference
  Authors
Wang D, Zaitsev S, Taylor G, d'Azzo A, Bonten E
  Title
Protective protein/cathepsin A rescues N-glycosylation defects in neuraminidase-1.
  Journal
Biochim Biophys Acta 1790:275-82 (2009)
DOI:10.1016/j.bbagen.2009.01.006

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